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Papers by mandira dasgupta

Research paper thumbnail of Study on the Change in Function of the Preserved Ovaries following Hysterectomy by Abdominal Versus Vaginal Route

Andrology & Gynecology: Current Research, 2017

Objectives: Our primary objective was to study any change in ovarian blood flow in the preserved ... more Objectives: Our primary objective was to study any change in ovarian blood flow in the preserved ovaries following hysterectomy either by abdominal (AH) or vaginal route (VH). Our secondary objectives were to study menopausal symptoms and change in hormonal parameters postoperatively in these two types of hysterectomy. Materials and methods: This prospective observational study was conducted in the departments of obstetrics and gynecology and radiology of Medical College Hospital, Kolkata. 90 patients undergoing hysterectomy with ovarian preservation - 42 by abdominal route(AH group) and 48 by vaginal route (VH group) were studied on 5th postoperative day and 6th postoperative month in terms of ovarian arterial doppler indices and clinical and hormonal changes suggestive of menopause and compared these postoperative parameters with the preoperative parameters. Results: There was statistically significant decrease in Vmax and PI at 5th day and 6th month in ovaries in both the groups. The reduction was greater at 6th postoperative month in VH group as compared to AH group. There was statistically significant increase in menopausal symptoms in VH group and serum FSH and LH level at 6th postoperative month, but no difference in these parameters between groups. Conclusion: Menopausal symptoms are more in VH group as compared to AH group due to reduced Vmax and PI in ovarian arteries in preserved ovaries as early as 6 months postoperatively.

Research paper thumbnail of Leiomyomas in Pregnancy - Clinical Implications

Objective: To assess the effect of pregnancy on leiomyomas, effect of leiomyomas on pregnancy, th... more Objective: To assess the effect of pregnancy on leiomyomas, effect of leiomyomas on pregnancy, the maternal morbidity and mortality and the perinatal outcome in pregnancies associated with leiomyoma. Materials and Methods: This prospective clinical study was conducted at Department of Obstetric and Gynecology, Medical College and Hospital, Kolkata from July 2012 to June 2013 on 40 pregnant women diagnosed with uterine leiomyoma. Results: Out of the total number of 40 cases, 87.5% were more than 25 years of age. Diagnosis was by antenatal ultrasound in 87.5%. Location of leiomyoma was subserous in 60%. They were 10-50cc in size in 50%of cases, single in 77.5%, 3 or more in number in only 15%. In pregnancy, size remained unaltered in 60%, 20% increased in size and 10% showed a decrease in size. At the end of puerperium they disappeared or decreased in size in 87.5% of cases. Complications developed in 35% of cases out of which 12.5% had complete abortions, 5.7% had placental abruption...

Research paper thumbnail of A Prospective Randomized Comparative Study Of Letrozole Vs Leuprolide Acetate In Symptomatic Relief Of Endometriosis

INTRODUCTION: This prospective randomized comparative study was conducted to evaluate and compare... more INTRODUCTION: This prospective randomized comparative study was conducted to evaluate and compare the efficacy and tolerability of aromatase inhibitor Letrozole acetate versus GnRH agonist Leuprolide in managing chronic pelvic pain in women with clinically suspected endometriosis. METHODOLOGY: Non pregnant women from 18-45 years of age with symptomatic (pain) endometriosis weer randomized to open label treatment of depot Leuprolide (3.75/mo) or Letrozole 2.5mg once daily for three months. A visual analog pain scale from 1-10 was used to assess the severity of pain. RESULTS: 50 women were randomized and all of them completed the study. No statistical or clinical significant difference on symptomatic relief was seen. Incidence of adverse events slightly higher in the Leuprolide group. But overall, satisfactory pain relief was achieved in only 36% of the total patients. DISCUSSION: The main complaints of study participants are chronic pelvic pain and dysmenorrhoea. Our results show tha...

