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Papers by dahlia tounouga

Our Dermatology Online

Background: Voluntary depigmentation (VD) is a cosmetic practice with potentially local and syste... more Background: Voluntary depigmentation (VD) is a cosmetic practice with potentially local and systemic complications such as hyperglycemia. The aim of this study was to find determinants of hyperglycemia in women who practices VD. Methodology: we carried out a retrospective cohort study with from February to August 2020 in four hospitals in Yaoundé, Cameroon. This study included two groups of women: one made up of women who practices VD (exposed group) and the other of women who does not practices VD (group of “unexposed”). Data were collected on CSPro 7.4 software and analyzed on SPSS 25 software. The association between hyperglycemia and VD was measured using Chi-square test. Results: We recruited 181 women: 60 exposed and 121 unexposed. Prevalence of hyperglycemia in the exposed group was 43.3% versus 27.3% in the unexposed group. After logistic regression, the relative risk was significantly higher (RR=5.7; 95% CI: 2.04-15.60) in women practicing DV (p=0.001). The second determina...

Clinical Case Reports

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-... more This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Clinical Case Reports

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial ... more This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Skin health and disease, Aug 24, 2022

Our Dermatology Online

Background: Acne is a chronic inflammatory disease of the pilosebaceous follicle. The aim of this... more Background: Acne is a chronic inflammatory disease of the pilosebaceous follicle. The aim of this study was to assess the level of adherence to acne treatment and to identify factors associated with adherence to therapy in patients with acne. Materials and Methods: This was a descriptive, analytical, cross-sectional study conducted from January to April 2017 in three hospitals in Yaoundé. We included patients followed for acne for at least one month. The sampling was consecutive and exhaustive. Adherence to treatment was assessed according to the Morisky score. Data was analyzed with Microsoft Excel 2013 and the SPSS software, version 23. We employed the ANOVA test to find associations between the different variables. p values below 0.05 were considered statistically significant. Results: A total of 113 patients were selected, with a mean age of 26.0 ? 6.4 years. The mean Morisky score was 5.6 ? 1.9. Adherence to treatment was low, medium, and high in 58 (51%), 31 (28%), and 24 (21%...

Diabetes Research and Clinical Practice

Annales de Dermatologie et de Vénéréologie, 2018

Supplementary Tables and Figures. (PDF 4252 kb)

