carlo biagini - Academia.edu (original) (raw)
Papers by carlo biagini
MATERIALS AND METHODS: First, computed tomographic (CT), magnetic resonance (MR), ultrasonographi... more MATERIALS AND METHODS: First, computed tomographic (CT), magnetic resonance (MR), ultrasonographic (US), and technetium 99m methoxyisobutyl-isonitrile (MIBI) scintigraphic images in 49 patients with primary hyperparathyroidism were retrospectively evaluated. A single-blind, prospective study that included 16 patients with primary hyperparathyroidism was then conducted. MR, US, scintigraphic, and color Doppler US images of the neck were obtained and analyzed.
Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements usi... more Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements using Spin-Echo Diffusion-Weighted Echo-Planar (SE-DW-EPI) sequences, as a function of Signal-to-Noise Ratio (SNR). Methods: multiple multi-b SE-DW-EPI scans with the same parameters but the lipid suppression technique have been compared on water phantom with a 3T MRI equipment. The SNR has been estimated using the method of difference. Images have been analyzed manually, comparing the signal intensities at different b-values. Results: All measurements show a high repeatability and strong self-consistency. A significant dependence of the ADC on SNR has been shown, and its lowest limitto obtain reliable quantitative answers has been stated. Conclusion: ADC measurements in vivo must be carefully designed to avoid systematic errors during acquisition and post-processing due to low SNR.
Communications in Computer and Information Science, 2017
Journal of Diagnostic Medical Sonography, 2017
Diagnostic medical sonography (DMS) is an operator and patient dependent examination where anatom... more Diagnostic medical sonography (DMS) is an operator and patient dependent examination where anatomical and hemodynamic analysis settings have to be adjusted in real-time while scanning. Several techniques were developed so far to perform the DMS acquisition and post processing adjustments quickly and to maximize their easiness. A new easyMode Technology was recently implemented in order to drastically simplify the operator system setup to only three macro-parameters related to the desired effect in terms of: resolution/penetration, contrast/soft, smooth/sharp. A multidimensional algorithm varies simultaneously several internal system parameters to modify the image in the direction of the macro-parameter varied by the user. No prior knowledge of ultrasound physics or technology is required to adjust the macro-parameter, the effects of which are directly visible on the sonographic image in real-time (for instance, to optimize the level of smoothness with respect to sonographic image co...
JOURNAL OF ADVANCES IN PHYSICS, 2014
Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements usi... more Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements using Spin-Echo Diffusion-Weighted Echo-Planar (SE-DW-EPI) sequences, as a function of Signal-to-Noise Ratio (SNR).Methods: multiple multi-b SE-DW-EPI scans with the same parameters but the lipid suppression technique have been compared on water phantom with a 3T MRI equipment. The SNR has been estimated using the method of difference. Images have been analyzed manually, comparing the signal intensities at different b-values.Results: All measurements show a high repeatability and strong self-consistency. A significant dependence of the ADC on SNR has been shown, and its lowest limitto obtain reliable quantitative answers has been stated.Conclusion: ADC measurements in vivo must be carefully designed to avoid systematic errors during acquisition and post-processing due to low SNR.
Familial cancer, Jan 22, 2015
Primary hyperparathyroidism (HPT) is the most common endocrinopathy in Multiple Endocrine Neoplas... more Primary hyperparathyroidism (HPT) is the most common endocrinopathy in Multiple Endocrine Neoplasia type 1 (MEN1) syndrome. Supernumerary and/or ectopic parathyroid glands, potentially causes of persistent or recurrent HPT after surgery, have been previously described. However, this is the first ever described case of ectopic parathyroid gland localized in the aortopulmunary window causing HPT in MEN1. After a consistent concordant pre-operative imaging assessment the patient, a 16 years old male affected by a severe hypercalcemia, underwent surgery. The parathyroid was found very deeply near the tracheal bifurcation, hidden by the aortic arch itself and for this reason not visible at the beginning of the dissection but only after being identified by palpation for its typical consistence. The intraoperative PTH decreased at normal level 10 min after removal of the ectopic gland. The patient remained with normal value of calcemia and PTH during the 10 months of follow-up.
