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Papers by bruce ruscio

Research paper thumbnail of US Department of State Perspective: Antimicrobial resistance and Food Security

Research paper thumbnail of REVIEW ARTICLE One Health a strategy for resilience in a changing arctic

The circumpolar north is uniquely vulnerable to the health impacts of climate change. While inter... more The circumpolar north is uniquely vulnerable to the health impacts of climate change. While international Arctic collaboration on health has enhanced partnerships and advanced the health of inhabitants, significant challenges lie ahead. One Health is an approach that considers the connections between the environment, plant, animal and human health. Understanding this is increasingly critical in assessing the impact of global climate change on the health of Arctic inhabitants. The effects of climate change are complex and difficult to predict with certainty. Health risks include changes in the distribution of infectious disease, expansion of zoonotic diseases and vectors, changing migration patterns, impacts on food security and changes in water availability and quality, among others. A regional network of diverse stakeholder and transdisciplinary specialists from circumpolar nations and Indigenous groups can advance the understanding of complex climate-driven health risks and provid...

Research paper thumbnail of Operation Everest II: comparison of four instruments for measuring blood O2 saturation

Journal of Applied Physiology, 1989

The bias and precision of four different methods for determining O2 saturation (SO2) were evaluat... more The bias and precision of four different methods for determining O2 saturation (SO2) were evaluated during a study of hypobaric hypoxia conducted with seven male subjects exposed progressively over a 40-day period to simulated altitudes from sea level (760 Torr) to 8,840 m (240 Torr). SO2 of arterial and mixed venous blood samples were measured with the Instrumentation Laboratory 282 CO-oximeter (CO-OX), the Radiometer ABL-300 (ABL), and the Lex-O2-Con-K (LEX). Noninvasive measurements of arterial SO2 were made with a Hewlett-Packard 47201A ear oximeter (EAR-OX). The CO-OX method was used as a secondary standard for comparison with the other methods because it has been validated against the classical Van Slyke method over a wide physiological range (Maas et al., Clin. Chim. Acta 29: 303-309, 1970). The LEX results most closely approximated but consistently underestimated those of the CO-OX: LEX = 0.93 CO-OX -0.86, standard error of the estimate (SEE) = 5.17, r = 0.98, n = 670. The A...

Research paper thumbnail of Environmental health risk assessment methodology for overseas military deployment

Johns Hopkins APL …, 1999

Page 1. JOHNS HOPKINS APL TECHNICAL DIGEST, VOLUME 20, NUMBER 3 (1999) 405 ENVIRONMENTAL HEALTH R... more Page 1. JOHNS HOPKINS APL TECHNICAL DIGEST, VOLUME 20, NUMBER 3 (1999) 405 ENVIRONMENTAL HEALTH RISK ASSESSMENT METHODOLOGY The Johns Hopkins University School of Hygiene and Public Health is developing ...

Research paper thumbnail of Operation everest ii incidence of retinal pathology during a simulated ascent of mount everest

Research paper thumbnail of A Public Health Approach to Injury Prevention: The U.S. Military Experience

: TITLE: A Process to Identify Military Injury Prevention Priorities Based on Injury Type and Lim... more : TITLE: A Process to Identify Military Injury Prevention Priorities Based on Injury Type and Limited Duty Days. BACKGROUND: Injuries, one of the leading public health problems in an otherwise healthy military population, affect operational readiness, increase healthcare costs, and result in disabilities and fatalities. This paper describes a systematic, data-driven, injury prevention-decision making process to rank potential injury prevention targets. METHODS: Medical surveillance and safety report data on injuries for 2004 were reviewed. Non-fatal injury diagnoses (ICD-9-CM codes) obtained from the Defense Medical Surveillance System were ranked according to incident visit frequency and estimated limited duty days. Data on the top five injury types resulting in the greatest estimated limited duty days were matched with hospitalization and Service Safety Centers' accident investigation data to identify leading causes. Experts scored and ranked the causes using predetermined cri...

