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Papers by dr ishrat khan

Emerging Science Journal

The analysis and classification of dates is based on their external features: size, appearance, s... more The analysis and classification of dates is based on their external features: size, appearance, shape, and colour. The process is currently performed manually after harvesting as part of the post-harvesting process. Grading manually is tedious because it usually results in time delays, product quality risks, and it is associated with time and cost delays as well. Although the use of computers and information technology has seen tremendous growth in many small and large sectors, it has been in its infancy in the cultivation of fruit and dates. Using image processing algorithms, we can enhance human vision capabilities through analysis and make images easier to comprehend. A major objective of computer vision-based algorithms for classifying and sorting of dates is to make the procedure fully automated by minimizing the manual component involved in the process. This paper presents an image processing-based algorithm that uses machine learning techniques to extract the characteristics ...

Computer Systems Science and Engineering

In early December 2019, the city of Wuhan, China, reported an outbreak of coronavirus disease (CO... more In early December 2019, the city of Wuhan, China, reported an outbreak of coronavirus disease (COVID-19), caused by a novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). On January 30, 2020, the World Health Organization (WHO) declared the outbreak a global pandemic crisis. In the face of the COVID-19 pandemic, the most important step has been the effective diagnosis and monitoring of infected patients. Identifying COVID-19 using Machine Learning (ML) technologies can help the health care unit through assistive diagnostic suggestions, which can reduce the health unit's burden to a certain extent. This paper investigates the possibilities of ML techniques in identifying/ detecting COVID-19 patients including both conventional and exploring from chest X-ray images the effect of viral infection. This approach includes preprocessing, feature extraction, and classification. However, the features are extracted using the Histogram of Oriented (HOG) and Local Binary Pattern (LBP) feature descriptors. Furthermore, for the extracted features classification, six ML models of Support Vector Machine (SVM) and K-Nearest Neighbor (KNN) is used. Experimental results show that the diagnostic accuracy of random forest classifier (RFC) on extracted HOG plusLBP features is as high as 94% followed by SVM at 93%. The sensitivity of the K-nearest neighbour model has reached an accuracy of 88%. Overall, the predicted approach has shown higher classification accuracy and effective diagnostic performance. It is a highly useful tool for clinical practitioners and radiologists to help them in diagnosing and tracking the cases of COVID-19.

RSC Advances, 2020

Chiral hairy nanoparticles (HNP), prepared by complexation of achiral HNPs with R- or S-mandelic ... more Chiral hairy nanoparticles (HNP), prepared by complexation of achiral HNPs with R- or S-mandelic acid, self-assemble into toroidal or donut like structures.

International Journal of Scientific & Technology Research, 2013

Grape (Vitisvinifera L.) is one of the important fruit crop. Zinc is a micronutrient which plays ... more Grape (Vitisvinifera L.) is one of the important fruit crop. Zinc is a micronutrient which plays important role in various metabolic processes in plants. Zinc works as auxin precursor in plants. The effect of zinc application to mothervine of Dog Ridge rootstock was studied in the present experiment. Zinc was applied in concentration of 0, 5.0, 10.0, 15.0 and 20.0 g/ mothervine and its effects were studied on rooting success and establishment. It was found that application of zinc resulted in early bud sprout as well as increase in rooting success in cuttings. It also resulted in better plant growth as well as increased leaf area.

Pakistan journal of pharmaceutical sciences, 2019

Camellia sinensis is being used for decades for its therapeutic efficacies against physiological ... more Camellia sinensis is being used for decades for its therapeutic efficacies against physiological problems and microbial infections. This study was undertaken to investigate the antibacterial and antifungal potential of aqueous extract of Camellia sinensis. Antibacterial activity was determined by disc and well diffusion assay. MIC and MBC were calculated by broth dilution method. Miles and Misra technique was used to find out colony forming unit per/ml. All the test organisms revealed a diverse range of vulnerability against aqueous extract. Among Gram positive, MRSA showed to be the most sensitive with least MIC and MBC while among Gram-negative Pseudomonas aeruginosa exhibited the highest sensitivity. In Miles and Misra, a progressive decline in log of CFU/ml was observed. In time-kill assay, a decline was noted in the viable count of S.aureus after exposure to 18% aqueous extract of Camellia sinensis. In the present study aqueous extract of Camellia sinensis found to be effective...

