farheen shaikh - Academia.edu (original) (raw)
Papers by farheen shaikh
Rawal Medical Journal, 2020
Pakistan Journal of Medical and Health Sciences, 2021
Background: COVID-19 is the alarming problem for all over the world due to its fast spread infect... more Background: COVID-19 is the alarming problem for all over the world due to its fast spread infection mode and uncertainty in mortality rate. The diabetic population is prone for comorbidity with COVID-19 due to injurious fashion develops in respiratory system. Aim: To compare the serum Lactate dehydrogenase levels in diabetic patients with COVID-19 & non diabetic patients with COVID-19. Methodology: This comparative study was done at Ali medical center Hala New District Matiari Sindh. 42 diabetic & non diabetic clinically suspected cases COVID -19 with fever, cough, shortness of breath, non-pneumonic opacities on digital X.ray with raised TLC, ESR & CRP. The data analyzed for significance on SPSS 19 by applying student t test. Results: The serum LDH levels was significantly raised (p<0.001) in group A contained COVID-19 patients with diabetes as compared to COVID-19 patients with no diabetes mellitus. Conclusion: COVID -19 diabetic population will be more prone to develop the res...
Background and Objective: Vitamin C play a vital role in fetal growth during pregnancy, the aim o... more Background and Objective: Vitamin C play a vital role in fetal growth during pregnancy, the aim of the present study was to estimate mothers which taking vitamin C properly having new born babies and detect its normal birth weight. Methods: The study was conducted on 100 pregnant women from Department of Obstetrics & Gynaecology, Liaquat University Hospital, Sindh, Pakistan who came to visit Antenatal clinic frequently. 50 pregnant females were taken Vitamin C supplements properly from last 3-6 months 100 mg/day. 50 pregnant females were not taking vitamin C properly. Results: Those pregnant females which taken proper vitamin C delivered the child with birth weight 2.3kg 2.8 kg (2.4±0.3kg) (1.7±0.2 kg). Those pregnant females which not take proper vitamin C delivered the child with birth weight 1.51.9 kg. Conclusion: Taking Vitamin C properly highly effect on the birth weight of child. A low vitamin C levels has been associated with premature rupture of the membrane sometimes caus...
Rawal Medical Journal, 2018
Objective: To analyze CoQ10 supplements during pregnancy and reduced the risk of pre-eclampsia in... more Objective: To analyze CoQ10 supplements during pregnancy and reduced the risk of pre-eclampsia in women as compared with normal healthy women Methodolgy:This case control, comparative study was conducted in department of Biochemistry, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro from February 2015 to October 2015 and patients were recruited from department of Obstetrics & Gynaecology of the hospitlal. A total 100 volunteers were recruited and divided into two groups; 50 were normotensive healthy pregnant women as a control group and 50 were patients with pre-eclampsia as experimental group. They were recruited based on sign and symptoms, obstetric history, anthropometric, clinical data. Blood samples were analysed for CoQ10 by High performance liquid chromatography (HPLC) with Diode Array Detector (DAD). Results: The plasma CoQ10 level before supplementation was found to be decreased in pre-eclamptic patients (0.22±0.09) μg/dl as compared with control group (1.0...
Journal of Pharmaceutical Research International, 2021
Objective: The objective of this study is to assess deficiency of Vitamin D among the Tuberculosi... more Objective: The objective of this study is to assess deficiency of Vitamin D among the Tuberculosis Patients at People’s Medical College Hospital (PMCH) Nawabshah, Pakistan. Methodology: This was a case-control study in which 184 new diagnosed tuberculosis patients aged between 30 to 50 years were selected and 200 were taken as control. The study was conducted from June 2020 to May 2021. Well-structured questionnaire was administered to both case and control groups. Body mass index (BMI) was recorded as (kg/m2). Blood samples were collected for the presence of Vitamin D3 levels. Statistical Software for Social Sciences (SPSS) version 23 was used to analyze the data. Results: The mean age and standard deviation (SD) of the patients was 45.11 ± 7.99 years and gender distribution was females 94/184 (51%) and males 90/184 (49%) in patients. There was Vitamin D deficiency in 79/184 (39%) patients. Conclusion: Vitamin D deficiency was common among tuberculosis patients in contrast to contr...