Research paper thumbnail of No Scalpel Vasectomy, Tubectomy, Spacing methods, Permanent Sterilization, Contraception

Research paper thumbnail of No Scalpel Vasectomy: An Emerging Option in Family Planning Practice

BACKGROUND: Both spacing and permanent birth control methods are the need of the hour. The popula... more BACKGROUND: Both spacing and permanent birth control methods are the need of the hour. The popularity of male sterilization i.e. vasectomy is low compared to female sterilization (tubectomy). However, being safe, effective, cheap, and having less surgical complications no scalpel vasectomy (NSV) is emerging as good option. AIMS: To study the various demographic and behavioural factors of NSV acceptors. SETTING & DESIGN: This is institution based retrospective study conducted in Department of Obstetrics and Gynaecology, Medical College, Kolkata during the time period of 1st April ‘2009 to 31st March’ 2015. METHODS AND MATERIAL: The patients who accepted NSV for family planning were analysed with respect to their age, residence, occupation, literacy, number of issues and complications. STATISTICAL ANALYSIS: Data were represented as simple proportions or percentages and graphs by using micro soft excel. RESULTS: Out of 13, 048 sterilization operations, there were 3737(28.64%) vasectomi...

Research paper thumbnail of Evaluation of the SERM Ormeloxifene in the Treatment of Uterine Fibroid in the Reproductive Age Group

Journal of Syndromes, 2016

Research paper thumbnail of Is N-acetylcysteine a better Insulin Sensitizer than Metformin in Polycystic Ovarian Syndrome?

Andrology & Gynecology: Current Research, 2015

Research paper thumbnail of A Study On Preferences And Awareness Regarding Prenatal Sex Determination Among Antenatal Women Attending Obstetrics And Gynecology Outdoor Of Medical College, Kolkata During The Time Period Of January To June, 2012

Context: Prenatal sex detection, allowing the selective abortions of female fetus is legally a pe... more Context: Prenatal sex detection, allowing the selective abortions of female fetus is legally a penal offence. It is prevailing in many parts of India resulting in gender imbalance and high masculinity, because Indian value system prefers male child over female. Methods and Material: We interviewed 175 antenatal mothers by systemic random sampling, excluding the unwilling, attending OPD of Medical College and Hospital, Kolkata during January to June, to assess the trends in gender preference and awareness regarding pre-natal sex determination among antenatal women. Result: Our study couples, who are mostly from urban areas, mainly in the 20-30 year age group, mostly from lower economic strata, are well aware of the social menace arising out of prenatal sex determination and female feticide. Although one quarter had strong male preference, none undergone PCPNDT to know the sex of the offspring, 43% were aware that PCPNDT is legally banned and 54% knew that female feticide is a crime according to law. Conclusions: Provision and strict implementation of law as well as improvement of socioeconomic condition, literacy through public education campaigns and lifting up the moral and ethical values are warranted to eradicate this social crime.

Research paper thumbnail of “ Comparison of short term morbidities following episiotomies repaired by rapidly absorbable polyglactin and chromic catgut ”

Objective: To compare the morbidity following episiotomy repair by rapidly absorbed polyglactin a... more Objective: To compare the morbidity following episiotomy repair by rapidly absorbed polyglactin and chromic catgut. Materials & Methods: This prospective longitudinal study was conducted in the Department of Obstetrics and Gynaecology, Medical College, Kolkata. 100 primigravida with episiotomy were divided into 2 groups Group I:CC (n=50) repaired with no 1,0 chromic catgut and Group II:VR (n=50) repaired with rapidly absorbed polyglactin and they were compared with respect to pain, wound complications, perineal edema and dyspareunia –at 2 hours, 2 days, 6 weeks and 3 months. Results: With regard to postoperative complications like pain, perineal edema and wound healing and resuturing, polyglactin was significantly better than chromic catgut. Moreover, persistent perineal pain and dyspareunia were significantly less in VR group at 6 weeks and 3 months. Conclusion: The shortterm morbidity following episiotomy repair with rapidly absorbed polyglactin is less when compared to chromic ca...

