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Papers by can ayhan kaya
Animals
The objective was to determine the impact of feeding MCE on ruminal and intestinal morphology and... more The objective was to determine the impact of feeding MCE on ruminal and intestinal morphology and microbiota composition of calves. A total of 10 male and 10 female crossbred (dairy × beef) calves (6 d of age) were assigned randomly to control (CTL; n = 10) or MCE-supplemented (TRT; n = 10) groups. The MCE was fed in the milk replacer and top-dressed on the calf starter during pre-weaning (6 to 49 d) and post-weaning (50 to 95 d) periods, respectively. Calves were slaughtered at 95 d to collect rumen and intestinal samples to determine volatile fatty acid (VFA) profile, mucosal morphology, and microbiota composition. The effects of MCE were analyzed by accounting for the sex and breed effects. Feeding MCE increased rumen papillae length (p = 0.010) and intestinal villus height: crypt depth (p < 0.030) compared to CTL but did not affect rumen VFA profile. The TRT had a negligible impact on microbial community composition in both the rumen and the jejunum. In conclusion, feeding MC...
Animals
The study objective was to examine the effects of supplementing Gln and BCAA on the SFI and ADG o... more The study objective was to examine the effects of supplementing Gln and BCAA on the SFI and ADG of weaning dairy calves. Holstein heifer calves (11 calves /treatment) at 35 d of age were assigned to: (1) no amino acids (CTL), (2) Gln (8.0 g/d) alone (GLN), or (3) Gln (8.0 g/d) and BCAA (GLNB; 17.0, 10.0, and 11.0 g/d leucine, isoleucine, and valine, respectively) supplementations in whole milk during a stepdown weaning scheme. Calves were weaned completely once they achieved ≥1.0 kg/d SFI. Neither GLN nor GLNB affected SFI or ADG in the first week during weaning. The GLNB decreased SFI compared to CTL, but the SFI was similar between CTL and GLN in the remainder of the weaning scheme. All calves were weaned at 50 d of age. The SFI of GLNB was lower than that of GLN, and the SFI of both GLN and GLNB were lower than CTL post-weaning. The decreased SFI did not alter ADG during weaning or post-weaning. The GLNB tended to have higher plasma leptin and lower plasma serotonin concentration...
International Dental Research, 2017
Aim: The aim of this study was to evaluate the dental students’ hepatitis B vaccination and serol... more Aim: The aim of this study was to evaluate the dental students’ hepatitis B vaccination and serological status according demographic data. Methodology: A questionnaire prepared related to hepatitis B virus infection and demographic data of 290 students, educating at University of Fırat and Dicle, Faculty of Dentistry in 2016-2017 academic year was distributed. Chi-square test analysis was used for statistical analysis. p<0.05 was considered statistically significant. Results: In the study, it was determined that 17.9% of the students had hepatitis B in the family and 17.9% of them had seen themselves at risk. Of the 290 students who participated in this study, 42% were HBV vaccinated, 21.6% completed the vaccination scheme, 35% of the students had HBV carriers and 20.7% were controlling HBV serology. The higher class of students, the rate of development of vaccination, control of HBV serology, HBV carrier, and protective response increased significantly (p<0.01). Gender, paren...
