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Papers by deron baker
… medicine and biology, 1998
1. Adv Exp Med Biol. 1998;442:155-62. Taurine inhibition of iron-stimulated catecholamine oxidati... more 1. Adv Exp Med Biol. 1998;442:155-62. Taurine inhibition of iron-stimulated catecholamine oxidation. Dawson R Jr, Tang E, Shih D, Hern H, Hu M, Baker D, Eppler B. Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA. ...
Neurotoxicity …, 2000
Taurine is an abundant amino acid found in mammalian tissues and it has been suggested to have cy... more Taurine is an abundant amino acid found in mammalian tissues and it has been suggested to have cytoprotective functions. The aim of the present study was to determine if taurine had the potential to reduce oxidative stress associated with metal-stimulated catecholamine oxidation. Taurine and structural analogs of taurine were tested for their ability to inhibit metal-stimulated quinone formation from dopamine or L-dopa. Oxidative damage to proteins and lipids were also assessed in vitro and the effects of taurine were determined. Taurine (20mM) was found to decrease significantly ferric iron (50-500~M)-and manganese (10 ~tM)-stimulated L-dopa or dopamine oxidation. Taurine had no effect on zinc-induced dopamine oxidation and slightly potentiated copperand NaIO4-stimulated quinone formation. Ferric iron-stimulated lipid peroxidation was not affected by taurine (1-20mM). Protein carbonyl formation induced by ferric iron (500 ~M) and L-dopa (500 ~M) was significantly reduced by 10mM taurine. The cytotoxicity of L-dopa (250 ~M) and ferric chloride (751~M) to LLC-PK1 cells was attenuated by 10mM taurine or hypotaurine. Homotaurine alone stimulated L-dopa oxidation and potentiated the cytotoxic effects of ferric iron. Homotaurine was found to be cytotoxic when combined with L-dopa or L-dopa/iron. In contrast, hypotaurine inhibited quinone formation and protected LLC-PK1 cells. These studies suggest that taurine may exhibit cytoprotective effects against the oxidation products of catecholamines by acting as a scavenger for free radicals and cytotoxic quinones.
… medicine and biology, 1998
1. Adv Exp Med Biol. 1998;442:155-62. Taurine inhibition of iron-stimulated catecholamine oxidati... more 1. Adv Exp Med Biol. 1998;442:155-62. Taurine inhibition of iron-stimulated catecholamine oxidation. Dawson R Jr, Tang E, Shih D, Hern H, Hu M, Baker D, Eppler B. Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA. ...
Neurotoxicity …, 2000
Taurine is an abundant amino acid found in mammalian tissues and it has been suggested to have cy... more Taurine is an abundant amino acid found in mammalian tissues and it has been suggested to have cytoprotective functions. The aim of the present study was to determine if taurine had the potential to reduce oxidative stress associated with metal-stimulated catecholamine oxidation. Taurine and structural analogs of taurine were tested for their ability to inhibit metal-stimulated quinone formation from dopamine or L-dopa. Oxidative damage to proteins and lipids were also assessed in vitro and the effects of taurine were determined. Taurine (20mM) was found to decrease significantly ferric iron (50-500~M)-and manganese (10 ~tM)-stimulated L-dopa or dopamine oxidation. Taurine had no effect on zinc-induced dopamine oxidation and slightly potentiated copperand NaIO4-stimulated quinone formation. Ferric iron-stimulated lipid peroxidation was not affected by taurine (1-20mM). Protein carbonyl formation induced by ferric iron (500 ~M) and L-dopa (500 ~M) was significantly reduced by 10mM taurine. The cytotoxicity of L-dopa (250 ~M) and ferric chloride (751~M) to LLC-PK1 cells was attenuated by 10mM taurine or hypotaurine. Homotaurine alone stimulated L-dopa oxidation and potentiated the cytotoxic effects of ferric iron. Homotaurine was found to be cytotoxic when combined with L-dopa or L-dopa/iron. In contrast, hypotaurine inhibited quinone formation and protected LLC-PK1 cells. These studies suggest that taurine may exhibit cytoprotective effects against the oxidation products of catecholamines by acting as a scavenger for free radicals and cytotoxic quinones.