La Radiologia medica, 1992
The correct assessment of T (depth of infiltration of bladder wall by cancer) is relevant to plan... more The correct assessment of T (depth of infiltration of bladder wall by cancer) is relevant to plan therapy. In fact, besides staging the local lesion, this can predict pelvic and lumboaortic lymphnode involvement (N parameter) statistically. At the INRCA Hospital in Florence, from January 1987 to December 1989, transurethral US was performed on 66 patients affected with bladder carcinomas, in order to assess the value of this diagnostic method; in all patients pathologic staging on surgical specimens from TUR (63 cases) and cystectomy (3 cases) was performed. Follow-up lasted 24 months at least. When comparing US staging (according to Holm classification) to postoperative histopathologic findings, our results showed that US tends to overstage the lesions, while no understaged tumors were seen in our series. Diagnostic accuracy was 70%. It must be pointed out that TRUS demonstrated hidden submucosal tumors in two patients previously treated with intravesical chemotherapy. Retrospectiv...
American journal of physical medicine, 1987
Three-months re-education treatment of genuine stress incontinence was given to 26 female outpati... more Three-months re-education treatment of genuine stress incontinence was given to 26 female outpatients: 22 patients completed the treatment programme and 4 interrupted it for various reasons. The aims of the treatment were both to correct compensatory habits that patients used to conceal or reduce leakage accidents and to give specific education and strengthening of pelvic floor muscles. All patients who completed the three-months treatment definitely improved and 7 were cured. Accordingly a marked reduction or absence of weekly incontinence episodes as well as a reduction of the daily frequency of micturition was observed. On vaginal palpation a clear-cut improvement of pubococcygeous muscle contractility was detectable. Urethral closure pressure profilometry showed significant improvement of functional urethral profile length at rest and of maximal urethral closure present both at rest and during maximal voluntary contraction of the pelvic floor muscles. Micturition cystourethrogra...
The Journal of Clinical Endocrinology & Metabolism, 2014
![Research paper thumbnail of [Risk of recurrence following partial thyroidectomy for benign lesions. Report of 58 patients 15-25 years after surgery]](https://attachments.academia-assets.com/84966239/thumbnails/1.jpg)
](Minerva chirurgica, 2003
Since the 1980's, thanks to the introduction of new techniques and methods for the study of t... more Since the 1980's, thanks to the introduction of new techniques and methods for the study of thyroid function, new light has been shed on certain aspects of thyroid disease that constitute the basis for surgical therapy. Multinodular goiter is a disorder affecting the entire gland, even when alterations mostly or exclusively involve a single lobe. The functional deficit resulting from partial or subtotal resection has a hypertophic/hyperplastic effect on the remaining parenchyma. Partial resections often lead to postoperative hypothyroidism, usually of a subclinical nature, which implies difficult management by means of replacement therapy. The authors report a series of 58 patients who underwent partial thyroidectomy to treat benign thyroid disease at the 2nd Surgical Department of the University of Florence during the period 1975-1985. Of these patients, operated on more than 15 years ago, 36.2% - the majority of whom (87.5%) have constantly been on substitutive therapy using L...
Journal of Sexual Medicine, 2009
Radiology, 2000
To determine the appropriate choice of imaging techniques for localization of nodular lesions of ... more To determine the appropriate choice of imaging techniques for localization of nodular lesions of parathyroid glands. First, computed tomographic (CT), magnetic resonance (MR), ultrasonographic (US), and technetium 99m methoxyisobutyl-isonitrile (MIBI) scintigraphic images in 49 patients with primary hyperparathyroidism were retrospectively evaluated. A single-blind, prospective study that included 16 patients with primary hyperparathyroidism was then conducted. MR, US, scintigraphic, and color Doppler US images of the neck were obtained and analyzed. In the retrospective study, CT, MR imaging, and US had low sensitivity (13%, 17%, and 27%, respectively) and specificity (39%, 65%, and 65%, respectively). Scintigraphy had 57% sensitivity and 85% specificity. In the prospective study, the use of latest-generation MR and US equipment and the participation of experienced operators led to improved sensitivity and specificity for these techniques. The combination of US and scintigraphy resulted in improved sensitivity (96%), specificity (83%), and positive and negative predictive values (88% and 94%, respectively), relative to the results obtained with either method alone. Doppler US was of little help in the setting of small glands. The combination of (99m)Tc MIBI scintigraphy and US performed by well-trained operators with up-to-date instruments appeared to be the best diagnostic tool for the preoperative diagnosis of parathyroid disease.