Journal of Dairy Science, 2022
Weaning dairy calves from a high milk volume (≥8.0 kg/d) can negatively affect the growth and wel... more Weaning dairy calves from a high milk volume (≥8.0 kg/d) can negatively affect the growth and welfare even if it is performed in a step-down manner. Supplementation of Gln improved gut development of preweaning calves and mitigated weaning stresses of piglets to extents achieved with antibiotics. The study objective was to examine the effect of initiating a step-down weaning scheme with a Gln supplement at an early age on calf starter intake (CSI), average daily gain (ADG), and paracellular permeability of the intestinal epithelium of calves fed a high volume of milk (9.0 kg/d). Thirty-six Holstein heifer calves were assigned to 3 treatments (n = 12) as follows: (1) initiating weaning at 49 d of age (LW), (2) initiating weaning at 35 d of age (EW), and (3) initiating weaning at 35 d with a Gln supplement (2.0% of dry matter intake) from 28 to 42 d of age (EWG). Calves were fed 9.0 kg/d of whole milk until weaning was initiated by abruptly decreasing the milk volume to 3.0 kg/d. Weaning was completed once calves achieved ≥1.0 kg/d of CSI. The paracellular permeability of the intestinal epithelium was assessed with lactulose-tomannitol ratio (LMR) in the blood on 1 d before, and 3 and 7 d after the initiation of weaning. The blood was analyzed for haptoglobin, lipopolysaccharide-binding protein (LBP), and metabolites including AA. The CSI increased once milk volume was restricted in all treatments. The CSI of LW was greater than that of EW and EWG during the first week of weaning. The LW, EW, and EWG took 11, 19, and 16 d to achieve ≥1.0 kg/d of CSI and were weaned at 60, 54, and 51 d of age, respectively. The body weight (BW) of LW, EW, and EWG at the initiation of weaning were 68.2, 58.7, and 59.5 kg, respectively. Both LW and EWG achieved similar ADG, but ADG of EW was lower than LW during the first week of weaning. All calves had similar ADG during the second week of weaning. The BW of LW, EW, and EWG at weaning were 74.8, 66.5, and 66.4 kg, representing a 2.0, 1.8, and 1.8-fold increase in birth weight, respectively. All calves had similar BW of 88.6 and 164.3 kg at 10 and 20 wk of age, respectively. Regardless of the age, serum haptoglobin and plasma LBP concentrations increased on d 3 and returned to baseline concentrations on d 7 during weaning. The EW had a lower plasma LBP concentration than LW and EWG on d 3 during weaning. The LMR was similar between treatments on d 3 but increased by 44% for EW and LW on d 7, whereas the LMR of EWG remained unchanged during weaning. The postprandial serum concentration of Gln, Met, Trp, and β-hydroxybutyrate were greater for EWG than EW during weaning. Beginning step-down weaning at 35 d with a Gln supplement can help maintain the gut barrier function and wean dairy calves with a satisfactory CSI at 7 wk of age without affecting postweaning growth.
2020 Iowa State University Animal Industry Report, 2021
Supplementationof L-glutamine (Gln) at 1.0% of DMI has shown to enhance immune function,alleviate... more Supplementationof L-glutamine (Gln) at 1.0% of DMI has shown to enhance immune function,alleviate stress and promote growth in weaned piglets. Branched-chain aminoacids (BCAA) particularly leucine are known to promote muscle growth. Thoseenhancements are critical for calves undergoing weaning particularly from ahigh volume of milk at an early age. In the present study we examined theeffects of a Gln supplement (1.0% of DMI) with or without BCAA on starterintake and growth performance of dairy calves weaned early (35 d of age) from ahigh milk volume (9.0 L/d). A separategroup of calves not receiving any amino acid supplement served as the control(CTL). All calves were partially weaned restrictingthe milk volume to 3.0 L/d at 35 d of age. The amino acids were fed mixing inmilk during the first week of weaning (35 to 42 d). While having 9.0 L of milk,calves consumed zero grain but had average daily gain (ADG) close to 0.9 kg/d. Eventhough milk volume restriction significantly increas...
European Oral Research, 2019
Purpose The aim of this study is to evalute the anti-inflammatory effects of morus migra on exper... more Purpose The aim of this study is to evalute the anti-inflammatory effects of morus migra on experimentally-induced periodontitis in rats. Materials and Methods Twenty-four Wistar-albino rats were randomly divided into three groups: control group (C, n=8), experimental periodontitis (PER, n=8), experimental periodontitis and treated with Morus nigra (MN+PER, n=8) (50 mg/kg per day for 21 days). After 21 days, the rats were sacrificed, and alveolar bones were evaluated histopathologically and histometrically analyzed to obtain level of alveolar bone loss. The detection of RANKL and OPG were immunohistochemically performed. Serum and tissue levels of MMP-8 and MMP-13 were also analyzed. Results Morus nigra treatment decreased tissue MMP-8 and MMP-13 levels and there were significant differences in the case of tissue levels of MMP-8 and MMP-13 between groups PER and MN+PER (p=0.035, p=0.041). There were no significant differences among all the groups serum levels of MMP-8 and MMP-13 (p=0.067, p=0.082). In the histometric evaluation, alveolar bone loss was greater in the PER group compared to C and MN groups (p=0.035). Immuno-histochemical staining of RANKL activities were found significantly lower (p=0.037) and OPG activities were found significantly higher in MN+PER group when compared to PER group (p=0.021). Conclusion The present study reveals that systemic administration of Morus nigra significantly inhibited the regional alveolar bone resorption and contributes to periodontal healing in the rat experimental-periodontitis models.