Research paper thumbnail of Ln Maximal cardiorespiratory responses to one-and two-leged 00 cycling during acute and long-term exposure to 4300 m

Research paper thumbnail of Expanding global and national influenza vaccine systems to match the COVID-19 pandemic response

Research paper thumbnail of Shaping meeting to explore the value of a coordinated work plan for epidemic and pandemic influenza vaccine preparedness

Research paper thumbnail of DoD Military Injury Prevention Priorities Working Group: Leading Injuries, Causes and Mitigation Recommendations

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.

Research paper thumbnail of Quality assessment of nonanthrax vaccination data in the Defense Medical Surveillance System (DMSS), 1998–2004

Vaccine, Mar 17, 2008

We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS)... more We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS) during 1998-2004. We sampled servicemembers' medical charts at 28 Military Treatment Facilities and estimated the agreement between DMSS electronic and medical chart vaccination data, conditional on the data in the medical charts. Our analysis included 3831 individuals who received 39,305 nonanthrax vaccine doses. Yellow fever vaccine category had the highest conditional sensitivity for exact date match (83.4%; 95% CI = 80.1, 86.3); most vaccine categories' conditional sensitivities improved over time. Our study suggests DMSS vaccination data may be acceptable for post-marketing vaccine safety studies for certain vaccines and timeframes.

Research paper thumbnail of Inhalation exposure risk during a military operation : a risk assessment approach /

Research paper thumbnail of One Health – a strategy for resilience in a changing arctic

International Journal of Circumpolar Health, 2015

The circumpolar north is uniquely vulnerable to the health impacts of climate change. While inter... more The circumpolar north is uniquely vulnerable to the health impacts of climate change. While international Arctic collaboration on health has enhanced partnerships and advanced the health of inhabitants, significant challenges lie ahead. One Health is an approach that considers the connections between the environment, plant, animal and human health. Understanding this is increasingly critical in assessing the impact of global climate change on the health of Arctic inhabitants. The effects of climate change are complex and difficult to predict with certainty. Health risks include changes in the distribution of infectious disease, expansion of zoonotic diseases and vectors, changing migration patterns, impacts on food security and changes in water availability and quality, among others. A regional network of diverse stakeholder and transdisciplinary specialists from circumpolar nations and Indigenous groups can advance the understanding of complex climate-driven health risks and provide community-based strategies for early identification, prevention and adaption of health risks in human, animals and environment. We propose a regional One Health approach for assessing interactions at the Arctic humanÁanimalÁenvironment interface to enhance the understanding of, and response to, the complexities of climate change on the health of the Arctic inhabitants.

Research paper thumbnail of Quality assessment of nonanthrax vaccination data in the Defense Medical Surveillance System (DMSS), 1998–2004

Vaccine, 2008

We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS)... more We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS) during 1998-2004. We sampled servicemembers' medical charts at 28 Military Treatment Facilities and estimated the agreement between DMSS electronic and medical chart vaccination data, conditional on the data in the medical charts. Our analysis included 3831 individuals who received 39,305 nonanthrax vaccine doses. Yellow fever vaccine category had the highest conditional sensitivity for exact date match (83.4%; 95% CI = 80.1, 86.3); most vaccine categories' conditional sensitivities improved over time. Our study suggests DMSS vaccination data may be acceptable for post-marketing vaccine safety studies for certain vaccines and timeframes.

Research paper thumbnail of Assessment of anthrax vaccination data in the Defense Medical Surveillance System, 1998–2004

