vishal bodke - Academia.edu (original) (raw)
Papers by vishal bodke
International Journal of Pharmacy and Pharmaceutical Sciences, Apr 1, 2024
The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through t... more The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.
International Journal of Pharmacy and Pharmaceutical Sciences, May 1, 2024
Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tw... more Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tween 80 as a surfactant and propylene glycol as a co-surfactant. Formulation of such drugs in nanoparticulate drug delivery will be advantageous for reducing dosing frequency, longer residence time, improved permeation, and patient compliance. Methods: High-speed homogenization method. The smilax china oil was prepared by collecting the extract of smilax china leaves into the coconut oil and then used as a solvent. The authentication studies of smilax china and coconut oil were evaluated for their organoleptic and physicochemical characteristics. The quantitative estimation and pre-formulation study of quercetin was carried out which has major anti-psoriatic properties. Surfactant and co-surfactant were selected and the solubility studies of oil and Surfactants were done. The nanoemulsion was characterized by particle size, polydispersity index, zeta potential, and entrapment efficiency (%). Results: This nanoemulsion provides the particle size and entrapment efficiency range between 80.52 to 89.78 nm and 68.66 to 70.16 % respectively. Batch SC1 showed the lowest particle size, PDI, and optimized drug entrapment effectiveness (%), indicating good particle size consistency within the remaining formulation batches. The optimized formulation SC 1 was found to be stable for 90 d. Conclusion: The formulated nanoemulsion showed significant antipsoriasis activity due to the presence of quercetin which has a rhetorical yield of 1.066 mg per 5 gm powder of smilax china leaves. Formulated smilax china-loaded nanoemulsion, has the potential as an effective antipsoriasis agent with a good spreading property with faster absorption which is beneficial for reducing drug concentration with maximum therapeutic effect.
International Journal of Pharmacy and Pharmaceutical Sciences, May 1, 2024
In recent years, there has been a rise in interest in the development of novel drug delivery syst... more In recent years, there has been a rise in interest in the development of novel drug delivery systems that utilize nanoparticles. In terms of high stability, high specificity, high drug-carrying capacity, controlled release, the ability to use different routes of administration, and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles can offer significant advantages over conventional drug delivery. We try to provide a detailed overview of template techniques designed for nanomaterial production. The pores and channels in the nanoporous "template" structures are used to generate the desired nanomaterials in template synthesis. Because this process has advantages over other methods, like allowing precise control over their size, shape, and structure, it is commonly used to generate nanoparticles. The first half of the review provides information on various template preparation processes. Templates are classified as "hard" or "soft" templates. Soft templates are often fluid-like, whereas hard templates are typically solid-state materials with distinct morphology and structure. This study discusses the effect of templates on morphologies and methodology and compares hard and soft templates.
International Journal of Drug Delivery Technology., 2024
Azithromycin has a low water solubility; Hence, dissolution represents a rate-limiting process. T... more Azithromycin has a low water solubility; Hence, dissolution represents a rate-limiting process. The goal of the present investigation is to improve azithromycin dissolution and solubility rate. The purpose of this study was to create, characterize, and test the dissolving characteristics of an Azithromycin solid dispersion with skimmed milk. Formulated tablet of optimized batch compared with marketed formulation and study its drug release and make a formulation that gives the highest rate of solubility. This experiment was conducted utilizing the solid dispersion method. The rationale for solid dispersion is that it produces better results than other methods while costing less. Skimmed milk is used as a carrier to increase the solubility of azithromycin. Azithromycin purity is certified using assessment tests such as HPLC assay, UV spectroscopy, FTIR, and DSC. Azithromycin solid dispersion (Azithromycin in skimmed milk) SD2 consistently performs well in all physiochemical tests as compared to all batches. The designed tablet F2 batch releases the drug more effectively than the marketed one. Azithromycin's solubility was successfully enhanced by utilizing the solid dispersion method with skimmed milk. Batch SD 2 gives the highest results in all parameters like solubility. Preformulation study, mainly in tablet formulation, also it gives the highest solubility.
International Journal of Pharmaceutical Sciences Review and Research, 2024
Since floating drug delivery systems may solve the disadvantages associated with traditional drug... more Since floating drug delivery systems may solve the disadvantages associated with traditional drug delivery systems, such as frequent dosing, limited bioavailability, etc., in comparison to quick stomach emptying time, they have attracted a lot of attention in recent decades. A system that stays in the stomach for an adequate amount of time and delivers the active medication continuously is known as an ideal floating drug delivery system. These continue to float over the stomach contents. prolonging the pharmacological effects and enhancing the drug's bioavailability. This overview of gastroretentive and floating tablets was written to gather recent research on the topic, as well as information on the floating tablets' principles, benefits, categorization, preparation, and assessment methods, and a list of medications that have been developed as floating tablets. formulation evaluation and future scope of floating tablets. The review concentrated on the types of floating medication delivery systems and the formulation aspect of effervescent floating drug delivery systems. The review's objective is to gather the research being done on this floating medicine delivery device. The review addresses several aspects that impact stomach retention (long duration) and offers useful information about the pharmaceutical formulation side of it.
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2024
Existing generation is a fast generation of allopathic drug, they supply fast consequence. This r... more Existing generation is a fast generation of allopathic drug, they supply fast consequence. This review is based on Aegle marmelos. Aegle marmelos is an primary aromatic medicinal tree of Indian root. From all only tree is aromatic, and remaining all the parts are medicinally essential Fruits, leaves, bark, roots, and seeds are used in ayurvedic to treat several ailments. Studies show that the extract of Aegle Marmelos
World Journal of Advanced Research and Reviews, 2024
Objective: The main objective of the study was to develop and evaluate the gastroretentive floati... more Objective: The main objective of the study was to develop and evaluate the gastroretentive floating tablet of esomeprazole magnesium trihydride, which is intended to increase patient compliance, deliver the medication in a controlled manner with less drug administration frequency, and increase the bioavailability of esomeprazole magnesium trihydrate. Methods: In the current investigation, sodium bicarbonate was used as a gas-generating agent to create effervescent Esomeprazole magnesium trihydate floating tablet formulations. Natural polymers like moringa gum, Azadirachta indica gum, sodium alginate, xanthan gum were used in the formulation of the tablets, which were made utilizing direct compression technology. Results: All of the developed formulations showed good In vitro buoyancy. The tablets remained buoyant for 12 hours. The drug release profiles revealed that Moringa gum tablets had a more uniform and regulated release, releasing 96% of the drug. In comparison, neem gum tablets released 89% of the drug, xanthan gum tablets released 93%, and sodium alginate tablets released 96%. Conclusion: Out of all the formulations developed, the F1 formulation had the highest In vitro dissolution results compared to the other batches, exhibiting the requisite sustained release time and acceptable floating qualities.
International journal of pharmacy and pharmaceutical sciences/International Journal of Pharmacy and Pharmaceutical Sciences, May 1, 2024
Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tw... more Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tween 80 as a surfactant and propylene glycol as a co-surfactant. Formulation of such drugs in nanoparticulate drug delivery will be advantageous for reducing dosing frequency, longer residence time, improved permeation, and patient compliance. Methods: High-speed homogenization method. The smilax china oil was prepared by collecting the extract of smilax china leaves into the coconut oil and then used as a solvent. The authentication studies of smilax china and coconut oil were evaluated for their organoleptic and physicochemical characteristics. The quantitative estimation and pre-formulation study of quercetin was carried out which has major anti-psoriatic properties. Surfactant and co-surfactant were selected and the solubility studies of oil and Surfactants were done. The nanoemulsion was characterized by particle size, polydispersity index, zeta potential, and entrapment efficiency (%). Results: This nanoemulsion provides the particle size and entrapment efficiency range between 80.52 to 89.78 nm and 68.66 to 70.16 % respectively. Batch SC1 showed the lowest particle size, PDI, and optimized drug entrapment effectiveness (%), indicating good particle size consistency within the remaining formulation batches. The optimized formulation SC 1 was found to be stable for 90 d. Conclusion: The formulated nanoemulsion showed significant antipsoriasis activity due to the presence of quercetin which has a rhetorical yield of 1.066 mg per 5 gm powder of smilax china leaves. Formulated smilax china-loaded nanoemulsion, has the potential as an effective antipsoriasis agent with a good spreading property with faster absorption which is beneficial for reducing drug concentration with maximum therapeutic effect.
African journal of biological science, 2024
Objective: The research aims to prepare and characterize solid lipid nanoparticles (SLNPs) contai... more Objective: The research aims to prepare and characterize
solid lipid nanoparticles (SLNPs) containing artemether.
Method: The solvent diffusion approach was employed
to produce artemether-loaded SLNPs. Artemether is one
of the most widely used antimalarial medications, and it
is the only one that can cure the relapsing form of malaria.
Artemisinin has low water solubility, low bioavailability,
and a short half-life, necessitating continual dose to
maintain
acceptable
therapeutic
drug-plasma
concentration; therefore, we solve this issue by creating
solid lipid nanoparticles. Nano formulation of
pharmaceuticals in an appropriate drug carrier system has
been extensively explored and found to have the potential
to improve bioavailability, hence increasing activity,
reducing dose frequency, and, as a result, lowering
toxicity.
Results: The produced SLNs had particle size,
polydispersity index (PDI), and zeta potential (ZP) values
ranging from 211.6 to 389.9 nm, 0.277 to 0.723, and -17.8
to -16.5 mV, respectively. SEM, XRD, PDI, Zeta
potential, Entrapment efficacy, and percentage yield, as
well as all other examinations, were completed
successfully. The optimized F6 batch released medicine
at a rate of 98.07%. Optimized batch involves research
like Differential scanning calorimeter thermograms
showed that the medication is more physically stable in
manufactured formulations. Negligible changes in drug
characteristic peaks in Fourier transform infrared spectra
indicated that there was no interaction between the
various components in the nanoparticle formulation.