The Lancet Child & Adolescent Health, 2022

BACKGROUND Halting the rise in cardiometabolic risk factors in children and adolescents is crucia... more BACKGROUND Halting the rise in cardiometabolic risk factors in children and adolescents is crucial to curb the global burden of cardiovascular diseases. We aim to provide global, regional, and national estimates of the prevalence of metabolic syndrome in children and adolescents to support the development of evidence-based prevention strategies. METHODS In this systematic review with modelling analysis, we searched PubMed, Embase, Africa Journal Online, and Global Index Medicus from database inception to Jan 30, 2021, with no restriction on language or geographical location. We included community-based and school-based cross-sectional studies and cross-sectional analysis of cohort studies that reported prevalence of metabolic syndrome in the general population of children (6-12 years) and adolescents (13-18 years). Only studies with a low risk of bias were considered. Eligible studies included at least 200 participants and used probabilistic-based sampling. Diagnosis of metabolic syndrome had to meet at least three of the following criteria: high systolic or diastolic blood pressure (≥90th percentile for age, sex, and height); waist circumference in at least the 90th percentile for age, sex, and ethnic group; fasting plasma glucose 5·6 mmol/L or greater; fasting plasma triglycerides 1·24 mmol/L or greater; and fasting plasma high density lipoprotein cholesterol 1·03 mmol/L or less. Independent investigators selected eligible studies and extracted relevant data. The primary outcome was a crude estimate of metabolic syndrome prevalence, assessed using a Bayesian hierarchical model. FINDINGS Our search yielded 6808 items, of which 169 studies were eligible for analysis, including 306 prevalence datapoints, with 550 405 children and adolescents from 44 countries in 13 regions. The between-study variance (τ2) was 0·52 (95% CI 0·42-0·67), which could reflect the measurement of each component of the metabolic syndrome and covariates as sources of between-study heterogeneity. We estimated the global prevalence of metabolic syndrome in 2020 at 2·8% (95% uncertainty interval [UI] 1·4-6·7) for children and 4·8% (2·9-8·5) for adolescents, equating to around 25·8 (12·6-61·0) million children and 35·5 (21·3-63·0) million adolescents living with metabolic syndrome. In children, the prevalence of metabolic syndrome was 2·2% (95% UI 1·4-3·6) in high-income countries, 3·1% (2·5-4·3) in upper-middle-income countries, 2·6% (0·9-8·3) in lower-middle-income countries, and 3·5% (1·0-8·0) in low-income countries. In adolescents, the prevalence of metabolic syndrome was 5·5% (4·1-8·4) in high-income countries, 3·9% (3·1-5·4) in upper-middle-income countries, 4·5% (2·6-8·4) in lower-middle-income countries, and 7·0% (2·4-15·7) in low-income countries. Prevalence in children varied from 1·4% (0·6-3·1) in northwestern Europe to 8·2% (6·9-10·1) in Central Latin America. Prevalence for adolescents ranged from 2·9% (95% UI 2·6-3·3) in east Asia to 6·7% (5·9-8·3) in high-income English-speaking countries. The three countries with the highest prevalence estimates in children were Nicaragua (5·2%, 2·8-10·4), Iran (8·8%, 8·0-9·6), and Mexico (12·3%, 11·0-13·7); and the three countries with the highest prevalence estimates in adolescents were Iran (9·0%, 8·4-9·7), United Arab Emirates (9·8%, 8·5-10·3), and Spain (9·9%, 9·1-10·8). INTERPRETATION In 2020, about 3% of children and 5% of adolescents had metabolic syndrome, with some variation across countries and regions. The prevalence of metabolic syndrome was not consistently higher with increasing level of development, suggesting that the problem is not mainly driven by country wealth. The high number of children and adolescents living with metabolic syndrome globally highlights the urgent need for multisectoral interventions to reduce the global burden of metabolic syndrome and the conditions that lead to it, including childhood overweight and obesity. FUNDING None.

HEALTH SCIENCES AND DISEASES, 2019

Introduction : La presentation clinique de la maladie de Kaposi (MK) au cours du VIH se distingue... more Introduction : La presentation clinique de la maladie de Kaposi (MK) au cours du VIH se distingue par une grande diffusion cutanee, une atteinte viscerale frequente et severe. Certains determinants influenceraient la survenue de la MK au cours du VIH. Les Objectifs de cette etude etaient de ressortir les determinants de survenue de la MK au cours du VIH et de determiner ses caracteristiques epidemiologiques et cliniques. Methode : Il s’agit d’une etude retrospective cas-temoin (1 :3) menee a l’hopital du jour de l'hopital central de Yaounde (Cameroun). Les cas etaient des patients atteints de VIH chez qui le diagnostic de MK a ete pose apres confirmation histologique. Les temoins etaient des patients seropositifs exempts de MK. Une analyse multivariee a permis d’identifier les facteurs de risque potentiels de la MK. Le seuil de significativite (valeur p) a ete fixe a 5%. Resultats : Nous avons recense 14 220 dossiers, parmi lesquels 316 cas de MK ont ete identifies, soit une inc...

How to cite this article: Kouotou EA, Nguena Feungue U, Tounouga DN, Engolo Fandio A, Ndjitoyap N... more How to cite this article: Kouotou EA, Nguena Feungue U, Tounouga DN, Engolo Fandio A, Ndjitoyap Ndam EC. Impact of prurigo nodularis on quality of life and psychiatric comorbidities among children and their parents in Yaoundé, Cameroon. Our Dermatol Online. 2021;(3):244-250. Submission: 16.03.2021; Acceptance: 31.05.2021 DOI: 10.7241/ourd.20213.3 Impact of prurigo nodularis on quality of life and psychiatric comorbidities among children and their parents in Yaoundé, Cameroon

