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Papers by dursun elmas

Research paper thumbnail of Nutritional Characteristics of the Patients Followed by the Nutrition Support Team and the Relationship Between the Nutritional Therapy Applied and the Results

Clinical science of nutrition, Mar 10, 2023

Research paper thumbnail of T He M Anagement of P Aget ' S D Isease of B One

AGET’S disease of bone is a localized, monostotic or polyostotic disease characterized by increas... more AGET’S disease of bone is a localized, monostotic or polyostotic disease characterized by increased bone remodeling, bone hypertrophy, and abnormal bone structure that leads in symptomatic patients to pain and bone deformity. Complications involve the bones (fractures and neoplastic degeneration), joints (osteoarthritis), and nervous system. The short-term objective of treatment is to alleviate bone pain, and the long-term objective is to minimize or prevent the progression of the disease. PATHOLOGY, EPIDEMIOLOGY,

Research paper thumbnail of Inflamatuar bağırsak hastalarında matriks metalloproteinaz-3, matriks metalloproteinaz-9 ve metalloproteinaz -1 doku inhibitörünün spondiloartropati gelişiminde rolü

Giris: Inflamatuvar Bagirsak Hastaliginda (Ulseratif Kolit ve Crohn Hastaligi) bagirsak disi bulg... more Giris: Inflamatuvar Bagirsak Hastaliginda (Ulseratif Kolit ve Crohn Hastaligi) bagirsak disi bulgularin sik goruldugu bilinmektedir. Bunlar arasinda en sik ortaya cikanlari eklem bulgularidir. Son yillarda yapilan calismalarda matriks metalloproteinazlarin ve doku metalloproteinaz inhibitorlerinin, IBH'da direkt olarak hastalik aktivitesi ve ekstraintestinal bulgularin ortaya cikmasinda; AS'de ise lokal hastalik seyrinde ve doku yeniden yapilanmasinda etkili olabilecegi dusunulmektedir. Bu calismada, IBH'li olgulardaki SpA ve AS gelisim riski hakkinda fikir edinebilmek amaciyla anti matriks metalloproteinaz-3, anti matriks metalloproteinaz- 9 ve matriks metalloproteinaz doku inhibitoru-1 antikorlarinin rollerinin arastirilmasi planlanmistir. Ayrica IBH+AS ve AS'li hastalarda serum MMP-3, MMP-9, TIMP-1 seviyelerinin, hastalik aktivitelerini belirlemede ESR ve CRP'ye gore klinikte kullanilabilirligini arastirmayi amacladik.Gerec ve Yontem: Bu calisma Haziran 2011- ...

Research paper thumbnail of Nutritional Characteristics of the Patients Followed by the Nutrition Support Team and the Relationship Between the Nutritional Therapy Applied and the Results

Clinical Science of Nutrition

Research paper thumbnail of Üst Gastrointestinal Sistem Kanaması Olan Yoğun Bakım Hastalarının Retrospektif Değerlendirilmesi

Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi, 2019

Aim: Upper gastrointestinal bleeding is an important cause of mortality and morbidity. The aim of... more Aim: Upper gastrointestinal bleeding is an important cause of mortality and morbidity. The aim of this study is to evaluate the risk factors of mortality in patients admitted to medical ICU with upper gastrointestinal bleeding. Methods: Patients admitted to medical ICU with upper GI bleeding or patients with new onset GIS bleeding during the ICU stay between January 2010-December 2016 were included. Patient datas were recorded from the hospitals database retrospectively. Results: There were 3990 patients between the study period. One hundred seventy six of these patients had gastrointestinal bleeding and enrolled the study. One hundred seventeen (66,5%) of 176 patients were male, 59 (33,5%) were female. Mean age of the patients was 63±16 years. While the number of the patients who underwent endoscopy procedure was 152 (86,4%); mortality rate of these patients was 46,1%; and 91,7% for the patients who did not undergo the endoscopy procedure. Mortality rates of patients with variceal and nonvariceal bleeding diagnose were 46% and 47,6%. Uremia, renal failure, increase of the leucocyte count during the follow up, coagulopathy, increased demand of erythrocyte suspension and lack of endoscopy procedure were determined as risk factors for mortality. Conclusion: Upper gastrointestinal bleeding in the intensive care unit is a situation which is with high mortality rate. Higher APACHE II Score, presence of comorbidities are determinants of prognosis.