Conclusion: Solid lipid nanoparticles containing
artemether were successfully developed. The improved
F6 batch released 98.07%
Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tw... more Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tween 80 as a surfactant and propylene glycol as a co-surfactant. Formulation of such drugs in nanoparticulate drug delivery will be advantageous for reducing dosing frequency, longer residence time, improved permeation, and patient compliance. Methods: High-speed homogenization method. The smilax china oil was prepared by collecting the extract of smilax china leaves into the coconut oil and then used as a solvent. The authentication studies of smilax china and coconut oil were evaluated for their organoleptic and physicochemical characteristics. The quantitative estimation and pre-formulation study of quercetin was carried out which has major anti-psoriatic properties. Surfactant and co-surfactant were selected and the solubility studies of oil and Surfactants were done. The nanoemulsion was characterized by particle size, polydispersity index, zeta potential, and entrapment efficiency (%). Results: This nanoemulsion provides the particle size and entrapment efficiency range between 80.52 to 89.78 nm and 68.66 to 70.16 % respectively. Batch SC1 showed the lowest particle size, PDI, and optimized drug entrapment effectiveness (%), indicating good particle size consistency within the remaining formulation batches. The optimized formulation SC 1 was found to be stable for 90 d. Conclusion: The formulated nanoemulsion showed significant antipsoriasis activity due to the presence of quercetin which has a rhetorical yield of 1.066 mg per 5 gm powder of smilax china leaves. Formulated smilax china-loaded nanoemulsion, has the potential as an effective antipsoriasis agent with a good spreading property with faster absorption which is beneficial for reducing drug concentration with maximum therapeutic effect.
International Journal of Current Pharmaceutical Research, 2024
There are numerous ways to categorize and treat depression, which is a diverse mood disease. The ... more There are numerous ways to categorize and treat depression, which is a diverse mood disease. The illness is caused by factors such as 5-HT, NA, and MAO-A inhibition and stimulation. Reduced curiosity about pleasure, feelings of inappropriate guilt or worthlessness, a drop in hunger and sexual desire, sleeplessness, and persistent suicidal thoughts are some of the symptoms. There are several synthetic medications used to treat depression, but not all of them make patients happy, and some of them may have negative side effects. Many have turned to well-liked traditional herbal remedies to avoid the negative effects of allopathic therapy. Due to their broad application, therapeutic efficacy, and little to negligible adverse effects, herbal medications are currently used worldwide. Several medicinal plants and medicines derived from these plants have shown antidepressant properties by the combined effect of their medicinal constituents. We discuss promising novel medicinal products targets for the management of major depressive illness in this review. We addre ss the potential antidepressant benefits of selectively targeting receptors, including opioid, G-protein-coupled, and metabotropic glutamate receptors. Since they may also have therapeutic value, we also talk about substances that target biological processes, including inflammation, the gut microbiota, the cholesterol biosynthesis pathway, and the hypothalamic-pituitary-adrenal axis. Lastly, we offer a synopsis of all the plants displayed in graphical format, together with an overview of the antidepressant plants which currently are widely accessible.
In recent years, there has been a rise in interest in the development of novel drug delivery syst... more In recent years, there has been a rise in interest in the development of novel drug delivery systems that utilize nanoparticles. In terms of high stability, high specificity, high drug-carrying capacity, controlled release, the ability to use different routes of administration, and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles can offer significant advantages over conventional drug delivery. We try to provide a detailed overview of template techniques designed for nanomaterial production. The pores and channels in the nanoporous "template" structures are used to generate the desired nanomaterials in template synthesis. Because this process has advantages over other methods, like allowing precise control over their size, shape, and structure, it is commonly used to generate nanoparticles. The first half of the review provides information on various template preparation processes. Templates are classified as "hard" or "soft" templates. Soft templates are often fluid-like, whereas hard templates are typically solid-state materials with distinct morphology and structure. This study discusses the effect of templates on morphologies and methodology and compares hard and soft templates.
International Journal of Pharmacy and Pharmaceutical Sciences, Apr 1, 2024
The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through t... more The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.
Review, 2024
Malaria is one of the infectious illnesses of the highest scientific significance and importance ... more Malaria is one of the infectious illnesses of the highest scientific significance and importance to international health organizations. Plasmodium falciparum, the parasite responsible for a highly severe form of the disease in Africa, has traditionally received the most attention. However, in the last two decades, the Plasmodium vivax parasite, which is linked to a large number of cases in Latin America, the Middle East, South and Southeast Asia, the Horn of Africa, and Oceania, has sparked enormous interest, owing to published evidence that it can cause severe malaria, among other things. Malaria is a worldwide public health problem, with a saw 247 million cases recorded in 2021. African countries accounted for approximately 94% of all reported cases. So far, over 200 distinct varieties of protozoa have been discovered and identified, with at least 13 of them being pathogenic to humans. The malaria parasite's life cycle is a complex process involving a mosquito with the species Anopheles and a vertebrate host. Artemether is a lipid-soluble artemisinin derivative. It is available in both oral and intramuscular forms. It is also available as a fixed-dose formulation with lumefantrine. Artemether-lumefantrine is one of the ACTs authorized by the WHO and is being used by the majority of countries transitioning from less effective medications to ACTs. However, the emergence of antimalarial medication resistance poses a significant challenge to malaria control. It works by killing the pathogenic organisms responsible for malaria. It is known as an antimalarial medication, and it is more effective than quinine therapies.
International Journal of Pharmacy and Pharmaceutical Sciences, Feb 1, 2024
Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before... more Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.
