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Papers by dwi sutiningsih

Pakistan Journal of Biological Sciences, 2021

Background and Objective: The use of the roots of the pasak bumi (E. longifolia Jack) to treat ca... more Background and Objective: The use of the roots of the pasak bumi (E. longifolia Jack) to treat cancer has been studied widely, however, the scientific basis of these plants used as an anticancer drug is widely unknown. The purpose of this study was to examine the anticancer activity of ethyl acetate and non-ethyl acetate fractions of pasak bumi roots in Raji cells. Materials and Methods: The cytotoxicity test is using the direct cell count method with trypan blue staining. The growth inhibition is using doubling time analysis of Raji cells. Observation of the apoptotic events of Raji cells used ethidium bromide staining, while observing the expression of p53 protein in Raji cells was done by immunohistochemical staining. Results: The results of the cytotoxicity and doubling time test showed that the activity of the non-ethyl acetate fraction was greater than that of the roots of pasak bumi. The lower concentration of non-ethyl acetate fraction of pasak bumi roots was able to delay the multiplication time of Raji cells which was greater than that of ethyl acetate. The results of the cytotoxicity and doubling time test showed that the activity of the non-ethyl acetate fraction was greater than that of the roots of pasak bumi. Conclusion: It can be concluded that the ethyl acetate and non-ethyl acetate fractions of the roots of pasak bumi have cytotoxic and antiproliferative activity on Raji cells, however they cannot induce apoptosis in Raji cells. The death of Raji cells is through the mechanism of inhibiting Raji cell proliferation as evidenced by an increase in p53 protein expression.

E3S Web of Conferences, 2020

Non-exclusive breastfeeding is defined as the provision of food or fluids in addition to drugs, v... more Non-exclusive breastfeeding is defined as the provision of food or fluids in addition to drugs, vitamins, and minerals to infants before the age of 6 months. Exclusive breastfeeding for infants is seen to prevent and cure stunting and other forms of malnutrition. Primary Health Care (PHC) Margorejo is the health center with the lowest exclusive breastfeeding coverage in Pati Regency in 2017 and 2018. The purpose of this study was to analyze the factors related to the behavior of non-exclusive breastfeeding in the working area of the PHC Margorejo in Pati Regency. This study uses a case control method. The research sample consisted of 70 consisting of 35 cases and 35 controls. The research targets were mothers who have 6-11 months old infants in the working area of the PHC Margorejo. Bivariate analysis showed a low level of maternal knowledge (p = 0.008), negative maternal attitudes (p = 0.022), and the absence of support from health workers (p = 0.002) related to non-exclusive breas...

Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi dan Kesehatan, 2020

The prevalence of DM in Riskesdas in 2018 according to the Perkeni consensus in 2015 is higher th... more The prevalence of DM in Riskesdas in 2018 according to the Perkeni consensus in 2015 is higher than according to the Perkeni consensus in 2011, the prevalence was10.9%. The disease can develop into diabetes nephropathy, Increased prevalence of diabetic nephropathy directly proportional with an increase in diabetes prevalence. Diabetic nephropathy is a microvascular complication in diabetics that develops around 30% in patients with type I DM and about 40% in patients with type II DM. Turmeric extract has antioxidant and anti-inflammatory effects to prevent the bad development of diabetes nephropathy. This study looked at the effect of giving a combination of noni and turmeric extract on histopathology of alloxan-induced renal rats. A total of 25 mice were divided into 5 treatment groups, namely the PI group (250 mg / kgBB extract dose), PII group (500 mg / kgBB extract dose), PIII group (750 mg / kgBB extract dose), positive control group (glibenklamid) and negative control group (w...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Multidrug-resistant organisms (MDRO) pose a significant challenge to healthcare facil... more Background: Multidrug-resistant organisms (MDRO) pose a significant challenge to healthcare facilities globally, impacting patient outcomes and healthcare costs. Understanding the distribution and prevalence of MDRO is crucial for effective infection control and prevention strategies. This study aimed to investigate the distribution and prevalence of MDROs, among MDRO-positive individuals at Dr. Kariadi Hospital.Methods: A retrospective analysis of secondary data was conducted, encompassing a diverse range of MDROs, including ESBL, carbapenem-resistant Enterobacteriaceae (CRE), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Staphylococcus aureus (VRSA). The study population consisted of individuals who tested positive for MDRO within the hospital.Results: A total of 100 MDRO-positive cases were identified during the study period. The most prevalent MDRO identified was ESBL-producing organisms, accounting for 59% of all cases. Other significant findings ...