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous reaction that usually occ... more Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous reaction that usually occurs after drug intake. Antimalarials like hydroxychloroquine have long been incriminated in the literature. This is a case of AGEP occurring after the consumption of an antimalarial other than hydroxychloroquine; labeled as Synriam® (piperaquine and arterolane). A 35-year-old Cameroonian woman presented to our outpatient unit for the sudden onset of generalized maculopapular and pustulous pruritic skin eruption, associated with fever (39.5°C). The eruption had started 4 days after the consumption of arterolane and piperaquine drug combination. The patient been living with Takayasu disease and chronic renal failure for 5 years. She had neutrophilia at 10 000/ul, a hypereosinophilia at 1500 /ul, and raised markers of inflammation with and transaminitis. This clinical picture was suggestive of AGEP. The treatment consisted of applying sterile Vaseline and betamethasone 0,05% cream with an a...

Background: There is little data on Accidental Exposure to Blood (AEB) in Cameroon.Objectives: to... more Background: There is little data on Accidental Exposure to Blood (AEB) in Cameroon.Objectives: to learn about the management of AEB among professional and non-professional patient at the day care unit of the Central Hospital of YaoundéMethod: This was a 10-year retrospective study in which data concerning socio-demographic characteristics, exposure and consultation circumstances, measures taken after the accident, the status of the source patient and of the patient consultant and the prescribed ARV protocol were analyzed.Results: Six hundred files were selected, including 49.2% professional exposure and 50.2% non-professional. The mean age was 30 ± 9.7 years with extremes of 11 and 67 years. The main circumstances of AEB were needle stick (professional AEB) and rape (non-professional AEB). Prophylaxis with triple antiretroviral therapy has been prescribed to all patients.Conclusion: Non-professional and professional AEB are found in equivalent proportions in our series. Triple antir...

International Journal of Dermatology, 2021

Localized or generalized hyperpigmentation is common in dermatology. The causes are multiple, and... more Localized or generalized hyperpigmentation is common in dermatology. The causes are multiple, and most of the time etiologic certitude is difficult. Hyperpigmentation because of nutrient deficiencies, particularly vitamin B12, is rare. This is at times associated with a vegetarian diet. The manifestations revealing such a deficit could be hematologic, neurologic, gastrointestinal, and cutaneous. Cutaneous manifestations are rare and are represented by vitiligo, angular cheilitis, stomatitis, and hyperpigmentation of the skin. We report two cases of hyperpigmentation revealing vitamin B12 deficiency.

Skin Health and Disease, 2021

Background: Prurigo Strophulus (PS) is a chronic and recurrent inflammatory disease caused by a h... more Background: Prurigo Strophulus (PS) is a chronic and recurrent inflammatory disease caused by a hypersensitivity reaction to arthropod bites. The objective of this study was to determine the prevalence of PS and its clinical characteristic in our context. Methods: We performed a cross-sectional study during February to May 2017 in Dermatology's units of six hospitals in Yaoundé. Children with clinical signs of PS were included. A questionnaire was administered for data collection. Results: A total of 112 children (62 boys and 50 girls) were included in the study, with a median age of 2 years; with range varied from 5 months to 16 years. The prevalence of PS was 5.4%. The most represented age group was 0-5 years (78.6%). PS lesions were most often located in exposed areas of body such as lower limbs (101/112; 90.2%), upper limbs (85/112; 75.9%) and face (19.6%). Papule-vesicle (87.5%) was the predominant type of lesions. Conclusion: PS is a common disease in Yaoundé (Cameroon). Papule-vesicle lesions are the most frequent signs. It is usually found in exposure areas of body. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Scientific Reports, 2020

Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis... more Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal Online to identify studies that reported enough data to compute the immunoglobulins (Ig) M or G seroprevalence estimates of Toxoplasma gondii in pregnant women up to December 31st, 2018, without any language restriction. The global and regional estimates were done using a random-effects meta-analysis. We included 250 studies with 723,655 pregnant women. The global IgM seroprevalence was 1.9% (95%CI: 1.7–2.3). At the regional level, Eastern Mediterranean had the highest IgM seroprevalence (4.1%, 95%CI: 2.8–5.5) and The Americas, the lowest (1.1%, 0.8–1.4), with a statistically significant difference between WHO regions (p < 0.0001). The global IgG seroprevalence was 32.9% (95%CI: 29.4–3...

