cristina frutuoso - Academia.edu (original) (raw)
Papers by cristina frutuoso
Objective: The aim of this study was to compare sexual function and satisfaction among premenopau... more Objective: The aim of this study was to compare sexual function and satisfaction among premenopausal women who underwent hysterectomy-only versus those who underwent hysterectomy with bilateral salpingo-oopherectomy. Material and Methods: An anonymous questionnaire on sexual function was distributed to premenopausal women who, in 2007, had been submitted in our institution to total hysterectomy by abdominal approach, with or without bilateral salpingo-oopherectomy, for benign gynaecologic conditions. Responses were compared between both groups. Results: Complete replies were received from 111 patients. Of these, 20 were excluded (six because they were sexually inactive, ive because they had received preoperative sexual counselling, and nine because they had been diagnosed with preoperative psychological disease). The remaining 91 constituted our study group: 40 were submitted to hysterectomy-only and 51 had undergone concomitant prophylactic bilateral salpingo-oopherectomy. Mean age at time of surgery was higher in the bilateral salpingo-oopherectomy group (42.1 vs 47.7, p<0.001) and at 6-months of follow up, more women in this group had initiated hormonal replacement therapy (7.5% vs 35.3%, p=0.002). No statistically signiicant differences were found between the two groups regarding the time taken to re-initiate sexual activity, the frequency of sexual intercourse, the rate of sexual dysfunctions appearing de novo and the degree of satisfaction with sexual life and with the surgery. The majority of women in both groups reported no change in frequency of sexual activity and sexual satisfaction before and after surgery. Conclusions: Prophylactic bilateral salpingo-oopherectomy at elective hysterectomy for benign disease in premenopausal women does not appear to affect patients' sexual function and satisfaction.
![Research paper thumbnail of [Wertheim-Meigs procedure. 10-year results]](https://attachments.academia-assets.com/112279207/thumbnails/1.jpg)
](PubMed, Oct 1, 1997
Wertheim-Meigs hysterectomy is used in the treatment of cervical cancer, but since 1988 we have a... more Wertheim-Meigs hysterectomy is used in the treatment of cervical cancer, but since 1988 we have also used it to stage and treat endometrial carcinoma. To evaluate the morbidity of Wertheim Meigs hysterectomy as well as node invasion incidence and its correlation with other prognostic factors, the authors made a retrospective study of 112 patients, from October 1986 to March 1996. Among the 112 cases evaluated, 52% had cervical carcinoma and 48% had endometrial carcinoma; mean ages were 45 +/- 10 and 60 +/- 8 years (p < 0.005). FIGO stage distribution was: I-94.8 and 33.3%; II-5.2 and 51.9%; III-0 and 13%; IV-0 and 1.8%, for cervical and endometrial carcinoma. Hemorrhagic and traumatic accidents happened in 24.3% and 1.7% respectively. We had 15.5% early post operative complications and 1.7% late post operative ones. The mean duration of surgery and hospitalization was 163 +/- 29 minutes and 10 +/- 5 days. Pelvic lymphadenectomy was performed in 70% of patients and para-aortic nodes were also excised in the other 30%. The mean number of lymphatic nodes excised were 17 +/- 9. Pelvic node invasion was found in 9% and in 3.7% of para-aortic ones. When we studied endometrial cancer, we found a positive correlation between external myometrium invasion and lymphovascular invasion and positive node (p < 0.05). From the data available we may conclude that the complication rate of Wertheim Meigs is quite important, even though all but one complication were transitory. It may be possible to make a better selection of patients who need this surgical procedure by correct evaluation of risk factors.