Indo American Journal of Pharmaceutical Research, 2024
Pharmacovigilance plays a key role in the health system through the evaluation, monitoring, and d... more Pharmacovigilance plays a key role in the health system through the evaluation, monitoring, and detection of drug interactions and their impact on humans. Therefore, drug safety requires monitoring of adverse reactions for each drug throughout its life cycle, during drug development, e.g. Pharmacovigilance deals with the detection, evaluation, understanding, and prevention of adverse effects. Metoprolol Observational studies suggest that betablockers may lower the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but randomized trials have not yet verified these findings. We can see Metoprolol's MOA and ADR in all of their forms. Metoprolol succinate, a BCS class I medication with a short half-life of 3-7 hours, is used to treat angina pectoris, heart attacks, and hypertension. The normal dosage is 25/50 mg three times each day. Due to the high frequency of delivery and oscillating plasma drug concentration, a sustained-release form of administration with prolonged clinical efficacy must be developed. To deliver the loading dose of the medicine in the stomach, decrease the frequency of administration, and boost the efficacy and bioavailability of the drug by delivering prolonged action, it is highly necessary to design a sustained-release bilayer.
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES, 2024
Because of their low solubility, pharmaceutical researchers encounter tremendous difficulties in ... more Because of their low solubility, pharmaceutical researchers encounter tremendous difficulties in creating sustainable and more soluble drugs (BCS class II). About 40% of oral dosage forms have formulation and development problems due to water insolubility. The rate of dissolving, absorption, distribution, and excretion of an active medicinal substance is determined by its solubility parameters. Based on their solubility, drugs are divided into four kinds under the BCS categorization system. BCS Class II and Class IV drugs have problems with solubility. Increasing both the bioavailability and the solubility of poorly soluble medications can be accomplished in several ways. Some techniques-like solid dispersion, solid complexation, liquisolid, hydrotropy, sonocrystallization, and self-emulsifying techniques-are commonly used for solubility augmentation. Until an orally active medication dissolves in the lining of the stomach and/or intestinal fluids, it cannot pass through the GI tract membrane and enter the bloodstream. Therefore, a medication that is insoluble in water will typically exhibit limited absorption by dissolution, and a medication that is weakly permeabilized via membranes would typically exhibit limited absorption through permeation. Consequently, improving the oral bioavailability of active substances is the focus of two areas of pharmaceutical research: (i) accelerating the process of dissolution and solubility of drugs that are poorly soluble in water, and (ii) accelerating the permeability of poorly permeable drugs.
PULSATILE DRUG DELIVERY, 2024
Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before... more Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.
International Journal of Current Pharmaceutical Research., 2024
Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tin... more Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tiny materials are used as diagnostic tools or to deliver therapeutic drugs to specific targeted locations in a controlled manner. Nanotechnology has numerous advantages in the treatment of chronic human diseases through the site-specific and target-oriented delivery of precise medications. There have recently been several notable applications of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, and so on) in the treatment of various disorders. Efficient use of pricey medications and excipients, as well as cost savings in manufacturing Beneficial to patients, improved therapy, comfort, and the standard of living. Lipids have been proposed as an alternate carrier to circumvent the constraints of polymeric nanoparticles, notably for lipophilic medicines. Such small particles of lipid are known as solid lipid nanoparticles (SLNs), and they are gaining popularity among formulators all over the world. SLNs are colloidal carriers that were developed in the last decade as a replacement for traditional carriers. Lipid nanoparticles have caught the interest of researchers during the last two decades and have shown considerable therapeutic success since the first clinical approval of Doxil in 1995. Simultaneously, lipid nanoparticles have shown significant promise in conveying nucleic acid medications, as proven by the approval of two RNA treatments and an mRNA COVID-19 vaccination.
Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tin... more Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tiny materials are used as diagnostic tools or to deliver therapeutic drugs to specific targeted locations in a controlled manner. Nanotechnology has numerous advantages in the treatment of chronic human diseases through the site-specific and target-oriented delivery of precise medications. There have recently been several notable applications of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, and so on) in the treatment of various disorders. Efficient use of pricey medications and excipients, as well as cost savings in manufacturing Beneficial to patients, improved therapy, comfort, and the standard of living. Lipids have been proposed as an alternate carrier to circumvent the constraints of polymeric nanoparticles, notably for lipophilic medicines. Such small particles of lipid are known as solid lipid nanoparticles (SLNs), and they are gaining popularity among formulators all over the world. SLNs are colloidal carriers that were developed in the last decade as a replacement for traditional carriers. Lipid nanoparticles have caught the interest of researchers during the last two decades and have shown considerable therapeutic success since the first clinical approval of Doxil in 1995. Simultaneously, lipid nanoparticles have shown significant promise in conveying nucleic acid medications, as proven by the approval of two RNA treatments and an mRNA COVID-19 vaccination.
International Journal of Pharmacy and Pharmaceutical Sciences, Apr 1, 2024
The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through t... more The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.