BMJ Open, 2019

IntroductionTo set priorities for public health policy, funding for public health interventions, ... more IntroductionTo set priorities for public health policy, funding for public health interventions, and healthcare planning which will ultimately contribute in bending the burden of toxoplasmosis towards maternal and neonatal health, it is necessary to have accurate data on the prevalence of toxoplasmosis in pregnancy. Therefore, we aimed to estimate the seroprevalence ofToxoplasma gondiiinfection in pregnant women by countries, WHO regions and globally.Methods and analysisWe will search multiple databases to identify studies that reported the prevalence (or enough data to compute this estimate) ofToxoplasma gondiiin the global population of pregnant women up till December 31, 2018 without any language restrictions. Study selection, data extraction and risk of bias assessment will be conducted independently by three pairs of investigators. For each country, we will estimate the prevalence based on empirical studies if there is either one nationally representative study, or two or more ...

BMJ Open, 2019

ObjectiveTo determine the prevalence estimates of some major risk factors for cardiovascular dise... more ObjectiveTo determine the prevalence estimates of some major risk factors for cardiovascular disease (CVD) in a young adult-aged population living in Yaoundé, Cameroon.DesignA cross-sectional study held from May to July 2017.SettingParticipantsStudents aged 18–35 years, with no known history of CVD, found at the campus during recruitment and who voluntarily agreed to be included in the study.Primary and secondary outcome measuresData were collected on personal and family history as well as lifestyle and nutritional habits; anthropometric parameters and blood pressure were also measured. Prevalence rates were calculated with their respective 95% CI.ResultsOverall, 931 participants (53.8% males) were included, with a median age of 23 years (IQR 21–25). The prevalence estimates for some major CVD risk factors were: 3.1% (95% CI 2.0 to 4.2) for family history of heart attack, 6.3% (95% CI 4.7 to 7.9) for family history of stroke, 26.7% (95% CI 23.9 to 29.5) for hazardous alcohol consump...

Our Dermatology Online

Background: Voluntary depigmentation (VD) is a cosmetic practice with potentially local and syste... more Background: Voluntary depigmentation (VD) is a cosmetic practice with potentially local and systemic complications such as hyperglycemia. The aim of this study was to find determinants of hyperglycemia in women who practices VD. Methodology: we carried out a retrospective cohort study with from February to August 2020 in four hospitals in Yaoundé, Cameroon. This study included two groups of women: one made up of women who practices VD (exposed group) and the other of women who does not practices VD (group of “unexposed”). Data were collected on CSPro 7.4 software and analyzed on SPSS 25 software. The association between hyperglycemia and VD was measured using Chi-square test. Results: We recruited 181 women: 60 exposed and 121 unexposed. Prevalence of hyperglycemia in the exposed group was 43.3% versus 27.3% in the unexposed group. After logistic regression, the relative risk was significantly higher (RR=5.7; 95% CI: 2.04-15.60) in women practicing DV (p=0.001). The second determina...

Clinical Case Reports

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-... more This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Clinical Case Reports

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial ... more This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Skin health and disease, Aug 24, 2022

Our Dermatology Online

Background: Acne is a chronic inflammatory disease of the pilosebaceous follicle. The aim of this... more Background: Acne is a chronic inflammatory disease of the pilosebaceous follicle. The aim of this study was to assess the level of adherence to acne treatment and to identify factors associated with adherence to therapy in patients with acne. Materials and Methods: This was a descriptive, analytical, cross-sectional study conducted from January to April 2017 in three hospitals in Yaoundé. We included patients followed for acne for at least one month. The sampling was consecutive and exhaustive. Adherence to treatment was assessed according to the Morisky score. Data was analyzed with Microsoft Excel 2013 and the SPSS software, version 23. We employed the ANOVA test to find associations between the different variables. p values below 0.05 were considered statistically significant. Results: A total of 113 patients were selected, with a mean age of 26.0 ? 6.4 years. The mean Morisky score was 5.6 ? 1.9. Adherence to treatment was low, medium, and high in 58 (51%), 31 (28%), and 24 (21%...