![Research paper thumbnail of [Prognosis value of p53, C-erB-2 and Ki67 proteins in ovarian carcinoma]](https://attachments.academia-assets.com/112279199/thumbnails/1.jpg)
](PubMed, Sep 13, 2001
The prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely... more The prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic factors, we studied paraffin-embedded tumor tissue from 81 patients with epithelial ovarian cancer and made a quantitative evaluation of C-erb-B2, p53 and Ki 67 expression by immunohistochemistry. The results were: age 5.4 +/- 15(22-88); 66% with normal physical activity; 48.2% with residual disease < 2 cm; initial stage--42% and advanced stage--58%. Age, performance status, residual disease and stage were correlated with 2 and 5 years survival. Positive immunostaining: p53--87%, C-erb B-2--51% and Ki67--100%. P53 and C-erb B-2 were associated with residual disease and stage; patients with no C-erbB-2 staining had a significantly better survival. A direct and significant correlation was found between p53 and Ki67 and between C-erb B-2 and p53. We conclude that these markers have a high expression in ovarian carcinoma and p53 and C-er B-2 correlate with stage and residual disease. Although C-erb B-2 was associated with better survival, it was not found to be an independent prognostic factor.
International Journal of Gynecological Cancer, 2004
A case of a 23-year-old woman with a paraovarian tumor is presented. The patient complained of pe... more A case of a 23-year-old woman with a paraovarian tumor is presented. The patient complained of pelvic pain and abdominal swelling. Cystectomy was the initial surgical treatment, but after the histological diagnosis, a staging surgery was carried out. The clinical aspects and subsequent management of related cases are discussed, and a literature review is made.
European Journal of Gynaecological Oncology, 2006
International Journal of Gynecological Cancer, Mar 1, 2003
Conclusions: Cytological examination of ascites may be negative in the presence of malignant dise... more Conclusions: Cytological examination of ascites may be negative in the presence of malignant disease. If a tumour consists of two components, puncture can miss one, which may lead to undertreatment. Punctures should be discouraged as a diagnostic tool in patients in whom an ovarian malignancy is suspected.
International Journal of Gynecologic Cancer, 2003
Conclusions: Cytological examination of ascites may be negative in the presence of malignant dise... more Conclusions: Cytological examination of ascites may be negative in the presence of malignant disease. If a tumour consists of two components, puncture can miss one, which may lead to undertreatment. Punctures should be discouraged as a diagnostic tool in patients in whom an ovarian malignancy is suspected.
European journal of gynaecological oncology, 2007
Primary chemotherapy is increasingly used in patients with large operable breast cancer. Docetaxe... more Primary chemotherapy is increasingly used in patients with large operable breast cancer. Docetaxel and epirubicin are the most active agents in breast cancer treatment. To evaluate clinical response rate, breast conserving surgery and pathological response rate in patients with large operable breast cancer treated with docetaxel followed by docetaxel and epirubicin as primary chemotherapy. Patients with operable breast cancer more than 3 cm in the longest diameter with T2N0, T2N1 and T3N0 disease were enrolled. Patients were treated with three cycles of docetaxel 100 mg/m2 followed by three cycles of docetaxel 75 mg/m2 and epirubicin 90 mg/m2 prior to surgery. Sixty-five patients were enrolled between 09/2002 and 12/2005. The median age was 48.9 years and 72.3% were premenopausal. Median tumour size was 4.26 cm, 10.8% were T3 tumours and 38.5% had clinical positive lymph nodes. Of the tumours 58.5% were grade 1/2, 33.9% ER positive and 21.5% c-erb negative. All six cycles were admin...
DOAJ (DOAJ: Directory of Open Access Journals), Jun 1, 2001
Hereditary Cancer in Clinical Practice
Purpose Triple negative breast cancer (TNBC) is an aggressive breast cancer strongly associated w... more Purpose Triple negative breast cancer (TNBC) is an aggressive breast cancer strongly associated with BRCA mutation. Standard neoadjuvant chemotherapy remains the standard of care for early stage TNBC, the optimal chemotherapy regimen is still a matter of discussion. Other agents, such as poly-ADP-ribosyl polymerase inhibitors (PARPi) and anti-vascular endothelial growth factor (VEGF) antibodies were evaluated in the neoadjuvant setting. This systematic review and meta-analysis intend to evaluate the impact of neoadjuvant treatments in pCR rates in TNBC gBRCA mutation, beyond traditional standard chemotherapy. Methods PubMed, Clinicaltrials.gov, Cochrane CENTRAL, Embase and key oncological meetings for trials were searched for studies reporting neoadjuvant chemo-immunotherapy in BRCA positive TNBC. Results Out of 1238 records reviewed, thirty-one trials were included, resulting in a total 619 BRCA-mutated TNBC patients. In BRCA mutated TNBC patients who received cisplatin in monother...