Journal of Hunan University Natural Sciences
This study aimed to analyze the adverse effects of heavy metals in tea on pregnant mothers and fe... more This study aimed to analyze the adverse effects of heavy metals in tea on pregnant mothers and fetal outcomes, using Camellia sinensis tea as a more common beverage after water. The tea constituents are flavonoids containing catechins, which are primary polyphenols recognized as having a strong anti-oxidant activity preventing cellular damage by free radicals. During pregnancy, excessive tea intake negatively impacts the newborn. Tea constituents and their contamination have gained attention as heavy metal contamination exceeds its critical concentrations in tea infusions which may cause adverse effects on both mother and fetus. A total of 400 pregnant women participated in the present study. A cross-sectional study was conducted at the department of Physiology of University of Sindh in collaboration with the Department of gynecology and obstetrics of Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, from September 2018 to August 2020. Selected pregnant women were...
Journal of Pharmaceutical Research International, 2021
Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations... more Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan. Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables. Results: The maternal serum vitamin D and calcium levels w...
Journal of Pharmaceutical Research International
Background: Breast cancer has recently become one of the most obsessing and life threatening issu... more Background: Breast cancer has recently become one of the most obsessing and life threatening issues in the world. Globally, females suffered mostly by breast cancer. Breast cancer is multifactorial etiological disorder. Trace elements are acts as cofactors and biological catalyst. They play a very essential role in the metabolic pathways. Methods: A cross sectional study with two hundred (200) subjects and divided into two groups. 50 females were normal healthy as a control while 150 females were patient with breast cancer. Blood was collected from all participant after taking history, clinical data, mammographic and histopathological findings. Consent and predesign porforma were filled by all participants of study. The trace elements (Na, K, Zn, Fe, Ca) were determined through atomic absorption spectrophotometer (ASS) and other biochemical analysis such as Total Protein, serum albumin and Total cholesterol were analyzed on Micro Lab.300. Data was entered on SPSS 22.0 version, and a...
Saudi Journal of Biological Sciences, 2021
Background/Aim Diabetes Mellitus (DM) is one of the important public health issues worldwide. The... more Background/Aim Diabetes Mellitus (DM) is one of the important public health issues worldwide. The Fat mass obesity (FTO) gene rs-9939609 variant identified single nucleotide polymorphism (SNP) with the T to A missense mutation, and has a strong association with T2DM. FTO gene is present on chromosome “16q12.2” comprising of nine exons. FTO gene rs-9939609 a variant is commonly found in the Pakistani Population. The purpose of the study was to alert the population about the rs-9939609 variant SNP, having a strong association with T2DM. Material and Methods Total of 190 participants were included in the present cross-sectional study. To collect the samples non-probability convenience technique was used. subjects were recruited and divided into three groups, normal healthy subjects, obese and T2DM. The patients were selected from the Medicine department Jamshoro/Hyderabad by filling the pre-designed proforma, as well as verbal and written consent taken from study participants. To analy...
Saudi Journal of Biological Sciences, 2022
Background Anemia in pregnancy is a globally health-related issue, that affects both mothers and ... more Background Anemia in pregnancy is a globally health-related issue, that affects both mothers and their newborn. Anemia during pregnancy across the world involves approximately 38% of the world population. To evaluate the effect of gestational anemia on perinatal outcome in the population. The aim of present study is to evaluate the effect of gestational anemia on perinatal outcome in the population of Hyderabad, Sindh, Pakistan. Methods A cross-sectional comparative analysis was conducted among pregnant mothers who were listed to give birth at Liaquat University of medical and health sciences Jamshoro/ Hyderabad during the period of September 2018 to September 2019. The study population 400 were selected by convenient random sampling, and grouped into 2 on the basis of their Hb levels, with Hb Results The prevalence of anemia was 51.5% in in total population out of which, the incidence of normocytic normochromic anemia was highest 52.4%microcytic hypochromic anemia was found in 19....