Marine Drugs, 2020

Fungi are a prospective resource of bioactive compounds, but conventional methods of drug discove... more Fungi are a prospective resource of bioactive compounds, but conventional methods of drug discovery are not effective enough to fully explore their metabolic potential. This study aimed to develop an easily attainable method to elicit the metabolic potential of fungi using Aspergillus nidulans laeA as a transcription regulation tool. In this study, functional analysis of Aspergillus nidulans laeA (AnLaeA) and Aspergillus sp. Z5 laeA (Az5LaeA) was done in the fungus Aspergillus sp. Z5. Heterologous AnLaeA-and native Az5LaeA-overexpression exhibited similar phenotypic effects and caused an increase in production of a bioactive compound diorcinol in Aspergillus sp. Z5, which proved the conserved function of this global regulator. In particular, heteroexpression of AnLaeA showed a significant impact on the expression of velvet complex genes, diorcinol synthesis-related genes, and different transcription factors (TFs). Moreover, heteroexpression of AnLaeA influenced the whole genome gene...

SERIES OF SOCIAL AND HUMAN SCIENCES, 2020

Б а с р е д а к т о р фил. ғ. докторы, проф., ҚР ҰҒА корр. мүшесі Қажыбек Е.З. Р е д а к ц и я а ... more Б а с р е д а к т о р фил. ғ. докторы, проф., ҚР ҰҒА корр. мүшесі Қажыбек Е.З. Р е д а к ц и я а л қ а с ы:

Functional Foods in Health and Disease, 2016

Background: Rising tide of chronic nutrition related non-communicable diseases yoked with extant ... more Background: Rising tide of chronic nutrition related non-communicable diseases yoked with extant under nutrition problems makes it imperative to carry out scientific research for finding functional foods. Although the emergence of these diseases are believed to be related to a constellation of dietary, socio-economic and lifestyle related risk factors, central to the pathogenesis of these diseases (or disease states) are free radicals, oxidative stress, and inflammatory processes typically accompanied by pain. Therefore, functional whole foods with physiologically active antioxidants, anti-inflammatory, and analgesic compounds seem to be the most promising option to deal with the pathogenesis of existing and emerging chronic diseases burden of Bangladesh.Methods: Edible portions of 70 commonly consumed Bangladeshi foods – including one cereal, five legumes, fourteen vegetables, four tea varieties, five oil seeds, twenty spices, and twenty one fruits – were evaluated for total phenol...

Think India, 2019

Tourism is a major economic and social activity of the present time. It is the temporary movement... more Tourism is a major economic and social activity of the present time. It is the temporary movement of people from their normal place of residence or work, mainly for pleasure. Due to the economic activities involved in the process of tourism, now it is emerged as an industry which is rapidly growing around the World. Tourism is the major source of foreign exchange earnings for many regions of the world. Tourism need to be addressed at the earliest as tourism has positive as well as negative impact on the cultural diversity, social standards, society and environment. The present study aimed to investigate the causal relationship between employment and income generation and tourist arrivals in district Srinagar of Jammu and Kashmir state. The results revealed that tourist arrivals accounts variation in the level of income and employment generation. Thus, tourism development has the potential to contribute to the economy of Srinagar district of Jammu and Kashmir State. Tourism is a majo...

Current Psychiatry Research and Reviews, 2019

Background:There has been an increasing interest in the past several decades to study the relatio... more Background:There has been an increasing interest in the past several decades to study the relationship between spirituality and religion with physical and mental health as well as the various quality of life measures. This trend has led to the creation of an area of study called epidemiology of religion and spirituality. The policy shifts at various levels, in the mental health field, has occurred as well to educate healthcare providers, and address patients’ spiritual /religious needs in clinical settings. Despite these advances in research and policy shift, there is still some resistance in the health care community to assess and address the spiritual needs of patients in clinical settings.Objective:The objective is to review the published articles on spirituality/religion and its relationship with mental and physical wellbeing and discuss limitations of such research. The review articles on assessment and interventions to address spiritual or religious needs in clinical settings ...

The Lancet Diabetes & Endocrinology, 2019

(19)30059-2. Please refer to any applicable terms of use of the publisher.