Biotechnology & Biotechnological Equipment, 2006
Systhemic diseases and hormonal changes are risk factors for periodontal diseases. In diabetes me... more Systhemic diseases and hormonal changes are risk factors for periodontal diseases. In diabetes mellitus patients periodontal destruction is more severe than systhemic healthy patients. The increase of hormones during pregnancy causes more gingival inflammation and gestational gingivitis. In recent studies ıt was hypothesed that the increase of the level of progesteron in circulation stimulates the release of prostaglandin E 2 (PGE 2) which causes to gestational gingivitis. The aim of our study is to determine the level of PGE 2 in gingival crevicular fluid (GCF) of the pregnant individuals with type II diabetes mellitus and periodontitis. In addition it is aimed to investigate the probable correlations between GCF PGE 2 level and the clical parameters and periodontal disease severity. A total of 40 pregnant individual in 24-32 weeks with periodontitis (20 pregnant individual with type II diabetes mellitus, 20 pregnat individual systhemically healthy) were examined. To determine all the individuals periodontal status pocket depth (PD), plaque index (PI), gingival index (GI) and gingival bleeding index (GBI) scores were recorded. The volume of the GCF was also measured from the sampling site in addition to the other measurements. GCF PGE 2 level was determined by radioimmunoassy (RIA) method. The GCF PGE 2 level was determined as 38.27±26.08 pg/ml in type II diabetic pregnant group and 39.13±23.19 pg/ml in systhemic healthy pregnant group. There was no important difference of GCF PGE 2 level among the groups (p>0.05). When the probable correlations between clinical parameters and GCF PGE 2 levels were investigated there was found no correlation in healthy pregnant group, but there was correlation determined in type II diabetic pregnant group. When the full mouth clinical parameters were compared there was important differnces determined in the case of GI and GBI among the groups (p<0.01), but there was no important differences determined in the case of PD and PI (p>0.05). This study results establishes that there is no difference between type II diabetes mellitus pregnant patients with peiodontitis and sythemic healthy pregnants with periodontitis in the cases of GCF PGE 2 level and periodontal disease severity. Pays attention that GCF PGE 2 level can be used as a marker for determining the periodontal disease severity among type II diabetes mellitus pregnant patients as sythemic healthy pregnants.
Humat ve Eterik Yag Asidi ceren Organik Asit Karisimlarinin Broylerlerde Besi Performansi,Karkas ... more Humat ve Eterik Yag Asidi ceren Organik Asit Karisimlarinin Broylerlerde Besi Performansi,Karkas Kalitesi ve Bazi Kan Parametreleri Uzerine EtkileriBu calismada humik asit, eterik yag iceren organik asit karisimi ve bu iki yem katkisininkombinasyonunun broylerlerde besi performansi, karkas kalitesi ve bazi kan parametreleri uzerineolan etkileri incelenmistir. Bu amacla 320 adet gunluk Ross 308 civciv 4 gruba ve her bir grup ise20'ser hayvandan olusan 4 alt gruba ayrilmistir: Deneme gruplari:1) hicbir katki ilavesi yapilmayanKontrol Grubu (K); 2) eterik yag iceren organik asit karisimi (1 kg/ton) ilavesi yapilan Grup (A); 3)humik asit ilavesi (2,5 kg/ton) yapilan Grup (H) ve 4) eterik yag iceren organik asit (1 kg/ton) ile humikasitin (2,5 kg/ton) birlikte ilave edildigi Grup (AH) seklinde duzenlenmistir. Deneme 42 gunsurdurulmustur.Arastirmanin sonunda K, A, H ve AH gruplarinin ortalama canli agirlik degerleri sirasiyla,1990,07; 2054,76; 2007,16 ve 1556,94 g olarak tespit edilmistir. K, A, H gruplari arasinda istatistikanlamda bir fark olusmazken (p>0,05), AH grubuna ait deger diger gruplarin bulgularindan oldukcadusuk bulunmustur (p 0,05), AH grubuna ait deger diger gruplarin bulgularindan oldukcadusuk bulunmustur (p 0,05), AH grubuna ait deger diger gruplarin bulgularindan oldukca dusuk bulunmustur(p 0,05).K, A ve H gruplarinin sicak ve soguk karkas randiman degerleri arasinda istatistik anlamda birfark tespit edilmezken, AH grubuna ait degerler diger gruplardan oldukca dusuk bulunmustur(p 0,05). Bu degerlerin sicak karkasa orani bakimindan AH grubununortalama karaciger ve taslik oranlari diger gruplardan farkli bulunmustur (p 0,05).Gruplarin ortalama total protein, trigliserit ve kolesterol degerleri arasinda istatistik anlamda birfark tespit edilmemistir (p>0,05).Sonuc olarak, broyler rasyonlarina