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Papers by carolina marotta

Phytoparasitica, 1994

The range of intraspecific variation in scale insects is often remarkably wide, and is favored by... more The range of intraspecific variation in scale insects is often remarkably wide, and is favored by polyphagy, parthenogenesis and wide distribution of several species. Variation is displayed in both morphological and biological characters. Many morphs have been described as separate species.

The Clinical Supervisor, 2010

Cognitive complexity is a crucial factor in counselor efficacy, yet an empirically validated inst... more Cognitive complexity is a crucial factor in counselor efficacy, yet an empirically validated instrument that measures counselors’ cognitions about clients does not exist. Development and preliminary psychometric support for such a measure, the Counselor Cognitions Questionnaire (CCQ), are described. Evidence of validity and reliability are reported.

Journal of Cognitive Neuroscience, 2005

& One of the most impressive disorders following brain damage to the ventral occipitotemporal cor... more & One of the most impressive disorders following brain damage to the ventral occipitotemporal cortex is prosopagnosia, or the inability to recognize faces. Although acquired prosopagnosia with preserved general visual and memory functions is rare, several cases have been described in the neuropsychological literature and studied at the functional and neural level over the last decades. Here we tested a braindamaged patient presenting a deficit restricted to the category of faces to clarify the nature of the missing and preserved components of the face processing system when it is selectively damaged. Following learning to identify 10 neutral and happy faces through extensive training, we investigated patient PS's recognition of faces using Bubbles, a response classification technique that sampled facial information across the faces in different bandwidths of spatial frequencies [Bubbles: A technique to reveal the use of information in recognition tasks. Vision Research, 41, 2261Research, 41, -2271Research, 41, , 2001. Although PS gradually used less information (i.e., the number of bubbles) to identify faces over testing, the total information required was much larger than for normal controls and decreased less steeply with practice. Most importantly, the facial information used to identify individual faces differed between PS and controls. Specifically, in marked contrast to controls, PS did not use the optimal eye information to identify familiar faces, but instead the lower part of the face, including the mouth and the external contours, as normal observers typically do when processing unfamiliar faces. Together, the findings reported here suggest that damage to the face processing system is characterized by an inability to use the information that is optimal to judge identity, focusing instead on suboptimal information. & D

Zoomorphology, 2003

The spermatozoa of two species supposed to be basal to Gastrotricha Chaetonotida, Neodasys ciritu... more The spermatozoa of two species supposed to be basal to Gastrotricha Chaetonotida, Neodasys ciritus and Musellifer delamarei, were studied in order to supply further elements to the understanding of sperm evolution in Chaetonotida, a group in which a fully parthenogenetic reproduction is dominant. Two considerably different sperm patterns were found: the spermatozoon of N. ciritus has a simple, conical acrosome, a short, condensed nucleus, few conventional mitochondria randomly arranged along the sperm head, and a 9×2+2 flagellum perpendicular to the sperm major axis. The spermatozoon of M. delamarei is a filiform cell with a simple acrosome, a partially condensed nucleus, four mitochondria at the nuclear base, and a flagellum with a 9×2+2 axoneme and large accessory fibers. Some sperm features of M. delamarei are comparable to those of Xenotrichulidae, the only other Chaetonotida producing conventional spermatozoa, whereas the sperm of N. ciritus appears different from all the other patterns known among Gastrotricha, thus knowledge of it does not help in solving the problem of the discussed phylogenetic position of the genus.

International Journal of Gastrointestinal Cancer, 1994

Mutations of the p53 tumor suppressor gene are quite common in pancreatic cancer. In l 7% of the ... more Mutations of the p53 tumor suppressor gene are quite common in pancreatic cancer. In l 7% of the patients with cancer of the pancreas autoantibodies, directed again.st this mutated nucleus protein (and-p53-Ab), are detectable. The aim of our study was to determine, whether the presence of and-p53-Ab has an influence in the development of distant metastases. Methods: Sere of 130 patients suffering from pancreatic carcinoma were tested for anti-p53-Ab via ELISA and immunoblorting using recombinant p53-protein as a target. These patients were classified according to UICC-criteria: stage I: 14%, stage II: 5%, stage III: 48% and stage IV: 32%. Results: In 22 patients anti-p53-Ab were detectable (stage I: 11%, stage II: 5%, stage III: 74% and stage IV: 1t%). Only 2./21 had liver metastases, Comparing primary tumor expansion (T3) with occurrence of liver metastases, we found that in the anti-p53-Ab negative group 65% of the patients with T3-mmor had liver metastases, whereas in the anti-p53-Ab positive group only 17% had liver metastases. Conclusion: Autoantibodies directed against p53 occur in 16% of patients with pancreatic cancer. The presence of these autoantibodies seems to have a protective function for the development of liver metastases. Further studies comparing anti-p53-Ab status with survival times and disease free suv:ival are in progress.

