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Papers by daniel souza

Research paper thumbnail of Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation

Research paper thumbnail of Laboratórios Remotos com Sistemas Hápticos para Educação à Distância

Laboratories are an important educational resource to provide experimentation and help in the kno... more Laboratories are an important educational resource to provide experimentation and help in the knowledge construction. Remote laboratories allow experimentation at distance and offer access to education. This work presents the development of an application that integrates haptics to remote laboratories to improve experiments whose comprehension involves mechanical material characterization. 1. Introdução

Research paper thumbnail of An intelligent and persistent browser-based game for oil drilling operators training

Oil exploration has become a steadily growing business. This is due to the ever increasing demand... more Oil exploration has become a steadily growing business. This is due to the ever increasing demand for oil derivatives in the international market. The extraction of this mineral, however, is not an easy process. It poses many hazards which may threaten the environment and the lives of workers at an oil well. In order to reduce the chances of accidents

Research paper thumbnail of A Virtual Reality Based Simulator for Gynecologic Exam Training

ieeexplore.ieee.org, 2007

Research paper thumbnail of Active hypertensive elderly have similar blood pressure during the day and smaller diastolic blood pressure fall during nighttime than sedentaries

American Journal of Hypertension, 2002

The aim of this study was to compare blood pressure (BP) of active and sedentary elderly individu... more The aim of this study was to compare blood pressure (BP) of active and sedentary elderly individuals measured by different methods, particulary BP fall during the sleep.We examined 106 individuals, 60-year-old or older, female or male sex, sedentary normotensives (SN)or hipertensives (SH)and active(at least 30 minutes of dynamic exercise, three times a week, for 6 months) normotensives (AN) and hipertensives

Research paper thumbnail of ARTIGO ORIGINAL Epidemiologia da paralisia cerebral Cerebral palsy epidemiology

Research paper thumbnail of A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury

Research paper thumbnail of Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum

Vaccine, Jan 3, 2015

Live attenuated Leishmania donovani parasites such as LdCen(-/-) have been shown elicit protectiv... more Live attenuated Leishmania donovani parasites such as LdCen(-/-) have been shown elicit protective immunity against leishmanial infection in mice and hamster models. Previously, we have reported on the induction of strong immunogenicity in dogs upon vaccination with LdCen(-/-) including an increase in immunoglobulin isotypes, higher lymphoproliferative response, higher frequencies of activated CD4(+) and CD8(+) T cells, IFN-γ production by CD8(+) T cells, increased secretion of TNF-α and IL-12/IL-23p40 and, finally, decreased secretion of IL-4. To further explore the potential of LdCen(-/-) parasites as vaccine candidates, we performed a 24-month follow up of LdCen(-/-) immunized dogs after challenge with virulent Leishmania infantum, aiming determination of parasite burden by qPCR, antibody production (ELISA) and cellular responses (T cell activation and cytokine production) by flow cytometry and sandwich ELISA. Our data demonstrated that vaccination with a single dose of LdCen(-/-...

Research paper thumbnail of Canine Skin and Conjunctival Swab Samples for the Detection and Quantification of Leishmania infantum DNA in an Endemic Urban Area in Brazil

PLoS Neglected Tropical Diseases, 2012

Research paper thumbnail of RNA Biomarkers in Schizophrenia

The deciphering of the human genome and the advances in transcriptome interrogation approaches an... more The deciphering of the human genome and the advances in transcriptome interrogation approaches and transformed RNA biomarkers make important promises for the understanding and management of psychiatric diseases. In this chapter we describe the techniques more widely used for gene expression analysis and present the main findings in the search for RNA biomarkers in schizophrenia such as the recurrent observation

Research paper thumbnail of Interferon-inducible guanylate binding protein (GBP)-2: A novel p53-regulated tumor marker in esophageal squamous cell carcinomas

International Journal of Cancer, 2009

Research paper thumbnail of Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation

Research paper thumbnail of Laboratórios Remotos com Sistemas Hápticos para Educação à Distância

Laboratories are an important educational resource to provide experimentation and help in the kno... more Laboratories are an important educational resource to provide experimentation and help in the knowledge construction. Remote laboratories allow experimentation at distance and offer access to education. This work presents the development of an application that integrates haptics to remote laboratories to improve experiments whose comprehension involves mechanical material characterization. 1. Introdução

Research paper thumbnail of An intelligent and persistent browser-based game for oil drilling operators training

Oil exploration has become a steadily growing business. This is due to the ever increasing demand... more Oil exploration has become a steadily growing business. This is due to the ever increasing demand for oil derivatives in the international market. The extraction of this mineral, however, is not an easy process. It poses many hazards which may threaten the environment and the lives of workers at an oil well. In order to reduce the chances of accidents

Research paper thumbnail of A Virtual Reality Based Simulator for Gynecologic Exam Training

ieeexplore.ieee.org, 2007

Research paper thumbnail of Active hypertensive elderly have similar blood pressure during the day and smaller diastolic blood pressure fall during nighttime than sedentaries

American Journal of Hypertension, 2002

The aim of this study was to compare blood pressure (BP) of active and sedentary elderly individu... more The aim of this study was to compare blood pressure (BP) of active and sedentary elderly individuals measured by different methods, particulary BP fall during the sleep.We examined 106 individuals, 60-year-old or older, female or male sex, sedentary normotensives (SN)or hipertensives (SH)and active(at least 30 minutes of dynamic exercise, three times a week, for 6 months) normotensives (AN) and hipertensives

Research paper thumbnail of ARTIGO ORIGINAL Epidemiologia da paralisia cerebral Cerebral palsy epidemiology

Research paper thumbnail of A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury

Research paper thumbnail of Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum

Vaccine, Jan 3, 2015

Live attenuated Leishmania donovani parasites such as LdCen(-/-) have been shown elicit protectiv... more Live attenuated Leishmania donovani parasites such as LdCen(-/-) have been shown elicit protective immunity against leishmanial infection in mice and hamster models. Previously, we have reported on the induction of strong immunogenicity in dogs upon vaccination with LdCen(-/-) including an increase in immunoglobulin isotypes, higher lymphoproliferative response, higher frequencies of activated CD4(+) and CD8(+) T cells, IFN-γ production by CD8(+) T cells, increased secretion of TNF-α and IL-12/IL-23p40 and, finally, decreased secretion of IL-4. To further explore the potential of LdCen(-/-) parasites as vaccine candidates, we performed a 24-month follow up of LdCen(-/-) immunized dogs after challenge with virulent Leishmania infantum, aiming determination of parasite burden by qPCR, antibody production (ELISA) and cellular responses (T cell activation and cytokine production) by flow cytometry and sandwich ELISA. Our data demonstrated that vaccination with a single dose of LdCen(-/-...

Research paper thumbnail of Canine Skin and Conjunctival Swab Samples for the Detection and Quantification of Leishmania infantum DNA in an Endemic Urban Area in Brazil

PLoS Neglected Tropical Diseases, 2012

Research paper thumbnail of RNA Biomarkers in Schizophrenia

The deciphering of the human genome and the advances in transcriptome interrogation approaches an... more The deciphering of the human genome and the advances in transcriptome interrogation approaches and transformed RNA biomarkers make important promises for the understanding and management of psychiatric diseases. In this chapter we describe the techniques more widely used for gene expression analysis and present the main findings in the search for RNA biomarkers in schizophrenia such as the recurrent observation

Research paper thumbnail of Interferon-inducible guanylate binding protein (GBP)-2: A novel p53-regulated tumor marker in esophageal squamous cell carcinomas

International Journal of Cancer, 2009

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