faiza shafi - Academia.edu (original) (raw)

Papers by faiza shafi

Research paper thumbnail of Rectal Versus Oral Analgesia for Perineal Pain Relief After Childbirth

Journal of Rawalpindi Medical College, 2011

Background: To compare the efficacy of rectally administered diclofenac sodium with orally admini... more Background: To compare the efficacy of rectally administered diclofenac sodium with orally administered mefenamic acid for relief of perineal pain associated with childbirth. Methods: In this randomized control trial, 324 women were randomly allocated in two groups(Group A and B) of 162 each. Groups A patients received diclofenac rectal suppositories and group B patients received oral mefenamic acid. Treatment packs contained either two 50mg diclofenac suppositories or mefenamic acid tablets 500mg. First suppository being inserted when suturing was complete, and second was offered 12-24 hours after birth. Women in group B were given oral mefenamic acid tablets 08 hourly. Women were asked to complete questionnaire at 24 and 48 hours, after birth, relating to their pain relief using validated short form of McGill pain questionnaire Results: There was statistically significant difference between the two groups for sensory, affective and total pain scores at rest or with movement at 24 ...

Research paper thumbnail of A study of maternal mortality in 8 principal hospitals in Pakistan in 2009

International Journal of Gynecology & Obstetrics, 2011

Objectives: To determine maternal mortality to assess the achievement of Millennium Development G... more Objectives: To determine maternal mortality to assess the achievement of Millennium Development Goal 5 in Pakistan and suggest remedial measures. Methods: Throughout 2009, maternal deaths occurring in obstetrics and gynecology departments in 8 hospitals in Rawalpindi and Islamabad, Pakistan, were recorded. A data form was filled in by the duty registrar at the time of death. Data were analyzed via SPSS. Results: During the study period, there were 47 209 live births and 108 maternal deaths (age 17-45 years). Among those who died, 30% were primigravidas, 50% had a parity of 1-4, and 20% had a parity of 5 or more; 20.4% had not delivered, 40.7% had vaginal delivery, and 36.1% had cesarean delivery; 67.6% were unbooked and 32.4% were booked (14 under care of a consultant and 21 under care of a medical officer); 73%, 22%, and 5% died in the first, second, and third trimesters, respectively; 17.5% died prenatally, 4.6% during labor, and 78% postpartum; 73% were in a critical condition and 8% were dead on arrival. Eclampsia, postpartum hemorrhage, and sepsis caused 23, 13, and 13 deaths, respectively. Conclusion: Maternal death can be effectively managed by skilled care during pregnancy, childbirth, and the postnatal period.

Research paper thumbnail of Phytochemical Screening and Anthelmintic Activity of Leafand Seed Extract of Cassia Occidentelis L

Eurasian Journal of Biological and Chemical Sciences, 2021

In present study the ethanolic extracts of leaf and seed of Cassia occidentalis were investigated... more In present study the ethanolic extracts of leaf and seed of Cassia occidentalis were investigated for their phytochemical properties and anthelmintic activity against Haemonchus controtus at different concentrations (100, 150, 200 mg/ml). Alkaloids, flavonoids, saponins, tannins, phenols, steroids and carbohydrates are present in both leaf and seeds crude extracts. The study is mainly concerned with the determination of time of paralysis and time of death of the worms. When there was a gradual increase in the dose, a gradual increase in the anthelmintic activity was observed. The least time for the death and paralysis was recorded at concentration of 50 mg/mL and maximum time for death and paralysis was recorded at 10mg/mL concentration. The ethanolic extract of the leaf and seed showed a significant anthelmintic activity at highest concentration of 50 mg/ml. So the C. occidentalis plant can be used as anthelmintic drug for the treatment of gastrointestinal helminthic infections after clinical trials, toxicological effects and isolation of chemical compounds.

Research paper thumbnail of Poor response to direct-acting antiviral therapy in HCV-infected elderly population: a real-life cohort study based on GeneXpert® technology

Future Virology, 2018

Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different eth... more Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different ethnicities and elderly population of Pakistan. Methods: We used GeneXpert® technology to quantify HCV RNA and evaluated treatment response in different cohorts that included HCV patients classified on the basis of their age-group and ethnicity. Results: The findings of our study suggest that 76% of nonresponder patients were older than 55 years of age which shows that age is the predictor of treatment outcome of direct-acting antiviral drugs. In addition to this, no differences were observed in overall efficacy by ethnicity. Conclusion: Treatment-regimen sofosbuvir+ribavirin has a limited effect on older patients; therefore, practitioners and healthcare professionals need to reconsider treatment options for elderly populations.

Research paper thumbnail of Rectal Versus Oral Analgesia for Perineal Pain Relief After Childbirth

Journal of Rawalpindi Medical College, 2011

Background: To compare the efficacy of rectally administered diclofenac sodium with orally admini... more Background: To compare the efficacy of rectally administered diclofenac sodium with orally administered mefenamic acid for relief of perineal pain associated with childbirth. Methods: In this randomized control trial, 324 women were randomly allocated in two groups(Group A and B) of 162 each. Groups A patients received diclofenac rectal suppositories and group B patients received oral mefenamic acid. Treatment packs contained either two 50mg diclofenac suppositories or mefenamic acid tablets 500mg. First suppository being inserted when suturing was complete, and second was offered 12-24 hours after birth. Women in group B were given oral mefenamic acid tablets 08 hourly. Women were asked to complete questionnaire at 24 and 48 hours, after birth, relating to their pain relief using validated short form of McGill pain questionnaire Results: There was statistically significant difference between the two groups for sensory, affective and total pain scores at rest or with movement at 24 ...

Research paper thumbnail of A study of maternal mortality in 8 principal hospitals in Pakistan in 2009

International Journal of Gynecology & Obstetrics, 2011

Objectives: To determine maternal mortality to assess the achievement of Millennium Development G... more Objectives: To determine maternal mortality to assess the achievement of Millennium Development Goal 5 in Pakistan and suggest remedial measures. Methods: Throughout 2009, maternal deaths occurring in obstetrics and gynecology departments in 8 hospitals in Rawalpindi and Islamabad, Pakistan, were recorded. A data form was filled in by the duty registrar at the time of death. Data were analyzed via SPSS. Results: During the study period, there were 47 209 live births and 108 maternal deaths (age 17-45 years). Among those who died, 30% were primigravidas, 50% had a parity of 1-4, and 20% had a parity of 5 or more; 20.4% had not delivered, 40.7% had vaginal delivery, and 36.1% had cesarean delivery; 67.6% were unbooked and 32.4% were booked (14 under care of a consultant and 21 under care of a medical officer); 73%, 22%, and 5% died in the first, second, and third trimesters, respectively; 17.5% died prenatally, 4.6% during labor, and 78% postpartum; 73% were in a critical condition and 8% were dead on arrival. Eclampsia, postpartum hemorrhage, and sepsis caused 23, 13, and 13 deaths, respectively. Conclusion: Maternal death can be effectively managed by skilled care during pregnancy, childbirth, and the postnatal period.

Research paper thumbnail of Phytochemical Screening and Anthelmintic Activity of Leafand Seed Extract of Cassia Occidentelis L

Eurasian Journal of Biological and Chemical Sciences, 2021

In present study the ethanolic extracts of leaf and seed of Cassia occidentalis were investigated... more In present study the ethanolic extracts of leaf and seed of Cassia occidentalis were investigated for their phytochemical properties and anthelmintic activity against Haemonchus controtus at different concentrations (100, 150, 200 mg/ml). Alkaloids, flavonoids, saponins, tannins, phenols, steroids and carbohydrates are present in both leaf and seeds crude extracts. The study is mainly concerned with the determination of time of paralysis and time of death of the worms. When there was a gradual increase in the dose, a gradual increase in the anthelmintic activity was observed. The least time for the death and paralysis was recorded at concentration of 50 mg/mL and maximum time for death and paralysis was recorded at 10mg/mL concentration. The ethanolic extract of the leaf and seed showed a significant anthelmintic activity at highest concentration of 50 mg/ml. So the C. occidentalis plant can be used as anthelmintic drug for the treatment of gastrointestinal helminthic infections after clinical trials, toxicological effects and isolation of chemical compounds.

Research paper thumbnail of Poor response to direct-acting antiviral therapy in HCV-infected elderly population: a real-life cohort study based on GeneXpert® technology

Future Virology, 2018

Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different eth... more Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different ethnicities and elderly population of Pakistan. Methods: We used GeneXpert® technology to quantify HCV RNA and evaluated treatment response in different cohorts that included HCV patients classified on the basis of their age-group and ethnicity. Results: The findings of our study suggest that 76% of nonresponder patients were older than 55 years of age which shows that age is the predictor of treatment outcome of direct-acting antiviral drugs. In addition to this, no differences were observed in overall efficacy by ethnicity. Conclusion: Treatment-regimen sofosbuvir+ribavirin has a limited effect on older patients; therefore, practitioners and healthcare professionals need to reconsider treatment options for elderly populations.