Research paper thumbnail of Association of Matrix Metalloproteinases and Their Tissue Inhibitor With Disease Activity and Development in Spondyloarthropathy and Inflammatory Bowel Disease

Archives of Rheumatology, 2015

Extra-intestinal involvement is a common manifestation in Inflammatory Bowel Disease (IBD). Joint... more Extra-intestinal involvement is a common manifestation in Inflammatory Bowel Disease (IBD). Joints are the most common site of involvement and the coexistence of IBD with spondylitis or peripheral arthritis (Asymmetric arthritis on lower extremity joints) is considered as Spondiloarthropathy (SpA), "enteropathic arthritis" or "arthritis related to IBD" according to the "European Spondiloartropathy Study Group" criteria. 1,2 The pathogenesis of extra-intestinal findings in IBD is poorly understood. Current theories suggest the impairment of mucosal immunoregulatory mechanisms in IBD, resulting in the transport of luminal content antigens to the systemic circulation. Also, lack of intestinal mucosal barrier protection mechanism, mucosal secretion of immunoglobulin A (IgA) and defense mechanism of mucosa against foreign proteins ABSTRACT Objectives: This study aims to investigate whether clinical measures of disease activity and function in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are associated with matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and if MMPs can be more useful than C-reactive protein and erythrocyte sedimentation rate in predicting disease activity in AS. Patients and methods: MMP-3, MMP-9 and TIMP-1 levels were measured by ELISA in 20 patients with AS, 20 patients with IBD, 20 patients with IBD and AS (35 males, 25 females; mean age 38.1 years; range 19 to 62 years), and 20 healthy volunteers (10 males, 10 females; median age 38.5 years; range 24 to 63 years) as a control group. Bath Ankylosing Spondylitis Disease Activity Index, Truelove-Witts activity criteria for ulcerative colitis, and Crohn's Disease of Activity Index scoring systems were used. Results: Highest MMP-3 level was in IBD group (33.51±59.56 ng/mL, p<0.045). MMP-3 levels were significantly higher in patients with IBD and IBD+AS than in patients with AS (p<0.007 and p<0.035, respectively). Highest MMP-9 levels were in the control group (10.35±2.61 ng/mL, p<0.48). MMP-9 levels were higher in AS group patients than those in IBD and IBD+AS groups, but the difference was not statistically significant (p<0.494 and p<0.260, respectively). Highest TIMP-1 levels were in the IBD group (8.11 ng/mL, p<0.006). TIMP-1 levels of IBD group were significantly higher than both AS and IBD+AS groups (p<0.033 and p<0.008, respectively). A statistically significant correlation was detected between serum MMP-3 levels and disease activity and Bath Ankylosing Spondylitis Disease Activity Index score in patients with AS (r=0.841, p<0.05). Conclusion: We concluded that serum MMP-3 levels may be a better biomarker than C-reactive protein and erythrocyte sedimentation rate in showing disease activity in AS.

Research paper thumbnail of Nutritional Characteristics of the Patients Followed by the Nutrition Support Team and the Relationship Between the Nutritional Therapy Applied and the Results

Clinical science of nutrition, Mar 10, 2023

Research paper thumbnail of T He M Anagement of P Aget ' S D Isease of B One

AGET’S disease of bone is a localized, monostotic or polyostotic disease characterized by increas... more AGET’S disease of bone is a localized, monostotic or polyostotic disease characterized by increased bone remodeling, bone hypertrophy, and abnormal bone structure that leads in symptomatic patients to pain and bone deformity. Complications involve the bones (fractures and neoplastic degeneration), joints (osteoarthritis), and nervous system. The short-term objective of treatment is to alleviate bone pain, and the long-term objective is to minimize or prevent the progression of the disease. PATHOLOGY, EPIDEMIOLOGY,

Research paper thumbnail of Inflamatuar bağırsak hastalarında matriks metalloproteinaz-3, matriks metalloproteinaz-9 ve metalloproteinaz -1 doku inhibitörünün spondiloartropati gelişiminde rolü

Giris: Inflamatuvar Bagirsak Hastaliginda (Ulseratif Kolit ve Crohn Hastaligi) bagirsak disi bulg... more Giris: Inflamatuvar Bagirsak Hastaliginda (Ulseratif Kolit ve Crohn Hastaligi) bagirsak disi bulgularin sik goruldugu bilinmektedir. Bunlar arasinda en sik ortaya cikanlari eklem bulgularidir. Son yillarda yapilan calismalarda matriks metalloproteinazlarin ve doku metalloproteinaz inhibitorlerinin, IBH'da direkt olarak hastalik aktivitesi ve ekstraintestinal bulgularin ortaya cikmasinda; AS'de ise lokal hastalik seyrinde ve doku yeniden yapilanmasinda etkili olabilecegi dusunulmektedir. Bu calismada, IBH'li olgulardaki SpA ve AS gelisim riski hakkinda fikir edinebilmek amaciyla anti matriks metalloproteinaz-3, anti matriks metalloproteinaz- 9 ve matriks metalloproteinaz doku inhibitoru-1 antikorlarinin rollerinin arastirilmasi planlanmistir. Ayrica IBH+AS ve AS'li hastalarda serum MMP-3, MMP-9, TIMP-1 seviyelerinin, hastalik aktivitelerini belirlemede ESR ve CRP'ye gore klinikte kullanilabilirligini arastirmayi amacladik.Gerec ve Yontem: Bu calisma Haziran 2011- ...