JURNAL BIOS LOGOS

One of the plants that can be used as a drug is a plant Pare (Momordica charantia L). This is bec... more One of the plants that can be used as a drug is a plant Pare (Momordica charantia L). This is because the leaves are nutritious for health. In general, the natural chemical compounds found in pare leaves are momordin, momordisin, trichosanic acid, resins, resinic acid, saponi, flavonoids, vitamins A and C, and fatty oils.The purpose of this study was to determine the effect of ethanol extract concentration of pare leaves (Momordica charantia L) to the inhibitory power of Staphylococcus aureus bacteria diffusion method. This research method is in the form of quasi experimental by using diffusion method to see extract inhibition zone. Leaf ethanol extract was obtained by maceration extraction method. The sample used was the concentration of pare leaf ethanol extract consisting of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%. The results obtained at concentration of 10% have inhibitory power of 66.5% and increase with the increase of concentration up to 100% concentration has ...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Worldwide healthcare workforce represents 12%, in Uganda, out of the 39000 healthcare... more Background: Worldwide healthcare workforce represents 12%, in Uganda, out of the 39000 healthcare workers (HCW), 500 have been deployed at Mbale regional referral hospital (MRRH). The deficient quality service delivery is attributed to adverse occupational health risk that are not addressed and acknowledged posing a great risk to patient safety. Study aims to investigate the unsafe acts and unsafe working conditions of health care workers at (MRRH).Methods: A quantitative observational study with a cross-section design was used using and a semi structured observation checklist for data collection among 120 health care workers of MRRH.Result: 45(37.5%) of the HCW never wore the necessary PPEs versus 75(62.5%) who wore, almost half 55(45.3%) worked over time and 65(54.6%) did not, as well the same figures represent those who over worked and those who did not over work respectively. 70% of the working places had defective working conditions for example no lighting, slippery floors and ...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Rhino-orbito-cerebral mucormycosis (ROCM) increasing incidence in the setting of COVI... more Background: Rhino-orbito-cerebral mucormycosis (ROCM) increasing incidence in the setting of COVID-19 in India and elsewhere has become a matter of immediate concern. In this observational case report we have observed the signs and symptoms of ROCM among coronavirus positive patients with reference to “Mucor code “as reported by Honavar SG 2021, we have reported cases been admitted to ICU for <2weeks in a community hospital in South India. Method: Patient informed consent was taken, Patient’s data (Medical record, medication charts, daily report) were collected using a designed data collection form, observed warning signs and symptoms, and predisposed factors was noted and ROCM is characterized with reference to the “Mucor code”.Results: Nasal stuffiness, Foul smell and Facial pain and among others were the most coherent warning signs and symptoms observed among the patients in <2weeks of admission in ICU. Other observed predisposing risk factors were regular administration of...

F1000Research

Background Long-term chemical drug consumption to treat hypertension may have side effects becaus... more Background Long-term chemical drug consumption to treat hypertension may have side effects because the levels are sometimes difficult for the body to tolerate. Therefore, some people have used plants as herbal medicine, including avocado leaves (Persea americana Mill.) as antihypertensive. This study aims to find out the differences in the effectiveness of modern drugs and natural antihypertensive ingredients in avocado leaf extract (containing flavonoids and quercetin compounds) in inhibiting the ACE enzyme, which causes decreasing systolic blood pressure (SBP) and diastolic blood pressure (DBP) as well as increasing urine volume. Methods This study used an experimental in vivo study design involving 24 white male Wistar rats (Rattus norvegicus), aged 2–3 months, weighing 130–250 g, and of a healthy condition with active movement. The samples were randomly divided into six treatment groups and post-test only research design with control group design. Results The result of the study...

International Journal of English Literature and Social Sciences, 2021

The mRNA 1273 vaccine by Modernahas recorded to be94.1% effective against laboratoryconfirmed Cov... more The mRNA 1273 vaccine by Modernahas recorded to be94.1% effective against laboratoryconfirmed Covid-19 infection. Health care workers in Indonesia are receiving third-booster vaccine by Moderna after the two doses of virus-inactivated vaccine. Further evaluation of Covid-19 mRNA vaccine post-injection effects on health care workers is necessary. This present study asssessed the postimmunization adverse events tohealth care workersin the Port Health Office of Semarang.This was a retrospective, cross-sectional, observational study aimed to the HCWs, both staff and non-staff, of the Port Health Office of Semarang.We identified and analyzed the adverse effects on 132 workers who had been receiving third-mRNA booster vaccine by Moderna. About 37.8% (50 out of 132)respondents experienced adverse events after receiving third-booster vaccine by Moderna. Among them, female workers (62%) had more incidents compared to males (38%). the most common symptoms were localized painon injected arm (1...