Diabetes Research and Clinical Practice

Annales de Dermatologie et de Vénéréologie, 2018

Supplementary Tables and Figures. (PDF 4252 kb)

The Lancet Child & Adolescent Health, 2022

BACKGROUND Halting the rise in cardiometabolic risk factors in children and adolescents is crucia... more BACKGROUND Halting the rise in cardiometabolic risk factors in children and adolescents is crucial to curb the global burden of cardiovascular diseases. We aim to provide global, regional, and national estimates of the prevalence of metabolic syndrome in children and adolescents to support the development of evidence-based prevention strategies. METHODS In this systematic review with modelling analysis, we searched PubMed, Embase, Africa Journal Online, and Global Index Medicus from database inception to Jan 30, 2021, with no restriction on language or geographical location. We included community-based and school-based cross-sectional studies and cross-sectional analysis of cohort studies that reported prevalence of metabolic syndrome in the general population of children (6-12 years) and adolescents (13-18 years). Only studies with a low risk of bias were considered. Eligible studies included at least 200 participants and used probabilistic-based sampling. Diagnosis of metabolic syndrome had to meet at least three of the following criteria: high systolic or diastolic blood pressure (≥90th percentile for age, sex, and height); waist circumference in at least the 90th percentile for age, sex, and ethnic group; fasting plasma glucose 5·6 mmol/L or greater; fasting plasma triglycerides 1·24 mmol/L or greater; and fasting plasma high density lipoprotein cholesterol 1·03 mmol/L or less. Independent investigators selected eligible studies and extracted relevant data. The primary outcome was a crude estimate of metabolic syndrome prevalence, assessed using a Bayesian hierarchical model. FINDINGS Our search yielded 6808 items, of which 169 studies were eligible for analysis, including 306 prevalence datapoints, with 550 405 children and adolescents from 44 countries in 13 regions. The between-study variance (τ2) was 0·52 (95% CI 0·42-0·67), which could reflect the measurement of each component of the metabolic syndrome and covariates as sources of between-study heterogeneity. We estimated the global prevalence of metabolic syndrome in 2020 at 2·8% (95% uncertainty interval [UI] 1·4-6·7) for children and 4·8% (2·9-8·5) for adolescents, equating to around 25·8 (12·6-61·0) million children and 35·5 (21·3-63·0) million adolescents living with metabolic syndrome. In children, the prevalence of metabolic syndrome was 2·2% (95% UI 1·4-3·6) in high-income countries, 3·1% (2·5-4·3) in upper-middle-income countries, 2·6% (0·9-8·3) in lower-middle-income countries, and 3·5% (1·0-8·0) in low-income countries. In adolescents, the prevalence of metabolic syndrome was 5·5% (4·1-8·4) in high-income countries, 3·9% (3·1-5·4) in upper-middle-income countries, 4·5% (2·6-8·4) in lower-middle-income countries, and 7·0% (2·4-15·7) in low-income countries. Prevalence in children varied from 1·4% (0·6-3·1) in northwestern Europe to 8·2% (6·9-10·1) in Central Latin America. Prevalence for adolescents ranged from 2·9% (95% UI 2·6-3·3) in east Asia to 6·7% (5·9-8·3) in high-income English-speaking countries. The three countries with the highest prevalence estimates in children were Nicaragua (5·2%, 2·8-10·4), Iran (8·8%, 8·0-9·6), and Mexico (12·3%, 11·0-13·7); and the three countries with the highest prevalence estimates in adolescents were Iran (9·0%, 8·4-9·7), United Arab Emirates (9·8%, 8·5-10·3), and Spain (9·9%, 9·1-10·8). INTERPRETATION In 2020, about 3% of children and 5% of adolescents had metabolic syndrome, with some variation across countries and regions. The prevalence of metabolic syndrome was not consistently higher with increasing level of development, suggesting that the problem is not mainly driven by country wealth. The high number of children and adolescents living with metabolic syndrome globally highlights the urgent need for multisectoral interventions to reduce the global burden of metabolic syndrome and the conditions that lead to it, including childhood overweight and obesity. FUNDING None.

