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Papers by dr abhijit swami

PubMed, Apr 1, 2022

Since December 2019, an emerging coronavirus called Severe Acute Respiratory Syndrome Coronavirus... more Since December 2019, an emerging coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) has been spreading worldwide. Older people and those with comorbidities are more likely to develop severe illness. Vaccines against coronavirus have been developed recently. In India, the two vaccine currently authorized to use are namely ChAdOx1 nCov, Covishield and Covaxin; both of which require 2 shots few weeks apart for adequate protection. Although COVID antibody test has not been done following vaccination in my subjects, it was observed that those who were vaccinated with one or two doses had less clinical severity compared to non vaccinated patients. In this study, we did a comparative analysis of the laboratory markers of severity in elderly COVID patients who were fully vaccinated, partially vaccinated and non vaccinatednon-vaccinated. Material: This study is conducted with COVID-19 patients in age group more than 65 years for duration of 6 months. Participants were divided in three group Fully Vaccinated group who received 2 doses, Partially Vaccinated group with only 1 dose and non-vaccinated group. Assessment of inflammatory markers like CRP, LDH and Ferritin, Procalcitonin, RDW and NLR were done in the three groups. Observation: A total of 52 fully vaccinated, 120 partially vaccinated and 458 non vaccinated patients were included in this study. The mean LDH, ferritin, procalcitonin, RDW, NLR in the fully vaccinated group were 381.61±167.53 U/l, 286.77±226.73 ng/ml, 0.40±0.32 ng/ml, 14.23±1.80 % and 8.85±10.36 respectively; that in the partially vaccinated group were 413.89±209.75 U/l, 387.44±317.55 ng/ml, 1.08±2.98 ng/ml, 14.45±1.42 % and 10.20±12.30 respectively; and in the non vaccinated group were 583.97±638.90 U/l, 479.03±332.85 ng/ml, 5.30±15.91 ng/ ml, 14.93±1.96 % and 11.97±12.57 respectively. Significant differences were found in terms of LDH, Ferritin, RDW and CRP among the groups with p values of <0.01, <0.0001, <0.01 and <0.05 respectively. However, no significant difference (p>0.05) was observed in terms of procalcitonin and NLR among the groups although the average values were found to increase from fully vaccinated to partially vaccinated to non-vaccinated groups. Conclusion: Vaccination was associated with less severity when analysed in terms of laborotary parameters in COVID-19 elderly patients.

Journal of HIV & Retro Virus, 2016

International Journal of Medical Science in Clinical Research and Review, Mar 1, 2021

Journal of Gastroenterology, Pancreatology & Liver Disorders, 2018

Case Reports in Infectious Diseases, 2012

Toxic epidermal necrolysis (TEN) is a potentially life-threatening disorder characterized by wide... more Toxic epidermal necrolysis (TEN) is a potentially life-threatening disorder characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes. Without proper management,TEN can cause sepsis leading to death of the patient. Though TEN is commonly drug induced, Isoniazid (INH) has been uncommonly associated with TEN. As INH is one of the first line drugs in treatment of tuberculosis, TEN induced INH needs modification of antitubercular therapy (ATT) with withdrawal of INH from the treatment regime along with other supportive treatments. Patients with HIV infection and disseminated tuberculosis need to be urgently initiated on an effective ATT on diagnosis of tuberculosis. However, if the patient develops potential life-threatening toxicity to first line antitubercular drugs like INH, an alternative effective ATT combination needs to be started as soon as the condition of the patient stabilizes as most of these patients present in advanced sta...

Indian Journal of Medical Specialities, 2011

Case Reports in Neurological Medicine, 2011

Pseudohypoparathyroidism is an infrequently encountered disease. It is one of the causes of Fahr ... more Pseudohypoparathyroidism is an infrequently encountered disease. It is one of the causes of Fahr syndrome which also is a rare clinical entity caused by multiple diseases. A 4-year-old man hospitalized for sudden onset left hemiparesis and hypertension was diagnosed to have right thalamic and midbrain hemorrhage on plain CT scan of the head which also revealed co-existent extensive intracranial calcifications involving the basal ganglia and cerebellum bilaterally. General physical examination revealed features of Albright hereditary osteodystrophy, goitre, hypertension, left hemiparesis, and signs of cerebellar dysfunction. Laboratory findings suggested hypocalcemia, hyperphosphatemia along with high TSH, low FT4, low FT3, and high anti-TPO antibody. Though bilateral intracranial calcifications are usually encountered as an incidental radiological finding in the CT scan of brain, in this case, the patient admitted for thalamic and midbrain hemorrhage was on investigation for associa...

The Lancet Regional Health - Southeast Asia

Indian Journal of Medical Specialities, May 3, 2011

Journal of gastroenterology, pancreatology & liver disorders, Feb 20, 2018

Case reports in neurological medicine, 2011

Case reports in infectious diseases, 2012

Over the years, adolescents have been diagnosed to be diabetic, the type of which do not fit into... more Over the years, adolescents have been diagnosed to be diabetic, the type of which do not fit into the classical types of diabetes - type 1 and type 2. These cases have been reported round the globe. They share features of both types of diabetes like obesity, acanathosis nigricans along with insulin resistance and can even have complications like Diabetic ketoacidosis. The present case study is about a newly diagnosed obese adolescent diabetic patient with acanthosis nigricans presenting with diabetic ketoacidosis who responded to standard treatment of Diabetic ketoacidosis. Subsequently, he was found to have low levels of C-peptide without insulin autoantibodies. Such cases have been variously referred as Double diabetes or 1.5 diabetes in literature and may constitute a subvariant of Diabetes.

The Journal of the Association of Physicians of India, 2016

Several chronic infections like HIV have reported an increased prevalence of metabolic syndrome. ... more Several chronic infections like HIV have reported an increased prevalence of metabolic syndrome. With the advent of highly active antiretroviral therapy (HAART), the prognosis of HIV patients have improved dramatically. However, multiple unforeseen complications have been seen in HIV patients on long-term HAART including metabolic syndrome. As multiple drugs are used for HAART with different backbones, the incidence of metabolic syndrome has been shown to vary with different regimes of antiretroviral therapy (ART), though the role of NNRTI-based ART has not been clearly implicated in the genesis of metabolic syndrome in treated HIV patients. The present study aims to study the effects of NNRTI on different components of metabolic syndrome in HIV patients. In this cross-sectional study, 70 HIV patients treated with ART (aged 20-50 years) and 64 ART-naive patients were included as control group. Metabolic syndrome prevalence was examined using the US Metabolic syndrome prevalence was ...

Archives of Rheumatology, 2017

HIV/AIDS Research and Treatment - Open Journal, 2015

Cerebral toxoplasmosis is one of the commonest opportunistic infection of the nervous system in H... more Cerebral toxoplasmosis is one of the commonest opportunistic infection of the nervous system in HIV patients. We present a case of gradual onset haemiparesis in an ART naive HIV patient with high CD4 count who was subsequently diagnosed to be a case of cerebral toxoplasmosis based on radiological and serological investigations. The patient responded to a regime of Cotrimoxazole and Pyrimethamine. His CD4 count at diagnosis was 299/µl. HAART was started after completion of treatment of cerebral toxoplasmosis. Prophylaxis against toxoplasmosis is recommended with cotrimoxazole if the CD4 count is below 200/µl. However, in this case as the patient had developed toxoplasmosis at a CD4 count value above the cut-off value for prophylaxis for cerebral toxoplasmosis, it may be worth considering to starting prophylaxis at a higher CD4 count than 200/µl and continuing for a longer time than the current guidelines.