E3S Web of Conferences, 2021

Coronavirus Disease-2019 (COVID-19) cases are still increasing, while the epidemiology data is st... more Coronavirus Disease-2019 (COVID-19) cases are still increasing, while the epidemiology data is still limited. This study’s purpose is to delineate characteristics of 31,407 COVID-19 patients in Central Java. This research involved secondary data acquired from the Health Office of Central Java, which was analysed univariately. The majority of the patients were 19-44-year-old (43.57%), females (50.81%), and private employees (10.53%). The most frequent symptoms were fever (18.85%), cough (18.19%), and shortness of breath (13.71%). Most of the cases were from Semarang City (17.2%), Kudus (6%), Jepara (6%), Demak (5.5%), and Kendal (4.3%), with an Incidence Rate (per 10,000) of 42.79; 14.53; 14.99; 14.90; and 13.84 respectively. Furthermore, most of the patients had no transit history (87.11%), while out of 25 of the foreign transit histories, the United States of America and China contributed 24% and 20%, sequentially. Three-fourths of the domestic transit history was in Central Java, ...

E3S Web of Conferences, 2020

Central Java reported 1,541 cases of Patients Under Surveillance until April 14th, 2020. It is ex... more Central Java reported 1,541 cases of Patients Under Surveillance until April 14th, 2020. It is expected to increase everyday. However, reports about the epidemiological characteristics of Patients Under Surveillance cases are still limited. This study aims to describe Patients Under Surveillance case of COVID-19. The study used quantitative descriptive design, whereas many as 1,541 cases were described based on the characteristics, contact history, history of transit, and the symptoms. The data are obtained from the Department of Health, Central Java and processed with descriptive statistical data analysis. Results showed from 1,541 cases as much as 59.9% were male and 43% aged 19-44 years. As many as 154 death cases were dominated by men (61.6%) and elderly ≥60 years (38.3%). The highest IR was Semarang (16.85/100,000 population). Symptoms that often found were cough, fever, dyspnea (8.3%), and 3.96% asymptomatic. The history of contact with the traveling person (4.7%). The most vi...

Bacillus thuringiensis israelensis merupakan bakteri yang toksik terhadap larva nyamuk Aedes aegy... more Bacillus thuringiensis israelensis merupakan bakteri yang toksik terhadap larva nyamuk Aedes aegypti. Namun kendala utama dalam produksi bioinsektisida adalah bahan baku media penumbuh yang masih impor. Sehingga diperlukan media penumbuh alternatif, salah satunya dengan menggunakan air perasan singkong. Tujian dari penelitian ini adalah mengetahui toksisitas isolat B. thuringiensis israelensis yang dibiakkan dalam air perasan singkong terhadap larva nyamuk Ae. aegypti. Jenis penelitian yang dgunakan adalah eksperimental dengan desain penelitian Posttest-only control group design. Populasi dalam penelitian ini adalah semua larva Ae. aegypti instar III. Perameter yang diamati yaiyu jumlah spora B. thuringiensis israelensisyang tumbuh pada media air perasan singkong dan mortalitas LC 50 dan LC 90 larva Ae. aegypti dengan analisis regresi probit. Konsentrasi yang dipakai dalam uji toksisitas adalah 0,89x10-3 ppm; 1,30x10-3 ppm; 1,49x10-3 ppm; 1,69x10-3 ppm; 2,20x10-3 ppm, 3,22x10-3 ppm dan 5,43x10-3 ppm.Hasil penelitian menunjukkan jumlah spora yang tumbuh pada mesdia air perasan singkong 1% yaitu sebanyak 230 x10 5 spora/ml. LC 50 dan LC 90 konsentrasi B. thuringiensis israelensis yaitu 3,674x10-3 ppm dan 14,254x10-3 ppm. Dari penelitian ini dapat disimpulkan bahwa B. thuringiensis israelensis yang dibiakkan dalam air perasan singkong toksik terhadap larva Ae. aegypti.

JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama

Rabies adalah penyakit zoonosis yang disebabkan oleh Lyssavirus yang ditularkan melalui gigitan h... more Rabies adalah penyakit zoonosis yang disebabkan oleh Lyssavirus yang ditularkan melalui gigitan hewan penular rabies seperti anjing, kucing, monyet, dan kelelawar. Namun belum diketahui jalur penularan rabies di Kabupaten Dompu. Penelitian ini bertujuan untuk menilai risiko pelepasan rabies. Penilaian risiko pelepasan rabies di Distrik Dompu menggunakan standar analisis risiko Office International des Epizooties (OIE). Teknik pengambilan sampel dalam penelitian ini dilakukan secara purposive sampling. Data yang dikumpulkan dibuat dalam pohon skenario. untuk mengetahui risiko perhitungan yang digunakan yang merujuk pada Biosecurity Australia dan memetakan jalur pelepasan rabies menggunakan ArcGIS® Versi 10.3. Perhitungan penilaian pelepasan kemungkinan risiko rabies di darat tinggi. Sementara kemungkinan risiko melepaskan rabies melalui kapal yang masuk dan keluar dapat diabaikan. Peluang penyebaran rabies di Kabupaten Dompu menunjukkan bahwa kurangnya pengawasan pelabuhan dan perger...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Several regions in Indonesia are classified as leptospirosis endemic including Klaten... more Background: Several regions in Indonesia are classified as leptospirosis endemic including Klaten Regency, which ranked 2nd highest case of leptospirosis in Central Java in 2018. Leptospirosis in human was transmitted by animals infected by the Leptospira bacteria, which rat was the main reservoir. This study aimed to identify rat reservoir to the existence of Leptospira bacteria in endemic areas.Methods: This study was an observational survey with cross sectional approach. The sample was rats caught by traps installed for 6 days in Dukuh Kalitengah, Kalitengah Village, Wedi Subdistrict, Klaten Regency in July 2019. The rats were identified and dissected to take their kidneys for laboratory testing using the Polymerase Chain Reaction (PCR) test to identity the existence of Leptospira bacteria.Result: The result showed that there were 17 rats and 6 Suncus murinus caught in 6 days and their species were Mus musculus (23.5%), Rattus tanezumi (41.2%), Rattus norvegicus (35.3%). The res...

Jurnal Epidemiologi Kesehatan Komunitas

Background: One of the causes of antibiotic resistance is the presence of antibiotic residues in ... more Background: One of the causes of antibiotic resistance is the presence of antibiotic residues in livestock, one of which is broiler chicken meat. Excessive use of antibiotics and not in accordance with the diagnosis will result in the discovery of antibiotic residue content in chicken meat and will endanger public health. The purpose of this study was to determine the description of the antibiotic residues of tetracycline in broiler chicken meat sold in traditional and modern markets in Jati District, Kudus Regency.Methods: This type of research is a descriptive observational study with a cross-sectional approach. The samples in this study were all broiler chicken meat sold in traditional markets (Bitingan Market, Sunggingan Ploso Market, and Baru Market) and in the modern Hypermart market with a total sample of 78 samples of broiler chicken meat taken with total population sampling technique. Sample testing was carried out at Balai Veteriner Boyolali using the Bioassay method.Resul...

Jurnal Epidemiologi Kesehatan Komunitas

Background: The rate of COVID-19 cases is still high in Jayapura City to date in one day it can c... more Background: The rate of COVID-19 cases is still high in Jayapura City to date in one day it can contribute 30 to 35 positive patients. The form of prevention behavior in students has not been optimally implemented. the addition of positive cases every day can be triggered due to the lack of information related to the corona virus. The purpose of this study was to describe the behavioral factors to prevent COVID-19 in students.Methods: The population in this study were students of Cenderawasih University, Jayapura City. The study was conducted in January – February 2021 on 100 subjects selected by purposive sampling technique. Subjects were measured using an online questionnaire containing questions and statements regarding research variables such as knowledge, attitudes, practices, sources of information, social support and support from health workers. Data were analyzed by univariate analysis and bivariate analysis.Result: The results showed that 67% of students' level of knowl...

Jurnal Epidemiologi Kesehatan Komunitas

ABSTRACTBackground: Complete basic immunization coverage in Indonesia in the last five years has ... more ABSTRACTBackground: Complete basic immunization coverage in Indonesia in the last five years has not reached the target set in the Ministry of Health's Strategic Plan. Public health center as the operator of immunization operations must be supported by the implementation of a good health management function. The purpose of this study was to analyze the influence of facilitating factors, enabling factors, reinforcing factors and factorsthat influence mothers in carrying out complete basic immunization for children in relation to UCI achievement at Miroto Public Health Center, Central Semarang District, Semarang City.Methods: This study is analitic observational research with cross-sectional study design. The population of this research is mothers who have a minimum age of 1 under five who reside at Miroto Health Center. The research sample was 50 mothers with simple random sampling technique. Processing and data analysis with quantitative methods with univariate and bivariate ana...

Pakistan Journal of Biological Sciences, 2021

Background and Objective: The use of the roots of the pasak bumi (E. longifolia Jack) to treat ca... more Background and Objective: The use of the roots of the pasak bumi (E. longifolia Jack) to treat cancer has been studied widely, however, the scientific basis of these plants used as an anticancer drug is widely unknown. The purpose of this study was to examine the anticancer activity of ethyl acetate and non-ethyl acetate fractions of pasak bumi roots in Raji cells. Materials and Methods: The cytotoxicity test is using the direct cell count method with trypan blue staining. The growth inhibition is using doubling time analysis of Raji cells. Observation of the apoptotic events of Raji cells used ethidium bromide staining, while observing the expression of p53 protein in Raji cells was done by immunohistochemical staining. Results: The results of the cytotoxicity and doubling time test showed that the activity of the non-ethyl acetate fraction was greater than that of the roots of pasak bumi. The lower concentration of non-ethyl acetate fraction of pasak bumi roots was able to delay the multiplication time of Raji cells which was greater than that of ethyl acetate. The results of the cytotoxicity and doubling time test showed that the activity of the non-ethyl acetate fraction was greater than that of the roots of pasak bumi. Conclusion: It can be concluded that the ethyl acetate and non-ethyl acetate fractions of the roots of pasak bumi have cytotoxic and antiproliferative activity on Raji cells, however they cannot induce apoptosis in Raji cells. The death of Raji cells is through the mechanism of inhibiting Raji cell proliferation as evidenced by an increase in p53 protein expression.

E3S Web of Conferences, 2020

Non-exclusive breastfeeding is defined as the provision of food or fluids in addition to drugs, v... more Non-exclusive breastfeeding is defined as the provision of food or fluids in addition to drugs, vitamins, and minerals to infants before the age of 6 months. Exclusive breastfeeding for infants is seen to prevent and cure stunting and other forms of malnutrition. Primary Health Care (PHC) Margorejo is the health center with the lowest exclusive breastfeeding coverage in Pati Regency in 2017 and 2018. The purpose of this study was to analyze the factors related to the behavior of non-exclusive breastfeeding in the working area of the PHC Margorejo in Pati Regency. This study uses a case control method. The research sample consisted of 70 consisting of 35 cases and 35 controls. The research targets were mothers who have 6-11 months old infants in the working area of the PHC Margorejo. Bivariate analysis showed a low level of maternal knowledge (p = 0.008), negative maternal attitudes (p = 0.022), and the absence of support from health workers (p = 0.002) related to non-exclusive breas...

Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi dan Kesehatan, 2020

The prevalence of DM in Riskesdas in 2018 according to the Perkeni consensus in 2015 is higher th... more The prevalence of DM in Riskesdas in 2018 according to the Perkeni consensus in 2015 is higher than according to the Perkeni consensus in 2011, the prevalence was10.9%. The disease can develop into diabetes nephropathy, Increased prevalence of diabetic nephropathy directly proportional with an increase in diabetes prevalence. Diabetic nephropathy is a microvascular complication in diabetics that develops around 30% in patients with type I DM and about 40% in patients with type II DM. Turmeric extract has antioxidant and anti-inflammatory effects to prevent the bad development of diabetes nephropathy. This study looked at the effect of giving a combination of noni and turmeric extract on histopathology of alloxan-induced renal rats. A total of 25 mice were divided into 5 treatment groups, namely the PI group (250 mg / kgBB extract dose), PII group (500 mg / kgBB extract dose), PIII group (750 mg / kgBB extract dose), positive control group (glibenklamid) and negative control group (w...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Multidrug-resistant organisms (MDRO) pose a significant challenge to healthcare facil... more Background: Multidrug-resistant organisms (MDRO) pose a significant challenge to healthcare facilities globally, impacting patient outcomes and healthcare costs. Understanding the distribution and prevalence of MDRO is crucial for effective infection control and prevention strategies. This study aimed to investigate the distribution and prevalence of MDROs, among MDRO-positive individuals at Dr. Kariadi Hospital.Methods: A retrospective analysis of secondary data was conducted, encompassing a diverse range of MDROs, including ESBL, carbapenem-resistant Enterobacteriaceae (CRE), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Staphylococcus aureus (VRSA). The study population consisted of individuals who tested positive for MDRO within the hospital.Results: A total of 100 MDRO-positive cases were identified during the study period. The most prevalent MDRO identified was ESBL-producing organisms, accounting for 59% of all cases. Other significant findings ...

JURNAL BIOS LOGOS

One of the plants that can be used as a drug is a plant Pare (Momordica charantia L). This is bec... more One of the plants that can be used as a drug is a plant Pare (Momordica charantia L). This is because the leaves are nutritious for health. In general, the natural chemical compounds found in pare leaves are momordin, momordisin, trichosanic acid, resins, resinic acid, saponi, flavonoids, vitamins A and C, and fatty oils.The purpose of this study was to determine the effect of ethanol extract concentration of pare leaves (Momordica charantia L) to the inhibitory power of Staphylococcus aureus bacteria diffusion method. This research method is in the form of quasi experimental by using diffusion method to see extract inhibition zone. Leaf ethanol extract was obtained by maceration extraction method. The sample used was the concentration of pare leaf ethanol extract consisting of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%. The results obtained at concentration of 10% have inhibitory power of 66.5% and increase with the increase of concentration up to 100% concentration has ...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Worldwide healthcare workforce represents 12%, in Uganda, out of the 39000 healthcare... more Background: Worldwide healthcare workforce represents 12%, in Uganda, out of the 39000 healthcare workers (HCW), 500 have been deployed at Mbale regional referral hospital (MRRH). The deficient quality service delivery is attributed to adverse occupational health risk that are not addressed and acknowledged posing a great risk to patient safety. Study aims to investigate the unsafe acts and unsafe working conditions of health care workers at (MRRH).Methods: A quantitative observational study with a cross-section design was used using and a semi structured observation checklist for data collection among 120 health care workers of MRRH.Result: 45(37.5%) of the HCW never wore the necessary PPEs versus 75(62.5%) who wore, almost half 55(45.3%) worked over time and 65(54.6%) did not, as well the same figures represent those who over worked and those who did not over work respectively. 70% of the working places had defective working conditions for example no lighting, slippery floors and ...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Rhino-orbito-cerebral mucormycosis (ROCM) increasing incidence in the setting of COVI... more Background: Rhino-orbito-cerebral mucormycosis (ROCM) increasing incidence in the setting of COVID-19 in India and elsewhere has become a matter of immediate concern. In this observational case report we have observed the signs and symptoms of ROCM among coronavirus positive patients with reference to “Mucor code “as reported by Honavar SG 2021, we have reported cases been admitted to ICU for <2weeks in a community hospital in South India. Method: Patient informed consent was taken, Patient’s data (Medical record, medication charts, daily report) were collected using a designed data collection form, observed warning signs and symptoms, and predisposed factors was noted and ROCM is characterized with reference to the “Mucor code”.Results: Nasal stuffiness, Foul smell and Facial pain and among others were the most coherent warning signs and symptoms observed among the patients in <2weeks of admission in ICU. Other observed predisposing risk factors were regular administration of...

F1000Research

Background Long-term chemical drug consumption to treat hypertension may have side effects becaus... more Background Long-term chemical drug consumption to treat hypertension may have side effects because the levels are sometimes difficult for the body to tolerate. Therefore, some people have used plants as herbal medicine, including avocado leaves (Persea americana Mill.) as antihypertensive. This study aims to find out the differences in the effectiveness of modern drugs and natural antihypertensive ingredients in avocado leaf extract (containing flavonoids and quercetin compounds) in inhibiting the ACE enzyme, which causes decreasing systolic blood pressure (SBP) and diastolic blood pressure (DBP) as well as increasing urine volume. Methods This study used an experimental in vivo study design involving 24 white male Wistar rats (Rattus norvegicus), aged 2–3 months, weighing 130–250 g, and of a healthy condition with active movement. The samples were randomly divided into six treatment groups and post-test only research design with control group design. Results The result of the study...

International Journal of English Literature and Social Sciences, 2021

The mRNA 1273 vaccine by Modernahas recorded to be94.1% effective against laboratoryconfirmed Cov... more The mRNA 1273 vaccine by Modernahas recorded to be94.1% effective against laboratoryconfirmed Covid-19 infection. Health care workers in Indonesia are receiving third-booster vaccine by Moderna after the two doses of virus-inactivated vaccine. Further evaluation of Covid-19 mRNA vaccine post-injection effects on health care workers is necessary. This present study asssessed the postimmunization adverse events tohealth care workersin the Port Health Office of Semarang.This was a retrospective, cross-sectional, observational study aimed to the HCWs, both staff and non-staff, of the Port Health Office of Semarang.We identified and analyzed the adverse effects on 132 workers who had been receiving third-mRNA booster vaccine by Moderna. About 37.8% (50 out of 132)respondents experienced adverse events after receiving third-booster vaccine by Moderna. Among them, female workers (62%) had more incidents compared to males (38%). the most common symptoms were localized painon injected arm (1...

E3S Web of Conferences, 2021

Coronavirus Disease-2019 (COVID-19) cases are still increasing, while the epidemiology data is st... more Coronavirus Disease-2019 (COVID-19) cases are still increasing, while the epidemiology data is still limited. This study’s purpose is to delineate characteristics of 31,407 COVID-19 patients in Central Java. This research involved secondary data acquired from the Health Office of Central Java, which was analysed univariately. The majority of the patients were 19-44-year-old (43.57%), females (50.81%), and private employees (10.53%). The most frequent symptoms were fever (18.85%), cough (18.19%), and shortness of breath (13.71%). Most of the cases were from Semarang City (17.2%), Kudus (6%), Jepara (6%), Demak (5.5%), and Kendal (4.3%), with an Incidence Rate (per 10,000) of 42.79; 14.53; 14.99; 14.90; and 13.84 respectively. Furthermore, most of the patients had no transit history (87.11%), while out of 25 of the foreign transit histories, the United States of America and China contributed 24% and 20%, sequentially. Three-fourths of the domestic transit history was in Central Java, ...

E3S Web of Conferences, 2020

Central Java reported 1,541 cases of Patients Under Surveillance until April 14th, 2020. It is ex... more Central Java reported 1,541 cases of Patients Under Surveillance until April 14th, 2020. It is expected to increase everyday. However, reports about the epidemiological characteristics of Patients Under Surveillance cases are still limited. This study aims to describe Patients Under Surveillance case of COVID-19. The study used quantitative descriptive design, whereas many as 1,541 cases were described based on the characteristics, contact history, history of transit, and the symptoms. The data are obtained from the Department of Health, Central Java and processed with descriptive statistical data analysis. Results showed from 1,541 cases as much as 59.9% were male and 43% aged 19-44 years. As many as 154 death cases were dominated by men (61.6%) and elderly ≥60 years (38.3%). The highest IR was Semarang (16.85/100,000 population). Symptoms that often found were cough, fever, dyspnea (8.3%), and 3.96% asymptomatic. The history of contact with the traveling person (4.7%). The most vi...

Bacillus thuringiensis israelensis merupakan bakteri yang toksik terhadap larva nyamuk Aedes aegy... more Bacillus thuringiensis israelensis merupakan bakteri yang toksik terhadap larva nyamuk Aedes aegypti. Namun kendala utama dalam produksi bioinsektisida adalah bahan baku media penumbuh yang masih impor. Sehingga diperlukan media penumbuh alternatif, salah satunya dengan menggunakan air perasan singkong. Tujian dari penelitian ini adalah mengetahui toksisitas isolat B. thuringiensis israelensis yang dibiakkan dalam air perasan singkong terhadap larva nyamuk Ae. aegypti. Jenis penelitian yang dgunakan adalah eksperimental dengan desain penelitian Posttest-only control group design. Populasi dalam penelitian ini adalah semua larva Ae. aegypti instar III. Perameter yang diamati yaiyu jumlah spora B. thuringiensis israelensisyang tumbuh pada media air perasan singkong dan mortalitas LC 50 dan LC 90 larva Ae. aegypti dengan analisis regresi probit. Konsentrasi yang dipakai dalam uji toksisitas adalah 0,89x10-3 ppm; 1,30x10-3 ppm; 1,49x10-3 ppm; 1,69x10-3 ppm; 2,20x10-3 ppm, 3,22x10-3 ppm dan 5,43x10-3 ppm.Hasil penelitian menunjukkan jumlah spora yang tumbuh pada mesdia air perasan singkong 1% yaitu sebanyak 230 x10 5 spora/ml. LC 50 dan LC 90 konsentrasi B. thuringiensis israelensis yaitu 3,674x10-3 ppm dan 14,254x10-3 ppm. Dari penelitian ini dapat disimpulkan bahwa B. thuringiensis israelensis yang dibiakkan dalam air perasan singkong toksik terhadap larva Ae. aegypti.

JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama

Rabies adalah penyakit zoonosis yang disebabkan oleh Lyssavirus yang ditularkan melalui gigitan h... more Rabies adalah penyakit zoonosis yang disebabkan oleh Lyssavirus yang ditularkan melalui gigitan hewan penular rabies seperti anjing, kucing, monyet, dan kelelawar. Namun belum diketahui jalur penularan rabies di Kabupaten Dompu. Penelitian ini bertujuan untuk menilai risiko pelepasan rabies. Penilaian risiko pelepasan rabies di Distrik Dompu menggunakan standar analisis risiko Office International des Epizooties (OIE). Teknik pengambilan sampel dalam penelitian ini dilakukan secara purposive sampling. Data yang dikumpulkan dibuat dalam pohon skenario. untuk mengetahui risiko perhitungan yang digunakan yang merujuk pada Biosecurity Australia dan memetakan jalur pelepasan rabies menggunakan ArcGIS® Versi 10.3. Perhitungan penilaian pelepasan kemungkinan risiko rabies di darat tinggi. Sementara kemungkinan risiko melepaskan rabies melalui kapal yang masuk dan keluar dapat diabaikan. Peluang penyebaran rabies di Kabupaten Dompu menunjukkan bahwa kurangnya pengawasan pelabuhan dan perger...

Jurnal Epidemiologi Kesehatan Komunitas

Background: Several regions in Indonesia are classified as leptospirosis endemic including Klaten... more Background: Several regions in Indonesia are classified as leptospirosis endemic including Klaten Regency, which ranked 2nd highest case of leptospirosis in Central Java in 2018. Leptospirosis in human was transmitted by animals infected by the Leptospira bacteria, which rat was the main reservoir. This study aimed to identify rat reservoir to the existence of Leptospira bacteria in endemic areas.Methods: This study was an observational survey with cross sectional approach. The sample was rats caught by traps installed for 6 days in Dukuh Kalitengah, Kalitengah Village, Wedi Subdistrict, Klaten Regency in July 2019. The rats were identified and dissected to take their kidneys for laboratory testing using the Polymerase Chain Reaction (PCR) test to identity the existence of Leptospira bacteria.Result: The result showed that there were 17 rats and 6 Suncus murinus caught in 6 days and their species were Mus musculus (23.5%), Rattus tanezumi (41.2%), Rattus norvegicus (35.3%). The res...

Jurnal Epidemiologi Kesehatan Komunitas

Background: One of the causes of antibiotic resistance is the presence of antibiotic residues in ... more Background: One of the causes of antibiotic resistance is the presence of antibiotic residues in livestock, one of which is broiler chicken meat. Excessive use of antibiotics and not in accordance with the diagnosis will result in the discovery of antibiotic residue content in chicken meat and will endanger public health. The purpose of this study was to determine the description of the antibiotic residues of tetracycline in broiler chicken meat sold in traditional and modern markets in Jati District, Kudus Regency.Methods: This type of research is a descriptive observational study with a cross-sectional approach. The samples in this study were all broiler chicken meat sold in traditional markets (Bitingan Market, Sunggingan Ploso Market, and Baru Market) and in the modern Hypermart market with a total sample of 78 samples of broiler chicken meat taken with total population sampling technique. Sample testing was carried out at Balai Veteriner Boyolali using the Bioassay method.Resul...

Jurnal Epidemiologi Kesehatan Komunitas

Background: The rate of COVID-19 cases is still high in Jayapura City to date in one day it can c... more Background: The rate of COVID-19 cases is still high in Jayapura City to date in one day it can contribute 30 to 35 positive patients. The form of prevention behavior in students has not been optimally implemented. the addition of positive cases every day can be triggered due to the lack of information related to the corona virus. The purpose of this study was to describe the behavioral factors to prevent COVID-19 in students.Methods: The population in this study were students of Cenderawasih University, Jayapura City. The study was conducted in January – February 2021 on 100 subjects selected by purposive sampling technique. Subjects were measured using an online questionnaire containing questions and statements regarding research variables such as knowledge, attitudes, practices, sources of information, social support and support from health workers. Data were analyzed by univariate analysis and bivariate analysis.Result: The results showed that 67% of students' level of knowl...

Jurnal Epidemiologi Kesehatan Komunitas

ABSTRACTBackground: Complete basic immunization coverage in Indonesia in the last five years has ... more ABSTRACTBackground: Complete basic immunization coverage in Indonesia in the last five years has not reached the target set in the Ministry of Health's Strategic Plan. Public health center as the operator of immunization operations must be supported by the implementation of a good health management function. The purpose of this study was to analyze the influence of facilitating factors, enabling factors, reinforcing factors and factorsthat influence mothers in carrying out complete basic immunization for children in relation to UCI achievement at Miroto Public Health Center, Central Semarang District, Semarang City.Methods: This study is analitic observational research with cross-sectional study design. The population of this research is mothers who have a minimum age of 1 under five who reside at Miroto Health Center. The research sample was 50 mothers with simple random sampling technique. Processing and data analysis with quantitative methods with univariate and bivariate ana...