James dahlgren - Academia.edu (original) (raw)
Papers by James dahlgren
Introduction: Contaminated wood treatment sites can result in adverse health effects to nearby re... more Introduction: Contaminated wood treatment sites can result in adverse health effects to nearby residents. Environmental exposure can be estimated by measuring concentrations of pollutants in air, water, food, or wipe tests. This environmental exposure value can be used as a surrogate to estimate individual exposure. The objective of this study was to determine whether or not pentachlorophenol (PCP) could be found in potentially exposed residents and if the dioxin levels are consistent with PCP exposure. A further objective of the study was to determine whether or not PAH-DNA adducts could be found in the potentially exposed residents.
Journal of Clinical Investigation, 1975
![Research paper thumbnail of Comment on “Residential and biological exposure assessment of chemicals from a wood treatment plant” by James Dahlgren et al. [Chemosphere 67(9) (2007) S279–S285]](https://attachments.academia-assets.com/119457784/thumbnails/1.jpg)
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Journal of Earth Science & Climatic Change, Jun 9, 2018
Research in Medicine, 2016
The combined use of cyclosporine (CSA) and nonsteroidal anti-inflammatory drugs (NSAIDs) in arthr... more The combined use of cyclosporine (CSA) and nonsteroidal anti-inflammatory drugs (NSAIDs) in arthritic conditions is common in clinical practice. Because CSA or NSAIDs negatively impacts cardiovascular/renal functions when used individually, we asked if these two drug modalities would provoke more detrimental consequences when used together. The roles of endothelin receptor, inflammatory and fibrotic pathways in these interactions have also been investigated. The treatment of rats with celecoxib, but not indomethacin, blunted the CSA-evoked increases in blood pressure (BP), renal perivascular fibrosis and arteriolar endothelin receptor expression (increases in ETA and decreases in ETB receptors). Alternatively, exaggerated nephrotoxicity was seen upon simultaneous treatment with CSA plus indomethacin as evidenced by greater elevations in serum creatinine and renal oxidative stress; renal infiltration of inflammatory cells and worsening of fibrotic and necrotic profiles; and increased...
Toxicology and Industrial Health, 2018
We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Forma... more We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Formaldehyde has been reported to cause asthma in other settings. The purpose of this article is to examine two cases of asthma in hairdressers exposed to hair smoothing products and to review the relevant literature on formaldehyde exposure and asthma. The results indicated that both subjects developed asthma from repeated occupational exposure to formaldehyde during hair treatments. Both subjects became unable to tolerate hair straightening activity in their vicinity. Formaldehyde-containing hair smoothing products are sources of exposure, and the risk of developing asthma is high in salon settings where hair straightening is performed using formaldehyde.
International journal of occupational and environmental health, Apr 1, 2016
Asbestos was used in spray applied textured ceilings from 1945 to at least 1980. Exposure to asbe... more Asbestos was used in spray applied textured ceilings from 1945 to at least 1980. Exposure to asbestos and the probability of developing lung disease is high in individuals who lived with these types of ceilings in their home. Asbestos exposure and frequency of disease is even higher in an apartment suffering from flooding, maintenance, and/or multiple structural impacts. Our goal is to examine a case of lung cancer in a non-smoking individual exposed to asbestos from the damaged acoustic ceilings in her apartment. The subject's medical and occupational records were obtained and reviewed and a physical examination was performed. Exposure ratings were obtained from previous literature for discussion purposes. Asbestos-textured ceilings are a possible source of asbestos exposure and there may be a risk of developing cancer in individuals exposed to ceiling deterioration.
Infertility, 1978
ABSTRACT The hypothalamic-pituitary-testicular axis was evaluated in ten men with occupational le... more ABSTRACT The hypothalamic-pituitary-testicular axis was evaluated in ten men with occupational lead exposure, nine of whom had noted a decrease in libido and frequency of intercourse following this exposure. Six of these men had clinically apparent lead-poisoning while four were classified as being only lead-exposed. The results of the endocrine evaluation of these patients were compared to those obtained on nine age and socioeconomically matched control patients. Both lead-poisoned and lead-exposed patients had reduced basal serum testosterone levels and normal basal serum testosterone-estradiol-binding globulin capacity, estradiol, LH, FSH, and prolactin levels. Both groups demonstrated an appropriate rise in serum testosterone following hCG stimulation and a normal increment in serum FSH in response to clomiphene citrate and gonadotropin-releasing hormone in comparison to the control group. The lead-poisoned patients demonstrated a significantly reduced increment in serum LH after clomiphene citrate and gonadotropin-releasing hormone administration while the lead-exposed patients had normal LH dynamics. Testicular biopsies carried out on the two most severely lead-poisoned men demonstrated peritubular fibrosis, oligospermia and vacuolization of the Sertoli cells. These results suggest that lead poisoning may lead to a pituitary-hypothalamic defect in LH secretion and may also result in direct testicular seminiferous tubular injury.
