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Annals of phytomedicine, Jul 1, 2022
![Research paper thumbnail of In-silico Studies, Synthesis and Antioxidant Studies of Different Substituted 7-Phenyl-5-(Thiophen-2-Yl)- 2-Thioxo-2,3-Dihydropyrido[2,3-D]Pyrimidine-4(1h)- Ones](https://attachments.academia-assets.com/117950791/thumbnails/1.jpg)
](Indian Journal of Pharmaceutical Education and Research
Background: Free radicals and ROS which are formed in normal physiological conditions, damages th... more Background: Free radicals and ROS which are formed in normal physiological conditions, damages the cells if it is not eliminated by endogenous system which causes oxidative stress. Pyridopyrimidines are important molecule in heterocyclic chemistry, gaining interest because of their biological and pharmacological activities, especially for their potential anti-tumor, antibacterial and tyrosine kinase inhibitors, among other pharmacological properties along with anti-oxidant properties. Materials and Methods: In the current study, novel pyridopyrimidines derivatives i.e different substituted 7-phenyl-5-(thiophen-2-yl)-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidine-4(1H)-one(3a-p) were synthesized to develop potent anti-oxidant agent. Based the in-silico studies, especially depending on the docking score, 8 compounds were selected for the synthesis and evaluated for their anti-oxidant potency. Selected compounds were synthesized using mercapto-4hydroxy-6-amino pyrimidine (1) and substituted α, βunsaturated ketones(2a-p). Results: Synthesized compounds were characterized by IR, NMR and Mass spectra. In-vitro antioxidant studies were performed for 8 best scored compounds by DPPH assay and nitric oxide inhibition assay. From the in-vitro result, compound 3j, 3a, and 3o are considered as promising molecules. Conclusion: The promising activity may be because of presence of electron releasing group (3a-p-OH, 3o-p-NH 2) and electron withdrawing group (3jp-CF 3) which can be considered as lead molecules for the further discovery.
Journal of Evidence Based Medicine and Healthcare, 2015
Gastrojejunostomy was one of most frequently performed surgical procedure 2-3 decades back before... more Gastrojejunostomy was one of most frequently performed surgical procedure 2-3 decades back before the era of proton pump inhibitors. Though other complications are more common, retrograde jejunogastric intussusception is a rare serious complication with few cases reported in world literature. Early diagnosis and high index of suspicion can dramatically reduce the mortality as this condition may lead to strangulation. We report a case of 55 year old man with history of gastrojejunostomy done 21 years back found to have retrograde jejunojejunogastric intussusecption that was managed successfully with dismantling of gastrojejunostomy and pyloroplasty.
Journal of Evolution of Medical and Dental Sciences, 2015
Annals of phytomedicine, Jul 1, 2022
Indian Journal of Pharmaceutical Education and Research
Background: Free radicals and ROS which are formed in normal physiological conditions, damages th... more Background: Free radicals and ROS which are formed in normal physiological conditions, damages the cells if it is not eliminated by endogenous system which causes oxidative stress. Pyridopyrimidines are important molecule in heterocyclic chemistry, gaining interest because of their biological and pharmacological activities, especially for their potential anti-tumor, antibacterial and tyrosine kinase inhibitors, among other pharmacological properties along with anti-oxidant properties. Materials and Methods: In the current study, novel pyridopyrimidines derivatives i.e different substituted 7-phenyl-5-(thiophen-2-yl)-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidine-4(1H)-one(3a-p) were synthesized to develop potent anti-oxidant agent. Based the in-silico studies, especially depending on the docking score, 8 compounds were selected for the synthesis and evaluated for their anti-oxidant potency. Selected compounds were synthesized using mercapto-4hydroxy-6-amino pyrimidine (1) and substituted α, βunsaturated ketones(2a-p). Results: Synthesized compounds were characterized by IR, NMR and Mass spectra. In-vitro antioxidant studies were performed for 8 best scored compounds by DPPH assay and nitric oxide inhibition assay. From the in-vitro result, compound 3j, 3a, and 3o are considered as promising molecules. Conclusion: The promising activity may be because of presence of electron releasing group (3a-p-OH, 3o-p-NH 2) and electron withdrawing group (3jp-CF 3) which can be considered as lead molecules for the further discovery.
Journal of Evidence Based Medicine and Healthcare, 2015
Gastrojejunostomy was one of most frequently performed surgical procedure 2-3 decades back before... more Gastrojejunostomy was one of most frequently performed surgical procedure 2-3 decades back before the era of proton pump inhibitors. Though other complications are more common, retrograde jejunogastric intussusception is a rare serious complication with few cases reported in world literature. Early diagnosis and high index of suspicion can dramatically reduce the mortality as this condition may lead to strangulation. We report a case of 55 year old man with history of gastrojejunostomy done 21 years back found to have retrograde jejunojejunogastric intussusecption that was managed successfully with dismantling of gastrojejunostomy and pyloroplasty.
Journal of Evolution of Medical and Dental Sciences, 2015