Dermatology Online Journal, 2009
We describe a 50-year-old woman with a 5-month history of multiple asymptomatic papulonodular les... more We describe a 50-year-old woman with a 5-month history of multiple asymptomatic papulonodular lesions on the left chest area. Biopsy was consistent with cutaneous metastases from a ductal breast carcinoma. No distant metastatic lesions were detected. The patient was referred to the Gynecologic Oncology Department. Treatment included chemotherapy, radiotherapy and surgery. At present the patient is well with no signs of recurrence. This case reports a clinically remarkable cutaneous metastatic breast carcinoma.
European Annals of Allergy and Clinical Immunology, 2021
Rapid drug desensitization (RDD) is a procedure performed when no alternative drug is considered ... more Rapid drug desensitization (RDD) is a procedure performed when no alternative drug is considered equally effective. The aim of our study is to describe the experience with RDD to cytostatics in patients being treated for gynaecological cancer in a Tertiary Hospital, over a period of 5 years. In this paper, we review 22 cases and 107 episodes of RDD; 86.3% of patients had advanced disease and the mortality rate at the time of data collection was 50.0%. RDD was performed on 81.8% patients for platinum, 13.6% for taxanes, and 4.5% for anthracyclines. The reintroduction of antineoplastic drugs in all patients with a previous history of immediate hypersensitivity reaction demonstrated the safety and efficacy of this procedure. There was serious complication (anaphylaxis) in only one case.
Gynecologic Oncology, 2021
Objectives: Family history is a representative risk factor for ovary cancer (OC), frequently asso... more Objectives: Family history is a representative risk factor for ovary cancer (OC), frequently associated with BRCA1/2 mutations. The primary objective was to determine the prevalence of BRCA1/2 mutations (somatic and germline) in patients with non-mucinous ovarian cancer (NMOC), invasive fallopian tube neoplasia (IFTN) or primary peritoneal carcinoma (PPC). Methods: National, interventional, retrospective and analytical study, with an estimated sample size of 261 women aged ≥18 years, diagnosed with NMOC, IFTN or PPC between 01/01/2014 and 31/12/2016 in the nine selected centers. Results: From 165 women eligible for analysis, the prevalence of BRCA1/2 mutation was 20% (24.2% somatic, 75.8% germline). For patients with a mutation, 54.5% had a mutation in BRCA1 (27.8% somatic, 72.2% germline), while 45.5% in BRCA2 (20.0% somatic, 80.0% germline). Mean age of the sample was 61.1 years (mutated 60.3 years, non-mutated 61.3 years For patients with a mutation, the ages of the subgroups wit...
Objective: To determine if preoperative variables can predict the functional results after surgic... more Objective: To determine if preoperative variables can predict the functional results after surgical transobturator approach techniques for the treatment of female urinary incontinence. Population: A total of 359 women submitted to surgical treatment for urinary incontinence using transobturator tape procedures between January 2003 and May 2007. Setting: A tertiary care university hospital. Design: Retrospective observational study. Methods: Patients were divided in two groups: Athose with cure or improvement of urinary incontinence and Bthose with persistent postoperative urinary incontinence. The two groups were compared in relation to age, parity, hormonal status, body mass index, co-morbidities, associated uro-genital prolapse, clinical and urodynamic characteristics of urinary incontinence, surgical technique, existence of previous or associated pelvic surgery and perior postoperative complications. Results: A total of 291 women were included in group A and 68 in group B. Mean a...
![Research paper thumbnail of [Dysmenorrhea in adolescents and young adults: prevalence, related factors and limitations in daily living]](https://attachments.academia-assets.com/103215254/thumbnails/1.jpg)
](Acta medica portuguesa, 2011
OBJECTIVE To determine the prevalence of dysmenorrhea, limitations in daily living and health car... more OBJECTIVE To determine the prevalence of dysmenorrhea, limitations in daily living and health care use due to menstrual pain. MATERIAL AND METHODS Observational transversal study of 274 adolescents and young adults (age ≤ 26) who had menstruated in the six months prior to the study, assisted at a Primary Health Care Center. Data were obtained by a 24-item anonymous questionnaire, which included questions about socio-demographic variables, menstrual cycle, presence, duration, severity, treatment and limitations of dysmenorrhea. RESULTS One hundred and seventy-two (62.8%) subjects experienced menstrual pain. Of these, 65.7% reported having limitations in their daily activities due to dysmenorrhea. The prevalence of limitations in daily living was influenced by the presence of additional symptoms (r=0.331; p <0.001), pain intensity (r=0.281; p <0.001) and pain duration (r=0.172; p=0.027). The most commonly mentioned limitation was anxiety/depression (42.5%). Fourteen of the subje...
Hereditary Cancer in Clinical Practice, 2019
Background: Triple negative breast cancers (TNBC) are associated with an aggressive clinical cour... more Background: Triple negative breast cancers (TNBC) are associated with an aggressive clinical course, earlier recurrence and short survival. BRCAmutated tumours represent up to 25% of all TNBC. BRCA status is being studied as a predictive biomarker of response to platinum agents. However, the predictive role of BRCA status is still uncertain in this setting. Since TNBC is a very heterogeneous group of diseases, it is important to identify subsets of TNBC patients that may benefit from platinum-based therapy. This study aims to establish if the presence of a germline BRCA mutation in women with TNBC improves the pathologic complete response (pCR) after neoadjuvant chemotherapy with platinum compounds. Methods: An extensive literature search was performed in MEDLINE, EMBASE and LILACS databases, WHO (WHO International Clinical Trials Registry Platform) and the Cochrane Controlled Trials Register Database, for online trial registries and conference proceedings. The measurement of pCR was assessed by pathology review of breast specimen and lymph nodes. Results: The overall OR was computed using random effects models. Seven studies were included, comprising a total of 808 TNBC patients, among which 159 were BRCA mutated. Among mutated TNBC patients, 93 (93/159; 58.4%) achieved pCR, while 410 wildtype patients (410/808; 50.7%) showed pCR (OR 1.459 CI 95% [0.953-2.34] p = 0.082) although this result did not reach statistical significance. Conclusions: This meta-analysis shows that the addition of platinum to chemotherapy regimens in the neoadjuvant setting increases pCR rate in BRCAmutated as compared to wild-type TNBC patients. However, this trend did not achieve statistical significance. Trial registration: CRD42018092341
Objective: The aim of this study was to compare sexual function and satisfaction among premenopau... more Objective: The aim of this study was to compare sexual function and satisfaction among premenopausal women who underwent hysterectomy-only versus those who underwent hysterectomy with bilateral salpingo-oopherectomy. Material and Methods: An anonymous questionnaire on sexual function was distributed to premenopausal women who, in 2007, had been submitted in our institution to total hysterectomy by abdominal approach, with or without bilateral salpingo-oopherectomy, for benign gynaecologic conditions. Responses were compared between both groups. Results: Complete replies were received from 111 patients. Of these, 20 were excluded (six because they were sexually inactive, ive because they had received preoperative sexual counselling, and nine because they had been diagnosed with preoperative psychological disease). The remaining 91 constituted our study group: 40 were submitted to hysterectomy-only and 51 had undergone concomitant prophylactic bilateral salpingo-oopherectomy. Mean age at time of surgery was higher in the bilateral salpingo-oopherectomy group (42.1 vs 47.7, p<0.001) and at 6-months of follow up, more women in this group had initiated hormonal replacement therapy (7.5% vs 35.3%, p=0.002). No statistically signiicant differences were found between the two groups regarding the time taken to re-initiate sexual activity, the frequency of sexual intercourse, the rate of sexual dysfunctions appearing de novo and the degree of satisfaction with sexual life and with the surgery. The majority of women in both groups reported no change in frequency of sexual activity and sexual satisfaction before and after surgery. Conclusions: Prophylactic bilateral salpingo-oopherectomy at elective hysterectomy for benign disease in premenopausal women does not appear to affect patients' sexual function and satisfaction.
PubMed, Oct 1, 1997
Wertheim-Meigs hysterectomy is used in the treatment of cervical cancer, but since 1988 we have a... more Wertheim-Meigs hysterectomy is used in the treatment of cervical cancer, but since 1988 we have also used it to stage and treat endometrial carcinoma. To evaluate the morbidity of Wertheim Meigs hysterectomy as well as node invasion incidence and its correlation with other prognostic factors, the authors made a retrospective study of 112 patients, from October 1986 to March 1996. Among the 112 cases evaluated, 52% had cervical carcinoma and 48% had endometrial carcinoma; mean ages were 45 +/- 10 and 60 +/- 8 years (p < 0.005). FIGO stage distribution was: I-94.8 and 33.3%; II-5.2 and 51.9%; III-0 and 13%; IV-0 and 1.8%, for cervical and endometrial carcinoma. Hemorrhagic and traumatic accidents happened in 24.3% and 1.7% respectively. We had 15.5% early post operative complications and 1.7% late post operative ones. The mean duration of surgery and hospitalization was 163 +/- 29 minutes and 10 +/- 5 days. Pelvic lymphadenectomy was performed in 70% of patients and para-aortic nodes were also excised in the other 30%. The mean number of lymphatic nodes excised were 17 +/- 9. Pelvic node invasion was found in 9% and in 3.7% of para-aortic ones. When we studied endometrial cancer, we found a positive correlation between external myometrium invasion and lymphovascular invasion and positive node (p < 0.05). From the data available we may conclude that the complication rate of Wertheim Meigs is quite important, even though all but one complication were transitory. It may be possible to make a better selection of patients who need this surgical procedure by correct evaluation of risk factors.
PubMed, Sep 13, 2001
The prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely... more The prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic factors, we studied paraffin-embedded tumor tissue from 81 patients with epithelial ovarian cancer and made a quantitative evaluation of C-erb-B2, p53 and Ki 67 expression by immunohistochemistry. The results were: age 5.4 +/- 15(22-88); 66% with normal physical activity; 48.2% with residual disease < 2 cm; initial stage--42% and advanced stage--58%. Age, performance status, residual disease and stage were correlated with 2 and 5 years survival. Positive immunostaining: p53--87%, C-erb B-2--51% and Ki67--100%. P53 and C-erb B-2 were associated with residual disease and stage; patients with no C-erbB-2 staining had a significantly better survival. A direct and significant correlation was found between p53 and Ki67 and between C-erb B-2 and p53. We conclude that these markers have a high expression in ovarian carcinoma and p53 and C-er B-2 correlate with stage and residual disease. Although C-erb B-2 was associated with better survival, it was not found to be an independent prognostic factor.
International Journal of Gynecological Cancer, 2004
A case of a 23-year-old woman with a paraovarian tumor is presented. The patient complained of pe... more A case of a 23-year-old woman with a paraovarian tumor is presented. The patient complained of pelvic pain and abdominal swelling. Cystectomy was the initial surgical treatment, but after the histological diagnosis, a staging surgery was carried out. The clinical aspects and subsequent management of related cases are discussed, and a literature review is made.
European Journal of Gynaecological Oncology, 2006
International Journal of Gynecological Cancer, Mar 1, 2003
Conclusions: Cytological examination of ascites may be negative in the presence of malignant dise... more Conclusions: Cytological examination of ascites may be negative in the presence of malignant disease. If a tumour consists of two components, puncture can miss one, which may lead to undertreatment. Punctures should be discouraged as a diagnostic tool in patients in whom an ovarian malignancy is suspected.
International Journal of Gynecologic Cancer, 2003
Conclusions: Cytological examination of ascites may be negative in the presence of malignant dise... more Conclusions: Cytological examination of ascites may be negative in the presence of malignant disease. If a tumour consists of two components, puncture can miss one, which may lead to undertreatment. Punctures should be discouraged as a diagnostic tool in patients in whom an ovarian malignancy is suspected.