California medicine, 1973
The number of cases of bacterial endocarditis in drug addicts seen at UCLA and Wadsworth Veterans... more The number of cases of bacterial endocarditis in drug addicts seen at UCLA and Wadsworth Veterans Administration hospitals increased sharply in 1971 over the average of the four preceding years. Enteric Gram-negative bacilli were the infecting organism in three of the seven cases seen in 1971 but were not found in any cases of endocarditis in the 1967-70 period. Medical treatment of the patients was, in general, unsuccessful in spite of the intensive use of newer antimicrobials active against enteric Gram-negative bacilli. One patient died with fulminant Pseudomonas endocarditis and two others (Pseudomonas and Serratia endocarditis) eventually required operations on the heart before a cure was achieved.
Electroencephalography and Clinical Neurophysiology, 1985
Journal of Infectious Diseases, 1974
Hydrocortisone produced choleresis in anesthetized dogs receiving taurocholate and ampicillin. Th... more Hydrocortisone produced choleresis in anesthetized dogs receiving taurocholate and ampicillin. There was an increase in mean concentration of ampicillin in serum after infusion of hydrocortisone with no change in mean rate of biliary excretion of ampicillin. In dogs receiving creatinine in addition to taurocholate and ampicillin, hydrocortisone also produced an increase in mean levels of ampicillin in serum. The mean rate of biliary excretion and the rate of renal clearance of ampicillin were constant in these dogs. In dogs receiving creatinine, taurocholate, and ampicillin without infusion of hydrocortisone, mean concentration of ampicillin in serum, minute biliary weight, and renal clearance rate of ampicillin remained constant throughout the 150 min of study, while mean biliary concentration of ampicillin and rate of excretion decreased during the last 40 min. The increased concentrations of ampicillin in serum of dogs during and after infusion of hydrocortisone seems due to decreased diffusion of ampicillin from plasma into the hepatocyte. Preliminary chromatographic studies of rat liver supernate on Sephadex G-75 indicate that bioactivity of ampicillin appears at a position in the elution pattern where Y protein should be eluted. Y protein binds anoinic metabolites of cortisol. Competitive or noncompetitive inhibition by hydrocortisone of binding of ampicillin to Y protein could explain the increased concentrations in serum during and after infusion of hydrocortisone.
European Journal of Endocrinology, 1967
The serum PBI concentration and the maximal thyroxine binding capacity for TBG and TBPA were dete... more The serum PBI concentration and the maximal thyroxine binding capacity for TBG and TBPA were determined in 100 adolescents. The subjects were classified according to sex and degree of sexual maturity. PBI was determined by an autoanalyzer method: Maximal thyroxine binding capacity for TBG fell with increasing maturation in males while TBPA capacity rose in both sexes. The slight changes in serum PBI noted with increasing sexual maturity correlated directly with the slight changes in TBG binding capacity; no correlation between PBI and TBPA binding capacity was observed as maturity progressed.
Archives of Clinical Neuropsychology, 2000
Antimicrobial Agents and Chemotherapy, 1975
Gentamicin blood levels were monitored in 86 patients. Twenty-one patients had valley levels over... more Gentamicin blood levels were monitored in 86 patients. Twenty-one patients had valley levels over 2 μg/ml and 36% of these patients developed abnormal serum creatinine or a further rise in creatinine. No patient had a rise in creatinine without a valley level over 2. The peak levels in patients with valleys over 2 were above 10 μg/ml in only one case, whereas four patients had peaks over 10 μg/ml without nephrotoxicity. The mean peak blood levels in patients with a normal creatinine were dose related. An initial dose of 2.0, 1.5, and 1.3 or less mpk (mg/kg) yielded mean peak blood levels of 5.2, 4.7, and 3.7, respectively. To assure an initial peak blood level over 4 μg/ml a loading dose of 2 mpk was required. A rise in peak and valley levels during therapy appeared dose related, being observed in all patients treated with 4.5 mpk daily but not in those receiving 3.0 mpk daily. A radioenzymatic assay was used to validate the standard agar diffusion assay method. The results from the...