humat ve eterik yag asidi iceren organik asit karisimlarininayri ayri katilmasi ile elde edilen bulgularin genelde kabul edilebilir duzeyde oldugu gozlenmistir.Ancak her iki yem katki maddesinin birlikte kullanilmalari durumunda, besi performansiparametrelerinin onemli derecelerde dusmesi her iki yem katki maddesi arasinda negatif bir etkilesimbulunabilecegini akla getirmektedir. Bu nedenle her ikisinin birlikte kullanilmalarinin uygun olmayacagikanisina varilmistir. AbstractThe effects of humates and organic acid mixtures containing etheric oils on fatteningperformance, carcass quality and some blood parameters of broilers.An experiment was conducted to investigate the effect of humic acid, organic acid mixture containingetheric oils and combination of these two additives on fattening performance, carcass quality andsome blood parameters of broilers. A total of 320 day-old Ross 308 broiler chicks were assigned to 4treatments with 4 replicates each containing 20 chicks. The treatment groups were employed: 1)Control group (K) without additive, 2) Group (A) which supplemented with 1kg/ton organic acid mixturecontaining etheric oils, 3) Group H supplemented with 2.5 kg/ton humic acid, and 4) Group (AH)supplemented with 1kg/ton organic acid mixture containing etheric oils plus 2.5 kg/ton humic acid.Experimental period lasted 42 days.At the end of the trial, mean live weight of the chicks in Groups K, A, H and AH were definedas 1990,07; 2054,76; 2007,16 and 1556,94 g respectively. The values of groups K, A and H weresimilar (p>0,05), however the value of Group AH was significantly lower (p 0,05), while the total weight gain ofGroup AH was significantly lower (p 0,05).There was no difference among the Groups K, A and H in hot and cold carcass yields.However, this value was determined significantly lower (p 0,05). It was found that mean pH value of intestinal contents of Groups H and AHwere statistically lower (p 0,05).There were no difference in blood total protein, triglyceride and cholesterol levels among thegroups (p>0,05).As a result, the values obtained by the separate addition of humates and organic acid mixturescontaining etheric oils to broiler ratios are generally in a acceptable level. It can be remined that anegative interaction occurs by the addition of the combination of these two feed additives, because ofthe significant decrease of the fattening performance parameters. Because of this, it is convicted thatthe usage of this two feed additives together is not appropriate.
International Dental Research, 2011
Aim: To evaluate the levels of interleukin1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis fa... more Aim: To evaluate the levels of interleukin1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the samples of gingival crevicular fluid (GCF) taken from the late adult rats during the orthodontic tooth movement and to evaluate the responses to orthodontic treatment . Methodology: In experiment 19 adult (120 days) Spraque-Dawley rats were used. Approximately 15 g force applying open coil spring was applied actively between the upper incisors of the rats. Before and after the activation on the 3rd and 7th and 10th days GCF samples were taken from the vestibular surfaces of appliance fixed teeth using periopaper®. Then the samples were biochemically analyzed. For the statistical analysis of working days of each cytokines repetitive variance analysis technique was used. Results: The levels of IL-1β, IL-6 and TNF-α were the highest in the 3rd day and started to decrease on the 7th and 10th days. Conclusions: The cytokine levels of orthodontic force applied teet...
Turkish Journal of Orthodontics, 2008
Journal of Animal and Veterinary Advances, 2009
This experiment was conducted to investigate the effects of an organic acids and etheric oils mix... more This experiment was conducted to investigate the effects of an organic acids and etheric oils mixture (BIACID TM ) on fattening performance, carcass quality and some blood parameters of broilers. Therefore, a total of 160 days-old Ross 308 broiler chicks were assigned to 2 ...
Journal of Animal and Veterinary Advances, 2009
This experiment was conducted to investigate the effect of humic acid on fattening performance, c... more This experiment was conducted to investigate the effect of humic acid on fattening performance, carcass quality and some blood parameters of broilers. Therefore, a total of 160 day-old Ross 308 broiler chicks were assigned to 2 treatments with 4 replicates each ...
Animals
The objective was to determine the impact of feeding MCE on ruminal and intestinal morphology and... more The objective was to determine the impact of feeding MCE on ruminal and intestinal morphology and microbiota composition of calves. A total of 10 male and 10 female crossbred (dairy × beef) calves (6 d of age) were assigned randomly to control (CTL; n = 10) or MCE-supplemented (TRT; n = 10) groups. The MCE was fed in the milk replacer and top-dressed on the calf starter during pre-weaning (6 to 49 d) and post-weaning (50 to 95 d) periods, respectively. Calves were slaughtered at 95 d to collect rumen and intestinal samples to determine volatile fatty acid (VFA) profile, mucosal morphology, and microbiota composition. The effects of MCE were analyzed by accounting for the sex and breed effects. Feeding MCE increased rumen papillae length (p = 0.010) and intestinal villus height: crypt depth (p < 0.030) compared to CTL but did not affect rumen VFA profile. The TRT had a negligible impact on microbial community composition in both the rumen and the jejunum. In conclusion, feeding MC...
Animals
The study objective was to examine the effects of supplementing Gln and BCAA on the SFI and ADG o... more The study objective was to examine the effects of supplementing Gln and BCAA on the SFI and ADG of weaning dairy calves. Holstein heifer calves (11 calves /treatment) at 35 d of age were assigned to: (1) no amino acids (CTL), (2) Gln (8.0 g/d) alone (GLN), or (3) Gln (8.0 g/d) and BCAA (GLNB; 17.0, 10.0, and 11.0 g/d leucine, isoleucine, and valine, respectively) supplementations in whole milk during a stepdown weaning scheme. Calves were weaned completely once they achieved ≥1.0 kg/d SFI. Neither GLN nor GLNB affected SFI or ADG in the first week during weaning. The GLNB decreased SFI compared to CTL, but the SFI was similar between CTL and GLN in the remainder of the weaning scheme. All calves were weaned at 50 d of age. The SFI of GLNB was lower than that of GLN, and the SFI of both GLN and GLNB were lower than CTL post-weaning. The decreased SFI did not alter ADG during weaning or post-weaning. The GLNB tended to have higher plasma leptin and lower plasma serotonin concentration...
International Dental Research, 2017
Aim: The aim of this study was to evaluate the dental students’ hepatitis B vaccination and serol... more Aim: The aim of this study was to evaluate the dental students’ hepatitis B vaccination and serological status according demographic data. Methodology: A questionnaire prepared related to hepatitis B virus infection and demographic data of 290 students, educating at University of Fırat and Dicle, Faculty of Dentistry in 2016-2017 academic year was distributed. Chi-square test analysis was used for statistical analysis. p<0.05 was considered statistically significant. Results: In the study, it was determined that 17.9% of the students had hepatitis B in the family and 17.9% of them had seen themselves at risk. Of the 290 students who participated in this study, 42% were HBV vaccinated, 21.6% completed the vaccination scheme, 35% of the students had HBV carriers and 20.7% were controlling HBV serology. The higher class of students, the rate of development of vaccination, control of HBV serology, HBV carrier, and protective response increased significantly (p<0.01). Gender, paren...