MATERIALS AND METHODS: First, computed tomographic (CT), magnetic resonance (MR), ultrasonographi... more MATERIALS AND METHODS: First, computed tomographic (CT), magnetic resonance (MR), ultrasonographic (US), and technetium 99m methoxyisobutyl-isonitrile (MIBI) scintigraphic images in 49 patients with primary hyperparathyroidism were retrospectively evaluated. A single-blind, prospective study that included 16 patients with primary hyperparathyroidism was then conducted. MR, US, scintigraphic, and color Doppler US images of the neck were obtained and analyzed.
Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements usi... more Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements using Spin-Echo Diffusion-Weighted Echo-Planar (SE-DW-EPI) sequences, as a function of Signal-to-Noise Ratio (SNR). Methods: multiple multi-b SE-DW-EPI scans with the same parameters but the lipid suppression technique have been compared on water phantom with a 3T MRI equipment. The SNR has been estimated using the method of difference. Images have been analyzed manually, comparing the signal intensities at different b-values. Results: All measurements show a high repeatability and strong self-consistency. A significant dependence of the ADC on SNR has been shown, and its lowest limitto obtain reliable quantitative answers has been stated. Conclusion: ADC measurements in vivo must be carefully designed to avoid systematic errors during acquisition and post-processing due to low SNR.
Communications in Computer and Information Science, 2017
Journal of Diagnostic Medical Sonography, 2017
Diagnostic medical sonography (DMS) is an operator and patient dependent examination where anatom... more Diagnostic medical sonography (DMS) is an operator and patient dependent examination where anatomical and hemodynamic analysis settings have to be adjusted in real-time while scanning. Several techniques were developed so far to perform the DMS acquisition and post processing adjustments quickly and to maximize their easiness. A new easyMode Technology was recently implemented in order to drastically simplify the operator system setup to only three macro-parameters related to the desired effect in terms of: resolution/penetration, contrast/soft, smooth/sharp. A multidimensional algorithm varies simultaneously several internal system parameters to modify the image in the direction of the macro-parameter varied by the user. No prior knowledge of ultrasound physics or technology is required to adjust the macro-parameter, the effects of which are directly visible on the sonographic image in real-time (for instance, to optimize the level of smoothness with respect to sonographic image co...
JOURNAL OF ADVANCES IN PHYSICS, 2014
Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements usi... more Purpose: To define experimental grounds for Apparent Diffusion Coefficient (ADC) measurements using Spin-Echo Diffusion-Weighted Echo-Planar (SE-DW-EPI) sequences, as a function of Signal-to-Noise Ratio (SNR).Methods: multiple multi-b SE-DW-EPI scans with the same parameters but the lipid suppression technique have been compared on water phantom with a 3T MRI equipment. The SNR has been estimated using the method of difference. Images have been analyzed manually, comparing the signal intensities at different b-values.Results: All measurements show a high repeatability and strong self-consistency. A significant dependence of the ADC on SNR has been shown, and its lowest limitto obtain reliable quantitative answers has been stated.Conclusion: ADC measurements in vivo must be carefully designed to avoid systematic errors during acquisition and post-processing due to low SNR.
Familial cancer, Jan 22, 2015
Primary hyperparathyroidism (HPT) is the most common endocrinopathy in Multiple Endocrine Neoplas... more Primary hyperparathyroidism (HPT) is the most common endocrinopathy in Multiple Endocrine Neoplasia type 1 (MEN1) syndrome. Supernumerary and/or ectopic parathyroid glands, potentially causes of persistent or recurrent HPT after surgery, have been previously described. However, this is the first ever described case of ectopic parathyroid gland localized in the aortopulmunary window causing HPT in MEN1. After a consistent concordant pre-operative imaging assessment the patient, a 16 years old male affected by a severe hypercalcemia, underwent surgery. The parathyroid was found very deeply near the tracheal bifurcation, hidden by the aortic arch itself and for this reason not visible at the beginning of the dissection but only after being identified by palpation for its typical consistence. The intraoperative PTH decreased at normal level 10 min after removal of the ectopic gland. The patient remained with normal value of calcemia and PTH during the 10 months of follow-up.
