fügen aker - Academia.edu (original) (raw)

Papers by fügen aker

JAMA: The Journal of the American Medical Association, 1963

Textiloma is a term used for retained cottonoid or surgical sponge in the operation field. Althou... more Textiloma is a term used for retained cottonoid or surgical sponge in the operation field. Although they occur mostly after thoracic or abdominal operation, they can also be encountered after surgery of extremities or the spine. There are few reports of spinal cases in which MR and CT imaging findings of textilomas have been described. In this report, two additional cases with MR, CT and pathological features of paraspinal textilomas are described. CT image demonstrated a paraspinal mass simulating a malignant tumour. While T1-weighted MR images showed the masses with low signal intensity, T2-weighted MR images showed heterogeneous masses with low and high signal intensities.

Annals of Neurosurgery, 2001

Acta Dermato-Venereologica, 2000

Acta Cytologica, 2012

Objective: To evaluate cytologic features of mammary myofibroblastoma in order to establish the p... more Objective: To evaluate cytologic features of mammary myofibroblastoma in order to establish the possibility of precise preoperative recognition. Study Design: This was a multi-institutional study of 6 patients with myofibroblastoma (5 men and 1 woman) in which preoperatively fine-needle aspiration cytology was performed. Four cases showed classical histologic features, 1 corresponded to the cellular variant and the remaining 1 to the fibrous form. Results: Except for 1 case, smears were cellular and distributed as irregular aggregates and single cells. Most groups showed a small amount of metachromatic stroma and capillaries. Cells retained cytoplasm and showed a spindle-to-plump oval morphology with moderate pleomorphism. Nuclear pleomorphism was present and was relevant in 1 case. Intranuclear pseudoinclusions and mast cells were present in 3 cases. No epithelial clusters were seen. Due to hypercellularity and pleomorphism 1 case was considered as suspicious for malignancy. The re...

Asian Journal of Neurosurgery

Objective: The aim of this study is to evaluate the demographic, radiological and histopathologic... more Objective: The aim of this study is to evaluate the demographic, radiological and histopathological findings, tumoral biomarkers, and survival rates of patients who underwent a stereotactic brain biopsy and those diagnosed with glioblastoma, metastasis, and lymphoma, and the changes in the diagnosis distribution over the years. Materials and Methods: The patients who underwent stereotactic biopsy in our clinic between 2012 and 2020 were evaluated retrospectively. Metastasis, glioblastoma, and lymphoma cases were evaluated as three main groups and the others were excluded. P53 gene expression, isocitrate dehydrogenase (IDH) mutation, and Ki-67 values in glioblastoma cases and Bcl-2, Bcl-6 proteins, and Ki-67 values in lymphomas and their relationship with survival were evaluated. Results: High p53 expression was observed in 27.5% cases diagnosed with glioblastoma. IDH mutation was negative in all glioblastoma cases. Presence of Bcl-2 and Bcl-6 proteins was not associated with surviva...

Acta Orthopaedica et Traumatologica Turcica, 2014

The aim of this study was to determine the effects of resveratrol on the tendon healing process o... more The aim of this study was to determine the effects of resveratrol on the tendon healing process of streptozotocin-induced diabetic rats. The study included 16 male Sprague-Dawley rats. Streptozotocin was administered to induce diabetes and bilateral tenorrhaphy of the Achilles tendons was performed. Intraperitoneal resveratrol was injected in the experimental group (n=8) and saline in the control group (n=8) during the postoperative period. Rats were sacrificed at the 14th day. Right side tendons were evaluated biomechanically and left side tendons histologically. Difference in mean tendon tensile strength was not statistically significant between groups (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;0.05). Histologic evaluations of the repair zones showed greater configuration of the newly synthesized collagen in the experimental group. The ratio of the newly synthesized collagen area to the healing region area was significantly higher in the experimental group then the control group (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01). Resveratrol appears to have a positive impact on the process of tendon healing in diabetic conditions in the first 14 days.

Journal of Plastic Surgery and Hand Surgery, Dec 6, 2013

Resveratrol is an antioxidant agent with multiple positive impacts on the body. It is known to ha... more Resveratrol is an antioxidant agent with multiple positive impacts on the body. It is known to have anti-diabetic, anti-inflammatory, anti-carcinogenic, and neuroprotective effects. The goal of this study is to demonstrate the antioxidant and anti-diabetic effects of resveratrol on flap survival in diabetic rats. Streptozotocin-induced diabetic Sprague-Dawley albino rats were treated with 10 mg/kg resveratrol following a flap surgery. Histological findings regarding polymorphonuclear leukocyte (PMNL) density, vascular proliferation, fibroblast density, and tissue necrosis were compared between resveratrol-treated and control rats. Significantly higher PMNL density was found in the control group (p = 0.005); while vascular proliferation and the fibroblast density were higher in the resveratrol group (p = 0.004 and p = 0.021, respectively). Collagen density was also higher in the resveratrol group and the difference has statistical significance (p = 0.024). Lymphocyte density was not significantly different between groups (p = 0.061). When the necrosis in the distal areas was evaluated histologically, 20% of the resveratrol group had epidermal tissue necrosis, thus 90% of the control group had epidermal or full-layer necrosis. Resveratrol improved flap survival significantly in diabetic rats. Therefore, diabetic patients requiring complex reconstructive procedures may benefit from resveratrol; so, clinical trials are required to support this study.

Türk Patoloji Dergisi, 2022

BACKGROUND: Programmed cell death ligand 1 (PD-L1) expression by the 22C3 pharmDx companion assay... more BACKGROUND: Programmed cell death ligand 1 (PD-L1) expression by the 22C3 pharmDx companion assay has been validated in surgical specimens to support pembrolizumab treatment decisions for patients with non-small cell lung carcinoma (NSCLC). The aims of this study were 1) to assess the adequacy of cytologic specimens for PD-L1 evaluation and 2) to explore correlations of PD-L1 expression with clinicopathologic and molecular features. METHODS: The study cohort included 100 cytology specimens (fluid [n = 28] and fine-needle aspiration [n = 72]) and 165 surgical specimens (biopsy [n = 138] and resection [n = 27]). The PD-L1 immunohistochemistry 22C3 assay and staining assessment were performed according to the manufacturer's instructions. PD-L1 expression was correlated with patients' demographics, pathologic characteristics, and molecular alterations. RESULTS: One hundred forty-two specimens (53.6%) were positive for PD-L1 expression (≥1%). No statistically significant difference in PD-L1 expression was identified between cytologic (56.0%) and surgical specimens (52.1%). Seventy-four of 190 tested cases (38.9%) had genetic alterations. PD-L1 positivity was significantly more prevalent in cases with genetic alterations than in cases without genetic alterations. Furthermore, both PD-L1 positivity and high PD-L1 expression (≥50%) had statistically significant associations with Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. PD-L1 expression had no significant association with histologic phenotypes or other clinicopathologic features. CONCLUSIONS: The data indicate that cytologic specimens are comparable to surgical specimens for PD-L1 evaluation. The association of PD-L1 expression with KRAS mutations may have clinical relevance in selecting patients with NSCLC for immunotherapy. Cancer Cytopathol 2019;0:1-11.

International Surgery, May 1, 2018

Gastrointestinal duplication cysts are rare lesions that typically present with acute abdomen in ... more Gastrointestinal duplication cysts are rare lesions that typically present with acute abdomen in childhood. They are rare in adults, with only a few adult cases having been reported thus far. Adults with these lesions are usually asymptomatic or manifest with subtle abdominal symptoms. They may, however, also present with obstruction, bleeding, perforation, or malignancy. Herein, we aimed to report a case of ileal duplication cyst at adult age that presenting with symptoms of acute abdomen and reviewed the reported cases of adult age duplication cysts.

Diagnostic Cytopathology, Sep 16, 2020

“Lingual actinomycosis” is an uncommon, suppurative inflammation of lingual mucosa, caused by Act... more “Lingual actinomycosis” is an uncommon, suppurative inflammation of lingual mucosa, caused by Actinomyces. Infectious oral lesions can mimic benign or malignant neoplasms and fine needle aspiration cytology (FNAC) is a simple, minimally invasive procedure for the assessment of patients with such lesions. Here, we describe the case of a 28‐year old patient presented with an asymptomatic, submucosal nodular mass of the tongue. Then, FNAC was performed by an experienced fine needle aspiration (FNA) pathologist (*) in our pathology department and the lesion diagnosed with actinomycosis. We also report a detailed review of cases in the literature, with clinical findings.

Marmara Medical Journal, 1997

We present a case of gastric glomus tumor (GGT). It is an unusual benign neoplasm of the stomach ... more We present a case of gastric glomus tumor (GGT). It is an unusual benign neoplasm of the stomach which can easily be confused with the other benign tumors such as leiomyoma. In this case report, most prominent diagnostic features of the gastric glomus tumor were reported. We also defined the computerized tomographic features of the GGT for the first time. Local excision of the tumor was carried out as an appropriate procedure for the treatment of the patient.

Renal Failure, Jan 10, 2011

Introduction: Organic solvents are liquid substances commonly used in everyday life at home and i... more Introduction: Organic solvents are liquid substances commonly used in everyday life at home and in industrial workplaces. These solvents are found primarily in paint as thinner. Because other narcotics are hard to find, thinner is used as a narcotic especially among youngsters of low socioeconomic level. The aim of this study is to determine the histopathological changes of rat kidney with exposure to chronic thinner inhalation. Methods: Randomized trial-the study was conducted at the animal care facility of Haydarpasa Numune Education and Research Hospital. Forty albino Wistar male rats were used throughout the experiment. Three groups of rats inhaled thinner in a glass cage for 1, 3, and 5 weeks, respectively. Ten rats inhaled only the air in the room as the control group. Results: We observed the development of inflammation in the kidneys that became more remarkable as exposure time extended. Development of inflammation because of thinner apparently differed between the groups of week 1 and week 5. There was no difference in granuloma development. If the experiment lasted longer, there might have been granuloma development. Conclusions: Based on histopathological evaluations, it was shown that exposure to chronic thinner inhalation causes detectable damage on the kidney, which becomes more prominent as exposure period extends. As we established disorders in movement and consciousness in the rats during thinner inhalation, we can conclude that thinner also has a damaging effect upon the central nervous system.

Diagnostic Cytopathology

BackgroundThe diagnostic performance of cytology was compared with the frozen results and its usa... more BackgroundThe diagnostic performance of cytology was compared with the frozen results and its usability was evaluated as a rapid diagnosis method in intraoperative thoracic surgery in a single institution (Istanbul, Turkey).MethodsAll 197 subsequent patient specimens (cases) from 158 patients who were sent to our department from the thoracic surgery clinic for an intraoperative diagnosis request between the years 2016 and 2021 were evaluated. Obtained results from frozen and cytology were compared with final paraffin section diagnoses. Lesions were grouped into three different groups as nonneoplastic, benign, and malignant neoplasms.ResultsDiagnostic accuracy values of cytology and frozen sections in intraoperative consultation were 98.8% and 99.4%, respectively. Sensitivity values of cytology and frozen sections in intraoperative consultation were 96.3% and 98.7%, respectively. Specificity values of cytology and frozen sections in intraoperative consultation were 100% and 100%, res...

Acta Orthopaedica et Traumatologica Turcica, 2000

Turkish Neurosurgery, 1998

An unusual ease of two primary brain tumors, meningioma and glioblastoma adjacent in the brain is... more An unusual ease of two primary brain tumors, meningioma and glioblastoma adjacent in the brain is presented. The cause of such combined tumors is uncertain. Simple coincidence may be the likely explanation in most cases, because both meningiomas and gliomas are relatively common. Preoperatively, these two separate lesions were detected on computerized tomography and magnetic resonance scans. Gross total removal of both tumors was accomplished at a single operation. The modern imaging methods such as computerized tomography and magnetic resonance not only provide the conditions for a better diagnosis before the operation but also direct the operation plan to excise both tumors in one procedure.

Journal of Cytology, 2022

Context: Diagnosis of papillary lesions of the breast by fine needle aspiration cytology (FNAC) i... more Context: Diagnosis of papillary lesions of the breast by fine needle aspiration cytology (FNAC) is problematic. For this reason, it is situated in the indeterminate zone in classification systems. Aims: To ascertain the accuracy of cytological diagnosis of papillary lesions in distinguishing papillary lesions from non-papillary lesions and to determine whether papillomas can be reliably distinguished from malignant papillary lesions by FNAC. Material and Methods: A total of 346 cases with the diagnoses of breast papillary lesions were selected among 5112 breast FNAC procedures performed in our center. One hundred and thirty-nine cases with excised lesions were included in this study, and their corresponding histology was reviewed. Results: Papillary lesion diagnosis was confirmed by histopathology in 103 (74.1%) of 139 patients. Cytology and histopathology results were not found to be compatible in 35 (25.2%) cases. The diagnostic accuracy of distinguishing papillary breast lesions ...

Journal of the College of Physicians and Surgeons Pakistan, 2022

Objective: To evaluate the effect of FDG-PET/CT in the radiological imaging of breast cancer (BC)... more Objective: To evaluate the effect of FDG-PET/CT in the radiological imaging of breast cancer (BC) patients planned for neoadjuvant treatment (NAT), on the clinical prognostic stage (CPS). Study Design: A descriptive study.

Overin monodermal teratomlari icerisinde en yaygin olani struma ovari olmakla birlikte tamamen ki... more Overin monodermal teratomlari icerisinde en yaygin olani struma ovari olmakla birlikte tamamen kistik struma ovari nadir olup, genellikle fokal alanda tiroid dokusu icermesi tam guclukleri yaratabilmektedir. 38 ve 67 yaslarindaki iki kadin hastada kistik struma ovari saptanmis olup, literatur bulgulari esliginde tartisilmistir.

ACS Biomaterials Science & Engineering, 2017

Polypropylene (PP) mesh has been widely used in hernia fixation operations for more than one hund... more Polypropylene (PP) mesh has been widely used in hernia fixation operations for more than one hundred years. On the other hand, peritoneal adhesion is still one of the main complications after hernia fixation operations. For preventing peritoneal adhesion, many solutions have been offered until today, such as gel systems, adhesion barrier membranes and bilayer meshes. Among these, bilayer meshes come to the forefront as they serve both for hernia repair and for adhesion prevention. In this study, we developed an easy and effective method to produce a multifunctional PP-integrated bilayer mesh which is composed of poly(lactide-co-glycolide) (PLGA) and chitosan, with no need for neutralization. We made the composite mesh by electrospinning a layer onto the PP mesh. We evaluated the material characteristics, in vitro bactericidal activities and the interactions between the cells and the materials. Then, we conducted in vivo efficiency studies. The results proved that the PPintegrated bilayer composite mesh is bactericidal against E.coli and S.aureus, and is tissuecompatible and it supremely prevents adhesion.