Research paper thumbnail of The Estrogen and Progesterone Receptors in Endometrial Carcinoma - An Update

Research paper thumbnail of English

Journal of Evolution of Medical and Dental Sciences, 2015

Research paper thumbnail of A prospective study for the prediction of preeclampsia with urinary calcium level

Journal of Obstetrics and Gynecology of India

To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and ... more To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women. A prospective study was conducted on 60 primi mothers in the age group of 20-30 years, and all were enrolled at 16 weeks of gestation with clinical follow up by 4 weeks and 24 h urinary calcium and creatinine estimation. Ten mothers developed preeclampsia (study groups) and fifty remained normotensive (control groups). By means of Receiver-operator curve, a cut-off level of urinary calcium in 24 h was chosen for predicting preeclampsia. Preeclamptic women excreted significantly less total urine calcium (87.0 ± 3.59 mg/24 h) than normotensive women (303.68 ± 17.699 mg/24 h) (p < 0.0001) at 40 weeks of gestation. Urinary calcium and calcium/creatinine (Ca:Cr) ratio decreases progressively from 28 weeks to 40 weeks in the study group when compared to normotensive group. Preeclamptic wome...

Research paper thumbnail of A Prospective Study for the Prediction of Preeclampsia with Urinary Calcium Level

The Journal of Obstetrics and Gynecology of India, 2012

Objectives To assess the efficacy of calciuria as a diagnostic test for the prediction of preecla... more Objectives To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women. Methods A prospective study was conducted on 60 primi mothers in the age group of 20-30 years, and all were enrolled at 16 weeks of gestation with clinical follow up by 4 weeks and 24 h urinary calcium and creatinine estimation. Ten mothers developed preeclampsia (study groups) and fifty remained normotensive (control groups). By means of Receiver-operator curve, a cut-off level of urinary calcium in 24 h was chosen for predicting preeclampsia. Results Preeclamptic women excreted significantly less total urine calcium (87.0 ± 3.59 mg/24 h) than normotensive women (303.68 ± 17.699 mg/24 h) (p \ 0.0001) at 40 weeks of gestation. Urinary calcium and calcium/ creatinine (Ca:Cr) ratio decreases progressively from 28 weeks to 40 weeks in the study group when compared to normotensive group. Conclusions Preeclamptic women excrete less calcium than normotensive women. This parameter would predict preeclampsia earlier in pregnancy.

Research paper thumbnail of Randomized, Placebo-Controlled Trial of Granisetron for Control of Nausea and Vomiting During Cesarean Delivery Under Spinal Anesthesia

The Journal of Obstetrics and Gynecology of India, 2012

The objective of this study was to evaluate the efficacy and safety of granisetron (5HT3 receptor... more The objective of this study was to evaluate the efficacy and safety of granisetron (5HT3 receptor antagonist) on the incidence of nausea and vomiting in cesarean deliveries under spinal anesthesia. In the randomized, double-blind study, 80 parturients received granisetron 40 μg/kg or placebo (n = 40 each) intravenously, immediately after clamping of the fetal umbilical cord. Nausea, vomiting, and adverse events were then observed for 24 h after administration of spinal anesthesia. A complete response (defined as no postoperative nausea and vomiting) during 0-4 h after administration of spinal anesthesia was achieved in 80 % of patients with granisetron and in 45 % of patients with placebo. The corresponding incidences during (4-24 h) were 82.5 and 55 % (P value &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). No difference in adverse events was observed in any of the groups. Prophylactic use of granisetron is effective for preventing emetic episodes during spinal anesthesia for cesarean delivery.

Research paper thumbnail of Inadvertent Intraarterial Injection Leading to Gangrene: A Rare but Devastating Postoperative Complication

The Journal of Obstetrics and Gynecology of India, 2012

Research paper thumbnail of An approach to evaluate the efficacy of vaginal misoprostol administered for a rapid management of first trimester spontaneous onset incomplete abortion, in comparison to surgical curettage

Archives of Gynecology and Obstetrics, 2013

The purpose of this study is to evaluate the efficacy and safety of the medical method in the man... more The purpose of this study is to evaluate the efficacy and safety of the medical method in the management of first trimester spontaneous onset incomplete abortion, by using misoprostol vaginal tablets, in comparison to surgical evacuation, with an intention of completing the procedure within 24 h. In this prospective, randomised study of 100 women admitted with features suggestive of incomplete abortion, 50 women received misoprostol vaginal tablets, while another 50 underwent suction curettage of products of conceptus. They were followed up after 24 h of last dosage of misoprostol or surgical intervention. Statistical analysis was done with respect to efficacy, safety and procedure-related side effects. In this study, when analysed after 24 h of treatment allocation, the efficacy of misoprostol was 91.3%, and the efficacy of the surgical method was 96%, with the statistical difference being insignificant. Procedure-related blood loss and pain perception between the two groups were statistically insignificant. However, the incidence of fever in the misoprostol group statistically appeared higher. Misoprostol could be a safe and easily accessible alternative to surgical evacuation, in cases of first trimester spontaneous onset incomplete miscarriage, and could be administered by the patient herself at home.

Research paper thumbnail of Is N-acetylcysteine a better Insulin Sensitizer than Metformin in Polycystic Ovarian Syndrome

The primary objective of this study was to examine the effect of NAC on IR by HOMA-IR compared to... more The primary objective of this study was to examine the effect of NAC on IR by HOMA-IR compared to that of MET in PCOS patients. The secondary objectives were to study their effects on other parameters: BMI, waist circumference, fasting blood glucose, fasting insulin, serum testosterone and clinical improvement of hyperandrogenic features.

Research paper thumbnail of Study on the Change in Function of the Preserved Ovaries following Hysterectomy by Abdominal Versus Vaginal Route

Andrology & Gynecology: Current Research, 2017

Objectives: Our primary objective was to study any change in ovarian blood flow in the preserved ... more Objectives: Our primary objective was to study any change in ovarian blood flow in the preserved ovaries following hysterectomy either by abdominal (AH) or vaginal route (VH). Our secondary objectives were to study menopausal symptoms and change in hormonal parameters postoperatively in these two types of hysterectomy. Materials and methods: This prospective observational study was conducted in the departments of obstetrics and gynecology and radiology of Medical College Hospital, Kolkata. 90 patients undergoing hysterectomy with ovarian preservation - 42 by abdominal route(AH group) and 48 by vaginal route (VH group) were studied on 5th postoperative day and 6th postoperative month in terms of ovarian arterial doppler indices and clinical and hormonal changes suggestive of menopause and compared these postoperative parameters with the preoperative parameters. Results: There was statistically significant decrease in Vmax and PI at 5th day and 6th month in ovaries in both the groups. The reduction was greater at 6th postoperative month in VH group as compared to AH group. There was statistically significant increase in menopausal symptoms in VH group and serum FSH and LH level at 6th postoperative month, but no difference in these parameters between groups. Conclusion: Menopausal symptoms are more in VH group as compared to AH group due to reduced Vmax and PI in ovarian arteries in preserved ovaries as early as 6 months postoperatively.