Pharmacoepidemiology and Drug Safety, 2007

Purpose Understanding the completeness and accuracy of U.S. military anthrax vaccination data is ... more Purpose Understanding the completeness and accuracy of U.S. military anthrax vaccination data is important to the design and interpretation of studies to assess the safety of anthrax vaccine. We estimated the agreement between electronically recorded anthrax vaccination data in the Defense Medical Surveillance System (DMSS) versus anthrax vaccination data abstracted from hardcopy medical charts in a representative sample of the U.S. military from 1998 to 2004. Methods Medical chart abstractions were conducted at 28 military treatment facilities for 4201 personnel. Abstracted anthrax vaccination data for 1817 personnel, representing 7400 anthrax vaccine doses, were compared with electronically captured data in the DMSS from 1998 to 2004. Sensitivity, positive predictive value (PPV), specificity and negative predictive value (NPV) were calculated using weighted analyses. Results Weighted person-level analysis revealed DMSS sensitivity ¼ 93.8% (95%CI ¼ 91.1, 95.8), specificity ¼ 87.0% (79.0, 92.3), PPV ¼ 85.6% (77.2, 91.3) and NPV ¼ 94.5% (91.7, 96.4). Report of anthrax vaccination within a AE7 days window in both medical chart and DMSS electronic data had a sensitivity of 88.3% (85.4, 90.7) and a PPV of 86.6% (84.9, 88.2) in the vaccine dose-level analysis.

Research paper thumbnail of Maximal cardiorespiratory responses to one- and two-legged cycling during acute and long-term exposure to 4300 meters altitude

European Journal of Applied Physiology and Occupational Physiology, 1988

Research paper thumbnail of A Public Health Approach to Injury Prevention: The US Military Experience

and sharing with colleagues.

Research paper thumbnail of A Short Medical School Course on Responding to Bioterrorism and Other Disasters

Academic Medicine, 2005

The events of 9/11 highlighted the limitations of the United States health care system in respond... more The events of 9/11 highlighted the limitations of the United States health care system in responding to large-scale public health emergencies. The key for an effective response to any mass casualty event is preparedness; thus, the education of medical students has become a priority. The Association of American Medical Colleges (AAMC) recommended that the nation's medical schools should thoroughly educate students about the public health and emergency services systems to ensure coordinated responses to weapons of mass destruction or other public health threats. In response, The Texas A&M University System Health Science Center College of Medicine, partnering with the Defense Institute for Medical Operations (DIMO), developed a one-week block of required (but not graded) instruction, the "Leadership Course in Disaster Response," first given in 2003-04 to 72 second-year students and taught by six military experts from DIMO. The course goal is to (1) educate students on resources available for regional disaster response; (2) define principles of resource management in disaster response; (3) identify specific agents associated with bioterrorism; and (4) understand the psychosocial aspects of disasters. The course was well received, and the 2004-05 session was improved, based on student and faculty feedback. The authors describe the details of the course (specifically, how the course was tailored to fit the AAMC guidelines), changes in students' knowledge and attitudes, and how the course was improved.

Research paper thumbnail of A Process to Identify Military Injury Prevention Priorities Based on Injury Type and Limited Duty Days

American Journal of Preventive Medicine, 2010

Background: Injuries, one of the leading public health problems in an otherwise healthy military ... more Background: Injuries, one of the leading public health problems in an otherwise healthy military population, affect operational readiness, increase healthcare costs, and result in disabilities and fatalities. This paper describes a systematic, data-driven, injury prevention-decision making process to rank potential injury prevention targets.

Research paper thumbnail of One Health – a strategy for resilience in a changing arctic

International Journal of Circumpolar Health, 2015

The circumpolar north is uniquely vulnerable to the health impacts of climate change. While inter... more The circumpolar north is uniquely vulnerable to the health impacts of climate change. While international Arctic collaboration on health has enhanced partnerships and advanced the health of inhabitants, significant challenges lie ahead. One Health is an approach that considers the connections between the environment, plant, animal and human health. Understanding this is increasingly critical in assessing the impact of global climate change on the health of Arctic inhabitants. The effects of climate change are complex and difficult to predict with certainty. Health risks include changes in the distribution of infectious disease, expansion of zoonotic diseases and vectors, changing migration patterns, impacts on food security and changes in water availability and quality, among others. A regional network of diverse stakeholder and transdisciplinary specialists from circumpolar nations and Indigenous groups can advance the understanding of complex climate-driven health risks and provide community-based strategies for early identification, prevention and adaption of health risks in human, animals and environment. We propose a regional One Health approach for assessing interactions at the Arctic humanÁanimalÁenvironment interface to enhance the understanding of, and response to, the complexities of climate change on the health of the Arctic inhabitants.