International Journal of Pharmacy and Pharmaceutical Sciences, May 1, 2024
Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tw... more Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tween 80 as a surfactant and propylene glycol as a co-surfactant. Formulation of such drugs in nanoparticulate drug delivery will be advantageous for reducing dosing frequency, longer residence time, improved permeation, and patient compliance. Methods: High-speed homogenization method. The smilax china oil was prepared by collecting the extract of smilax china leaves into the coconut oil and then used as a solvent. The authentication studies of smilax china and coconut oil were evaluated for their organoleptic and physicochemical characteristics. The quantitative estimation and pre-formulation study of quercetin was carried out which has major anti-psoriatic properties. Surfactant and co-surfactant were selected and the solubility studies of oil and Surfactants were done. The nanoemulsion was characterized by particle size, polydispersity index, zeta potential, and entrapment efficiency (%). Results: This nanoemulsion provides the particle size and entrapment efficiency range between 80.52 to 89.78 nm and 68.66 to 70.16 % respectively. Batch SC1 showed the lowest particle size, PDI, and optimized drug entrapment effectiveness (%), indicating good particle size consistency within the remaining formulation batches. The optimized formulation SC 1 was found to be stable for 90 d. Conclusion: The formulated nanoemulsion showed significant antipsoriasis activity due to the presence of quercetin which has a rhetorical yield of 1.066 mg per 5 gm powder of smilax china leaves. Formulated smilax china-loaded nanoemulsion, has the potential as an effective antipsoriasis agent with a good spreading property with faster absorption which is beneficial for reducing drug concentration with maximum therapeutic effect.
International Journal of Pharmacy and Pharmaceutical Sciences, May 1, 2024
In recent years, there has been a rise in interest in the development of novel drug delivery syst... more In recent years, there has been a rise in interest in the development of novel drug delivery systems that utilize nanoparticles. In terms of high stability, high specificity, high drug-carrying capacity, controlled release, the ability to use different routes of administration, and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles can offer significant advantages over conventional drug delivery. We try to provide a detailed overview of template techniques designed for nanomaterial production. The pores and channels in the nanoporous "template" structures are used to generate the desired nanomaterials in template synthesis. Because this process has advantages over other methods, like allowing precise control over their size, shape, and structure, it is commonly used to generate nanoparticles. The first half of the review provides information on various template preparation processes. Templates are classified as "hard" or "soft" templates. Soft templates are often fluid-like, whereas hard templates are typically solid-state materials with distinct morphology and structure. This study discusses the effect of templates on morphologies and methodology and compares hard and soft templates.
International Journal of Drug Delivery Technology., 2024
Azithromycin has a low water solubility; Hence, dissolution represents a rate-limiting process. T... more Azithromycin has a low water solubility; Hence, dissolution represents a rate-limiting process. The goal of the present investigation is to improve azithromycin dissolution and solubility rate. The purpose of this study was to create, characterize, and test the dissolving characteristics of an Azithromycin solid dispersion with skimmed milk. Formulated tablet of optimized batch compared with marketed formulation and study its drug release and make a formulation that gives the highest rate of solubility. This experiment was conducted utilizing the solid dispersion method. The rationale for solid dispersion is that it produces better results than other methods while costing less. Skimmed milk is used as a carrier to increase the solubility of azithromycin. Azithromycin purity is certified using assessment tests such as HPLC assay, UV spectroscopy, FTIR, and DSC. Azithromycin solid dispersion (Azithromycin in skimmed milk) SD2 consistently performs well in all physiochemical tests as compared to all batches. The designed tablet F2 batch releases the drug more effectively than the marketed one. Azithromycin's solubility was successfully enhanced by utilizing the solid dispersion method with skimmed milk. Batch SD 2 gives the highest results in all parameters like solubility. Preformulation study, mainly in tablet formulation, also it gives the highest solubility.
International Journal of Pharmaceutical Sciences Review and Research, 2024
Since floating drug delivery systems may solve the disadvantages associated with traditional drug... more Since floating drug delivery systems may solve the disadvantages associated with traditional drug delivery systems, such as frequent dosing, limited bioavailability, etc., in comparison to quick stomach emptying time, they have attracted a lot of attention in recent decades. A system that stays in the stomach for an adequate amount of time and delivers the active medication continuously is known as an ideal floating drug delivery system. These continue to float over the stomach contents. prolonging the pharmacological effects and enhancing the drug's bioavailability. This overview of gastroretentive and floating tablets was written to gather recent research on the topic, as well as information on the floating tablets' principles, benefits, categorization, preparation, and assessment methods, and a list of medications that have been developed as floating tablets. formulation evaluation and future scope of floating tablets. The review concentrated on the types of floating medication delivery systems and the formulation aspect of effervescent floating drug delivery systems. The review's objective is to gather the research being done on this floating medicine delivery device. The review addresses several aspects that impact stomach retention (long duration) and offers useful information about the pharmaceutical formulation side of it.
