claude remacle - Academia.edu (original) (raw)
Papers by claude remacle
Diabetologia, 2004
Aims/hypothesis. We hypothesised that nutritional taurine, which is important for the development... more Aims/hypothesis. We hypothesised that nutritional taurine, which is important for the development of the endocrine pancreas and reduces cytokine-induced apoptosis in pancreatic beta cells, would prevent or delay the onset of autoimmune diabetes, if given early in life to the non-obese diabetic (NOD) mouse. Methods. Pregnant NOD mice received a diet supplemented with taurine throughout gestation or until weaning, and the pancreas of the offspring was examined using immunohistochemistry. This was done at postnatal day 14 and after 8 weeks (assessment of insulitis). The animals were also monitored until they became diabetic. Results. At 14 days, pancreatic islet mass was significantly greater in animals treated with taurine than in controls. This finding was associated with a greater incidence of islet cell proliferation and a lower incidence of apoptosis. At age 8 weeks the number of islets manifesting insulitis was reduced by more than half, and the area of insulitis was reduced by 90%. Taurine treatment delayed the mean onset time of diabetes from 18 to 30 weeks in females, and from 30 to 38 weeks in males, while 20% of treated females remained free of diabetes after one year. Conclusions/interpretation. Taurine supplementation in early life altered islet development, reduced insulitis and delayed the onset of diabetes in NOD mice.
Proceedings of the Nutrition Society, 1995
Development of the Biology of the Endocrine Pancreas 'Whosoever was the father of a disease, an i... more Development of the Biology of the Endocrine Pancreas 'Whosoever was the father of a disease, an ill diet was the mother' 'But more so with a poor diet during pregnancy'
Anticancer Research : international journal of cancer research and treatment, 1987
A substantial body of evidence now suggests that poor intrauterine milieu elicited by maternal nu... more A substantial body of evidence now suggests that poor intrauterine milieu elicited by maternal nutritional disturbance or placental insufficiency may programme susceptibility in the foetus to later develop chronic degenerative diseases, such as obesity, hypertension, cardiovascular diseases and diabetes. Further data showing the developmental programming of the metabolic syndrome are now available thanks to animal studies in which the foetal environment has been manipulated. This review examines the developmental programming of glucose intolerance by disturbed intrauterine metabolic condition in rats. It focuses on the alteration of the endocrine pancreas at birth. Long-term consequences, deterioration of glucose tolerance and even transgenerational effects are reported. Maternal protein, caloric restriction and diabetes during gestation/lactation lead to altered �-cell mass. This review also tempts to identify cellular and molecular mechanisms involved in this process.
Early Human Development, 2006
Journées annuelles de diabétologie de l'Hôtel-Dieu, 2005
Maternal obesity is increasingly prevalent and may affect the long-term health of the child. We i... more Maternal obesity is increasingly prevalent and may affect the long-term health of the child. We investigated the effects of maternal diet-induced obesity in mice on offspring metabolic and cardiovascular function. Female C57BL/6J mice were fed either a standard chow (3% fat, 7% sugar) or a palatable obesogenic diet (16% fat, 33% sugar) for 6 weeks before mating and throughout pregnancy and lactation. Offspring of control (OC) and obese dams (OO) were weaned onto standard chow and studied at 3 and 6 months of age. OO were hyperphagic from 4 to 6 weeks of age compared with OC and at 3 months locomotor activity was reduced and adiposity increased (abdominal fat pad mass; P 0.01). OO were heavier than OC at 6 months (body weight, P 0.05). OO abdominal obesity was associated with adipocyte hypertrophy and altered mRNA expression of -adrenoceptor 2 and 3, 11 HSD-1, and PPAR2. OO showed resistance artery endothelial dysfunction at 3 months, and were hypertensive, as assessed by radioteleme...