Research paper thumbnail of US Department of State Perspective: Antimicrobial resistance and Food Security

Research paper thumbnail of REVIEW ARTICLE One Health a strategy for resilience in a changing arctic

The circumpolar north is uniquely vulnerable to the health impacts of climate change. While inter... more The circumpolar north is uniquely vulnerable to the health impacts of climate change. While international Arctic collaboration on health has enhanced partnerships and advanced the health of inhabitants, significant challenges lie ahead. One Health is an approach that considers the connections between the environment, plant, animal and human health. Understanding this is increasingly critical in assessing the impact of global climate change on the health of Arctic inhabitants. The effects of climate change are complex and difficult to predict with certainty. Health risks include changes in the distribution of infectious disease, expansion of zoonotic diseases and vectors, changing migration patterns, impacts on food security and changes in water availability and quality, among others. A regional network of diverse stakeholder and transdisciplinary specialists from circumpolar nations and Indigenous groups can advance the understanding of complex climate-driven health risks and provid...

Research paper thumbnail of Operation Everest II: comparison of four instruments for measuring blood O2 saturation

Journal of Applied Physiology, 1989

The bias and precision of four different methods for determining O2 saturation (SO2) were evaluat... more The bias and precision of four different methods for determining O2 saturation (SO2) were evaluated during a study of hypobaric hypoxia conducted with seven male subjects exposed progressively over a 40-day period to simulated altitudes from sea level (760 Torr) to 8,840 m (240 Torr). SO2 of arterial and mixed venous blood samples were measured with the Instrumentation Laboratory 282 CO-oximeter (CO-OX), the Radiometer ABL-300 (ABL), and the Lex-O2-Con-K (LEX). Noninvasive measurements of arterial SO2 were made with a Hewlett-Packard 47201A ear oximeter (EAR-OX). The CO-OX method was used as a secondary standard for comparison with the other methods because it has been validated against the classical Van Slyke method over a wide physiological range (Maas et al., Clin. Chim. Acta 29: 303-309, 1970). The LEX results most closely approximated but consistently underestimated those of the CO-OX: LEX = 0.93 CO-OX -0.86, standard error of the estimate (SEE) = 5.17, r = 0.98, n = 670. The A...

Research paper thumbnail of Environmental health risk assessment methodology for overseas military deployment

Johns Hopkins APL …, 1999

Page 1. JOHNS HOPKINS APL TECHNICAL DIGEST, VOLUME 20, NUMBER 3 (1999) 405 ENVIRONMENTAL HEALTH R... more Page 1. JOHNS HOPKINS APL TECHNICAL DIGEST, VOLUME 20, NUMBER 3 (1999) 405 ENVIRONMENTAL HEALTH RISK ASSESSMENT METHODOLOGY The Johns Hopkins University School of Hygiene and Public Health is developing ...

Research paper thumbnail of Operation everest ii incidence of retinal pathology during a simulated ascent of mount everest

Research paper thumbnail of A Public Health Approach to Injury Prevention: The U.S. Military Experience

: TITLE: A Process to Identify Military Injury Prevention Priorities Based on Injury Type and Lim... more : TITLE: A Process to Identify Military Injury Prevention Priorities Based on Injury Type and Limited Duty Days. BACKGROUND: Injuries, one of the leading public health problems in an otherwise healthy military population, affect operational readiness, increase healthcare costs, and result in disabilities and fatalities. This paper describes a systematic, data-driven, injury prevention-decision making process to rank potential injury prevention targets. METHODS: Medical surveillance and safety report data on injuries for 2004 were reviewed. Non-fatal injury diagnoses (ICD-9-CM codes) obtained from the Defense Medical Surveillance System were ranked according to incident visit frequency and estimated limited duty days. Data on the top five injury types resulting in the greatest estimated limited duty days were matched with hospitalization and Service Safety Centers' accident investigation data to identify leading causes. Experts scored and ranked the causes using predetermined cri...