European journal of gynaecological oncology, 2007
Primary chemotherapy is increasingly used in patients with large operable breast cancer. Docetaxe... more Primary chemotherapy is increasingly used in patients with large operable breast cancer. Docetaxel and epirubicin are the most active agents in breast cancer treatment. To evaluate clinical response rate, breast conserving surgery and pathological response rate in patients with large operable breast cancer treated with docetaxel followed by docetaxel and epirubicin as primary chemotherapy. Patients with operable breast cancer more than 3 cm in the longest diameter with T2N0, T2N1 and T3N0 disease were enrolled. Patients were treated with three cycles of docetaxel 100 mg/m2 followed by three cycles of docetaxel 75 mg/m2 and epirubicin 90 mg/m2 prior to surgery. Sixty-five patients were enrolled between 09/2002 and 12/2005. The median age was 48.9 years and 72.3% were premenopausal. Median tumour size was 4.26 cm, 10.8% were T3 tumours and 38.5% had clinical positive lymph nodes. Of the tumours 58.5% were grade 1/2, 33.9% ER positive and 21.5% c-erb negative. All six cycles were admin...
DOAJ (DOAJ: Directory of Open Access Journals), Jun 1, 2001
Hereditary Cancer in Clinical Practice
Purpose Triple negative breast cancer (TNBC) is an aggressive breast cancer strongly associated w... more Purpose Triple negative breast cancer (TNBC) is an aggressive breast cancer strongly associated with BRCA mutation. Standard neoadjuvant chemotherapy remains the standard of care for early stage TNBC, the optimal chemotherapy regimen is still a matter of discussion. Other agents, such as poly-ADP-ribosyl polymerase inhibitors (PARPi) and anti-vascular endothelial growth factor (VEGF) antibodies were evaluated in the neoadjuvant setting. This systematic review and meta-analysis intend to evaluate the impact of neoadjuvant treatments in pCR rates in TNBC gBRCA mutation, beyond traditional standard chemotherapy. Methods PubMed, Clinicaltrials.gov, Cochrane CENTRAL, Embase and key oncological meetings for trials were searched for studies reporting neoadjuvant chemo-immunotherapy in BRCA positive TNBC. Results Out of 1238 records reviewed, thirty-one trials were included, resulting in a total 619 BRCA-mutated TNBC patients. In BRCA mutated TNBC patients who received cisplatin in monother...
Dermatology Online Journal, 2009
We describe a 50-year-old woman with a 5-month history of multiple asymptomatic papulonodular les... more We describe a 50-year-old woman with a 5-month history of multiple asymptomatic papulonodular lesions on the left chest area. Biopsy was consistent with cutaneous metastases from a ductal breast carcinoma. No distant metastatic lesions were detected. The patient was referred to the Gynecologic Oncology Department. Treatment included chemotherapy, radiotherapy and surgery. At present the patient is well with no signs of recurrence. This case reports a clinically remarkable cutaneous metastatic breast carcinoma.
European Annals of Allergy and Clinical Immunology, 2021
Rapid drug desensitization (RDD) is a procedure performed when no alternative drug is considered ... more Rapid drug desensitization (RDD) is a procedure performed when no alternative drug is considered equally effective. The aim of our study is to describe the experience with RDD to cytostatics in patients being treated for gynaecological cancer in a Tertiary Hospital, over a period of 5 years. In this paper, we review 22 cases and 107 episodes of RDD; 86.3% of patients had advanced disease and the mortality rate at the time of data collection was 50.0%. RDD was performed on 81.8% patients for platinum, 13.6% for taxanes, and 4.5% for anthracyclines. The reintroduction of antineoplastic drugs in all patients with a previous history of immediate hypersensitivity reaction demonstrated the safety and efficacy of this procedure. There was serious complication (anaphylaxis) in only one case.
Gynecologic Oncology, 2021
Objectives: Family history is a representative risk factor for ovary cancer (OC), frequently asso... more Objectives: Family history is a representative risk factor for ovary cancer (OC), frequently associated with BRCA1/2 mutations. The primary objective was to determine the prevalence of BRCA1/2 mutations (somatic and germline) in patients with non-mucinous ovarian cancer (NMOC), invasive fallopian tube neoplasia (IFTN) or primary peritoneal carcinoma (PPC). Methods: National, interventional, retrospective and analytical study, with an estimated sample size of 261 women aged ≥18 years, diagnosed with NMOC, IFTN or PPC between 01/01/2014 and 31/12/2016 in the nine selected centers. Results: From 165 women eligible for analysis, the prevalence of BRCA1/2 mutation was 20% (24.2% somatic, 75.8% germline). For patients with a mutation, 54.5% had a mutation in BRCA1 (27.8% somatic, 72.2% germline), while 45.5% in BRCA2 (20.0% somatic, 80.0% germline). Mean age of the sample was 61.1 years (mutated 60.3 years, non-mutated 61.3 years For patients with a mutation, the ages of the subgroups wit...
