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Marine and Freshwater Research, 2015

During the austral spring of 2009 several significant dust storms occurred in south-east Australi... more During the austral spring of 2009 several significant dust storms occurred in south-east Australia including the so-called ‘Red Dawn’ event in late September. Estimates of 2.5 Mt total suspended particulate sediment lost off the Australian coast in the 3000km long dust plume make it the largest off-continent loss of soil ever reported. Much of this material was transported over the coastline of New South Wales and into the adjacent Tasman Sea. Long-term model simulations of dust deposition over the south-west Tasman Sea suggest the amount deposited during the spring of 2009 was approximately three times the long-term monthly average. Previous satellite-based analyses of the biological response of Tasman Sea waters to dust-derived nutrients are equivocal or have observed no response. Satellite-derived surface chlorophyll concentrations in the southern Tasman during the spring of 2009 are well above the climatological mean, with positive anomalies as high as 0.5mgm–3. Dust transport s...

Cell Calcium, Jan 31, 2008

Proceedings of the National Academy of Sciences of the United States of America, Nov 1, 1987

European Journal of Biochemistry, 1985

A newly developed human hepatoma cell line, designated Hep G-2, expresses high-affinity insulin r... more A newly developed human hepatoma cell line, designated Hep G-2, expresses high-affinity insulin receptors meeting all the expected criteria for classic insulin receptors. 125I-insulin binding is time-dependent and temperature-dependent and unlabeled insulin competes for the labeled hormone with a half-maximal displacement of 1-3 ng/ml. This indicates a Kd of about 10(-10) M. Since Scatchard analysis of the binding data results in a curvilinear plot and unlabeled insulin accelerates the dissociation of bound hormone, these receptors exhibit the negative cooperative interactions characteristic of insulin receptors in many other cell and tissue types. Proinsulin and des(Ala, Asp)-insulin compete for 125I-insulin binding with 4% and 2%, respectively, of the potency of insulin. Anti-(insulin receptor) antibody competes fully for insulin binding. The two insulin-like growth factors, multiplication-stimulating activity and IGF-I are 2% as potent as insulin against the Hep G-2 insulin receptor. Furthermore, Hep G-2 cells respond to insulin in several bioassays. Glucose uptake, glycogen synthase, uridine incorporation into RNA and acetate incorporation into lipid are all stimulated to varying degrees by physiological concentrations of insulin. In addition, these cells 'down-regulate' their insulin receptor, internalize 125I-insulin and degrade insulin in a manner similar to freshly isolated rodent hepatocytes. This is the first available human liver cell line in permanent culture in which both insulin receptors and biological responses have been carefully examined.