Research paper thumbnail of Ln Maximal cardiorespiratory responses to one-and two-leged 00 cycling during acute and long-term exposure to 4300 m

Research paper thumbnail of Expanding global and national influenza vaccine systems to match the COVID-19 pandemic response

Research paper thumbnail of Shaping meeting to explore the value of a coordinated work plan for epidemic and pandemic influenza vaccine preparedness

Research paper thumbnail of DoD Military Injury Prevention Priorities Working Group: Leading Injuries, Causes and Mitigation Recommendations

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.

Research paper thumbnail of Quality assessment of nonanthrax vaccination data in the Defense Medical Surveillance System (DMSS), 1998–2004

Vaccine, Mar 17, 2008

We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS)... more We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS) during 1998-2004. We sampled servicemembers' medical charts at 28 Military Treatment Facilities and estimated the agreement between DMSS electronic and medical chart vaccination data, conditional on the data in the medical charts. Our analysis included 3831 individuals who received 39,305 nonanthrax vaccine doses. Yellow fever vaccine category had the highest conditional sensitivity for exact date match (83.4%; 95% CI = 80.1, 86.3); most vaccine categories' conditional sensitivities improved over time. Our study suggests DMSS vaccination data may be acceptable for post-marketing vaccine safety studies for certain vaccines and timeframes.

Research paper thumbnail of Inhalation exposure risk during a military operation : a risk assessment approach /

Research paper thumbnail of One Health – a strategy for resilience in a changing arctic

International Journal of Circumpolar Health, 2015

The circumpolar north is uniquely vulnerable to the health impacts of climate change. While inter... more The circumpolar north is uniquely vulnerable to the health impacts of climate change. While international Arctic collaboration on health has enhanced partnerships and advanced the health of inhabitants, significant challenges lie ahead. One Health is an approach that considers the connections between the environment, plant, animal and human health. Understanding this is increasingly critical in assessing the impact of global climate change on the health of Arctic inhabitants. The effects of climate change are complex and difficult to predict with certainty. Health risks include changes in the distribution of infectious disease, expansion of zoonotic diseases and vectors, changing migration patterns, impacts on food security and changes in water availability and quality, among others. A regional network of diverse stakeholder and transdisciplinary specialists from circumpolar nations and Indigenous groups can advance the understanding of complex climate-driven health risks and provide community-based strategies for early identification, prevention and adaption of health risks in human, animals and environment. We propose a regional One Health approach for assessing interactions at the Arctic humanÁanimalÁenvironment interface to enhance the understanding of, and response to, the complexities of climate change on the health of the Arctic inhabitants.

Research paper thumbnail of Quality assessment of nonanthrax vaccination data in the Defense Medical Surveillance System (DMSS), 1998–2004

Vaccine, 2008

We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS)... more We assessed nonanthrax vaccination data quality in the Defense Medical Surveillance System (DMSS) during 1998-2004. We sampled servicemembers' medical charts at 28 Military Treatment Facilities and estimated the agreement between DMSS electronic and medical chart vaccination data, conditional on the data in the medical charts. Our analysis included 3831 individuals who received 39,305 nonanthrax vaccine doses. Yellow fever vaccine category had the highest conditional sensitivity for exact date match (83.4%; 95% CI = 80.1, 86.3); most vaccine categories' conditional sensitivities improved over time. Our study suggests DMSS vaccination data may be acceptable for post-marketing vaccine safety studies for certain vaccines and timeframes.

Research paper thumbnail of Assessment of anthrax vaccination data in the Defense Medical Surveillance System, 1998–2004