Rawal Medical Journal, 2020
Objective: To analysed the serum Testosterone in obese and Diabetes Mellitus Type-II Males indivi... more Objective: To analysed the serum Testosterone in obese and Diabetes Mellitus Type-II Males individuals. Study design: A Cross-Sectional Comparative Study. Place and Duration of Study: The patients were recruited from Department of Medicine unit-II Liaquat hospital Jamshoro and analysis at Institute of Biotechnology and Genetic Engineering, University of Sindh, Jamshoro during the period of April 2018 to September 2018. Methodology: Total 150 males were included in this study and divided into three group, out of which Group A: n=50 were healthy normal males, Group B: n=50 were obese males(BMI>25) and Group C: n=50 were Type II- diabetic males ages 20-70 years old. Blood sample were collected from the all participants for performing various biochemical tests Fasting blood sugar (FBS)and Random blood sugar (RBS), HbA1c, Insulin, Testosterone by filling Performa and written consent by explaining them about study purpose. The ANOVA test was applied for the analysis of continuous varia...
Journal of Pharmaceutical Research International
Objective: To determine the effect of CoQ10 supplementation in reduction of oxidative stress by i... more Objective: To determine the effect of CoQ10 supplementation in reduction of oxidative stress by index marker, Malondialdehyde (MDA), super oxidase dismutase(SOD), catalase(CAT) and glutathione peroxidase (GPx) in patients with pre-eclampsia. Methodology: A cross-sectional study was conducted at the Department of Biochemistry LUMHS, Jamshoro. During the period of January 2018 to June 2018. Total 200 pregnant women were recruited and divided into two groups. 50 females were normotensive pregnant women as a control group, 150 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken before and after a 3 months’ supplementation to analyse Malondialdehyde (MDA). The CoQ10 was evaluated by High performance liquid chromatography (HPLC-DAD) and MDA, SOD, CAT and GPx were performed on UV- spectrophotometer. Data was analysed by using SPSS version 22. Student ttest was u...
Journal of Liaquat University of Medical & Health Sciences
OBJECTIVES: Pre-eclampsia is hypertensive and multi-system related disorder of pregnancy. It has ... more OBJECTIVES: Pre-eclampsia is hypertensive and multi-system related disorder of pregnancy. It has frequently labeled as "disease of theories". 5-10% of pregnancies complicated due to pre-eclampsia and it is most common health problem worldwide. This study intended to estimates the copper, zinc and magnesium levels in patients with pre-eclampsia. METHOD: Total eighty subjects were included in the present study, from which 40 voluntaries were normotensive healthy pregnant women (controls), 40 were pre-eclamptic patients (cases). The subjects were recruited having symptoms of interest after taking obstetric history, anthropometric and clinical data. After taking informed consent, blood sample collected and stored for biochemical analysis. The serum zinc, copper and magnesium levels were analyzed by Atomic Absorption Spectrophotometer. The study was conducted in biochemistry department during period of eight months from October 2015 to June 2016. RESULTS: Total eighty subjects were included in present study. The trace elements decreased and shows significant difference between control healthy pregnant and pre-eclamptic women (p<0.05). The mean difference of copper (0.15±0.07), zinc (2.94±0.45) and Mg ++ (0.15±0.09) mg/dl for the cases group and for control group copper was (0.20±0.03), zinc (5.11±0.21) and Mg ++ (2.17±0.21) mg/dl respectively. CONCLUSION: Trace elements are essential for the healthy pregnancy, suppressed concentration of serum Zinc, Copper and Magnesium may put forward the possible involvement in the pathology of pre-eclampsia. The aim of this study was to protects the mothers as well as her coming newborn from such life threating disease.
