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In the present scenario, there is an ever increasing demand for more patient compliant dosage for... more In the present scenario, there is an ever increasing demand for more patient compliant dosage forms. One of an important innovation in this direction is the development of mouth dissolving tablets that dissolve or disintegrate instantly upon contact with recipient's tongue or buccal mucosa. They have proved to be ideal for geriatric and pediatric population, people suffering from dysphagia, clinical conditions where water intake is not available and for drugs undergoing high first pass metabolism. Mouth dissolving tablets (MDT) are the one which suit the concept of better patient compliance, rapid absorption, rapid onset of action, more efficacy, enough bioavailability to show required pharmacological action and less toxicity. It is found that about 26% of patients experience difficulty to swallow the solid dosage forms like tablets and capsules etc. MDTs show rapid disintegration or dissolution in no time through various mechanisms when placed over the tongue without the need of water and overcome the disadvantages of conventional solid dosage forms. Mouth dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems which aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The aim of this review is to describe the past and the present of mouth dissolving tablet dosage form.
Scientia Pharmaceutica, 2014
The present research was aimed at the enhancement of the dissolution rate of atorvastatin calcium... more The present research was aimed at the enhancement of the dissolution rate of atorvastatin calcium by the solid dispersion technique using modified locust bean gum. Solid dispersions (SD) using modified locust bean gum were prepared by the modified solvent evaporation method. Other mixtures were also prepared by physical mixing, co-grinding, and the kneading method. The locust bean gum was subjected to heat for modification. The prepared solid dispersions and other mixtures were evaluated for equilibrium solubility studies, content uniformity, FTIR, DSC, XRD, in vitro drug release, and in vivo pharmacodynamic studies. The equilibrium solubility was enhanced in the solid dispersions (in a drug:polymer ratio of 1:6) and other mixtures such as the cogrinding mixture (CGM) and kneading mixture (KM). Maximum dissolution rate was observed in the solid dispersion batch SD3 (i.e. 50% within 15 min) with maximum drug release after 2 h (80%) out of all solid dispersions. The cogrinding mixture also exhibited a significant enhancement in the dissolution rate among the other mixtures. FTIR studies revealed the absence of drug-polymer interaction in the solid dispersions. Minor shifts in the endothermic peaks of the DSC thermograms of SD3 and CGM indicated slight changes in drug crystallinity. XRD studies further confirmed the results of DSC and FTIR. Topological changes were observed in SEM images of SD3 and CGM. In vivo pharmacodynamic studies indicated an improved efficacy of the optimized batch SD3 as compared to the pure drug at a dose of 3 mg/kg/day. Modified locust bean gum can be a promising carrier for solubility enhancement of poorly water-D. Panghal et al.:
In the present scenario, there is an ever increasing demand for more patient compliant dosage for... more In the present scenario, there is an ever increasing demand for more patient compliant dosage forms. One of an important innovation in this direction is the development of mouth dissolving tablets that dissolve or disintegrate instantly upon contact with recipient's tongue or buccal mucosa. They have proved to be ideal for geriatric and pediatric population, people suffering from dysphagia, clinical conditions where water intake is not available and for drugs undergoing high first pass metabolism. Mouth dissolving tablets (MDT) are the one which suit the concept of better patient compliance, rapid absorption, rapid onset of action, more efficacy, enough bioavailability to show required pharmacological action and less toxicity. It is found that about 26% of patients experience difficulty to swallow the solid dosage forms like tablets and capsules etc. MDTs show rapid disintegration or dissolution in no time through various mechanisms when placed over the tongue without the need of water and overcome the disadvantages of conventional solid dosage forms. Mouth dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems which aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. The aim of this review is to describe the past and the present of mouth dissolving tablet dosage form.
Scientia Pharmaceutica, 2014
The present research was aimed at the enhancement of the dissolution rate of atorvastatin calcium... more The present research was aimed at the enhancement of the dissolution rate of atorvastatin calcium by the solid dispersion technique using modified locust bean gum. Solid dispersions (SD) using modified locust bean gum were prepared by the modified solvent evaporation method. Other mixtures were also prepared by physical mixing, co-grinding, and the kneading method. The locust bean gum was subjected to heat for modification. The prepared solid dispersions and other mixtures were evaluated for equilibrium solubility studies, content uniformity, FTIR, DSC, XRD, in vitro drug release, and in vivo pharmacodynamic studies. The equilibrium solubility was enhanced in the solid dispersions (in a drug:polymer ratio of 1:6) and other mixtures such as the cogrinding mixture (CGM) and kneading mixture (KM). Maximum dissolution rate was observed in the solid dispersion batch SD3 (i.e. 50% within 15 min) with maximum drug release after 2 h (80%) out of all solid dispersions. The cogrinding mixture also exhibited a significant enhancement in the dissolution rate among the other mixtures. FTIR studies revealed the absence of drug-polymer interaction in the solid dispersions. Minor shifts in the endothermic peaks of the DSC thermograms of SD3 and CGM indicated slight changes in drug crystallinity. XRD studies further confirmed the results of DSC and FTIR. Topological changes were observed in SEM images of SD3 and CGM. In vivo pharmacodynamic studies indicated an improved efficacy of the optimized batch SD3 as compared to the pure drug at a dose of 3 mg/kg/day. Modified locust bean gum can be a promising carrier for solubility enhancement of poorly water-D. Panghal et al.: