divya reddy - Academia.edu (original) (raw)

Papers by divya reddy

Journal of Clinical Medicine, 2021

Regular prophylaxis with exogenous factor VIII (FVIII) is recommended for individuals with severe... more Regular prophylaxis with exogenous factor VIII (FVIII) is recommended for individuals with severe haemophilia A (HA), but standardised data are scarce. Here, we report real-world data from a global cohort. Participants were men ≥18 years old with severe HA (FVIII ≤ 1 IU/dL) receiving regular prophylaxis with FVIII. Participants provided 6 months of retrospective data and were prospectively followed for up to 12 months. Annualised bleeding rate (ABR) and FVIII utilisation and infusion rates were calculated. Differences between geographic regions were explored. Of 294 enrolled participants, 225 (76.5%) completed ≥6 months of prospective follow-up. Pre-baseline and on-study, the median (range) ABR values for treated bleeds were 2.00 (0–86.0) and 1.85 (0–37.8), respectively; the median (range) annualised FVIII utilisation rates were 3629.0 (1008.5–13541.7) and 3708.0 (1311.0–14633.4) IU/kg/year, respectively; and the median (range) annualised FVIII infusion rates were 120.0 (52.0–364.0)...

PLOS ONE, 2021

Background Undernutrition impairs immunity to Mycobacterium tuberculosis and is a risk factor for... more Background Undernutrition impairs immunity to Mycobacterium tuberculosis and is a risk factor for tuberculosis disease (TB). We aim to investigate if severe undernutrition affects the tuberculin skin test (TST) response among household contacts (HHCs) of pulmonary TB cases. Methods We analyzed data from HHCs (> five years) of pulmonary TB cases in Southern India. Undernutrition was defined as per World Health Organization based on body mass index (BMI) for adults (undernutrition 16–18.4 and severe undernutrition <16 kg/m2) and BMI relative to the mean for children (undernutrition 2SD-3SD and severe undernutrition < 3SDs below mean). Univariate and multivariate models of TST positivity (> five mm) were calculated using logistic regression with generalized estimating equations. Results Among 1189 HHCs, 342 were children (age 5–17 years) and 847 were adults. Prevalence of TST positivity in well-nourished, undernourished and severely undernourished children was 135/251 (53.8...

CVR Journal of Science & Technology, 2015

Embedded system plays an important role in various industry applications. An embedded system is c... more Embedded system plays an important role in various industry applications. An embedded system is consisting of software and hardware. The hardware platform of conventional embedded system is typically based on IC chips that have fixed resources. Besides, with the development of FPGA, an emerging approach for designing embedded system is implementing soft IP cores on FPGAs. Soft IP cores are synthesizable hardware blocks described in HDL language. Their source code can be either open or close to public. For example, Open RISC 1200, is an open source 32bit RISC microprocessor. In addition, the increasing complexity of embedded system forces software developers to consider operating system support to reduce their workload. Thus, in this paper, a prototype of open source IP based embedded system with Linux is implemented on Atlys (Xilinx Spartan-6) FPGA board and the goal is to evaluate if the system is appropriate for industrial applications. The hardware platform is ORPSOC, which is a reference SoC design based on Open RISC 1200 processor. For software, Linux operating system is installed. Furthermore, an application executes on Linux is developed that reads the output of an I2C compass sensor-LSM303DLM. With the success of the application and the investigation of license issues, the conclusion is drawn that open source IP based embedded system with Linux is usable for industry. Although comparing to conventional embedded system, the open source IP based embedded system with Linux has following cons, such as high product cost, basic-supported development environment and more difficult software development if Linux driver doesn't support the hardware. However, its pros are high flexibility and scalability, high software portability, low software development difficulty and high reusability that make it more suitable for industry usage.

A storage device and a method allowing processing of Entabbildungsbefehlen. In one aspect, the me... more A storage device and a method allowing processing of Entabbildungsbefehlen. In one aspect, the method (1) includes determining whether a magnitude of a Entabbildungsbefehls size threshold met (for example, greater than or equal to this is), (2) when the size of Entabbildungsbefehls meets the size threshold, performing one or more operations of a first Entabbildungsprozesses, wherein the first Entabbildungsprozess storing a mapping table in non-volatile memory of a storage device fails (excludes) and (3) if the size of Entabbildungsbefehls does not meet the size threshold, performing one or more operations of a second Entabbildungsprozesses, wherein the second Entabbildungsprozess storing the mapping table in non-volatile memory of the storage device fails (excludes) and flushing a write cache in non-volatile memory of the storage device fails (excludes).

