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Papers by brij tiwari
Novel Approaches in Cancer Study, 2020
Materials Today: Proceedings, 2022
Abstract The extraordinary amount of solar irradiative energy all around the Earth has one of the... more Abstract The extraordinary amount of solar irradiative energy all around the Earth has one of the motivational factors to work with such systems that utilize these for the services towards the benefits of mankind and its progressive growth, and that makes a powerful society and commendable nation. However, in the current era an unavoidable problem for the scarcity of potable water is going on, as brackish water keeps increasing faster than the approachable fresh water resources. For this, solar still systems for water treatment are one of the best solutions that utilize the solar energy as a prime source of working to the system. Out of those systems, energy matrix is one of the important performing factors that indicate the overall usability, payout characteristics, life cycle performing efficiency, etc. of the system. The current presentation reflects that active parameters undertaken in previous studies especially based on the energy matrix for active solar stills. A comparative result has been shown that results better in favor of nanoparticles and lower embodied energetic systems. Based on the overall performances and influencive parameters, a discussion and focused concluding remarks has been framed that suitably justifies the development towards this technology.
Evergreen, 2021
dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) wa... more dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) was prepared by condensation of 4-hydroxy coumarin and 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzene sulfonamide (sulphafurazole). The structure of synthesized compound was established using IR, 1 H and 13 C-NMR spectral analysis. On evaluation of in-vitro anti-herpetic activity of this compound against HSV-1, compound was found able to inhibit viral replication at late stages of infection by inhibiting the replication of HSV-1. This anti herpetic nature of HDF was evidenced by the reduction of specific gene productsβ-(ICP-6) and γ-(ICP-5 and gB) groups in western blotting.
Evergreen, 2021
dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) wa... more dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) was prepared by condensation of 4-hydroxy coumarin and 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzene sulfonamide (sulphafurazole). The structure of synthesized compound was established using IR, 1 H and 13 C-NMR spectral analysis. On evaluation of in-vitro anti-herpetic activity of this compound against HSV-1, compound was found able to inhibit viral replication at late stages of infection by inhibiting the replication of HSV-1. This anti herpetic nature of HDF was evidenced by the reduction of specific gene productsβ-(ICP-6) and γ-(ICP-5 and gB) groups in western blotting.
In the present work, a quantitative structure activity study has been performed to develop mathem... more In the present work, a quantitative structure activity study has been performed to develop mathematical relationship between structural descriptors and biological activity log1/C (cytotoxic concentration) of 19 TIBO derivatives with the help of Hyperchem7 software 2 , ACD Chemsketch 1. Non-conventional physicochemical descriptors used in present study are calculated using Hyperchem7 software. All classical physicochemical properties are calculated using ACD Chemsketch software and the multiple linear regression analysis is carried out for obtaining QSAR model. The objective of the work is to obtain more information about the structural requirements underlying the cytotoxicity of inhibitors of NNRT-1. On the basis of the result obtained we model the compound having having predictive potential.
Lecture Notes in Mechanical Engineering, 2021
QSAR studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase inhibitors were perfo... more QSAR studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase inhibitors were performed using hydration energy and logP as predictor parameters. The results obtained demonstrate in detail, which specify that molar volume and density and polarisibility and hydrophobic parameters of the compounds play a significant role in developing QSAR models. The significance of presence and absence of substituents on particular position is successfully explored with the help of indicator parameters. The results are critically discussed on the basis of multiple linear regression parameters.
Novel Approaches in Cancer Study, 2020
Materials Today: Proceedings, 2022
Abstract The extraordinary amount of solar irradiative energy all around the Earth has one of the... more Abstract The extraordinary amount of solar irradiative energy all around the Earth has one of the motivational factors to work with such systems that utilize these for the services towards the benefits of mankind and its progressive growth, and that makes a powerful society and commendable nation. However, in the current era an unavoidable problem for the scarcity of potable water is going on, as brackish water keeps increasing faster than the approachable fresh water resources. For this, solar still systems for water treatment are one of the best solutions that utilize the solar energy as a prime source of working to the system. Out of those systems, energy matrix is one of the important performing factors that indicate the overall usability, payout characteristics, life cycle performing efficiency, etc. of the system. The current presentation reflects that active parameters undertaken in previous studies especially based on the energy matrix for active solar stills. A comparative result has been shown that results better in favor of nanoparticles and lower embodied energetic systems. Based on the overall performances and influencive parameters, a discussion and focused concluding remarks has been framed that suitably justifies the development towards this technology.
Evergreen, 2021
dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) wa... more dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) was prepared by condensation of 4-hydroxy coumarin and 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzene sulfonamide (sulphafurazole). The structure of synthesized compound was established using IR, 1 H and 13 C-NMR spectral analysis. On evaluation of in-vitro anti-herpetic activity of this compound against HSV-1, compound was found able to inhibit viral replication at late stages of infection by inhibiting the replication of HSV-1. This anti herpetic nature of HDF was evidenced by the reduction of specific gene productsβ-(ICP-6) and γ-(ICP-5 and gB) groups in western blotting.
Evergreen, 2021
dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) wa... more dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)b enzene sulfonamide (HDF) was prepared by condensation of 4-hydroxy coumarin and 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzene sulfonamide (sulphafurazole). The structure of synthesized compound was established using IR, 1 H and 13 C-NMR spectral analysis. On evaluation of in-vitro anti-herpetic activity of this compound against HSV-1, compound was found able to inhibit viral replication at late stages of infection by inhibiting the replication of HSV-1. This anti herpetic nature of HDF was evidenced by the reduction of specific gene productsβ-(ICP-6) and γ-(ICP-5 and gB) groups in western blotting.
In the present work, a quantitative structure activity study has been performed to develop mathem... more In the present work, a quantitative structure activity study has been performed to develop mathematical relationship between structural descriptors and biological activity log1/C (cytotoxic concentration) of 19 TIBO derivatives with the help of Hyperchem7 software 2 , ACD Chemsketch 1. Non-conventional physicochemical descriptors used in present study are calculated using Hyperchem7 software. All classical physicochemical properties are calculated using ACD Chemsketch software and the multiple linear regression analysis is carried out for obtaining QSAR model. The objective of the work is to obtain more information about the structural requirements underlying the cytotoxicity of inhibitors of NNRT-1. On the basis of the result obtained we model the compound having having predictive potential.
Lecture Notes in Mechanical Engineering, 2021
QSAR studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase inhibitors were perfo... more QSAR studies on 104 flavonoid derivatives as p56lck protein tyrosine kinase inhibitors were performed using hydration energy and logP as predictor parameters. The results obtained demonstrate in detail, which specify that molar volume and density and polarisibility and hydrophobic parameters of the compounds play a significant role in developing QSAR models. The significance of presence and absence of substituents on particular position is successfully explored with the help of indicator parameters. The results are critically discussed on the basis of multiple linear regression parameters.