La Radiologia medica, 1992
The correct assessment of T (depth of infiltration of bladder wall by cancer) is relevant to plan... more The correct assessment of T (depth of infiltration of bladder wall by cancer) is relevant to plan therapy. In fact, besides staging the local lesion, this can predict pelvic and lumboaortic lymphnode involvement (N parameter) statistically. At the INRCA Hospital in Florence, from January 1987 to December 1989, transurethral US was performed on 66 patients affected with bladder carcinomas, in order to assess the value of this diagnostic method; in all patients pathologic staging on surgical specimens from TUR (63 cases) and cystectomy (3 cases) was performed. Follow-up lasted 24 months at least. When comparing US staging (according to Holm classification) to postoperative histopathologic findings, our results showed that US tends to overstage the lesions, while no understaged tumors were seen in our series. Diagnostic accuracy was 70%. It must be pointed out that TRUS demonstrated hidden submucosal tumors in two patients previously treated with intravesical chemotherapy. Retrospectiv...
American journal of physical medicine, 1987
Three-months re-education treatment of genuine stress incontinence was given to 26 female outpati... more Three-months re-education treatment of genuine stress incontinence was given to 26 female outpatients: 22 patients completed the treatment programme and 4 interrupted it for various reasons. The aims of the treatment were both to correct compensatory habits that patients used to conceal or reduce leakage accidents and to give specific education and strengthening of pelvic floor muscles. All patients who completed the three-months treatment definitely improved and 7 were cured. Accordingly a marked reduction or absence of weekly incontinence episodes as well as a reduction of the daily frequency of micturition was observed. On vaginal palpation a clear-cut improvement of pubococcygeous muscle contractility was detectable. Urethral closure pressure profilometry showed significant improvement of functional urethral profile length at rest and of maximal urethral closure present both at rest and during maximal voluntary contraction of the pelvic floor muscles. Micturition cystourethrogra...
The Journal of Clinical Endocrinology & Metabolism, 2014
Minerva chirurgica, 2003
Since the 1980's, thanks to the introduction of new techniques and methods for the study of t... more Since the 1980's, thanks to the introduction of new techniques and methods for the study of thyroid function, new light has been shed on certain aspects of thyroid disease that constitute the basis for surgical therapy. Multinodular goiter is a disorder affecting the entire gland, even when alterations mostly or exclusively involve a single lobe. The functional deficit resulting from partial or subtotal resection has a hypertophic/hyperplastic effect on the remaining parenchyma. Partial resections often lead to postoperative hypothyroidism, usually of a subclinical nature, which implies difficult management by means of replacement therapy. The authors report a series of 58 patients who underwent partial thyroidectomy to treat benign thyroid disease at the 2nd Surgical Department of the University of Florence during the period 1975-1985. Of these patients, operated on more than 15 years ago, 36.2% - the majority of whom (87.5%) have constantly been on substitutive therapy using L...
Journal of Sexual Medicine, 2009
Radiology, 2000
To determine the appropriate choice of imaging techniques for localization of nodular lesions of ... more To determine the appropriate choice of imaging techniques for localization of nodular lesions of parathyroid glands. First, computed tomographic (CT), magnetic resonance (MR), ultrasonographic (US), and technetium 99m methoxyisobutyl-isonitrile (MIBI) scintigraphic images in 49 patients with primary hyperparathyroidism were retrospectively evaluated. A single-blind, prospective study that included 16 patients with primary hyperparathyroidism was then conducted. MR, US, scintigraphic, and color Doppler US images of the neck were obtained and analyzed. In the retrospective study, CT, MR imaging, and US had low sensitivity (13%, 17%, and 27%, respectively) and specificity (39%, 65%, and 65%, respectively). Scintigraphy had 57% sensitivity and 85% specificity. In the prospective study, the use of latest-generation MR and US equipment and the participation of experienced operators led to improved sensitivity and specificity for these techniques. The combination of US and scintigraphy resulted in improved sensitivity (96%), specificity (83%), and positive and negative predictive values (88% and 94%, respectively), relative to the results obtained with either method alone. Doppler US was of little help in the setting of small glands. The combination of (99m)Tc MIBI scintigraphy and US performed by well-trained operators with up-to-date instruments appeared to be the best diagnostic tool for the preoperative diagnosis of parathyroid disease.