The Clinical journal of pain, Jan 24, 2017

Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and ps... more Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High Omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids in OA. Based on recommended and typical ranges of the n-6:n-3 ratio, we hypothesized that in adults with knee pain, those with a high n-6:n-3 ratio would have greater pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to those with a low n-6:n-3 ratio. A cross-sectional investigation of clinical and experimental pain and physical and ps...

Journal of the American Geriatrics Society, Jan 3, 2017

To describe latent tuberculosis infection (LTBI) testing practices in long-term care facilities (... more To describe latent tuberculosis infection (LTBI) testing practices in long-term care facilities (LTCFs). Retrospective cohort study. Three Boston-area LTCFs. Residents admitted between January 1 and December 31, 2011. Resident demographic characteristics, comorbidities, LTCF stay, and LTBI testing and treatment. Data for 291 LTCF residents admitted in 2011 were reviewed. Of the 257 without a history of LTBI and with documentation of testing, 162 (63%) were tested; 114 of 186 (61%) with a stay less than 90 days and 48 of 71 (68%) with a stay of 90 days or longer were tested. Of 196 residents with data on prior LTBI testing, 39 (19.9%) had LTBI; 12 of these (30.8%) were diagnosed at the LTCF. Hispanic participants were more likely than black participants to undergo LTBI testing (adjusted odds ratio (aOR) = 2.4, P = .003). Having a length of stay of less than 90 days (aOR = 0.7, P < .001) and history of illicit drug use (aOR = 0.7, P < .001) were associated with lower odds of LTB...

The Journal of Pain, 2016

Neuroplastic changes in brain structure and function are not only a consequence of chronic pain b... more Neuroplastic changes in brain structure and function are not only a consequence of chronic pain but are involved in the maintenance of pain symptoms. Thus, promoting adaptive, treatment responsive neuroplasticity represents a promising clinical target. Emerging evidence about the human brain's response to an array of behavioral and environmental interventions may assist in identifying targets to facilitate increased neurobiological receptivity, promoting healthy neuroplastic changes. Specifically, strategies to maximize neuroplastic responsiveness to chronic pain treatment could enhance treatment gains by optimizing learning and positive central nervous system (CNS) adaptation. Periods of heightened plasticity have been traditionally identified with the early years of development. More recent research however has identified a wide spectrum of methods that can be used to "re-open" and enhance plasticity and learning in adults. In addition to transcranial direct current stimulation and transcranial magnetic stimulation, behavioral and pharmacological interventions have been investigated. Intermittent fasting and glucose administration are two propitious strategies, which are non-invasive, inexpensive to administer, implementable in numerous settings, and may be applicable across differing chronic pain treatments. Key findings and neurophysiological mechanisms are summarized, providing evidence for the potential clinical contributions of these two strategies toward ameliorating chronic pain.

<p>(A) Gelatin zymography showing minimal MMP2 activity in serum-free media at 24 hr in all... more <p>(A) Gelatin zymography showing minimal MMP2 activity in serum-free media at 24 hr in all the clones. 200 nM PDBu treatment induced MMP2 and MMP9 activity significantly. PFN-WT expressed highest MMP2 activity whereas PFN-S137A the least. MMP9 activity was most expressed in PFN-R74E and PFN-WT followed by PFN-H133S. PFN-S137A showed the least MMP9 activity comparable to EV. (B) Nuclear translocation of profilin 1 and its mutants increases with time upon exposure to 200 nM PDBu when compared to serum starved cells except for PFN-S137A that remains constant throughout. PFN-S137A was comparable to EV.</p

Indian Dermatology Online Journal, 2015

Porokeratosis is a disorder of epidermal proliferation in which many different clinical variants ... more Porokeratosis is a disorder of epidermal proliferation in which many different clinical variants can be distinguished. Herein we report a rare case of porokeratosis involving almost all parts of the body with simultaneous occurrence of various forms of the disease in the same individual (classical porokeratosis of Mibelli, disseminated superficial actinic porokeratosis, hypertrophic porokeratosis, and genital porokeratosis).