Objective: To determine if preoperative variables can predict the functional results after surgic... more Objective: To determine if preoperative variables can predict the functional results after surgical transobturator approach techniques for the treatment of female urinary incontinence. Population: A total of 359 women submitted to surgical treatment for urinary incontinence using transobturator tape procedures between January 2003 and May 2007. Setting: A tertiary care university hospital. Design: Retrospective observational study. Methods: Patients were divided in two groups: Athose with cure or improvement of urinary incontinence and Bthose with persistent postoperative urinary incontinence. The two groups were compared in relation to age, parity, hormonal status, body mass index, co-morbidities, associated uro-genital prolapse, clinical and urodynamic characteristics of urinary incontinence, surgical technique, existence of previous or associated pelvic surgery and perior postoperative complications. Results: A total of 291 women were included in group A and 68 in group B. Mean a...
Acta medica portuguesa, 2011
OBJECTIVE To determine the prevalence of dysmenorrhea, limitations in daily living and health car... more OBJECTIVE To determine the prevalence of dysmenorrhea, limitations in daily living and health care use due to menstrual pain. MATERIAL AND METHODS Observational transversal study of 274 adolescents and young adults (age ≤ 26) who had menstruated in the six months prior to the study, assisted at a Primary Health Care Center. Data were obtained by a 24-item anonymous questionnaire, which included questions about socio-demographic variables, menstrual cycle, presence, duration, severity, treatment and limitations of dysmenorrhea. RESULTS One hundred and seventy-two (62.8%) subjects experienced menstrual pain. Of these, 65.7% reported having limitations in their daily activities due to dysmenorrhea. The prevalence of limitations in daily living was influenced by the presence of additional symptoms (r=0.331; p <0.001), pain intensity (r=0.281; p <0.001) and pain duration (r=0.172; p=0.027). The most commonly mentioned limitation was anxiety/depression (42.5%). Fourteen of the subje...
Hereditary Cancer in Clinical Practice, 2019
Background: Triple negative breast cancers (TNBC) are associated with an aggressive clinical cour... more Background: Triple negative breast cancers (TNBC) are associated with an aggressive clinical course, earlier recurrence and short survival. BRCAmutated tumours represent up to 25% of all TNBC. BRCA status is being studied as a predictive biomarker of response to platinum agents. However, the predictive role of BRCA status is still uncertain in this setting. Since TNBC is a very heterogeneous group of diseases, it is important to identify subsets of TNBC patients that may benefit from platinum-based therapy. This study aims to establish if the presence of a germline BRCA mutation in women with TNBC improves the pathologic complete response (pCR) after neoadjuvant chemotherapy with platinum compounds. Methods: An extensive literature search was performed in MEDLINE, EMBASE and LILACS databases, WHO (WHO International Clinical Trials Registry Platform) and the Cochrane Controlled Trials Register Database, for online trial registries and conference proceedings. The measurement of pCR was assessed by pathology review of breast specimen and lymph nodes. Results: The overall OR was computed using random effects models. Seven studies were included, comprising a total of 808 TNBC patients, among which 159 were BRCA mutated. Among mutated TNBC patients, 93 (93/159; 58.4%) achieved pCR, while 410 wildtype patients (410/808; 50.7%) showed pCR (OR 1.459 CI 95% [0.953-2.34] p = 0.082) although this result did not reach statistical significance. Conclusions: This meta-analysis shows that the addition of platinum to chemotherapy regimens in the neoadjuvant setting increases pCR rate in BRCAmutated as compared to wild-type TNBC patients. However, this trend did not achieve statistical significance. Trial registration: CRD42018092341