International Journal for The Advancement of Counselling, 2008

The concept of globalization elicits a wide range of reactions among the public, policy makers, a... more The concept of globalization elicits a wide range of reactions among the public, policy makers, and academics (Bennhold 2007; Bradsher 2006; Cheng 2005; Dobbs 2004; Friedman 2005; Gilbert 2006; Oppenheimer 2005; Stiglitz 2006; Winestock 2001; World Commission on the Social Dimension of Globalization 2004). Increased understanding of globalization can help counselors recognize their influential role as one of the few groups of professionals that operate in schools, mental health, and career counseling settings. Because the consequences of globalization impact every aspect of life, counselors have a responsibility to understand globalization systemically, including how it impacts the practice of counseling and how to help their clients function effectively in the context of globalization. In this article, which is intended as a primer for continued dialogue, globalization is introduced as an issue to be further studied and responded to by professional organizations around the world. Examples of globalization are offered and a case is made for continued collaboration between quality assurance and membership organizations in addressing globalization.

Archives of Clinical Neuropsychology, 2010

Cancer Cell, 2011

TP53 missense mutations dramatically influence tumor progression, however, their mechanism of act... more TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness. Furthermore, we identified a transcriptional signature associated with poor prognosis in breast cancer and, in a cohort of patients, Pin1 overexpression influenced the prognostic value of p53 mutation. These results define a Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers.

Cancer Cell, 2011

TP53 missense mutations dramatically influence tumor progression, however, their mechanism of act... more TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness. Furthermore, we identified a transcriptional signature associated with poor prognosis in breast cancer and, in a cohort of patients, Pin1 overexpression influenced the prognostic value of p53 mutation. These results define a Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers.

Phytoparasitica, 1994

The range of intraspecific variation in scale insects is often remarkably wide, and is favored by... more The range of intraspecific variation in scale insects is often remarkably wide, and is favored by polyphagy, parthenogenesis and wide distribution of several species. Variation is displayed in both morphological and biological characters. Many morphs have been described as separate species.

The Clinical Supervisor, 2010

Cognitive complexity is a crucial factor in counselor efficacy, yet an empirically validated inst... more Cognitive complexity is a crucial factor in counselor efficacy, yet an empirically validated instrument that measures counselors’ cognitions about clients does not exist. Development and preliminary psychometric support for such a measure, the Counselor Cognitions Questionnaire (CCQ), are described. Evidence of validity and reliability are reported.

Journal of Cognitive Neuroscience, 2005

& One of the most impressive disorders following brain damage to the ventral occipitotemporal cor... more & One of the most impressive disorders following brain damage to the ventral occipitotemporal cortex is prosopagnosia, or the inability to recognize faces. Although acquired prosopagnosia with preserved general visual and memory functions is rare, several cases have been described in the neuropsychological literature and studied at the functional and neural level over the last decades. Here we tested a braindamaged patient presenting a deficit restricted to the category of faces to clarify the nature of the missing and preserved components of the face processing system when it is selectively damaged. Following learning to identify 10 neutral and happy faces through extensive training, we investigated patient PS's recognition of faces using Bubbles, a response classification technique that sampled facial information across the faces in different bandwidths of spatial frequencies [Bubbles: A technique to reveal the use of information in recognition tasks. Vision Research, 41, 2261Research, 41, -2271Research, 41, , 2001. Although PS gradually used less information (i.e., the number of bubbles) to identify faces over testing, the total information required was much larger than for normal controls and decreased less steeply with practice. Most importantly, the facial information used to identify individual faces differed between PS and controls. Specifically, in marked contrast to controls, PS did not use the optimal eye information to identify familiar faces, but instead the lower part of the face, including the mouth and the external contours, as normal observers typically do when processing unfamiliar faces. Together, the findings reported here suggest that damage to the face processing system is characterized by an inability to use the information that is optimal to judge identity, focusing instead on suboptimal information. & D