![Research paper thumbnail of Comment on “Persistent organic pollutants in 9/11 world trade center rescue workers: Reduction following detoxification” by James Dahlgren, Marie Cecchini, Harpreet Takhar, and Olaf Paepke [Chemosphere 69/8 (2007) 1320–1325]](https://attachments.academia-assets.com/89539391/thumbnails/1.jpg)
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Open Journal of Rheumatology and Autoimmune Diseases, 2013
Introduction: Contaminated wood treatment sites can result in adverse health effects to nearby re... more Introduction: Contaminated wood treatment sites can result in adverse health effects to nearby residents. Environmental exposure can be estimated by measuring concentrations of pollutants in air, water, food, or wipe tests. This environmental exposure value can be used as a surrogate to estimate individual exposure. The objective of this study was to determine whether or not pentachlorophenol (PCP) could be found in potentially exposed residents and if the dioxin levels are consistent with PCP exposure. A further objective of the study was to determine whether or not PAH-DNA adducts could be found in the potentially exposed residents.
Journal of Clinical Investigation, 1975
Journal of Earth Science & Climatic Change, Jun 9, 2018
Research in Medicine, 2016
The combined use of cyclosporine (CSA) and nonsteroidal anti-inflammatory drugs (NSAIDs) in arthr... more The combined use of cyclosporine (CSA) and nonsteroidal anti-inflammatory drugs (NSAIDs) in arthritic conditions is common in clinical practice. Because CSA or NSAIDs negatively impacts cardiovascular/renal functions when used individually, we asked if these two drug modalities would provoke more detrimental consequences when used together. The roles of endothelin receptor, inflammatory and fibrotic pathways in these interactions have also been investigated. The treatment of rats with celecoxib, but not indomethacin, blunted the CSA-evoked increases in blood pressure (BP), renal perivascular fibrosis and arteriolar endothelin receptor expression (increases in ETA and decreases in ETB receptors). Alternatively, exaggerated nephrotoxicity was seen upon simultaneous treatment with CSA plus indomethacin as evidenced by greater elevations in serum creatinine and renal oxidative stress; renal infiltration of inflammatory cells and worsening of fibrotic and necrotic profiles; and increased...
Toxicology and Industrial Health, 2018
We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Forma... more We report two cases of formaldehyde-containing hair straighteners causing new onset asthma. Formaldehyde has been reported to cause asthma in other settings. The purpose of this article is to examine two cases of asthma in hairdressers exposed to hair smoothing products and to review the relevant literature on formaldehyde exposure and asthma. The results indicated that both subjects developed asthma from repeated occupational exposure to formaldehyde during hair treatments. Both subjects became unable to tolerate hair straightening activity in their vicinity. Formaldehyde-containing hair smoothing products are sources of exposure, and the risk of developing asthma is high in salon settings where hair straightening is performed using formaldehyde.
International journal of occupational and environmental health, Apr 1, 2016
Asbestos was used in spray applied textured ceilings from 1945 to at least 1980. Exposure to asbe... more Asbestos was used in spray applied textured ceilings from 1945 to at least 1980. Exposure to asbestos and the probability of developing lung disease is high in individuals who lived with these types of ceilings in their home. Asbestos exposure and frequency of disease is even higher in an apartment suffering from flooding, maintenance, and/or multiple structural impacts. Our goal is to examine a case of lung cancer in a non-smoking individual exposed to asbestos from the damaged acoustic ceilings in her apartment. The subject's medical and occupational records were obtained and reviewed and a physical examination was performed. Exposure ratings were obtained from previous literature for discussion purposes. Asbestos-textured ceilings are a possible source of asbestos exposure and there may be a risk of developing cancer in individuals exposed to ceiling deterioration.
Infertility, 1978
ABSTRACT The hypothalamic-pituitary-testicular axis was evaluated in ten men with occupational le... more ABSTRACT The hypothalamic-pituitary-testicular axis was evaluated in ten men with occupational lead exposure, nine of whom had noted a decrease in libido and frequency of intercourse following this exposure. Six of these men had clinically apparent lead-poisoning while four were classified as being only lead-exposed. The results of the endocrine evaluation of these patients were compared to those obtained on nine age and socioeconomically matched control patients. Both lead-poisoned and lead-exposed patients had reduced basal serum testosterone levels and normal basal serum testosterone-estradiol-binding globulin capacity, estradiol, LH, FSH, and prolactin levels. Both groups demonstrated an appropriate rise in serum testosterone following hCG stimulation and a normal increment in serum FSH in response to clomiphene citrate and gonadotropin-releasing hormone in comparison to the control group. The lead-poisoned patients demonstrated a significantly reduced increment in serum LH after clomiphene citrate and gonadotropin-releasing hormone administration while the lead-exposed patients had normal LH dynamics. Testicular biopsies carried out on the two most severely lead-poisoned men demonstrated peritubular fibrosis, oligospermia and vacuolization of the Sertoli cells. These results suggest that lead poisoning may lead to a pituitary-hypothalamic defect in LH secretion and may also result in direct testicular seminiferous tubular injury.