Journal of Pharmaceutical Research, 2021
Introduction: Pregnancy presents uncommon issues regarding anti-infection treatment. A significan... more Introduction: Pregnancy presents uncommon issues regarding anti-infection treatment. A significant concern is the conceivable teratogenic or harmful impact on the fetus. Objectives: The objectives of this study are to assess the infections and use of antibiotics in pregnancy among the pregnant women reported at Gynae OPD Civil Hospital Khairpur Mirs Pakistan. Original Research Article Pathan et al.; JPRI, 33(16): 69-75, 2021; Article no.JPRI.67104 70 Methodology: This was an observational cross-section study conducted at Gynae OPD Civil Hospital Khairpur Mirs Pakistan from July 2020 to January 2021. A total of 400 sample size was calculated by using Slovin’s Formula. Data were collected by purposive sampling technique. Finally, collected data were analyzed by using a statistical package for social science (SPSS) software version 24. Results: Results reported commonly prescribed antibiotics during the pregnancy in which Phenoxymethylpenicillin was most commonly prescribed i.e. 31% an...
Journal of Pharmaceutical Research, 2021
Department of Obstetrics & Gynae, Khairpur Medical College (KMC), Khairpur Mirs, Sindh, Pakistan.... more Department of Obstetrics & Gynae, Khairpur Medical College (KMC), Khairpur Mirs, Sindh, Pakistan. Department of Biochemistry, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan. 3 Department of Anatomy, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan. 4 Department of Physiology, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan. Institute of Pharmaceutical Sciences, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan.
Journal of Pharmaceutical Research International
Objective: To evaluate the effects of Green tea on obesity and hyperglycemia. Methodology: This o... more Objective: To evaluate the effects of Green tea on obesity and hyperglycemia. Methodology: This observational study was carried out at the department of physiology, in affiliation to Medical Research Centre Liaquat University of Medical and Health Sciences Jamshoro. The sample was collected by convenient random sampling. Total 100 participants, 50 controls and 50 obese diabetics were enrolled. Informed written consent was taken from participants. The body mass index (BMI) of the participants was taken at the time of recruitment, and later at 16 weeks of consuming green tea. The serum glucose levels were assessed by fasting (FBS) and random blood sugar (RBS) levels, and HbA1C. The levels of serum Blood glucose were obtained with the glucose oxidase method. Data analysis was done on SPSS 21.0, analysis of variables was done by applying student t-test, the p-value of <0.05 was taken as statistically significant. Results:100 participants recruited out of which 50 controls and 50 obes...
Rawal Medical Journal, 2020
Pakistan Journal of Medical and Health Sciences, 2021
Background: COVID-19 is the alarming problem for all over the world due to its fast spread infect... more Background: COVID-19 is the alarming problem for all over the world due to its fast spread infection mode and uncertainty in mortality rate. The diabetic population is prone for comorbidity with COVID-19 due to injurious fashion develops in respiratory system. Aim: To compare the serum Lactate dehydrogenase levels in diabetic patients with COVID-19 & non diabetic patients with COVID-19. Methodology: This comparative study was done at Ali medical center Hala New District Matiari Sindh. 42 diabetic & non diabetic clinically suspected cases COVID -19 with fever, cough, shortness of breath, non-pneumonic opacities on digital X.ray with raised TLC, ESR & CRP. The data analyzed for significance on SPSS 19 by applying student t test. Results: The serum LDH levels was significantly raised (p<0.001) in group A contained COVID-19 patients with diabetes as compared to COVID-19 patients with no diabetes mellitus. Conclusion: COVID -19 diabetic population will be more prone to develop the res...
Background and Objective: Vitamin C play a vital role in fetal growth during pregnancy, the aim o... more Background and Objective: Vitamin C play a vital role in fetal growth during pregnancy, the aim of the present study was to estimate mothers which taking vitamin C properly having new born babies and detect its normal birth weight. Methods: The study was conducted on 100 pregnant women from Department of Obstetrics & Gynaecology, Liaquat University Hospital, Sindh, Pakistan who came to visit Antenatal clinic frequently. 50 pregnant females were taken Vitamin C supplements properly from last 3-6 months 100 mg/day. 50 pregnant females were not taking vitamin C properly. Results: Those pregnant females which taken proper vitamin C delivered the child with birth weight 2.3kg 2.8 kg (2.4±0.3kg) (1.7±0.2 kg). Those pregnant females which not take proper vitamin C delivered the child with birth weight 1.51.9 kg. Conclusion: Taking Vitamin C properly highly effect on the birth weight of child. A low vitamin C levels has been associated with premature rupture of the membrane sometimes caus...