Research paper thumbnail of Nutritional Characteristics of the Patients Followed by the Nutrition Support Team and the Relationship Between the Nutritional Therapy Applied and the Results

Clinical Science of Nutrition

Research paper thumbnail of Üst Gastrointestinal Sistem Kanaması Olan Yoğun Bakım Hastalarının Retrospektif Değerlendirilmesi

Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi, 2019

Aim: Upper gastrointestinal bleeding is an important cause of mortality and morbidity. The aim of... more Aim: Upper gastrointestinal bleeding is an important cause of mortality and morbidity. The aim of this study is to evaluate the risk factors of mortality in patients admitted to medical ICU with upper gastrointestinal bleeding. Methods: Patients admitted to medical ICU with upper GI bleeding or patients with new onset GIS bleeding during the ICU stay between January 2010-December 2016 were included. Patient datas were recorded from the hospitals database retrospectively. Results: There were 3990 patients between the study period. One hundred seventy six of these patients had gastrointestinal bleeding and enrolled the study. One hundred seventeen (66,5%) of 176 patients were male, 59 (33,5%) were female. Mean age of the patients was 63±16 years. While the number of the patients who underwent endoscopy procedure was 152 (86,4%); mortality rate of these patients was 46,1%; and 91,7% for the patients who did not undergo the endoscopy procedure. Mortality rates of patients with variceal and nonvariceal bleeding diagnose were 46% and 47,6%. Uremia, renal failure, increase of the leucocyte count during the follow up, coagulopathy, increased demand of erythrocyte suspension and lack of endoscopy procedure were determined as risk factors for mortality. Conclusion: Upper gastrointestinal bleeding in the intensive care unit is a situation which is with high mortality rate. Higher APACHE II Score, presence of comorbidities are determinants of prognosis.

Research paper thumbnail of Association of Matrix Metalloproteinases and Their Tissue Inhibitor With Disease Activity and Development in Spondyloarthropathy and Inflammatory Bowel Disease

Archives of Rheumatology, 2015

Extra-intestinal involvement is a common manifestation in Inflammatory Bowel Disease (IBD). Joint... more Extra-intestinal involvement is a common manifestation in Inflammatory Bowel Disease (IBD). Joints are the most common site of involvement and the coexistence of IBD with spondylitis or peripheral arthritis (Asymmetric arthritis on lower extremity joints) is considered as Spondiloarthropathy (SpA), "enteropathic arthritis" or "arthritis related to IBD" according to the "European Spondiloartropathy Study Group" criteria. 1,2 The pathogenesis of extra-intestinal findings in IBD is poorly understood. Current theories suggest the impairment of mucosal immunoregulatory mechanisms in IBD, resulting in the transport of luminal content antigens to the systemic circulation. Also, lack of intestinal mucosal barrier protection mechanism, mucosal secretion of immunoglobulin A (IgA) and defense mechanism of mucosa against foreign proteins ABSTRACT Objectives: This study aims to investigate whether clinical measures of disease activity and function in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are associated with matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), and if MMPs can be more useful than C-reactive protein and erythrocyte sedimentation rate in predicting disease activity in AS. Patients and methods: MMP-3, MMP-9 and TIMP-1 levels were measured by ELISA in 20 patients with AS, 20 patients with IBD, 20 patients with IBD and AS (35 males, 25 females; mean age 38.1 years; range 19 to 62 years), and 20 healthy volunteers (10 males, 10 females; median age 38.5 years; range 24 to 63 years) as a control group. Bath Ankylosing Spondylitis Disease Activity Index, Truelove-Witts activity criteria for ulcerative colitis, and Crohn's Disease of Activity Index scoring systems were used. Results: Highest MMP-3 level was in IBD group (33.51±59.56 ng/mL, p<0.045). MMP-3 levels were significantly higher in patients with IBD and IBD+AS than in patients with AS (p<0.007 and p<0.035, respectively). Highest MMP-9 levels were in the control group (10.35±2.61 ng/mL, p<0.48). MMP-9 levels were higher in AS group patients than those in IBD and IBD+AS groups, but the difference was not statistically significant (p<0.494 and p<0.260, respectively). Highest TIMP-1 levels were in the IBD group (8.11 ng/mL, p<0.006). TIMP-1 levels of IBD group were significantly higher than both AS and IBD+AS groups (p<0.033 and p<0.008, respectively). A statistically significant correlation was detected between serum MMP-3 levels and disease activity and Bath Ankylosing Spondylitis Disease Activity Index score in patients with AS (r=0.841, p<0.05). Conclusion: We concluded that serum MMP-3 levels may be a better biomarker than C-reactive protein and erythrocyte sedimentation rate in showing disease activity in AS.