Previous studies indicate that insulin secretion from the fetuses of dams fed a low protein (LP) ... more Previous studies indicate that insulin secretion from the fetuses of dams fed a low protein (LP) diet is reduced in response to leucine or arginine. The aim of this study was to locate the defect in the insulin secretion pathway induced by a LP diet during gestation. The effects of various secretagogues acting at different levels of the insulin secretion cascade were investigated in vitro in fetal islets from dams fed either a normal or a LP diet during pregnancy. Insulin content, insulin secretion and the cAMP content were then measured. Although insulin content of LP islets did not differ from that of control islets, insulin secretion from LP fetal islets was reduced when challenged by amino acids or cAMP enhancers. This reduction did not appear to be related solely to an altered islet cAMP content. An impairment of insulin secretion remained after stimulation of fetal LP islets with either metabolic or nonmetabolic secretagogues. The insulin secretion by LP islets was restored to...
Chez l'homme, les etudes epidemiologiques montrent qu'une nutrition inadequate en protein... more Chez l'homme, les etudes epidemiologiques montrent qu'une nutrition inadequate en proteines, une infection ou un mauvais etat de sante de la mere sont associes et pourraient etre a l'origine du diabete type II non insulino-dependant. Ces facteurs peuvent entrainer un retard de croissance fœtale et une correlation existe aussi entre ce retard ainsi que celui du jeune enfant et l'apparition de maladies cardio-vasculaires ainsi que d'hypertension chez le jeune adulte. Nos etudes experimentales confirment ces relations. Un regime pauvre en proteines administre a la ratte gestante entraine des alterations majeures de la structure et de la fonction du pancreas endocrine du fœtus et du nouveau-ne
Acarologia, 1984
The gnathosoma of Tetranychus urticae has been studied through light microscopy, S.E.M. and T.E.M... more The gnathosoma of Tetranychus urticae has been studied through light microscopy, S.E.M. and T.E.M. From a functional point of view, the study indicates that the chelicerae are a piercing-sucking structure; the interlocked stylets are actively protracted but passively retracted. The pathway of food through the gnathosoma is redescribed accordingly. Comparative morphology reveals severa! new structures unique to Tetranychidae such as the cervical canaliculus and the prelabial and supralabral cavities. Descriptive terminology is standardized with that used for other mites.
Biology of the Cell, 1982
European Journal of Cell Biology, 1980
Diabetologia, 2004
Aims/hypothesis. We hypothesised that nutritional taurine, which is important for the development... more Aims/hypothesis. We hypothesised that nutritional taurine, which is important for the development of the endocrine pancreas and reduces cytokine-induced apoptosis in pancreatic beta cells, would prevent or delay the onset of autoimmune diabetes, if given early in life to the non-obese diabetic (NOD) mouse. Methods. Pregnant NOD mice received a diet supplemented with taurine throughout gestation or until weaning, and the pancreas of the offspring was examined using immunohistochemistry. This was done at postnatal day 14 and after 8 weeks (assessment of insulitis). The animals were also monitored until they became diabetic. Results. At 14 days, pancreatic islet mass was significantly greater in animals treated with taurine than in controls. This finding was associated with a greater incidence of islet cell proliferation and a lower incidence of apoptosis. At age 8 weeks the number of islets manifesting insulitis was reduced by more than half, and the area of insulitis was reduced by 90%. Taurine treatment delayed the mean onset time of diabetes from 18 to 30 weeks in females, and from 30 to 38 weeks in males, while 20% of treated females remained free of diabetes after one year. Conclusions/interpretation. Taurine supplementation in early life altered islet development, reduced insulitis and delayed the onset of diabetes in NOD mice.
Proceedings of the Nutrition Society, 1995
Development of the Biology of the Endocrine Pancreas 'Whosoever was the father of a disease, an i... more Development of the Biology of the Endocrine Pancreas 'Whosoever was the father of a disease, an ill diet was the mother' 'But more so with a poor diet during pregnancy'
Anticancer Research : international journal of cancer research and treatment, 1987
A substantial body of evidence now suggests that poor intrauterine milieu elicited by maternal nu... more A substantial body of evidence now suggests that poor intrauterine milieu elicited by maternal nutritional disturbance or placental insufficiency may programme susceptibility in the foetus to later develop chronic degenerative diseases, such as obesity, hypertension, cardiovascular diseases and diabetes. Further data showing the developmental programming of the metabolic syndrome are now available thanks to animal studies in which the foetal environment has been manipulated. This review examines the developmental programming of glucose intolerance by disturbed intrauterine metabolic condition in rats. It focuses on the alteration of the endocrine pancreas at birth. Long-term consequences, deterioration of glucose tolerance and even transgenerational effects are reported. Maternal protein, caloric restriction and diabetes during gestation/lactation lead to altered �-cell mass. This review also tempts to identify cellular and molecular mechanisms involved in this process.