Research paper thumbnail of Leiomyomas in Pregnancy - Clinical Implications

Objective: To assess the effect of pregnancy on leiomyomas, effect of leiomyomas on pregnancy, th... more Objective: To assess the effect of pregnancy on leiomyomas, effect of leiomyomas on pregnancy, the maternal morbidity and mortality and the perinatal outcome in pregnancies associated with leiomyoma. Materials and Methods: This prospective clinical study was conducted at Department of Obstetric and Gynecology, Medical College and Hospital, Kolkata from July 2012 to June 2013 on 40 pregnant women diagnosed with uterine leiomyoma. Results: Out of the total number of 40 cases, 87.5% were more than 25 years of age. Diagnosis was by antenatal ultrasound in 87.5%. Location of leiomyoma was subserous in 60%. They were 10-50cc in size in 50%of cases, single in 77.5%, 3 or more in number in only 15%. In pregnancy, size remained unaltered in 60%, 20% increased in size and 10% showed a decrease in size. At the end of puerperium they disappeared or decreased in size in 87.5% of cases. Complications developed in 35% of cases out of which 12.5% had complete abortions, 5.7% had placental abruption...

Research paper thumbnail of A Prospective Randomized Comparative Study Of Letrozole Vs Leuprolide Acetate In Symptomatic Relief Of Endometriosis

INTRODUCTION: This prospective randomized comparative study was conducted to evaluate and compare... more INTRODUCTION: This prospective randomized comparative study was conducted to evaluate and compare the efficacy and tolerability of aromatase inhibitor Letrozole acetate versus GnRH agonist Leuprolide in managing chronic pelvic pain in women with clinically suspected endometriosis. METHODOLOGY: Non pregnant women from 18-45 years of age with symptomatic (pain) endometriosis weer randomized to open label treatment of depot Leuprolide (3.75/mo) or Letrozole 2.5mg once daily for three months. A visual analog pain scale from 1-10 was used to assess the severity of pain. RESULTS: 50 women were randomized and all of them completed the study. No statistical or clinical significant difference on symptomatic relief was seen. Incidence of adverse events slightly higher in the Leuprolide group. But overall, satisfactory pain relief was achieved in only 36% of the total patients. DISCUSSION: The main complaints of study participants are chronic pelvic pain and dysmenorrhoea. Our results show tha...

Research paper thumbnail of No Scalpel Vasectomy, Tubectomy, Spacing methods, Permanent Sterilization, Contraception

Research paper thumbnail of No Scalpel Vasectomy: An Emerging Option in Family Planning Practice

BACKGROUND: Both spacing and permanent birth control methods are the need of the hour. The popula... more BACKGROUND: Both spacing and permanent birth control methods are the need of the hour. The popularity of male sterilization i.e. vasectomy is low compared to female sterilization (tubectomy). However, being safe, effective, cheap, and having less surgical complications no scalpel vasectomy (NSV) is emerging as good option. AIMS: To study the various demographic and behavioural factors of NSV acceptors. SETTING & DESIGN: This is institution based retrospective study conducted in Department of Obstetrics and Gynaecology, Medical College, Kolkata during the time period of 1st April ‘2009 to 31st March’ 2015. METHODS AND MATERIAL: The patients who accepted NSV for family planning were analysed with respect to their age, residence, occupation, literacy, number of issues and complications. STATISTICAL ANALYSIS: Data were represented as simple proportions or percentages and graphs by using micro soft excel. RESULTS: Out of 13, 048 sterilization operations, there were 3737(28.64%) vasectomi...

Research paper thumbnail of Evaluation of the SERM Ormeloxifene in the Treatment of Uterine Fibroid in the Reproductive Age Group

Journal of Syndromes, 2016

Research paper thumbnail of Is N-acetylcysteine a better Insulin Sensitizer than Metformin in Polycystic Ovarian Syndrome?