Rawal Medical Journal, 2018
Objective: To analyze CoQ10 supplements during pregnancy and reduced the risk of pre-eclampsia in... more Objective: To analyze CoQ10 supplements during pregnancy and reduced the risk of pre-eclampsia in women as compared with normal healthy women Methodolgy:This case control, comparative study was conducted in department of Biochemistry, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro from February 2015 to October 2015 and patients were recruited from department of Obstetrics & Gynaecology of the hospitlal. A total 100 volunteers were recruited and divided into two groups; 50 were normotensive healthy pregnant women as a control group and 50 were patients with pre-eclampsia as experimental group. They were recruited based on sign and symptoms, obstetric history, anthropometric, clinical data. Blood samples were analysed for CoQ10 by High performance liquid chromatography (HPLC) with Diode Array Detector (DAD). Results: The plasma CoQ10 level before supplementation was found to be decreased in pre-eclamptic patients (0.22±0.09) μg/dl as compared with control group (1.0...
Journal of Pharmaceutical Research International, 2021
Objective: The objective of this study is to assess deficiency of Vitamin D among the Tuberculosi... more Objective: The objective of this study is to assess deficiency of Vitamin D among the Tuberculosis Patients at People’s Medical College Hospital (PMCH) Nawabshah, Pakistan. Methodology: This was a case-control study in which 184 new diagnosed tuberculosis patients aged between 30 to 50 years were selected and 200 were taken as control. The study was conducted from June 2020 to May 2021. Well-structured questionnaire was administered to both case and control groups. Body mass index (BMI) was recorded as (kg/m2). Blood samples were collected for the presence of Vitamin D3 levels. Statistical Software for Social Sciences (SPSS) version 23 was used to analyze the data. Results: The mean age and standard deviation (SD) of the patients was 45.11 ± 7.99 years and gender distribution was females 94/184 (51%) and males 90/184 (49%) in patients. There was Vitamin D deficiency in 79/184 (39%) patients. Conclusion: Vitamin D deficiency was common among tuberculosis patients in contrast to contr...
Journal of Hunan University Natural Sciences
This study aimed to analyze the adverse effects of heavy metals in tea on pregnant mothers and fe... more This study aimed to analyze the adverse effects of heavy metals in tea on pregnant mothers and fetal outcomes, using Camellia sinensis tea as a more common beverage after water. The tea constituents are flavonoids containing catechins, which are primary polyphenols recognized as having a strong anti-oxidant activity preventing cellular damage by free radicals. During pregnancy, excessive tea intake negatively impacts the newborn. Tea constituents and their contamination have gained attention as heavy metal contamination exceeds its critical concentrations in tea infusions which may cause adverse effects on both mother and fetus. A total of 400 pregnant women participated in the present study. A cross-sectional study was conducted at the department of Physiology of University of Sindh in collaboration with the Department of gynecology and obstetrics of Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, from September 2018 to August 2020. Selected pregnant women were...
Journal of Pharmaceutical Research International, 2021
Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations... more Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan. Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables. Results: The maternal serum vitamin D and calcium levels w...
Journal of Pharmaceutical Research International
Background: Breast cancer has recently become one of the most obsessing and life threatening issu... more Background: Breast cancer has recently become one of the most obsessing and life threatening issues in the world. Globally, females suffered mostly by breast cancer. Breast cancer is multifactorial etiological disorder. Trace elements are acts as cofactors and biological catalyst. They play a very essential role in the metabolic pathways. Methods: A cross sectional study with two hundred (200) subjects and divided into two groups. 50 females were normal healthy as a control while 150 females were patient with breast cancer. Blood was collected from all participant after taking history, clinical data, mammographic and histopathological findings. Consent and predesign porforma were filled by all participants of study. The trace elements (Na, K, Zn, Fe, Ca) were determined through atomic absorption spectrophotometer (ASS) and other biochemical analysis such as Total Protein, serum albumin and Total cholesterol were analyzed on Micro Lab.300. Data was entered on SPSS 22.0 version, and a...