Marine drugs, Jan 10, 2017

Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, ... more Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increase in the number of deaths caused by cancer due to chemotherapy resistance as well. Accordingly, marine cyanobacteria, being the oldest prokaryotic microorganisms belonging to a monophyletic group, have proven themselves as being able to generate pharmaceutically important natural products. They have long been known to produce distinct and structurally complex secondary metabolites including peptides, polyketides, alkaloids, lipids, and terpenes with potent biological properties and applications. As such, this review will focus on recently published novel compounds isolated from marine cyanobacteria along with their potential bioactivities such as antibacterial, antifun...

Clinical endocrinology, Jan 29, 2018

Uncorrected thyroid dysfunction in pregnancy has well recognised deleterious effects on fetal and... more Uncorrected thyroid dysfunction in pregnancy has well recognised deleterious effects on fetal and maternal health. The early gestation period is one of critical fetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for ensuring optimal thyroid disease outcomes in pregnancy. Preconception planning in women with hypothyroidism should pre-empt and mirror the adaptive changes of the thyroid gland by careful levothyroxine dose adjustments to ensure adequate fetal thyroid hormone delivery in pregnancy. In hyperthyroidism the goal of preconception therapy is to control hyperthyroidism while curtailing the unwanted side effects of fetal and maternal exposure to antithyroid drugs. Thus, pregnancy should be deferred until a stable euthyroid state is achieved and definitive therapy with radioiodine or surgery should be considered in women with Graves' disease planning future pregnancy. Women with...

Journal of Medical Microbiology, 2017

One of the crucial determinants for successful administration of lactobacilli to the vaginal nich... more One of the crucial determinants for successful administration of lactobacilli to the vaginal niche is the use of appropriate Lactobacillus species. In this cross-sectional study 54 human immunodeficiency virus (HIV)-negative and 76 HIV-positive antiretroviral treatment-naïve women were evaluated for culturable vaginal lactobacilli and their association with genital HIV-1 shedding. Lactobacillus species were identified by 16S rDNA sequencing while cervical and plasma HIV-1 viral load was determined by Abbott real-time PCR. Lactobacilli were isolated in 77.8 % HIV-negative and 73.7 % HIV-positive women. The mean log 10 plasma and cervical HIV-1 viral loads (RNA copies ml À1) were 3.73±1.02 and 2.85±0.32 respectively. We observed that presence of L. crispatus, L. gasseri or L. jensenii species was associated with undetectable cervical HIV-1 (P=0.046) and reduced genital HIV-1 shedding (P=0.048) compared to other species. Our findings endorse using Lactobacillusbased strategies to aid the prevention of HIV-1 transmission among Indian women, however confirmation by future prospective studies is indeed warranted.

Systematic reviews, Mar 21, 2017

Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amo... more Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the evidence is lacking. This review aims to appraise and quantify the extent to which clinical, behavioural and pharmacogenomic factors affect levothyroxine therapy in patients with primary hypothyroidism. The databases Web of Science, Cochrane Library, EMBASE and PubMed will be searched. Patients must be adults over the age of 18 years, suffering from primary hypothyroidism including overt and subclinical hypothyroidism and receiving levothyroxine treatment. Studies in children, pregnant women and patients with secondary or tertiary hypothyroidism will not be included. We will also exclude studies focused ...

Frontiers in Plant Science, 2016

Carbon (C) and nitrogen (N) are two essential elements that influence plant growth and developmen... more Carbon (C) and nitrogen (N) are two essential elements that influence plant growth and development. The C and N metabolic pathways influence each other to affect gene expression, but little is known about which genes are regulated by interaction between C and N or the mechanisms by which the pathways interact. In the present investigation, proteome analysis of N-efficient and N-inefficient Indian mustard, grown under varied combinations of low-N, sufficient-N, ambient [CO 2 ], and elevated [CO 2 ] was carried out to identify proteins and the encoding genes of the interactions between C and N. Two-dimensional gel electrophoresis (2-DE) revealed 158 candidate protein spots. Among these, 72 spots were identified by matrix-assisted laser desorption ionization-time of flight/time of flight mass spectrometry (MALDI-TOF/TOF). The identified proteins are related to various molecular processes including photosynthesis, energy metabolism, protein synthesis, transport and degradation, signal transduction, nitrogen metabolism and defense to oxidative, water and heat stresses. Identification of proteins like PII-like protein, cyclophilin, elongation factor-TU, oxygen-evolving enhancer protein and rubisco activase offers a peculiar overview of changes elicited by elevated [CO 2 ], providing clues about how N-efficient cultivar of Indian mustard adapt to low N supply under elevated [CO 2 ] conditions. This study provides new insights and novel information for a better understanding of adaptive responses to elevated [CO 2 ] under N deficiency in Indian mustard.

