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Research paper thumbnail of An entry-level course in computational engineering and science

ACM Sigcse Bulletin, 1995

We set out in the summer of 1993 to develop our new course, which we named Engineering Computing.... more We set out in the summer of 1993 to develop our new course, which we named Engineering Computing. The initial impetus for developing the course came from two sources. The dean of our 'College of Engineering asked us to design a modern alternative to the single programming class (in Fortran or C) that nearly every student in the College is required to take. At about the same time, we became charter members of the Department of Energy's national working group on Undergraduate Computational Engineering and Science ( ...

Research paper thumbnail of chronic myeloid leukemia Bcr-Abl kinase domain mutations, drug resistance and the road to a cure of

Mutations in the kinase domain (KD) of Bcr-Abl are the most prevalent mechanism of acquired imati... more Mutations in the kinase domain (KD) of Bcr-Abl are the most prevalent mechanism of acquired imatinib resistance in patients with chronic myeloid leukemia (CML). Here we examine predisposing factors underlying acquisition of KD mutations, evidence for acquisition of mutations prior to and during therapy, and whether the detection of a KD mutation universally implies resistance. We also provide a perspective on how the second-line Abl inhibitors dasatinib and nilotinib are faring in the treatment of imatinibresistant CML, especially in relation to specific KD mutations. We discuss the growing importance of the multi-inhibitor-resistant T315I mutant and the therapeutic potential that a T315I inhibitor would have. Lastly, we assess the potential of Abl kinase inhibitor combinations to induce stable responses even in advanced CML and interpret the emerging data in the context of CML pathogenesis.

Research paper thumbnail of An entry-level course in computational engineering and science

ACM Sigcse Bulletin, 1995

We set out in the summer of 1993 to develop our new course, which we named Engineering Computing.... more We set out in the summer of 1993 to develop our new course, which we named Engineering Computing. The initial impetus for developing the course came from two sources. The dean of our 'College of Engineering asked us to design a modern alternative to the single programming class (in Fortran or C) that nearly every student in the College is required to take. At about the same time, we became charter members of the Department of Energy's national working group on Undergraduate Computational Engineering and Science ( ...

Research paper thumbnail of chronic myeloid leukemia Bcr-Abl kinase domain mutations, drug resistance and the road to a cure of

Mutations in the kinase domain (KD) of Bcr-Abl are the most prevalent mechanism of acquired imati... more Mutations in the kinase domain (KD) of Bcr-Abl are the most prevalent mechanism of acquired imatinib resistance in patients with chronic myeloid leukemia (CML). Here we examine predisposing factors underlying acquisition of KD mutations, evidence for acquisition of mutations prior to and during therapy, and whether the detection of a KD mutation universally implies resistance. We also provide a perspective on how the second-line Abl inhibitors dasatinib and nilotinib are faring in the treatment of imatinibresistant CML, especially in relation to specific KD mutations. We discuss the growing importance of the multi-inhibitor-resistant T315I mutant and the therapeutic potential that a T315I inhibitor would have. Lastly, we assess the potential of Abl kinase inhibitor combinations to induce stable responses even in advanced CML and interpret the emerging data in the context of CML pathogenesis.

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