Early Human Development, 2006
Journées annuelles de diabétologie de l'Hôtel-Dieu, 2005
Maternal obesity is increasingly prevalent and may affect the long-term health of the child. We i... more Maternal obesity is increasingly prevalent and may affect the long-term health of the child. We investigated the effects of maternal diet-induced obesity in mice on offspring metabolic and cardiovascular function. Female C57BL/6J mice were fed either a standard chow (3% fat, 7% sugar) or a palatable obesogenic diet (16% fat, 33% sugar) for 6 weeks before mating and throughout pregnancy and lactation. Offspring of control (OC) and obese dams (OO) were weaned onto standard chow and studied at 3 and 6 months of age. OO were hyperphagic from 4 to 6 weeks of age compared with OC and at 3 months locomotor activity was reduced and adiposity increased (abdominal fat pad mass; P 0.01). OO were heavier than OC at 6 months (body weight, P 0.05). OO abdominal obesity was associated with adipocyte hypertrophy and altered mRNA expression of -adrenoceptor 2 and 3, 11 HSD-1, and PPAR2. OO showed resistance artery endothelial dysfunction at 3 months, and were hypertensive, as assessed by radioteleme...
Previous studies indicate that insulin secretion from the fetuses of dams fed a low protein (LP) ... more Previous studies indicate that insulin secretion from the fetuses of dams fed a low protein (LP) diet is reduced in response to leucine or arginine. The aim of this study was to locate the defect in the insulin secretion pathway induced by a LP diet during gestation. The effects of various secretagogues acting at different levels of the insulin secretion cascade were investigated in vitro in fetal islets from dams fed either a normal or a LP diet during pregnancy. Insulin content, insulin secretion and the cAMP content were then measured. Although insulin content of LP islets did not differ from that of control islets, insulin secretion from LP fetal islets was reduced when challenged by amino acids or cAMP enhancers. This reduction did not appear to be related solely to an altered islet cAMP content. An impairment of insulin secretion remained after stimulation of fetal LP islets with either metabolic or nonmetabolic secretagogues. The insulin secretion by LP islets was restored to...
Chez l'homme, les etudes epidemiologiques montrent qu'une nutrition inadequate en protein... more Chez l'homme, les etudes epidemiologiques montrent qu'une nutrition inadequate en proteines, une infection ou un mauvais etat de sante de la mere sont associes et pourraient etre a l'origine du diabete type II non insulino-dependant. Ces facteurs peuvent entrainer un retard de croissance fœtale et une correlation existe aussi entre ce retard ainsi que celui du jeune enfant et l'apparition de maladies cardio-vasculaires ainsi que d'hypertension chez le jeune adulte. Nos etudes experimentales confirment ces relations. Un regime pauvre en proteines administre a la ratte gestante entraine des alterations majeures de la structure et de la fonction du pancreas endocrine du fœtus et du nouveau-ne
Acarologia, 1984
The gnathosoma of Tetranychus urticae has been studied through light microscopy, S.E.M. and T.E.M... more The gnathosoma of Tetranychus urticae has been studied through light microscopy, S.E.M. and T.E.M. From a functional point of view, the study indicates that the chelicerae are a piercing-sucking structure; the interlocked stylets are actively protracted but passively retracted. The pathway of food through the gnathosoma is redescribed accordingly. Comparative morphology reveals severa! new structures unique to Tetranychidae such as the cervical canaliculus and the prelabial and supralabral cavities. Descriptive terminology is standardized with that used for other mites.
Biology of the Cell, 1982
European Journal of Cell Biology, 1980