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 2024
Existing generation is a fast generation of allopathic drug, they supply fast consequence. This r... more Existing generation is a fast generation of allopathic drug, they supply fast consequence. This review is based on Aegle marmelos. Aegle marmelos is an primary aromatic medicinal tree of Indian root. From all only tree is aromatic, and remaining all the parts are medicinally essential Fruits, leaves, bark, roots, and seeds are used in ayurvedic to treat several ailments. Studies show that the extract of Aegle Marmelos
World Journal of Advanced Research and Reviews, 2024
Objective: The main objective of the study was to develop and evaluate the gastroretentive floati... more Objective: The main objective of the study was to develop and evaluate the gastroretentive floating tablet of esomeprazole magnesium trihydride, which is intended to increase patient compliance, deliver the medication in a controlled manner with less drug administration frequency, and increase the bioavailability of esomeprazole magnesium trihydrate. Methods: In the current investigation, sodium bicarbonate was used as a gas-generating agent to create effervescent Esomeprazole magnesium trihydate floating tablet formulations. Natural polymers like moringa gum, Azadirachta indica gum, sodium alginate, xanthan gum were used in the formulation of the tablets, which were made utilizing direct compression technology. Results: All of the developed formulations showed good In vitro buoyancy. The tablets remained buoyant for 12 hours. The drug release profiles revealed that Moringa gum tablets had a more uniform and regulated release, releasing 96% of the drug. In comparison, neem gum tablets released 89% of the drug, xanthan gum tablets released 93%, and sodium alginate tablets released 96%. Conclusion: Out of all the formulations developed, the F1 formulation had the highest In vitro dissolution results compared to the other batches, exhibiting the requisite sustained release time and acceptable floating qualities.
International journal of pharmacy and pharmaceutical sciences/International Journal of Pharmacy and Pharmaceutical Sciences, May 1, 2024
Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tw... more Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tween 80 as a surfactant and propylene glycol as a co-surfactant. Formulation of such drugs in nanoparticulate drug delivery will be advantageous for reducing dosing frequency, longer residence time, improved permeation, and patient compliance. Methods: High-speed homogenization method. The smilax china oil was prepared by collecting the extract of smilax china leaves into the coconut oil and then used as a solvent. The authentication studies of smilax china and coconut oil were evaluated for their organoleptic and physicochemical characteristics. The quantitative estimation and pre-formulation study of quercetin was carried out which has major anti-psoriatic properties. Surfactant and co-surfactant were selected and the solubility studies of oil and Surfactants were done. The nanoemulsion was characterized by particle size, polydispersity index, zeta potential, and entrapment efficiency (%). Results: This nanoemulsion provides the particle size and entrapment efficiency range between 80.52 to 89.78 nm and 68.66 to 70.16 % respectively. Batch SC1 showed the lowest particle size, PDI, and optimized drug entrapment effectiveness (%), indicating good particle size consistency within the remaining formulation batches. The optimized formulation SC 1 was found to be stable for 90 d. Conclusion: The formulated nanoemulsion showed significant antipsoriasis activity due to the presence of quercetin which has a rhetorical yield of 1.066 mg per 5 gm powder of smilax china leaves. Formulated smilax china-loaded nanoemulsion, has the potential as an effective antipsoriasis agent with a good spreading property with faster absorption which is beneficial for reducing drug concentration with maximum therapeutic effect.
African journal of biological science, 2024
Objective: The research aims to prepare and characterize solid lipid nanoparticles (SLNPs) contai... more Objective: The research aims to prepare and characterize
solid lipid nanoparticles (SLNPs) containing artemether.
Method: The solvent diffusion approach was employed
to produce artemether-loaded SLNPs. Artemether is one
of the most widely used antimalarial medications, and it
is the only one that can cure the relapsing form of malaria.
Artemisinin has low water solubility, low bioavailability,
and a short half-life, necessitating continual dose to
maintain
acceptable
therapeutic
drug-plasma
concentration; therefore, we solve this issue by creating
solid lipid nanoparticles. Nano formulation of
pharmaceuticals in an appropriate drug carrier system has
been extensively explored and found to have the potential
to improve bioavailability, hence increasing activity,
reducing dose frequency, and, as a result, lowering
toxicity.
Results: The produced SLNs had particle size,
polydispersity index (PDI), and zeta potential (ZP) values
ranging from 211.6 to 389.9 nm, 0.277 to 0.723, and -17.8
to -16.5 mV, respectively. SEM, XRD, PDI, Zeta
potential, Entrapment efficacy, and percentage yield, as
well as all other examinations, were completed
successfully. The optimized F6 batch released medicine
at a rate of 98.07%. Optimized batch involves research
like Differential scanning calorimeter thermograms
showed that the medication is more physically stable in
manufactured formulations. Negligible changes in drug
characteristic peaks in Fourier transform infrared spectra
indicated that there was no interaction between the
various components in the nanoparticle formulation.
Conclusion: Solid lipid nanoparticles containing
artemether were successfully developed. The improved
F6 batch released 98.07%
Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tw... more Objective: The present investigation aimed to prepare a smilax china loaded nanoemulsion using tween 80 as a surfactant and propylene glycol as a co-surfactant. Formulation of such drugs in nanoparticulate drug delivery will be advantageous for reducing dosing frequency, longer residence time, improved permeation, and patient compliance. Methods: High-speed homogenization method. The smilax china oil was prepared by collecting the extract of smilax china leaves into the coconut oil and then used as a solvent. The authentication studies of smilax china and coconut oil were evaluated for their organoleptic and physicochemical characteristics. The quantitative estimation and pre-formulation study of quercetin was carried out which has major anti-psoriatic properties. Surfactant and co-surfactant were selected and the solubility studies of oil and Surfactants were done. The nanoemulsion was characterized by particle size, polydispersity index, zeta potential, and entrapment efficiency (%). Results: This nanoemulsion provides the particle size and entrapment efficiency range between 80.52 to 89.78 nm and 68.66 to 70.16 % respectively. Batch SC1 showed the lowest particle size, PDI, and optimized drug entrapment effectiveness (%), indicating good particle size consistency within the remaining formulation batches. The optimized formulation SC 1 was found to be stable for 90 d. Conclusion: The formulated nanoemulsion showed significant antipsoriasis activity due to the presence of quercetin which has a rhetorical yield of 1.066 mg per 5 gm powder of smilax china leaves. Formulated smilax china-loaded nanoemulsion, has the potential as an effective antipsoriasis agent with a good spreading property with faster absorption which is beneficial for reducing drug concentration with maximum therapeutic effect.