PLoS ONE, 2014

Background: Profilins are actin-modulating proteins regulating many intracellular functions based... more Background: Profilins are actin-modulating proteins regulating many intracellular functions based on their multiple and diverse ligand interactions. They have been implicated to play a role in many pathological conditions such as allergies, cardiovascular diseases, muscular atrophy, diabetes, dementia and cancer. Post-translational modifications of profilin 1 can alter its properties and subsequently its function in a cell. In the present study, we identify the importance of phosphorylation of profilin 1 at serine 137 (S137) residue in breast cancer progression. Methods/Principal Findings: We found elevated profilin 1 (PFN) in human breast cancer tissues when compared to adjacent normal tissues. Overexpression of wild-type profilin 1 (PFN-WT) in breast cancer MCF7 cells made them more migratory, invasive and adherent independent in comparison to empty vector transfected cells. Mutation in serine phosphorylation site (S137) of profilin 1 (PFN-S137A) significantly abrogated these properties. Mutation affecting actinbinding ability (PFN-R74E) of profilin 1 enhanced its tumorigenic function whereas mutation affecting its poly-L-proline binding function (PFN-H133S) alleviated these mechanisms in breast cancer cells. PFN-WT was found to activate matrix metalloproteinases by zymography, MMP2 and MMP9 in presence of PDBu (phorbol 12, 13 dibutyrate, PI3K agonist) to enhance migration and invasion in MCF7 cells while PFN-S137A did not. Phosphorylation increased migration and invasion in other mutants of profilin 1. Nuclear profilin levels also increased in the presence of PDBu. Conclusions: Previous studies show that profilin could be executing a dual role in cancer by either suppressing or promoting tumorigenesis in a context dependent manner. In this study we demonstrate for the first time that phosphorylation of profilin 1 at serine 137 enhances oncogenic properties in breast cancer cells. Inhibitors targeting profilin 1 phosphorylation directly or indirectly through inhibition of kinases that phosphorylate profilin could be valuable therapeutic agents that can alter its activity and thereby control the progression of cancer.

International Journal of Clinical Pediatric Dentistry, 2010

Background: The main factor related to gingival/periodontal problems in disabled individuals is t... more Background: The main factor related to gingival/periodontal problems in disabled individuals is the inadequacy of the plaque removal from the teeth. Motor coordination problems and muscular limitation in neuromuscularly disabled individuals along with the difficulty in understanding the importance of oral hygiene in mentally disabled individuals have resulted in the progression of inflammatory diseases. Case report: This report describes a case of cerebral palsy child who developed gingival hyperplasia due to poor oral hygiene practices which remarkably improved by proper motivation and adaptation of oral hygiene measures. Conclusion: It is important that the caretakers especially mother is informed about the importance of maintaining proper oral hygiene and the harmful effects of not doing so. It forms our duty to guide them towards maintaining good oral hygiene and thereby help in improving overall health of these children.

International Journal of Clinical Pediatric Dentistry, 2008

The objective of this study was to determine the prevalence of malocclusion among school children... more The objective of this study was to determine the prevalence of malocclusion among school children of Bangalore city, India during their mixed dentition period. The sample consisted of 745 children (388 males and 357 females) in the age group of 8-12 years randomly selected from twelve different schools in Bangalore city. The subjects were randomly selected, and none had received previous orthodontic treatment. Occlusal anteroposterior relationships were assessed based on the Angle classification. Also various malocclusion features associated with class I malocclusion according to Dewey's modification of Angle's classification were assessed. The results showed that about 71% of the subjects had malocclusion. Class I malocclusion constituted the major proportion of malocclusion which was found in 62% of the studied population. No significant difference was found between boys and girls neither in the overall prevalence of malocclusion nor in various forms of malocclusion. Crowded incisors was found to be most common finding in subjects with class I malocclusion. A number of studies have been conducted to determine the prevalence of malocclusion among Indian children and it has been reported that the results range from a value as low as 19.6% (Miglani DC, Chennai 1961) to as high as 90% (Sidhu SS, Delhi). This varied range emphasizes the need to standardize criteria for assessing malocclusion.

ipcsit.com

Abstract. This paper proposes a load control routing scheme for intra cluster routing in wireless... more Abstract. This paper proposes a load control routing scheme for intra cluster routing in wireless mesh networks. Unlike other existing schemes proposed for load balancing for wireless mesh networks, this routing scheme implements in a different manner for both ...

Physica B: Condensed Matter, 2011

... D. Amaranatha Reddy, A. Divya, G. Murali , RP Vijayalakshmi* and BK Reddy. Department of Phys... more ... D. Amaranatha Reddy, A. Divya, G. Murali , RP Vijayalakshmi* and BK Reddy. Department of Physics, Sri Venkateswara University, Tirupati 517502, India. ... [22] Richa Bhargava, prashant K. Sharma, Sanjeev Kumar, Avinash C. Pandey, Naresh Kumar, J. Solid State Chem. ...