Journal of Dairy Science, 2022
Weaning dairy calves from a high milk volume (≥8.0 kg/d) can negatively affect the growth and wel... more Weaning dairy calves from a high milk volume (≥8.0 kg/d) can negatively affect the growth and welfare even if it is performed in a step-down manner. Supplementation of Gln improved gut development of preweaning calves and mitigated weaning stresses of piglets to extents achieved with antibiotics. The study objective was to examine the effect of initiating a step-down weaning scheme with a Gln supplement at an early age on calf starter intake (CSI), average daily gain (ADG), and paracellular permeability of the intestinal epithelium of calves fed a high volume of milk (9.0 kg/d). Thirty-six Holstein heifer calves were assigned to 3 treatments (n = 12) as follows: (1) initiating weaning at 49 d of age (LW), (2) initiating weaning at 35 d of age (EW), and (3) initiating weaning at 35 d with a Gln supplement (2.0% of dry matter intake) from 28 to 42 d of age (EWG). Calves were fed 9.0 kg/d of whole milk until weaning was initiated by abruptly decreasing the milk volume to 3.0 kg/d. Weaning was completed once calves achieved ≥1.0 kg/d of CSI. The paracellular permeability of the intestinal epithelium was assessed with lactulose-tomannitol ratio (LMR) in the blood on 1 d before, and 3 and 7 d after the initiation of weaning. The blood was analyzed for haptoglobin, lipopolysaccharide-binding protein (LBP), and metabolites including AA. The CSI increased once milk volume was restricted in all treatments. The CSI of LW was greater than that of EW and EWG during the first week of weaning. The LW, EW, and EWG took 11, 19, and 16 d to achieve ≥1.0 kg/d of CSI and were weaned at 60, 54, and 51 d of age, respectively. The body weight (BW) of LW, EW, and EWG at the initiation of weaning were 68.2, 58.7, and 59.5 kg, respectively. Both LW and EWG achieved similar ADG, but ADG of EW was lower than LW during the first week of weaning. All calves had similar ADG during the second week of weaning. The BW of LW, EW, and EWG at weaning were 74.8, 66.5, and 66.4 kg, representing a 2.0, 1.8, and 1.8-fold increase in birth weight, respectively. All calves had similar BW of 88.6 and 164.3 kg at 10 and 20 wk of age, respectively. Regardless of the age, serum haptoglobin and plasma LBP concentrations increased on d 3 and returned to baseline concentrations on d 7 during weaning. The EW had a lower plasma LBP concentration than LW and EWG on d 3 during weaning. The LMR was similar between treatments on d 3 but increased by 44% for EW and LW on d 7, whereas the LMR of EWG remained unchanged during weaning. The postprandial serum concentration of Gln, Met, Trp, and β-hydroxybutyrate were greater for EWG than EW during weaning. Beginning step-down weaning at 35 d with a Gln supplement can help maintain the gut barrier function and wean dairy calves with a satisfactory CSI at 7 wk of age without affecting postweaning growth.
2020 Iowa State University Animal Industry Report, 2021
Supplementationof L-glutamine (Gln) at 1.0% of DMI has shown to enhance immune function,alleviate... more Supplementationof L-glutamine (Gln) at 1.0% of DMI has shown to enhance immune function,alleviate stress and promote growth in weaned piglets. Branched-chain aminoacids (BCAA) particularly leucine are known to promote muscle growth. Thoseenhancements are critical for calves undergoing weaning particularly from ahigh volume of milk at an early age. In the present study we examined theeffects of a Gln supplement (1.0% of DMI) with or without BCAA on starterintake and growth performance of dairy calves weaned early (35 d of age) from ahigh milk volume (9.0 L/d). A separategroup of calves not receiving any amino acid supplement served as the control(CTL). All calves were partially weaned restrictingthe milk volume to 3.0 L/d at 35 d of age. The amino acids were fed mixing inmilk during the first week of weaning (35 to 42 d). While having 9.0 L of milk,calves consumed zero grain but had average daily gain (ADG) close to 0.9 kg/d. Eventhough milk volume restriction significantly increas...
European Oral Research, 2019
Purpose The aim of this study is to evalute the anti-inflammatory effects of morus migra on exper... more Purpose The aim of this study is to evalute the anti-inflammatory effects of morus migra on experimentally-induced periodontitis in rats. Materials and Methods Twenty-four Wistar-albino rats were randomly divided into three groups: control group (C, n=8), experimental periodontitis (PER, n=8), experimental periodontitis and treated with Morus nigra (MN+PER, n=8) (50 mg/kg per day for 21 days). After 21 days, the rats were sacrificed, and alveolar bones were evaluated histopathologically and histometrically analyzed to obtain level of alveolar bone loss. The detection of RANKL and OPG were immunohistochemically performed. Serum and tissue levels of MMP-8 and MMP-13 were also analyzed. Results Morus nigra treatment decreased tissue MMP-8 and MMP-13 levels and there were significant differences in the case of tissue levels of MMP-8 and MMP-13 between groups PER and MN+PER (p=0.035, p=0.041). There were no significant differences among all the groups serum levels of MMP-8 and MMP-13 (p=0.067, p=0.082). In the histometric evaluation, alveolar bone loss was greater in the PER group compared to C and MN groups (p=0.035). Immuno-histochemical staining of RANKL activities were found significantly lower (p=0.037) and OPG activities were found significantly higher in MN+PER group when compared to PER group (p=0.021). Conclusion The present study reveals that systemic administration of Morus nigra significantly inhibited the regional alveolar bone resorption and contributes to periodontal healing in the rat experimental-periodontitis models.
