fausto mazzi - Academia.edu (original) (raw)
Papers by fausto mazzi
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Schizophrenia Bulletin, Oct 9, 2017
Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar d... more Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis. The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP). Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates. We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS). We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset.
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Rivista di psichiatria, 2002, 37, 2 53 RIASSUNTO. Nella prima parte di questo contributo è stato ... more Rivista di psichiatria, 2002, 37, 2 53 RIASSUNTO. Nella prima parte di questo contributo è stato messo in evidenza che un corpus di ricerche ampio e riproducibile ha dimostrato che un deficit di varie funzioni cognitive rappresenta un riscontro pressoché universale nelle persone affette da un disturbo di tipo schizofrenico. Nella seconda parte viene quindi discussa la relazione esistente tra il deterioramento cognitivo, che spesso caratterizza il disturbo schizofrenico, ed il funzionamento psicosociale, ponendo l’enfasi sulle implicazioni che questi dati hanno per la pratica riabilitativa. Vengono infine discussi gli effetti del trattamento farmacologico con i vecchi ed i nuovi farmaci antipsicotici sulle funzioni cognitive stesse: anche se alcune evidenze mostrano che i farmaci antipsicotici atipici possono produrre dei benefici sul piano cognitivo maggiori di quelli conseguiti con i neurolettici tradizionali, è ancora presto per poter affermare che tali benefici sono ampi, durevoli nel tempo ed associati a parallele evoluzioni del quadro clinico.
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Epidemiologia e Psichiatria …, 2005
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Psychiatry Research: Neuroimaging
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Rivista Di Psichiatria, 2002
Schizofrenia e funzioni cognitive: una revisione critica della letteratura 1. Modelli sperimental... more Schizofrenia e funzioni cognitive: una revisione critica della letteratura 1. Modelli sperimentali e valutazione dei deficit cognitivi ... Schizophrenia and cognitive functioning: 1. Experimental models and assessment of cognitive deficits ... JAMES GOLD1, GIOVANNI DE ...
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European Psychiatry, 2013
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Epidemiologia e psichiatria sociale, Oct 1, 2005
To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disor... more To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disorders in Italy; and the socio-demographic correlates and comorbidity patterns of these estimated disorders. A representative random sample of non-institutionalised citizens of Italy aged 18 or older (N=4,712) was interviewed between January 2001 and July 2003, with a weighted response rate of 71.3%. DSM-IV disorders were assessed by lay interviewers using Version 3.0 of the Composite International Diagnostic Interview (CIDI). A total of 11% of respondents reported a lifetime history of any mood disorder, 10.3% any anxiety disorder and 1.3% any alcohol disorder. About 5% reported having an anxiety disorder in the past 12 months compared to 3.3% for any mood disorder and 0.2% for any alcohol disorder. Major depression and specific phobia were the most common mental disorders. Women were twice as likely as men to report a mood disorder and four times as likely as men to report an anxiety disorder, while men were twice as likely as women to report an alcohol disorder. High comorbidity of mood and anxiety disorders was observed. Prevalence estimates were generally lower than in parallel surveys carried out in other Western European countries. A high proportion of adults in Italy have a history of mood, anxiety or alcohol disorders. The lower than expected prevalence estimate of alcohol use disorder may be due to under-reporting or to low social harm from alcohol consumption.
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International Journal of Social Psychiatry, Jun 2, 2013
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Social Psychiatry and Psychiatric Epidemiology, Jun 19, 2011
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Acta Psychiatrica Scandinavica, Jun 1, 2004
Objective: The European Study of Epidemiology of Mental Disorders (ESEMeD) project was designed t... more Objective: The European Study of Epidemiology of Mental Disorders (ESEMeD) project was designed to evaluate the prevalence, the impact and the treatment patterns in Europe. This paper presents an overview of the methods implemented in the project.Method: ESEMeD is a cross‐sectional study in a representative sample of 21 425 adults, 18 or older, from the general population of Belgium, France, Germany, Italy, the Netherlands and Spain. The Composite International Diagnostic Interview (WMH‐CIDI) was administered by home interviews from January 2001 to August 2003 using Computer Assisted Personal Interview (CAPI) technology. Data quality was controlled to ensure reliability and validity of the information obtained.Results: Response rate varied from 78.6% in Spain to 45.9% in France. Less than 4% of the individuals had errors in the checking procedures performed.Conclusion: The sampling methodologies, comprehensive psychiatric instruments and quality control procedures used have rendered the ESEMeD database a unique and important source of information about the prevalence, the disability burden and unmet medical needs of mental disorders within Europe.
