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Abstract. The increasing implementation of standardisation techniques in brain research and clini... more Abstract. The increasing implementation of standardisation techniques in brain research and clinical diagnosis has highlighted the importance of reliable baseline data from normal control subjects for inter-subject analysis. In this context, knowledge of the regional cerebral blood flow (rCBF) distribution in normal ageing is a factor of the utmost importance. In the present study, rCBF was investigated in 50 healthy volunteers (25 men, 25 women), aged 31–78 years, who were examined at rest by means of single-photon emission tomography (SPET) using technetium-99m d,l-hexamethylpropylene amine oxime (HMPAO). After normalising the CBF data, 27 left and 27 right volumes of interest (VOIs) were selected and automatically outlined by standardisation software (computerised brain atlas). The heavy load of flow data thus obtained was reduced in number and grouped in factors by means of principal component analysis (PCA). PCA extracted 12 components explaining 81% of the variance and includi...
Biological Psychiatry, 2008
Background: Neuroimaging investigations in PTSD have mostly reported findings for either function... more Background: Neuroimaging investigations in PTSD have mostly reported findings for either functional or structural data separately. The aim of this study was to analyse in occupational trauma-exposed subjects structural-functional correlations of brain regions implicated in the pathophysiology of PTSD. Methods: Thirty six train drivers having being exposed to traumatic experiences at work were separated in two groups: symptomatic (S) or not symptomatic (NS), according to PTSD diagnosis. SPECT, following administration of an individualised trauma script, and MRI were performed at an average of three years after the trauma. CBF and volumetric analysis were performed on the temporal lobes and the hippocampi. Results: Analysis of Variance showed a significantly higher 99mTc-HMPAO distribution in the left temporal lobe of S as compared to NS. This significance was still present after covarying for the corresponding volumes. MRI showed a larger temporal lobe volume on the right hemisphere....
The purpose of this study was to determine the part played by each hemisphere in a novelty detect... more The purpose of this study was to determine the part played by each hemisphere in a novelty detection task and the role of sex in cerebral asymmetries. Letter and line pairs were presented to the left or to the right visual field and the Subjects were instructed to report if the incoming stimulus had been a new one. Performance was scored recording to nonparametric estimates of sensitivity and criterion. The main results were : a) a clear-cut dissociation between the two measures; b) a greater sensitivity for the right visual field presentation, irrespective of the type of material and c) different effects on detection and response bias for men and for women. The importance of these findings with respect to lateralization and information processing is discussed.
■ Abstract Objective Psychological trauma leads to posttraumatic stress disorder (PTSD) in suscep... more ■ Abstract Objective Psychological trauma leads to posttraumatic stress disorder (PTSD) in susceptible subjects. The aim of this study was to investigate the differences in regional cerebral blood flow (rCBF) between two groups of subjects exposed to different types of traumatic stressor either developing or not developing PTSD. Method Twenty subjects developing (S) and 27 not developing (NS) PTSD after being exposed to either earlier person-under-the-train accident (NA) or being assaulted in the underground environment (A) were included in the study. 99mTc-HMPAO SPECT was performed and the uptake in 29 regions of the brain (VOIs), bilaterally, was assessed. rCBF distribution was compared, using analysis of variance (ANOVA), between groups (S/NS) and type (A/NA) during a situation involving an auditory evoked re-experiencing of the traumatic event. Discriminant analysis was applied to test the concordance between clinical diagnosis and SPECT findings. Results In the general analyses...
Journal of Neurology, Neurosurgery & Psychiatry, 2010
significantly (the shift is greater in Italy than France). In both countries, patient and caregiv... more significantly (the shift is greater in Italy than France). In both countries, patient and caregiver HRQoL are affected greatly and to the same extent, regardless of the instrument used. For patients, physical, mental and social HRQoL domains are all seriously affected. Conclusions Euro-HDB is the first study to comprehensively asses the cost of illness of HD and shows that it is associated with significant costs.
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2009
Two experiments were conducted to test the hypothesis of an hemispheric specialization in the spa... more Two experiments were conducted to test the hypothesis of an hemispheric specialization in the spatial frequency analysis. Reaction times were collected for gratings of different spatial frequencies presented to the left and to the right visual field. An interaction was found between visual fields and spatial frequencies, with a clear left visual field-right hemisphere advantage for high spatial frequency processing. Results are discussed in terms of the relative spatial/temporal properties of visual stimuli that could activate mechanisms specific of each hemisphere.