Saudi Journal of Biological Sciences, 2021
Background/Aim Diabetes Mellitus (DM) is one of the important public health issues worldwide. The... more Background/Aim Diabetes Mellitus (DM) is one of the important public health issues worldwide. The Fat mass obesity (FTO) gene rs-9939609 variant identified single nucleotide polymorphism (SNP) with the T to A missense mutation, and has a strong association with T2DM. FTO gene is present on chromosome “16q12.2” comprising of nine exons. FTO gene rs-9939609 a variant is commonly found in the Pakistani Population. The purpose of the study was to alert the population about the rs-9939609 variant SNP, having a strong association with T2DM. Material and Methods Total of 190 participants were included in the present cross-sectional study. To collect the samples non-probability convenience technique was used. subjects were recruited and divided into three groups, normal healthy subjects, obese and T2DM. The patients were selected from the Medicine department Jamshoro/Hyderabad by filling the pre-designed proforma, as well as verbal and written consent taken from study participants. To analy...
Saudi Journal of Biological Sciences, 2022
Background Anemia in pregnancy is a globally health-related issue, that affects both mothers and ... more Background Anemia in pregnancy is a globally health-related issue, that affects both mothers and their newborn. Anemia during pregnancy across the world involves approximately 38% of the world population. To evaluate the effect of gestational anemia on perinatal outcome in the population. The aim of present study is to evaluate the effect of gestational anemia on perinatal outcome in the population of Hyderabad, Sindh, Pakistan. Methods A cross-sectional comparative analysis was conducted among pregnant mothers who were listed to give birth at Liaquat University of medical and health sciences Jamshoro/ Hyderabad during the period of September 2018 to September 2019. The study population 400 were selected by convenient random sampling, and grouped into 2 on the basis of their Hb levels, with Hb Results The prevalence of anemia was 51.5% in in total population out of which, the incidence of normocytic normochromic anemia was highest 52.4%microcytic hypochromic anemia was found in 19....
Rawal Medical Journal, 2020
Objective: To analysed the serum Testosterone in obese and Diabetes Mellitus Type-II Males indivi... more Objective: To analysed the serum Testosterone in obese and Diabetes Mellitus Type-II Males individuals. Study design: A Cross-Sectional Comparative Study. Place and Duration of Study: The patients were recruited from Department of Medicine unit-II Liaquat hospital Jamshoro and analysis at Institute of Biotechnology and Genetic Engineering, University of Sindh, Jamshoro during the period of April 2018 to September 2018. Methodology: Total 150 males were included in this study and divided into three group, out of which Group A: n=50 were healthy normal males, Group B: n=50 were obese males(BMI>25) and Group C: n=50 were Type II- diabetic males ages 20-70 years old. Blood sample were collected from the all participants for performing various biochemical tests Fasting blood sugar (FBS)and Random blood sugar (RBS), HbA1c, Insulin, Testosterone by filling Performa and written consent by explaining them about study purpose. The ANOVA test was applied for the analysis of continuous varia...
Journal of Pharmaceutical Research International
Objective: To determine the effect of CoQ10 supplementation in reduction of oxidative stress by i... more Objective: To determine the effect of CoQ10 supplementation in reduction of oxidative stress by index marker, Malondialdehyde (MDA), super oxidase dismutase(SOD), catalase(CAT) and glutathione peroxidase (GPx) in patients with pre-eclampsia. Methodology: A cross-sectional study was conducted at the Department of Biochemistry LUMHS, Jamshoro. During the period of January 2018 to June 2018. Total 200 pregnant women were recruited and divided into two groups. 50 females were normotensive pregnant women as a control group, 150 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken before and after a 3 months’ supplementation to analyse Malondialdehyde (MDA). The CoQ10 was evaluated by High performance liquid chromatography (HPLC-DAD) and MDA, SOD, CAT and GPx were performed on UV- spectrophotometer. Data was analysed by using SPSS version 22. Student ttest was u...