Biotechnology & Biotechnological Equipment, 2006
Systhemic diseases and hormonal changes are risk factors for periodontal diseases. In diabetes me... more Systhemic diseases and hormonal changes are risk factors for periodontal diseases. In diabetes mellitus patients periodontal destruction is more severe than systhemic healthy patients. The increase of hormones during pregnancy causes more gingival inflammation and gestational gingivitis. In recent studies ıt was hypothesed that the increase of the level of progesteron in circulation stimulates the release of prostaglandin E 2 (PGE 2) which causes to gestational gingivitis. The aim of our study is to determine the level of PGE 2 in gingival crevicular fluid (GCF) of the pregnant individuals with type II diabetes mellitus and periodontitis. In addition it is aimed to investigate the probable correlations between GCF PGE 2 level and the clical parameters and periodontal disease severity. A total of 40 pregnant individual in 24-32 weeks with periodontitis (20 pregnant individual with type II diabetes mellitus, 20 pregnat individual systhemically healthy) were examined. To determine all the individuals periodontal status pocket depth (PD), plaque index (PI), gingival index (GI) and gingival bleeding index (GBI) scores were recorded. The volume of the GCF was also measured from the sampling site in addition to the other measurements. GCF PGE 2 level was determined by radioimmunoassy (RIA) method. The GCF PGE 2 level was determined as 38.27±26.08 pg/ml in type II diabetic pregnant group and 39.13±23.19 pg/ml in systhemic healthy pregnant group. There was no important difference of GCF PGE 2 level among the groups (p>0.05). When the probable correlations between clinical parameters and GCF PGE 2 levels were investigated there was found no correlation in healthy pregnant group, but there was correlation determined in type II diabetic pregnant group. When the full mouth clinical parameters were compared there was important differnces determined in the case of GI and GBI among the groups (p<0.01), but there was no important differences determined in the case of PD and PI (p>0.05). This study results establishes that there is no difference between type II diabetes mellitus pregnant patients with peiodontitis and sythemic healthy pregnants with periodontitis in the cases of GCF PGE 2 level and periodontal disease severity. Pays attention that GCF PGE 2 level can be used as a marker for determining the periodontal disease severity among type II diabetes mellitus pregnant patients as sythemic healthy pregnants.
Humat ve Eterik Yag Asidi ceren Organik Asit Karisimlarinin Broylerlerde Besi Performansi,Karkas ... more Humat ve Eterik Yag Asidi ceren Organik Asit Karisimlarinin Broylerlerde Besi Performansi,Karkas Kalitesi ve Bazi Kan Parametreleri Uzerine EtkileriBu calismada humik asit, eterik yag iceren organik asit karisimi ve bu iki yem katkisininkombinasyonunun broylerlerde besi performansi, karkas kalitesi ve bazi kan parametreleri uzerineolan etkileri incelenmistir. Bu amacla 320 adet gunluk Ross 308 civciv 4 gruba ve her bir grup ise20'ser hayvandan olusan 4 alt gruba ayrilmistir: Deneme gruplari:1) hicbir katki ilavesi yapilmayanKontrol Grubu (K); 2) eterik yag iceren organik asit karisimi (1 kg/ton) ilavesi yapilan Grup (A); 3)humik asit ilavesi (2,5 kg/ton) yapilan Grup (H) ve 4) eterik yag iceren organik asit (1 kg/ton) ile humikasitin (2,5 kg/ton) birlikte ilave edildigi Grup (AH) seklinde duzenlenmistir. Deneme 42 gunsurdurulmustur.Arastirmanin sonunda K, A, H ve AH gruplarinin ortalama canli agirlik degerleri sirasiyla,1990,07; 2054,76; 2007,16 ve 1556,94 g olarak tespit edilmistir. K, A, H gruplari arasinda istatistikanlamda bir fark olusmazken (p>0,05), AH grubuna ait deger diger gruplarin bulgularindan oldukcadusuk bulunmustur (p 0,05), AH grubuna ait deger diger gruplarin bulgularindan oldukcadusuk bulunmustur (p 0,05), AH grubuna ait deger diger gruplarin bulgularindan oldukca dusuk bulunmustur(p 0,05).K, A ve H gruplarinin sicak ve soguk karkas randiman degerleri arasinda istatistik anlamda birfark tespit edilmezken, AH grubuna ait degerler diger gruplardan oldukca dusuk bulunmustur(p 0,05). Bu degerlerin sicak karkasa orani bakimindan AH grubununortalama karaciger ve taslik oranlari diger gruplardan farkli bulunmustur (p 0,05).Gruplarin ortalama total protein, trigliserit ve kolesterol degerleri arasinda istatistik anlamda birfark tespit edilmemistir (p>0,05).Sonuc olarak, broyler rasyonlarina