International Journal of Current Pharmaceutical Research, 2024
There are numerous ways to categorize and treat depression, which is a diverse mood disease. The ... more There are numerous ways to categorize and treat depression, which is a diverse mood disease. The illness is caused by factors such as 5-HT, NA, and MAO-A inhibition and stimulation. Reduced curiosity about pleasure, feelings of inappropriate guilt or worthlessness, a drop in hunger and sexual desire, sleeplessness, and persistent suicidal thoughts are some of the symptoms. There are several synthetic medications used to treat depression, but not all of them make patients happy, and some of them may have negative side effects. Many have turned to well-liked traditional herbal remedies to avoid the negative effects of allopathic therapy. Due to their broad application, therapeutic efficacy, and little to negligible adverse effects, herbal medications are currently used worldwide. Several medicinal plants and medicines derived from these plants have shown antidepressant properties by the combined effect of their medicinal constituents. We discuss promising novel medicinal products targets for the management of major depressive illness in this review. We addre ss the potential antidepressant benefits of selectively targeting receptors, including opioid, G-protein-coupled, and metabotropic glutamate receptors. Since they may also have therapeutic value, we also talk about substances that target biological processes, including inflammation, the gut microbiota, the cholesterol biosynthesis pathway, and the hypothalamic-pituitary-adrenal axis. Lastly, we offer a synopsis of all the plants displayed in graphical format, together with an overview of the antidepressant plants which currently are widely accessible.
In recent years, there has been a rise in interest in the development of novel drug delivery syst... more In recent years, there has been a rise in interest in the development of novel drug delivery systems that utilize nanoparticles. In terms of high stability, high specificity, high drug-carrying capacity, controlled release, the ability to use different routes of administration, and the ability to deliver both hydrophilic and hydrophobic drug molecules, nanoparticles can offer significant advantages over conventional drug delivery. We try to provide a detailed overview of template techniques designed for nanomaterial production. The pores and channels in the nanoporous "template" structures are used to generate the desired nanomaterials in template synthesis. Because this process has advantages over other methods, like allowing precise control over their size, shape, and structure, it is commonly used to generate nanoparticles. The first half of the review provides information on various template preparation processes. Templates are classified as "hard" or "soft" templates. Soft templates are often fluid-like, whereas hard templates are typically solid-state materials with distinct morphology and structure. This study discusses the effect of templates on morphologies and methodology and compares hard and soft templates.
International Journal of Pharmacy and Pharmaceutical Sciences, Apr 1, 2024
The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through t... more The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.
Review, 2024
Malaria is one of the infectious illnesses of the highest scientific significance and importance ... more Malaria is one of the infectious illnesses of the highest scientific significance and importance to international health organizations. Plasmodium falciparum, the parasite responsible for a highly severe form of the disease in Africa, has traditionally received the most attention. However, in the last two decades, the Plasmodium vivax parasite, which is linked to a large number of cases in Latin America, the Middle East, South and Southeast Asia, the Horn of Africa, and Oceania, has sparked enormous interest, owing to published evidence that it can cause severe malaria, among other things. Malaria is a worldwide public health problem, with a saw 247 million cases recorded in 2021. African countries accounted for approximately 94% of all reported cases. So far, over 200 distinct varieties of protozoa have been discovered and identified, with at least 13 of them being pathogenic to humans. The malaria parasite's life cycle is a complex process involving a mosquito with the species Anopheles and a vertebrate host. Artemether is a lipid-soluble artemisinin derivative. It is available in both oral and intramuscular forms. It is also available as a fixed-dose formulation with lumefantrine. Artemether-lumefantrine is one of the ACTs authorized by the WHO and is being used by the majority of countries transitioning from less effective medications to ACTs. However, the emergence of antimalarial medication resistance poses a significant challenge to malaria control. It works by killing the pathogenic organisms responsible for malaria. It is known as an antimalarial medication, and it is more effective than quinine therapies.
International Journal of Pharmacy and Pharmaceutical Sciences, Feb 1, 2024
Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before... more Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.
Indo American Journal of Pharmaceutical Research, 2024
Pharmacovigilance plays a key role in the health system through the evaluation, monitoring, and d... more Pharmacovigilance plays a key role in the health system through the evaluation, monitoring, and detection of drug interactions and their impact on humans. Therefore, drug safety requires monitoring of adverse reactions for each drug throughout its life cycle, during drug development, e.g. Pharmacovigilance deals with the detection, evaluation, understanding, and prevention of adverse effects. Metoprolol Observational studies suggest that betablockers may lower the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but randomized trials have not yet verified these findings. We can see Metoprolol's MOA and ADR in all of their forms. Metoprolol succinate, a BCS class I medication with a short half-life of 3-7 hours, is used to treat angina pectoris, heart attacks, and hypertension. The normal dosage is 25/50 mg three times each day. Due to the high frequency of delivery and oscillating plasma drug concentration, a sustained-release form of administration with prolonged clinical efficacy must be developed. To deliver the loading dose of the medicine in the stomach, decrease the frequency of administration, and boost the efficacy and bioavailability of the drug by delivering prolonged action, it is highly necessary to design a sustained-release bilayer.