Endocrinology, Diabetes & Metabolism Case Reports, 2016

Summary TSH receptor antibodies (TRAbs) are the pathological hallmark of Graves’ disease, present... more Summary TSH receptor antibodies (TRAbs) are the pathological hallmark of Graves’ disease, present in nearly all patients with the disease. Euthyroid Graves’ ophthalmopathy (EGO) is a well-recognized clinical entity, but its occurrence in patients with negative TRAbs is a potential source of diagnostic confusion. A 66-year-old female presented to our endocrinology clinic with right eye pain and diplopia in the absence of thyroid dysfunction. TRAbs were negative, as measured with a highly sensitive third-generation thyrotropin-binding inhibitory immunoglobulin (TBII) ELISA assay. CT and MRI scans of the orbit showed asymmetrical thickening of the inferior rectus muscles but no other inflammatory or malignant orbital pathology. Graves’ ophthalmopathy (GO) was diagnosed on the basis of the clinical and radiological features, and she underwent surgical recession of the inferior rectus muscle with complete resolution of the diplopia and orbital pain. She remained euthyroid over the course...

Endocrine Abstracts, 2015

Mutations in several proteins functioning as endolysosomal components cause monogenic autoimmune ... more Mutations in several proteins functioning as endolysosomal components cause monogenic autoimmune diseases, of which pathogenesis is linked to increased endoplasmic reticulum stress, inefficient autophagy, and defective recycling of immune receptors. We report here a heterozygous TOM1 p.G307D missense mutation, detected by whole-exome sequencing, in two related patients presenting with early-onset autoimmunity, antibody deficiency, and features of combined immunodeficiency. The index patient suffered from recurrent respiratory tract infections and oligoarthritis since early teens, and later developed persistent lowcopy EBV-viremia, as well as an antibody deficiency. Her infant son developed hypogammaglobulinemia, autoimmune enteropathy, interstitial lung disease, profound growth failure, and treatment-resistant psoriasis vulgaris. Consistent with previous knowledge on TOM1 protein function, we detected impaired autophagy and enhanced susceptibility to apoptosis in patient-derived cells. In addition, we noted diminished STAT and ERK1/2 signaling in patient fibroblasts, as well as poor IFN-γ and IL-17 secretion in T cells. The mutant TOM1 failed to interact with TOLLIP, a protein required for IL-1 recycling, PAMP signaling and autophagosome maturation, further strengthening the link between the candidate mutation and patient pathophysiology. In sum, we report here an identification of a novel gene, TOM1, associating with early-onset autoimmunity, antibody deficiency, and features of combined immunodeficiency. Other patient cases from unrelated families are needed to firmly establish a causal relationship between the genotype and the phenotype.

Case Reports in Endocrinology, 2015

Adrenal incidentalomas (AIs) are mostly benign and nonsecretory. Management algorithms lack sensi... more Adrenal incidentalomas (AIs) are mostly benign and nonsecretory. Management algorithms lack sensitivity when assessing malignant potential, although functional status is easier to assess. We present a subject whose AI was a retroperitoneal leiomyosarcoma (RL).Case Presentation. A woman on warfarin with SLE and the antiphospholipid syndrome, presented with left loin pain. She was normotensive and clinically normal. Ultrasound scans demonstrated left kidney scarring, but CT scans revealed an AI. MRI scans later confirmed the AI without significant fat and no interval growth. Cortisol after 1 mg dexamethasone, urinary free cortisol and catecholamines, plasma aldosterone renin ratio, and 17-hydroxyprogesterone were within the reference range. Initially, adrenal haemorrhage was diagnosed because of warfarin therapy and the acute presentation. However, she underwent adrenalectomy because of interval growth of the AI. Histology confirmed an RL. The patient received adjuvant radiotherapy.Di...