humat ve eterik yag asidi iceren organik asit karisimlarininayri ayri katilmasi ile elde edilen bulgularin genelde kabul edilebilir duzeyde oldugu gozlenmistir.Ancak her iki yem katki maddesinin birlikte kullanilmalari durumunda, besi performansiparametrelerinin onemli derecelerde dusmesi her iki yem katki maddesi arasinda negatif bir etkilesimbulunabilecegini akla getirmektedir. Bu nedenle her ikisinin birlikte kullanilmalarinin uygun olmayacagikanisina varilmistir. AbstractThe effects of humates and organic acid mixtures containing etheric oils on fatteningperformance, carcass quality and some blood parameters of broilers.An experiment was conducted to investigate the effect of humic acid, organic acid mixture containingetheric oils and combination of these two additives on fattening performance, carcass quality andsome blood parameters of broilers. A total of 320 day-old Ross 308 broiler chicks were assigned to 4treatments with 4 replicates each containing 20 chicks. The treatment groups were employed: 1)Control group (K) without additive, 2) Group (A) which supplemented with 1kg/ton organic acid mixturecontaining etheric oils, 3) Group H supplemented with 2.5 kg/ton humic acid, and 4) Group (AH)supplemented with 1kg/ton organic acid mixture containing etheric oils plus 2.5 kg/ton humic acid.Experimental period lasted 42 days.At the end of the trial, mean live weight of the chicks in Groups K, A, H and AH were definedas 1990,07; 2054,76; 2007,16 and 1556,94 g respectively. The values of groups K, A and H weresimilar (p>0,05), however the value of Group AH was significantly lower (p 0,05), while the total weight gain ofGroup AH was significantly lower (p 0,05).There was no difference among the Groups K, A and H in hot and cold carcass yields.However, this value was determined significantly lower (p 0,05). It was found that mean pH value of intestinal contents of Groups H and AHwere statistically lower (p 0,05).There were no difference in blood total protein, triglyceride and cholesterol levels among thegroups (p>0,05).As a result, the values obtained by the separate addition of humates and organic acid mixturescontaining etheric oils to broiler ratios are generally in a acceptable level. It can be remined that anegative interaction occurs by the addition of the combination of these two feed additives, because ofthe significant decrease of the fattening performance parameters. Because of this, it is convicted thatthe usage of this two feed additives together is not appropriate.
International Dental Research, 2011
Aim: To evaluate the levels of interleukin1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis fa... more Aim: To evaluate the levels of interleukin1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the samples of gingival crevicular fluid (GCF) taken from the late adult rats during the orthodontic tooth movement and to evaluate the responses to orthodontic treatment . Methodology: In experiment 19 adult (120 days) Spraque-Dawley rats were used. Approximately 15 g force applying open coil spring was applied actively between the upper incisors of the rats. Before and after the activation on the 3rd and 7th and 10th days GCF samples were taken from the vestibular surfaces of appliance fixed teeth using periopaper®. Then the samples were biochemically analyzed. For the statistical analysis of working days of each cytokines repetitive variance analysis technique was used. Results: The levels of IL-1β, IL-6 and TNF-α were the highest in the 3rd day and started to decrease on the 7th and 10th days. Conclusions: The cytokine levels of orthodontic force applied teet...
Turkish Journal of Orthodontics, 2008
Journal of Animal and Veterinary Advances, 2009
This experiment was conducted to investigate the effects of an organic acids and etheric oils mix... more This experiment was conducted to investigate the effects of an organic acids and etheric oils mixture (BIACID TM ) on fattening performance, carcass quality and some blood parameters of broilers. Therefore, a total of 160 days-old Ross 308 broiler chicks were assigned to 2 ...
Journal of Animal and Veterinary Advances, 2009
This experiment was conducted to investigate the effect of humic acid on fattening performance, c... more This experiment was conducted to investigate the effect of humic acid on fattening performance, carcass quality and some blood parameters of broilers. Therefore, a total of 160 day-old Ross 308 broiler chicks were assigned to 2 treatments with 4 replicates each ...