HEALTH SCIENCES AND DISEASES, 2019

Introduction : La presentation clinique de la maladie de Kaposi (MK) au cours du VIH se distingue... more Introduction : La presentation clinique de la maladie de Kaposi (MK) au cours du VIH se distingue par une grande diffusion cutanee, une atteinte viscerale frequente et severe. Certains determinants influenceraient la survenue de la MK au cours du VIH. Les Objectifs de cette etude etaient de ressortir les determinants de survenue de la MK au cours du VIH et de determiner ses caracteristiques epidemiologiques et cliniques. Methode : Il s’agit d’une etude retrospective cas-temoin (1 :3) menee a l’hopital du jour de l'hopital central de Yaounde (Cameroun). Les cas etaient des patients atteints de VIH chez qui le diagnostic de MK a ete pose apres confirmation histologique. Les temoins etaient des patients seropositifs exempts de MK. Une analyse multivariee a permis d’identifier les facteurs de risque potentiels de la MK. Le seuil de significativite (valeur p) a ete fixe a 5%. Resultats : Nous avons recense 14 220 dossiers, parmi lesquels 316 cas de MK ont ete identifies, soit une inc...

How to cite this article: Kouotou EA, Nguena Feungue U, Tounouga DN, Engolo Fandio A, Ndjitoyap N... more How to cite this article: Kouotou EA, Nguena Feungue U, Tounouga DN, Engolo Fandio A, Ndjitoyap Ndam EC. Impact of prurigo nodularis on quality of life and psychiatric comorbidities among children and their parents in Yaoundé, Cameroon. Our Dermatol Online. 2021;(3):244-250. Submission: 16.03.2021; Acceptance: 31.05.2021 DOI: 10.7241/ourd.20213.3 Impact of prurigo nodularis on quality of life and psychiatric comorbidities among children and their parents in Yaoundé, Cameroon

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous reaction that usually occ... more Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous reaction that usually occurs after drug intake. Antimalarials like hydroxychloroquine have long been incriminated in the literature. This is a case of AGEP occurring after the consumption of an antimalarial other than hydroxychloroquine; labeled as Synriam® (piperaquine and arterolane). A 35-year-old Cameroonian woman presented to our outpatient unit for the sudden onset of generalized maculopapular and pustulous pruritic skin eruption, associated with fever (39.5°C). The eruption had started 4 days after the consumption of arterolane and piperaquine drug combination. The patient been living with Takayasu disease and chronic renal failure for 5 years. She had neutrophilia at 10 000/ul, a hypereosinophilia at 1500 /ul, and raised markers of inflammation with and transaminitis. This clinical picture was suggestive of AGEP. The treatment consisted of applying sterile Vaseline and betamethasone 0,05% cream with an a...

Background: There is little data on Accidental Exposure to Blood (AEB) in Cameroon.Objectives: to... more Background: There is little data on Accidental Exposure to Blood (AEB) in Cameroon.Objectives: to learn about the management of AEB among professional and non-professional patient at the day care unit of the Central Hospital of YaoundéMethod: This was a 10-year retrospective study in which data concerning socio-demographic characteristics, exposure and consultation circumstances, measures taken after the accident, the status of the source patient and of the patient consultant and the prescribed ARV protocol were analyzed.Results: Six hundred files were selected, including 49.2% professional exposure and 50.2% non-professional. The mean age was 30 ± 9.7 years with extremes of 11 and 67 years. The main circumstances of AEB were needle stick (professional AEB) and rape (non-professional AEB). Prophylaxis with triple antiretroviral therapy has been prescribed to all patients.Conclusion: Non-professional and professional AEB are found in equivalent proportions in our series. Triple antir...

International Journal of Dermatology, 2021

Localized or generalized hyperpigmentation is common in dermatology. The causes are multiple, and... more Localized or generalized hyperpigmentation is common in dermatology. The causes are multiple, and most of the time etiologic certitude is difficult. Hyperpigmentation because of nutrient deficiencies, particularly vitamin B12, is rare. This is at times associated with a vegetarian diet. The manifestations revealing such a deficit could be hematologic, neurologic, gastrointestinal, and cutaneous. Cutaneous manifestations are rare and are represented by vitiligo, angular cheilitis, stomatitis, and hyperpigmentation of the skin. We report two cases of hyperpigmentation revealing vitamin B12 deficiency.