Andrology & Gynecology: Current Research, 2015

Research paper thumbnail of A Study On Preferences And Awareness Regarding Prenatal Sex Determination Among Antenatal Women Attending Obstetrics And Gynecology Outdoor Of Medical College, Kolkata During The Time Period Of January To June, 2012

Context: Prenatal sex detection, allowing the selective abortions of female fetus is legally a pe... more Context: Prenatal sex detection, allowing the selective abortions of female fetus is legally a penal offence. It is prevailing in many parts of India resulting in gender imbalance and high masculinity, because Indian value system prefers male child over female. Methods and Material: We interviewed 175 antenatal mothers by systemic random sampling, excluding the unwilling, attending OPD of Medical College and Hospital, Kolkata during January to June, to assess the trends in gender preference and awareness regarding pre-natal sex determination among antenatal women. Result: Our study couples, who are mostly from urban areas, mainly in the 20-30 year age group, mostly from lower economic strata, are well aware of the social menace arising out of prenatal sex determination and female feticide. Although one quarter had strong male preference, none undergone PCPNDT to know the sex of the offspring, 43% were aware that PCPNDT is legally banned and 54% knew that female feticide is a crime according to law. Conclusions: Provision and strict implementation of law as well as improvement of socioeconomic condition, literacy through public education campaigns and lifting up the moral and ethical values are warranted to eradicate this social crime.

Research paper thumbnail of “ Comparison of short term morbidities following episiotomies repaired by rapidly absorbable polyglactin and chromic catgut ”

Objective: To compare the morbidity following episiotomy repair by rapidly absorbed polyglactin a... more Objective: To compare the morbidity following episiotomy repair by rapidly absorbed polyglactin and chromic catgut. Materials & Methods: This prospective longitudinal study was conducted in the Department of Obstetrics and Gynaecology, Medical College, Kolkata. 100 primigravida with episiotomy were divided into 2 groups Group I:CC (n=50) repaired with no 1,0 chromic catgut and Group II:VR (n=50) repaired with rapidly absorbed polyglactin and they were compared with respect to pain, wound complications, perineal edema and dyspareunia –at 2 hours, 2 days, 6 weeks and 3 months. Results: With regard to postoperative complications like pain, perineal edema and wound healing and resuturing, polyglactin was significantly better than chromic catgut. Moreover, persistent perineal pain and dyspareunia were significantly less in VR group at 6 weeks and 3 months. Conclusion: The shortterm morbidity following episiotomy repair with rapidly absorbed polyglactin is less when compared to chromic ca...

Research paper thumbnail of The Estrogen and Progesterone Receptors in Endometrial Carcinoma - An Update

Research paper thumbnail of English

Journal of Evolution of Medical and Dental Sciences, 2015

Research paper thumbnail of A prospective study for the prediction of preeclampsia with urinary calcium level

Journal of Obstetrics and Gynecology of India

To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and ... more To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women. A prospective study was conducted on 60 primi mothers in the age group of 20-30 years, and all were enrolled at 16 weeks of gestation with clinical follow up by 4 weeks and 24 h urinary calcium and creatinine estimation. Ten mothers developed preeclampsia (study groups) and fifty remained normotensive (control groups). By means of Receiver-operator curve, a cut-off level of urinary calcium in 24 h was chosen for predicting preeclampsia. Preeclamptic women excreted significantly less total urine calcium (87.0 ± 3.59 mg/24 h) than normotensive women (303.68 ± 17.699 mg/24 h) (p < 0.0001) at 40 weeks of gestation. Urinary calcium and calcium/creatinine (Ca:Cr) ratio decreases progressively from 28 weeks to 40 weeks in the study group when compared to normotensive group. Preeclamptic wome...

Research paper thumbnail of A Prospective Study for the Prediction of Preeclampsia with Urinary Calcium Level