Zoomorphology, 2003

The spermatozoa of two species supposed to be basal to Gastrotricha Chaetonotida, Neodasys ciritu... more The spermatozoa of two species supposed to be basal to Gastrotricha Chaetonotida, Neodasys ciritus and Musellifer delamarei, were studied in order to supply further elements to the understanding of sperm evolution in Chaetonotida, a group in which a fully parthenogenetic reproduction is dominant. Two considerably different sperm patterns were found: the spermatozoon of N. ciritus has a simple, conical acrosome, a short, condensed nucleus, few conventional mitochondria randomly arranged along the sperm head, and a 9×2+2 flagellum perpendicular to the sperm major axis. The spermatozoon of M. delamarei is a filiform cell with a simple acrosome, a partially condensed nucleus, four mitochondria at the nuclear base, and a flagellum with a 9×2+2 axoneme and large accessory fibers. Some sperm features of M. delamarei are comparable to those of Xenotrichulidae, the only other Chaetonotida producing conventional spermatozoa, whereas the sperm of N. ciritus appears different from all the other patterns known among Gastrotricha, thus knowledge of it does not help in solving the problem of the discussed phylogenetic position of the genus.

International Journal of Gastrointestinal Cancer, 1994

Mutations of the p53 tumor suppressor gene are quite common in pancreatic cancer. In l 7% of the ... more Mutations of the p53 tumor suppressor gene are quite common in pancreatic cancer. In l 7% of the patients with cancer of the pancreas autoantibodies, directed again.st this mutated nucleus protein (and-p53-Ab), are detectable. The aim of our study was to determine, whether the presence of and-p53-Ab has an influence in the development of distant metastases. Methods: Sere of 130 patients suffering from pancreatic carcinoma were tested for anti-p53-Ab via ELISA and immunoblorting using recombinant p53-protein as a target. These patients were classified according to UICC-criteria: stage I: 14%, stage II: 5%, stage III: 48% and stage IV: 32%. Results: In 22 patients anti-p53-Ab were detectable (stage I: 11%, stage II: 5%, stage III: 74% and stage IV: 1t%). Only 2./21 had liver metastases, Comparing primary tumor expansion (T3) with occurrence of liver metastases, we found that in the anti-p53-Ab negative group 65% of the patients with T3-mmor had liver metastases, whereas in the anti-p53-Ab positive group only 17% had liver metastases. Conclusion: Autoantibodies directed against p53 occur in 16% of patients with pancreatic cancer. The presence of these autoantibodies seems to have a protective function for the development of liver metastases. Further studies comparing anti-p53-Ab status with survival times and disease free suv:ival are in progress.

International Journal for The Advancement of Counselling, 2008

The concept of globalization elicits a wide range of reactions among the public, policy makers, a... more The concept of globalization elicits a wide range of reactions among the public, policy makers, and academics (Bennhold 2007; Bradsher 2006; Cheng 2005; Dobbs 2004; Friedman 2005; Gilbert 2006; Oppenheimer 2005; Stiglitz 2006; Winestock 2001; World Commission on the Social Dimension of Globalization 2004). Increased understanding of globalization can help counselors recognize their influential role as one of the few groups of professionals that operate in schools, mental health, and career counseling settings. Because the consequences of globalization impact every aspect of life, counselors have a responsibility to understand globalization systemically, including how it impacts the practice of counseling and how to help their clients function effectively in the context of globalization. In this article, which is intended as a primer for continued dialogue, globalization is introduced as an issue to be further studied and responded to by professional organizations around the world. Examples of globalization are offered and a case is made for continued collaboration between quality assurance and membership organizations in addressing globalization.

Archives of Clinical Neuropsychology, 2010

Cancer Cell, 2011

TP53 missense mutations dramatically influence tumor progression, however, their mechanism of act... more TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness. Furthermore, we identified a transcriptional signature associated with poor prognosis in breast cancer and, in a cohort of patients, Pin1 overexpression influenced the prognostic value of p53 mutation. These results define a Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers.

Cancer Cell, 2011

TP53 missense mutations dramatically influence tumor progression, however, their mechanism of act... more TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions. Pin1 enhances tumorigenesis in a Li-Fraumeni mouse model and cooperates with mutant p53 in Ras-dependent transformation. In breast cancer cells, Pin1 promotes mutant p53 dependent inhibition of the antimetastatic factor p63 and induction of a mutant p53 transcriptional program to increase aggressiveness. Furthermore, we identified a transcriptional signature associated with poor prognosis in breast cancer and, in a cohort of patients, Pin1 overexpression influenced the prognostic value of p53 mutation. These results define a Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers.