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Journal of Equine Science, 2002
ABSTRACT We report four cases resembling Australian stringhalt observed for the first time in Jap... more ABSTRACT We report four cases resembling Australian stringhalt observed for the first time in Japan. Between June and July 2000, three of four 4-year-old thoroughbred mares that had been grazed on the same pasture suddenly suffered exaggerated flexion of both hindlimbs. Subsequently, the remaining horse also exhibited mild stringhalt in October. The last horse recovered without treatment one month after occurrence, but the other three horses exhibited severe stringhalt even 5-6 months after occurrence. In one horse, endoscopic examination revealed a left laryngeal hemiplegia. Three of four cases were treated with a combination of drug based treatment (baclofen and phenytoin) and exercise. While phenytoin was effective in treating the stringhalt, the baclofen had no effect. Once the stringhalt improved, treadmill exercise was started to improve hindlimb function. As a result, two of the three horses were able to canter. Three cases underwent electromyography examination and motion analysis. Before treatment, high amplitude electric discharges were observed in the long digital extensor muscle and the lateral digital extensor muscle in the swing and stance phase. The angle of each joint flexed extensively in the swing phase. While Australian stringhalt may heal spontaneously over time, therapy with phenytoin and exercise may hasten a cure.
Veterinary Parasitology, 2005
Serum samples from 145 dairy and 65 beef cattle with reproductive disorders and 54 normally calvi... more Serum samples from 145 dairy and 65 beef cattle with reproductive disorders and 54 normally calving dairy cattle (controls) in Japan were tested for presence of Neospora caninum antibodies by use of an indirect fluorescent antibody test (IFAT, titer 1:200). Overall, seroprevalence of N. caninum was significantly higher (P < 0.001) in dairy cattle (20.0%, 29/145) than in beef cattle (1.5%, 1/65). In cattle which aborted, seroprevalence of N. caninum was significantly higher (P = 0.041) in dairy cattle (26.1%, 23/88, compared with controls (3.7%, 2/54)) than in beef cattle (5.0%, 1/20), indicating that neosporosis might be a more common problem in dairy cattle than in beef cattle in Japan. Seropositive cattle were 9.2 times more likely to abort compared to seronegative cows. Abortions associated with N. caninum seropositivity in this study were most frequently observed in the second trimester, and the mean gestational age of the fetuses aborted from seropositive dams was 5.7 months. In conclusions, N. caninum seems to be causing serious economic losses in the dairy industry in Japan. This is the first report on an objective comparison of seroprevalence of dairy and beef cattle with reproductive disorders in Asia. #
Bone and Mineral, 1994
We investigated the androgen receptor (AR), metabolism and effects of androgens in osteoblastic M... more We investigated the androgen receptor (AR), metabolism and effects of androgens in osteoblastic MC3T3-E1 cells. AR was proved as a transcript of a 10-kb mRNA and as a 110-kDa protein. An immunocytochemical study showed that AR was located mainly in the nuclei. Specific binding of [3H]DHT was observed in both the nuclear and cytosol fractions. MC3T3-E1 cells possessed approximately 1190 binding sites per cell and most of the sites (1150 sites) situated in the nucleus. The apparent Kd value in the nuclear fraction was 1.35 nM for [3H]DHT binding, and it was similar to that for [3H]testosterone. In the competition analysis, there was not much difference in the displacement of the [3H]DHT binding from AR between the addition of radioinert DHT and testosterone. In studies of 5 alpha-reductase activity and aromatase activity of the cells, both activities were lower than the respective values in classical androgen target tissues. Androgens stimulated the incorporation of [3H]thymidine into the cell, and DHT and testosterone had a similar potency on the cell proliferation. Thus, these results suggest testosterone itself acts mainly on the osteoblasts without conversion to DHT.
Internal Medicine, 1994
We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-year-old wo... more We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-year-old woman who had a parathyroid adenoma. Her older sister had a parathyroid adenoma with cementifying jaw fibroma and her younger sister died of parathyroid adenocarcinoma with pulmonary metastasis at the age of 38. We have not yet obtained evidence for other endocrine disorders suggesting multiple endocrine neoplasia (MEN) in this pedigree. The proband is complicated with Wilms' tumor. It is now widely accepted that respective predisposed genes of MEN type 1 and Wilms' tumor, and PTH gene are located on chromosome 11. The manifestation observed in this case may be related to mutational abnormalities on chromosome 11.
IEEE Transactions on Electron Devices, 2006
In this paper, the potential for sub-10-nm junction formation of partial-melt laser annealing (PM... more In this paper, the potential for sub-10-nm junction formation of partial-melt laser annealing (PMLA), which is a combination of solid-phase regrowth and heat-assisted laser annealing (HALA), is demonstrated. HALA and PMLA are effective for reducing laser-energy density for dopant activation and for improving heating uniformity of device structure. The absence of melting at the dopant profile tail for PMLA results in a negligibly small diffusion at this region. A high activation rate is achievable by melting the upper part of the amorphous-silicon layer. The obtained sheet resistance of 10-nm-deep junctions was about 700 Ω/sq. for both n + /p and p + /n junctions. These results imply that PMLA is applicable for much shallower junction formation.
Sesungguhnya adab yang paling agung, yang mencakup seluruh adab Islami, baik perkataan maupun per... more Sesungguhnya adab yang paling agung, yang mencakup seluruh adab Islami, baik perkataan maupun perbuatan, yang menatanya, mendorong kepadanya, merumuskan langkah-langkah dan perinciannya adalah adab kepada Allah Subhanahu wa Ta"ala dan Rasul-Nya shallallahu "alaihi wa sallam. Karena pada hakikatnya, itulah agama secara menyeluruh. Oleh karena itu, saya menjadikannya sebagai pembuka pasal-pasal buku ini agar menjadi pedoman dan pendorong kepadanya.
Journal of Equine Science, 2002
ABSTRACT We report four cases resembling Australian stringhalt observed for the first time in Jap... more ABSTRACT We report four cases resembling Australian stringhalt observed for the first time in Japan. Between June and July 2000, three of four 4-year-old thoroughbred mares that had been grazed on the same pasture suddenly suffered exaggerated flexion of both hindlimbs. Subsequently, the remaining horse also exhibited mild stringhalt in October. The last horse recovered without treatment one month after occurrence, but the other three horses exhibited severe stringhalt even 5-6 months after occurrence. In one horse, endoscopic examination revealed a left laryngeal hemiplegia. Three of four cases were treated with a combination of drug based treatment (baclofen and phenytoin) and exercise. While phenytoin was effective in treating the stringhalt, the baclofen had no effect. Once the stringhalt improved, treadmill exercise was started to improve hindlimb function. As a result, two of the three horses were able to canter. Three cases underwent electromyography examination and motion analysis. Before treatment, high amplitude electric discharges were observed in the long digital extensor muscle and the lateral digital extensor muscle in the swing and stance phase. The angle of each joint flexed extensively in the swing phase. While Australian stringhalt may heal spontaneously over time, therapy with phenytoin and exercise may hasten a cure.
Veterinary Parasitology, 2005
Serum samples from 145 dairy and 65 beef cattle with reproductive disorders and 54 normally calvi... more Serum samples from 145 dairy and 65 beef cattle with reproductive disorders and 54 normally calving dairy cattle (controls) in Japan were tested for presence of Neospora caninum antibodies by use of an indirect fluorescent antibody test (IFAT, titer 1:200). Overall, seroprevalence of N. caninum was significantly higher (P < 0.001) in dairy cattle (20.0%, 29/145) than in beef cattle (1.5%, 1/65). In cattle which aborted, seroprevalence of N. caninum was significantly higher (P = 0.041) in dairy cattle (26.1%, 23/88, compared with controls (3.7%, 2/54)) than in beef cattle (5.0%, 1/20), indicating that neosporosis might be a more common problem in dairy cattle than in beef cattle in Japan. Seropositive cattle were 9.2 times more likely to abort compared to seronegative cows. Abortions associated with N. caninum seropositivity in this study were most frequently observed in the second trimester, and the mean gestational age of the fetuses aborted from seropositive dams was 5.7 months. In conclusions, N. caninum seems to be causing serious economic losses in the dairy industry in Japan. This is the first report on an objective comparison of seroprevalence of dairy and beef cattle with reproductive disorders in Asia. #
Bone and Mineral, 1994
We investigated the androgen receptor (AR), metabolism and effects of androgens in osteoblastic M... more We investigated the androgen receptor (AR), metabolism and effects of androgens in osteoblastic MC3T3-E1 cells. AR was proved as a transcript of a 10-kb mRNA and as a 110-kDa protein. An immunocytochemical study showed that AR was located mainly in the nuclei. Specific binding of [3H]DHT was observed in both the nuclear and cytosol fractions. MC3T3-E1 cells possessed approximately 1190 binding sites per cell and most of the sites (1150 sites) situated in the nucleus. The apparent Kd value in the nuclear fraction was 1.35 nM for [3H]DHT binding, and it was similar to that for [3H]testosterone. In the competition analysis, there was not much difference in the displacement of the [3H]DHT binding from AR between the addition of radioinert DHT and testosterone. In studies of 5 alpha-reductase activity and aromatase activity of the cells, both activities were lower than the respective values in classical androgen target tissues. Androgens stimulated the incorporation of [3H]thymidine into the cell, and DHT and testosterone had a similar potency on the cell proliferation. Thus, these results suggest testosterone itself acts mainly on the osteoblasts without conversion to DHT.
Internal Medicine, 1994
We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-year-old wo... more We describe a familial occurrence of primary hyperparathyroidism. The proband is a 60-year-old woman who had a parathyroid adenoma. Her older sister had a parathyroid adenoma with cementifying jaw fibroma and her younger sister died of parathyroid adenocarcinoma with pulmonary metastasis at the age of 38. We have not yet obtained evidence for other endocrine disorders suggesting multiple endocrine neoplasia (MEN) in this pedigree. The proband is complicated with Wilms' tumor. It is now widely accepted that respective predisposed genes of MEN type 1 and Wilms' tumor, and PTH gene are located on chromosome 11. The manifestation observed in this case may be related to mutational abnormalities on chromosome 11.
IEEE Transactions on Electron Devices, 2006
In this paper, the potential for sub-10-nm junction formation of partial-melt laser annealing (PM... more In this paper, the potential for sub-10-nm junction formation of partial-melt laser annealing (PMLA), which is a combination of solid-phase regrowth and heat-assisted laser annealing (HALA), is demonstrated. HALA and PMLA are effective for reducing laser-energy density for dopant activation and for improving heating uniformity of device structure. The absence of melting at the dopant profile tail for PMLA results in a negligibly small diffusion at this region. A high activation rate is achievable by melting the upper part of the amorphous-silicon layer. The obtained sheet resistance of 10-nm-deep junctions was about 700 Ω/sq. for both n + /p and p + /n junctions. These results imply that PMLA is applicable for much shallower junction formation.
Sesungguhnya adab yang paling agung, yang mencakup seluruh adab Islami, baik perkataan maupun per... more Sesungguhnya adab yang paling agung, yang mencakup seluruh adab Islami, baik perkataan maupun perbuatan, yang menatanya, mendorong kepadanya, merumuskan langkah-langkah dan perinciannya adalah adab kepada Allah Subhanahu wa Ta"ala dan Rasul-Nya shallallahu "alaihi wa sallam. Karena pada hakikatnya, itulah agama secara menyeluruh. Oleh karena itu, saya menjadikannya sebagai pembuka pasal-pasal buku ini agar menjadi pedoman dan pendorong kepadanya.