Journal of Liaquat University of Medical & Health Sciences
OBJECTIVES: Pre-eclampsia is hypertensive and multi-system related disorder of pregnancy. It has ... more OBJECTIVES: Pre-eclampsia is hypertensive and multi-system related disorder of pregnancy. It has frequently labeled as "disease of theories". 5-10% of pregnancies complicated due to pre-eclampsia and it is most common health problem worldwide. This study intended to estimates the copper, zinc and magnesium levels in patients with pre-eclampsia. METHOD: Total eighty subjects were included in the present study, from which 40 voluntaries were normotensive healthy pregnant women (controls), 40 were pre-eclamptic patients (cases). The subjects were recruited having symptoms of interest after taking obstetric history, anthropometric and clinical data. After taking informed consent, blood sample collected and stored for biochemical analysis. The serum zinc, copper and magnesium levels were analyzed by Atomic Absorption Spectrophotometer. The study was conducted in biochemistry department during period of eight months from October 2015 to June 2016. RESULTS: Total eighty subjects were included in present study. The trace elements decreased and shows significant difference between control healthy pregnant and pre-eclamptic women (p<0.05). The mean difference of copper (0.15±0.07), zinc (2.94±0.45) and Mg ++ (0.15±0.09) mg/dl for the cases group and for control group copper was (0.20±0.03), zinc (5.11±0.21) and Mg ++ (2.17±0.21) mg/dl respectively. CONCLUSION: Trace elements are essential for the healthy pregnancy, suppressed concentration of serum Zinc, Copper and Magnesium may put forward the possible involvement in the pathology of pre-eclampsia. The aim of this study was to protects the mothers as well as her coming newborn from such life threating disease.
Journal of Pharmaceutical Research, 2021
Introduction: Pregnancy presents uncommon issues regarding anti-infection treatment. A significan... more Introduction: Pregnancy presents uncommon issues regarding anti-infection treatment. A significant concern is the conceivable teratogenic or harmful impact on the fetus. Objectives: The objectives of this study are to assess the infections and use of antibiotics in pregnancy among the pregnant women reported at Gynae OPD Civil Hospital Khairpur Mirs Pakistan. Original Research Article Pathan et al.; JPRI, 33(16): 69-75, 2021; Article no.JPRI.67104 70 Methodology: This was an observational cross-section study conducted at Gynae OPD Civil Hospital Khairpur Mirs Pakistan from July 2020 to January 2021. A total of 400 sample size was calculated by using Slovin’s Formula. Data were collected by purposive sampling technique. Finally, collected data were analyzed by using a statistical package for social science (SPSS) software version 24. Results: Results reported commonly prescribed antibiotics during the pregnancy in which Phenoxymethylpenicillin was most commonly prescribed i.e. 31% an...
Journal of Pharmaceutical Research, 2021
Department of Obstetrics & Gynae, Khairpur Medical College (KMC), Khairpur Mirs, Sindh, Pakistan.... more Department of Obstetrics & Gynae, Khairpur Medical College (KMC), Khairpur Mirs, Sindh, Pakistan. Department of Biochemistry, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan. 3 Department of Anatomy, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan. 4 Department of Physiology, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan. Institute of Pharmaceutical Sciences, People’s University of Medical and Health Sciences for Women (PUMHSW), Nawabshah, Sindh, Pakistan.
Journal of Pharmaceutical Research International
Objective: To evaluate the effects of Green tea on obesity and hyperglycemia. Methodology: This o... more Objective: To evaluate the effects of Green tea on obesity and hyperglycemia. Methodology: This observational study was carried out at the department of physiology, in affiliation to Medical Research Centre Liaquat University of Medical and Health Sciences Jamshoro. The sample was collected by convenient random sampling. Total 100 participants, 50 controls and 50 obese diabetics were enrolled. Informed written consent was taken from participants. The body mass index (BMI) of the participants was taken at the time of recruitment, and later at 16 weeks of consuming green tea. The serum glucose levels were assessed by fasting (FBS) and random blood sugar (RBS) levels, and HbA1C. The levels of serum Blood glucose were obtained with the glucose oxidase method. Data analysis was done on SPSS 21.0, analysis of variables was done by applying student t-test, the p-value of <0.05 was taken as statistically significant. Results:100 participants recruited out of which 50 controls and 50 obes...