The Journal of Obstetrics and Gynecology of India, 2012

Objectives To assess the efficacy of calciuria as a diagnostic test for the prediction of preecla... more Objectives To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women. Methods A prospective study was conducted on 60 primi mothers in the age group of 20-30 years, and all were enrolled at 16 weeks of gestation with clinical follow up by 4 weeks and 24 h urinary calcium and creatinine estimation. Ten mothers developed preeclampsia (study groups) and fifty remained normotensive (control groups). By means of Receiver-operator curve, a cut-off level of urinary calcium in 24 h was chosen for predicting preeclampsia. Results Preeclamptic women excreted significantly less total urine calcium (87.0 ± 3.59 mg/24 h) than normotensive women (303.68 ± 17.699 mg/24 h) (p \ 0.0001) at 40 weeks of gestation. Urinary calcium and calcium/ creatinine (Ca:Cr) ratio decreases progressively from 28 weeks to 40 weeks in the study group when compared to normotensive group. Conclusions Preeclamptic women excrete less calcium than normotensive women. This parameter would predict preeclampsia earlier in pregnancy.

Research paper thumbnail of Randomized, Placebo-Controlled Trial of Granisetron for Control of Nausea and Vomiting During Cesarean Delivery Under Spinal Anesthesia

The Journal of Obstetrics and Gynecology of India, 2012

The objective of this study was to evaluate the efficacy and safety of granisetron (5HT3 receptor... more The objective of this study was to evaluate the efficacy and safety of granisetron (5HT3 receptor antagonist) on the incidence of nausea and vomiting in cesarean deliveries under spinal anesthesia. In the randomized, double-blind study, 80 parturients received granisetron 40 μg/kg or placebo (n = 40 each) intravenously, immediately after clamping of the fetal umbilical cord. Nausea, vomiting, and adverse events were then observed for 24 h after administration of spinal anesthesia. A complete response (defined as no postoperative nausea and vomiting) during 0-4 h after administration of spinal anesthesia was achieved in 80 % of patients with granisetron and in 45 % of patients with placebo. The corresponding incidences during (4-24 h) were 82.5 and 55 % (P value &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.05). No difference in adverse events was observed in any of the groups. Prophylactic use of granisetron is effective for preventing emetic episodes during spinal anesthesia for cesarean delivery.

Research paper thumbnail of Inadvertent Intraarterial Injection Leading to Gangrene: A Rare but Devastating Postoperative Complication

The Journal of Obstetrics and Gynecology of India, 2012

Research paper thumbnail of An approach to evaluate the efficacy of vaginal misoprostol administered for a rapid management of first trimester spontaneous onset incomplete abortion, in comparison to surgical curettage

Archives of Gynecology and Obstetrics, 2013

The purpose of this study is to evaluate the efficacy and safety of the medical method in the man... more The purpose of this study is to evaluate the efficacy and safety of the medical method in the management of first trimester spontaneous onset incomplete abortion, by using misoprostol vaginal tablets, in comparison to surgical evacuation, with an intention of completing the procedure within 24 h. In this prospective, randomised study of 100 women admitted with features suggestive of incomplete abortion, 50 women received misoprostol vaginal tablets, while another 50 underwent suction curettage of products of conceptus. They were followed up after 24 h of last dosage of misoprostol or surgical intervention. Statistical analysis was done with respect to efficacy, safety and procedure-related side effects. In this study, when analysed after 24 h of treatment allocation, the efficacy of misoprostol was 91.3%, and the efficacy of the surgical method was 96%, with the statistical difference being insignificant. Procedure-related blood loss and pain perception between the two groups were statistically insignificant. However, the incidence of fever in the misoprostol group statistically appeared higher. Misoprostol could be a safe and easily accessible alternative to surgical evacuation, in cases of first trimester spontaneous onset incomplete miscarriage, and could be administered by the patient herself at home.

Research paper thumbnail of Is N-acetylcysteine a better Insulin Sensitizer than Metformin in Polycystic Ovarian Syndrome

The primary objective of this study was to examine the effect of NAC on IR by HOMA-IR compared to... more The primary objective of this study was to examine the effect of NAC on IR by HOMA-IR compared to that of MET in PCOS patients. The secondary objectives were to study their effects on other parameters: BMI, waist circumference, fasting blood glucose, fasting insulin, serum testosterone and clinical improvement of hyperandrogenic features.