Abstract. The increasing implementation of standardisation techniques in brain research and clini... more Abstract. The increasing implementation of standardisation techniques in brain research and clinical diagnosis has highlighted the importance of reliable baseline data from normal control subjects for inter-subject analysis. In this context, knowledge of the regional cerebral blood flow (rCBF) distribution in normal ageing is a factor of the utmost importance. In the present study, rCBF was investigated in 50 healthy volunteers (25 men, 25 women), aged 31–78 years, who were examined at rest by means of single-photon emission tomography (SPET) using technetium-99m d,l-hexamethylpropylene amine oxime (HMPAO). After normalising the CBF data, 27 left and 27 right volumes of interest (VOIs) were selected and automatically outlined by standardisation software (computerised brain atlas). The heavy load of flow data thus obtained was reduced in number and grouped in factors by means of principal component analysis (PCA). PCA extracted 12 components explaining 81% of the variance and includi...
Biological Psychiatry, 2008
Background: Neuroimaging investigations in PTSD have mostly reported findings for either function... more Background: Neuroimaging investigations in PTSD have mostly reported findings for either functional or structural data separately. The aim of this study was to analyse in occupational trauma-exposed subjects structural-functional correlations of brain regions implicated in the pathophysiology of PTSD. Methods: Thirty six train drivers having being exposed to traumatic experiences at work were separated in two groups: symptomatic (S) or not symptomatic (NS), according to PTSD diagnosis. SPECT, following administration of an individualised trauma script, and MRI were performed at an average of three years after the trauma. CBF and volumetric analysis were performed on the temporal lobes and the hippocampi. Results: Analysis of Variance showed a significantly higher 99mTc-HMPAO distribution in the left temporal lobe of S as compared to NS. This significance was still present after covarying for the corresponding volumes. MRI showed a larger temporal lobe volume on the right hemisphere....
The purpose of this study was to determine the part played by each hemisphere in a novelty detect... more The purpose of this study was to determine the part played by each hemisphere in a novelty detection task and the role of sex in cerebral asymmetries. Letter and line pairs were presented to the left or to the right visual field and the Subjects were instructed to report if the incoming stimulus had been a new one. Performance was scored recording to nonparametric estimates of sensitivity and criterion. The main results were : a) a clear-cut dissociation between the two measures; b) a greater sensitivity for the right visual field presentation, irrespective of the type of material and c) different effects on detection and response bias for men and for women. The importance of these findings with respect to lateralization and information processing is discussed.
■ Abstract Objective Psychological trauma leads to posttraumatic stress disorder (PTSD) in suscep... more ■ Abstract Objective Psychological trauma leads to posttraumatic stress disorder (PTSD) in susceptible subjects. The aim of this study was to investigate the differences in regional cerebral blood flow (rCBF) between two groups of subjects exposed to different types of traumatic stressor either developing or not developing PTSD. Method Twenty subjects developing (S) and 27 not developing (NS) PTSD after being exposed to either earlier person-under-the-train accident (NA) or being assaulted in the underground environment (A) were included in the study. 99mTc-HMPAO SPECT was performed and the uptake in 29 regions of the brain (VOIs), bilaterally, was assessed. rCBF distribution was compared, using analysis of variance (ANOVA), between groups (S/NS) and type (A/NA) during a situation involving an auditory evoked re-experiencing of the traumatic event. Discriminant analysis was applied to test the concordance between clinical diagnosis and SPECT findings. Results In the general analyses...
Journal of Neurology, Neurosurgery & Psychiatry, 2010
significantly (the shift is greater in Italy than France). In both countries, patient and caregiv... more significantly (the shift is greater in Italy than France). In both countries, patient and caregiver HRQoL are affected greatly and to the same extent, regardless of the instrument used. For patients, physical, mental and social HRQoL domains are all seriously affected. Conclusions Euro-HDB is the first study to comprehensively asses the cost of illness of HD and shows that it is associated with significant costs.
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2009
Two experiments were conducted to test the hypothesis of an hemispheric specialization in the spa... more Two experiments were conducted to test the hypothesis of an hemispheric specialization in the spatial frequency analysis. Reaction times were collected for gratings of different spatial frequencies presented to the left and to the right visual field. An interaction was found between visual fields and spatial frequencies, with a clear left visual field-right hemisphere advantage for high spatial frequency processing. Results are discussed in terms of the relative spatial/temporal properties of visual stimuli that could activate mechanisms specific of each hemisphere.