Pharmacoepidemiology and Drug Safety, 2007

Purpose Understanding the completeness and accuracy of U.S. military anthrax vaccination data is ... more Purpose Understanding the completeness and accuracy of U.S. military anthrax vaccination data is important to the design and interpretation of studies to assess the safety of anthrax vaccine. We estimated the agreement between electronically recorded anthrax vaccination data in the Defense Medical Surveillance System (DMSS) versus anthrax vaccination data abstracted from hardcopy medical charts in a representative sample of the U.S. military from 1998 to 2004. Methods Medical chart abstractions were conducted at 28 military treatment facilities for 4201 personnel. Abstracted anthrax vaccination data for 1817 personnel, representing 7400 anthrax vaccine doses, were compared with electronically captured data in the DMSS from 1998 to 2004. Sensitivity, positive predictive value (PPV), specificity and negative predictive value (NPV) were calculated using weighted analyses. Results Weighted person-level analysis revealed DMSS sensitivity ¼ 93.8% (95%CI ¼ 91.1, 95.8), specificity ¼ 87.0% (79.0, 92.3), PPV ¼ 85.6% (77.2, 91.3) and NPV ¼ 94.5% (91.7, 96.4). Report of anthrax vaccination within a AE7 days window in both medical chart and DMSS electronic data had a sensitivity of 88.3% (85.4, 90.7) and a PPV of 86.6% (84.9, 88.2) in the vaccine dose-level analysis.

Research paper thumbnail of Maximal cardiorespiratory responses to one- and two-legged cycling during acute and long-term exposure to 4300 meters altitude

European Journal of Applied Physiology and Occupational Physiology, 1988

Research paper thumbnail of A Public Health Approach to Injury Prevention: The US Military Experience

and sharing with colleagues.

Research paper thumbnail of A Short Medical School Course on Responding to Bioterrorism and Other Disasters

Academic Medicine, 2005

The events of 9/11 highlighted the limitations of the United States health care system in respond... more The events of 9/11 highlighted the limitations of the United States health care system in responding to large-scale public health emergencies. The key for an effective response to any mass casualty event is preparedness; thus, the education of medical students has become a priority. The Association of American Medical Colleges (AAMC) recommended that the nation's medical schools should thoroughly educate students about the public health and emergency services systems to ensure coordinated responses to weapons of mass destruction or other public health threats. In response, The Texas A&M University System Health Science Center College of Medicine, partnering with the Defense Institute for Medical Operations (DIMO), developed a one-week block of required (but not graded) instruction, the "Leadership Course in Disaster Response," first given in 2003-04 to 72 second-year students and taught by six military experts from DIMO. The course goal is to (1) educate students on resources available for regional disaster response; (2) define principles of resource management in disaster response; (3) identify specific agents associated with bioterrorism; and (4) understand the psychosocial aspects of disasters. The course was well received, and the 2004-05 session was improved, based on student and faculty feedback. The authors describe the details of the course (specifically, how the course was tailored to fit the AAMC guidelines), changes in students' knowledge and attitudes, and how the course was improved.

Research paper thumbnail of A Process to Identify Military Injury Prevention Priorities Based on Injury Type and Limited Duty Days

American Journal of Preventive Medicine, 2010

Background: Injuries, one of the leading public health problems in an otherwise healthy military ... more Background: Injuries, one of the leading public health problems in an otherwise healthy military population, affect operational readiness, increase healthcare costs, and result in disabilities and fatalities. This paper describes a systematic, data-driven, injury prevention-decision making process to rank potential injury prevention targets.

Research paper thumbnail of One Health – a strategy for resilience in a changing arctic

International Journal of Circumpolar Health, 2015

The circumpolar north is uniquely vulnerable to the health impacts of climate change. While inter... more The circumpolar north is uniquely vulnerable to the health impacts of climate change. While international Arctic collaboration on health has enhanced partnerships and advanced the health of inhabitants, significant challenges lie ahead. One Health is an approach that considers the connections between the environment, plant, animal and human health. Understanding this is increasingly critical in assessing the impact of global climate change on the health of Arctic inhabitants. The effects of climate change are complex and difficult to predict with certainty. Health risks include changes in the distribution of infectious disease, expansion of zoonotic diseases and vectors, changing migration patterns, impacts on food security and changes in water availability and quality, among others. A regional network of diverse stakeholder and transdisciplinary specialists from circumpolar nations and Indigenous groups can advance the understanding of complex climate-driven health risks and provide community-based strategies for early identification, prevention and adaption of health risks in human, animals and environment. We propose a regional One Health approach for assessing interactions at the Arctic humanÁanimalÁenvironment interface to enhance the understanding of, and response to, the complexities of climate change on the health of the Arctic inhabitants.