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES, 2024
Because of their low solubility, pharmaceutical researchers encounter tremendous difficulties in ... more Because of their low solubility, pharmaceutical researchers encounter tremendous difficulties in creating sustainable and more soluble drugs (BCS class II). About 40% of oral dosage forms have formulation and development problems due to water insolubility. The rate of dissolving, absorption, distribution, and excretion of an active medicinal substance is determined by its solubility parameters. Based on their solubility, drugs are divided into four kinds under the BCS categorization system. BCS Class II and Class IV drugs have problems with solubility. Increasing both the bioavailability and the solubility of poorly soluble medications can be accomplished in several ways. Some techniques-like solid dispersion, solid complexation, liquisolid, hydrotropy, sonocrystallization, and self-emulsifying techniques-are commonly used for solubility augmentation. Until an orally active medication dissolves in the lining of the stomach and/or intestinal fluids, it cannot pass through the GI tract membrane and enter the bloodstream. Therefore, a medication that is insoluble in water will typically exhibit limited absorption by dissolution, and a medication that is weakly permeabilized via membranes would typically exhibit limited absorption through permeation. Consequently, improving the oral bioavailability of active substances is the focus of two areas of pharmaceutical research: (i) accelerating the process of dissolution and solubility of drugs that are poorly soluble in water, and (ii) accelerating the permeability of poorly permeable drugs.
PULSATILE DRUG DELIVERY, 2024
Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before... more Oral pulsatile drug delivery systems (PDDS) are intended to induce programmable lag phases before a quick and quantifiable, repeated, or prolonged medication release. As a result, they are gaining popularity due to their inherent suitability for achieving chronotherapeutic goals, which have just been highlighted concerning several prevalent chronic illnesses characterized by typical night or early-morning recurring symptoms (e. g. bronchial asthma, heart attack, rheumatoid arthritis, early-morningawakening). Furthermore, time-based colonic release is possible when pulsatile delivery devices are correctly modified to overcome unexpected gastric emptying and give delay periods that roughly match the small intestine transit time. Oral pulsatile administration is accomplished using several release platforms, including reservoir, capsular, and osmotic devices. The current review article addressed the topics that followed: the reason pulsatile drug delivery systems have been invented; diseases for which pulsatile release is necessary; classification, advantages and disadvantages; methods used in the current systems; the situation nowadays and its potential for the future; recent advancements, and especially, the previous five to ten years of research on pulsatile drug delivery conducted by researchers using a variety of drugs for a variety of diseases.
International Journal of Current Pharmaceutical Research., 2024
Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tin... more Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tiny materials are used as diagnostic tools or to deliver therapeutic drugs to specific targeted locations in a controlled manner. Nanotechnology has numerous advantages in the treatment of chronic human diseases through the site-specific and target-oriented delivery of precise medications. There have recently been several notable applications of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, and so on) in the treatment of various disorders. Efficient use of pricey medications and excipients, as well as cost savings in manufacturing Beneficial to patients, improved therapy, comfort, and the standard of living. Lipids have been proposed as an alternate carrier to circumvent the constraints of polymeric nanoparticles, notably for lipophilic medicines. Such small particles of lipid are known as solid lipid nanoparticles (SLNs), and they are gaining popularity among formulators all over the world. SLNs are colloidal carriers that were developed in the last decade as a replacement for traditional carriers. Lipid nanoparticles have caught the interest of researchers during the last two decades and have shown considerable therapeutic success since the first clinical approval of Doxil in 1995. Simultaneously, lipid nanoparticles have shown significant promise in conveying nucleic acid medications, as proven by the approval of two RNA treatments and an mRNA COVID-19 vaccination.
Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tin... more Nanomedicine along with nano-delivery systems, are a young but fast-emerging science in which tiny materials are used as diagnostic tools or to deliver therapeutic drugs to specific targeted locations in a controlled manner. Nanotechnology has numerous advantages in the treatment of chronic human diseases through the site-specific and target-oriented delivery of precise medications. There have recently been several notable applications of nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents, and so on) in the treatment of various disorders. Efficient use of pricey medications and excipients, as well as cost savings in manufacturing Beneficial to patients, improved therapy, comfort, and the standard of living. Lipids have been proposed as an alternate carrier to circumvent the constraints of polymeric nanoparticles, notably for lipophilic medicines. Such small particles of lipid are known as solid lipid nanoparticles (SLNs), and they are gaining popularity among formulators all over the world. SLNs are colloidal carriers that were developed in the last decade as a replacement for traditional carriers. Lipid nanoparticles have caught the interest of researchers during the last two decades and have shown considerable therapeutic success since the first clinical approval of Doxil in 1995. Simultaneously, lipid nanoparticles have shown significant promise in conveying nucleic acid medications, as proven by the approval of two RNA treatments and an mRNA COVID-19 vaccination.