California medicine, 1973
The number of cases of bacterial endocarditis in drug addicts seen at UCLA and Wadsworth Veterans... more The number of cases of bacterial endocarditis in drug addicts seen at UCLA and Wadsworth Veterans Administration hospitals increased sharply in 1971 over the average of the four preceding years. Enteric Gram-negative bacilli were the infecting organism in three of the seven cases seen in 1971 but were not found in any cases of endocarditis in the 1967-70 period. Medical treatment of the patients was, in general, unsuccessful in spite of the intensive use of newer antimicrobials active against enteric Gram-negative bacilli. One patient died with fulminant Pseudomonas endocarditis and two others (Pseudomonas and Serratia endocarditis) eventually required operations on the heart before a cure was achieved.
Electroencephalography and Clinical Neurophysiology, 1985
Journal of Infectious Diseases, 1974
Hydrocortisone produced choleresis in anesthetized dogs receiving taurocholate and ampicillin. Th... more Hydrocortisone produced choleresis in anesthetized dogs receiving taurocholate and ampicillin. There was an increase in mean concentration of ampicillin in serum after infusion of hydrocortisone with no change in mean rate of biliary excretion of ampicillin. In dogs receiving creatinine in addition to taurocholate and ampicillin, hydrocortisone also produced an increase in mean levels of ampicillin in serum. The mean rate of biliary excretion and the rate of renal clearance of ampicillin were constant in these dogs. In dogs receiving creatinine, taurocholate, and ampicillin without infusion of hydrocortisone, mean concentration of ampicillin in serum, minute biliary weight, and renal clearance rate of ampicillin remained constant throughout the 150 min of study, while mean biliary concentration of ampicillin and rate of excretion decreased during the last 40 min. The increased concentrations of ampicillin in serum of dogs during and after infusion of hydrocortisone seems due to decreased diffusion of ampicillin from plasma into the hepatocyte. Preliminary chromatographic studies of rat liver supernate on Sephadex G-75 indicate that bioactivity of ampicillin appears at a position in the elution pattern where Y protein should be eluted. Y protein binds anoinic metabolites of cortisol. Competitive or noncompetitive inhibition by hydrocortisone of binding of ampicillin to Y protein could explain the increased concentrations in serum during and after infusion of hydrocortisone.
European Journal of Endocrinology, 1967
The serum PBI concentration and the maximal thyroxine binding capacity for TBG and TBPA were dete... more The serum PBI concentration and the maximal thyroxine binding capacity for TBG and TBPA were determined in 100 adolescents. The subjects were classified according to sex and degree of sexual maturity. PBI was determined by an autoanalyzer method: Maximal thyroxine binding capacity for TBG fell with increasing maturation in males while TBPA capacity rose in both sexes. The slight changes in serum PBI noted with increasing sexual maturity correlated directly with the slight changes in TBG binding capacity; no correlation between PBI and TBPA binding capacity was observed as maturity progressed.
Archives of Clinical Neuropsychology, 2000
Antimicrobial Agents and Chemotherapy, 1975
Gentamicin blood levels were monitored in 86 patients. Twenty-one patients had valley levels over... more Gentamicin blood levels were monitored in 86 patients. Twenty-one patients had valley levels over 2 μg/ml and 36% of these patients developed abnormal serum creatinine or a further rise in creatinine. No patient had a rise in creatinine without a valley level over 2. The peak levels in patients with valleys over 2 were above 10 μg/ml in only one case, whereas four patients had peaks over 10 μg/ml without nephrotoxicity. The mean peak blood levels in patients with a normal creatinine were dose related. An initial dose of 2.0, 1.5, and 1.3 or less mpk (mg/kg) yielded mean peak blood levels of 5.2, 4.7, and 3.7, respectively. To assure an initial peak blood level over 4 μg/ml a loading dose of 2 mpk was required. A rise in peak and valley levels during therapy appeared dose related, being observed in all patients treated with 4.5 mpk daily but not in those receiving 3.0 mpk daily. A radioenzymatic assay was used to validate the standard agar diffusion assay method. The results from the...
Open Journal of Rheumatology and Autoimmune Diseases, 2013