Skin Health and Disease, 2021

Background: Prurigo Strophulus (PS) is a chronic and recurrent inflammatory disease caused by a h... more Background: Prurigo Strophulus (PS) is a chronic and recurrent inflammatory disease caused by a hypersensitivity reaction to arthropod bites. The objective of this study was to determine the prevalence of PS and its clinical characteristic in our context. Methods: We performed a cross-sectional study during February to May 2017 in Dermatology's units of six hospitals in Yaoundé. Children with clinical signs of PS were included. A questionnaire was administered for data collection. Results: A total of 112 children (62 boys and 50 girls) were included in the study, with a median age of 2 years; with range varied from 5 months to 16 years. The prevalence of PS was 5.4%. The most represented age group was 0-5 years (78.6%). PS lesions were most often located in exposed areas of body such as lower limbs (101/112; 90.2%), upper limbs (85/112; 75.9%) and face (19.6%). Papule-vesicle (87.5%) was the predominant type of lesions. Conclusion: PS is a common disease in Yaoundé (Cameroon). Papule-vesicle lesions are the most frequent signs. It is usually found in exposure areas of body. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Scientific Reports, 2020

Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis... more Efficient health-care for pregnant women require accurate data on the prevalence of toxoplasmosis in pregnancy at global, regional, and country levels. In this systematic review with meta- and modelling-analysis, we searched PubMed, EMBASE, Web of Knowledge, Global Index Medicus, and Africa Journal Online to identify studies that reported enough data to compute the immunoglobulins (Ig) M or G seroprevalence estimates of Toxoplasma gondii in pregnant women up to December 31st, 2018, without any language restriction. The global and regional estimates were done using a random-effects meta-analysis. We included 250 studies with 723,655 pregnant women. The global IgM seroprevalence was 1.9% (95%CI: 1.7–2.3). At the regional level, Eastern Mediterranean had the highest IgM seroprevalence (4.1%, 95%CI: 2.8–5.5) and The Americas, the lowest (1.1%, 0.8–1.4), with a statistically significant difference between WHO regions (p < 0.0001). The global IgG seroprevalence was 32.9% (95%CI: 29.4–3...

BMJ Open, 2019

IntroductionTo set priorities for public health policy, funding for public health interventions, ... more IntroductionTo set priorities for public health policy, funding for public health interventions, and healthcare planning which will ultimately contribute in bending the burden of toxoplasmosis towards maternal and neonatal health, it is necessary to have accurate data on the prevalence of toxoplasmosis in pregnancy. Therefore, we aimed to estimate the seroprevalence ofToxoplasma gondiiinfection in pregnant women by countries, WHO regions and globally.Methods and analysisWe will search multiple databases to identify studies that reported the prevalence (or enough data to compute this estimate) ofToxoplasma gondiiin the global population of pregnant women up till December 31, 2018 without any language restrictions. Study selection, data extraction and risk of bias assessment will be conducted independently by three pairs of investigators. For each country, we will estimate the prevalence based on empirical studies if there is either one nationally representative study, or two or more ...

BMJ Open, 2019

ObjectiveTo determine the prevalence estimates of some major risk factors for cardiovascular dise... more ObjectiveTo determine the prevalence estimates of some major risk factors for cardiovascular disease (CVD) in a young adult-aged population living in Yaoundé, Cameroon.DesignA cross-sectional study held from May to July 2017.SettingParticipantsStudents aged 18–35 years, with no known history of CVD, found at the campus during recruitment and who voluntarily agreed to be included in the study.Primary and secondary outcome measuresData were collected on personal and family history as well as lifestyle and nutritional habits; anthropometric parameters and blood pressure were also measured. Prevalence rates were calculated with their respective 95% CI.ResultsOverall, 931 participants (53.8% males) were included, with a median age of 23 years (IQR 21–25). The prevalence estimates for some major CVD risk factors were: 3.1% (95% CI 2.0 to 4.2) for family history of heart attack, 6.3% (95% CI 4.7 to 7.9) for family history of stroke, 26.7% (95% CI 23.9 to 29.5) for hazardous alcohol consump...