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International Journal of Methods in Psychiatric Research, Jun 1, 2002
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Social Psychiatry and Psychiatric Epidemiology, Aug 16, 2006
To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disor... more To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disorders in Italy; and the socio-demographic correlates and comorbidity patterns of these estimated disorders. A representative random sample of non-institutionalised citizens of Italy aged 18 or older (N=4,712) was interviewed between January 2001 and July 2003, with a weighted response rate of 71.3%. DSM-IV disorders were assessed by lay interviewers using Version 3.0 of the Composite International Diagnostic Interview (CIDI). A total of 11% of respondents reported a lifetime history of any mood disorder, 10.3% any anxiety disorder and 1.3% any alcohol disorder. About 5% reported having an anxiety disorder in the past 12 months compared to 3.3% for any mood disorder and 0.2% for any alcohol disorder. Major depression and specific phobia were the most common mental disorders. Women were twice as likely as men to report a mood disorder and four times as likely as men to report an anxiety disorder, while men were twice as likely as women to report an alcohol disorder. High comorbidity of mood and anxiety disorders was observed. Prevalence estimates were generally lower than in parallel surveys carried out in other Western European countries. A high proportion of adults in Italy have a history of mood, anxiety or alcohol disorders. The lower than expected prevalence estimate of alcohol use disorder may be due to under-reporting or to low social harm from alcohol consumption.
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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European Psychiatry, 2015
Background We aimed is to describe the phenomenology of mental disorders in migrants referred to ... more Background We aimed is to describe the phenomenology of mental disorders in migrants referred to Bologna West Community Mental Health Centre(CMHC), by analysing the psychopathological dimensions that underlie their clinical diagnoses. Methods We recruited all migrants who attended the Bologna West CMHC between May 1999 andJuly 2009. The psychopathological assessment was conducted with the Association for Methodology and Documentation in Psychiatry (AMDP) and clinical diagnoses were formulated according to ICD-10. We proceeded through a two-step analysis:(1) comparing the prevalence rates of psychopathological symptoms across diagnoses; then (2) conducting a factor analysis to assess how those symptoms configure psychopathological dimensions and how these dimensions underlieclinical diagnoses. Results We found significant associations between diagnoses and the prevalence of their core psychopathological symptoms. Factor analysis revealed a strong polymorphism ofthe psychopathological presentation of mental disorders and unexpectedly showed that in each diagnostic cluster, the first extracted factor was not composed of core symptoms. Conclusions A mixed categorical-dimensional approach adds relevant information regarding psychopathological dimensions useful to the understanding of the peculiar clinical expressivity of migrants patients.
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Transplantation Proceedings, 2008
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Schizophrenia Bulletin, Oct 9, 2017
Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar d... more Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis. The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP). Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates. We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS). We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset.
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Not availabl
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Rivista di psichiatria, 2002, 37, 2 53 RIASSUNTO. Nella prima parte di questo contributo è stato ... more Rivista di psichiatria, 2002, 37, 2 53 RIASSUNTO. Nella prima parte di questo contributo è stato messo in evidenza che un corpus di ricerche ampio e riproducibile ha dimostrato che un deficit di varie funzioni cognitive rappresenta un riscontro pressoché universale nelle persone affette da un disturbo di tipo schizofrenico. Nella seconda parte viene quindi discussa la relazione esistente tra il deterioramento cognitivo, che spesso caratterizza il disturbo schizofrenico, ed il funzionamento psicosociale, ponendo l’enfasi sulle implicazioni che questi dati hanno per la pratica riabilitativa. Vengono infine discussi gli effetti del trattamento farmacologico con i vecchi ed i nuovi farmaci antipsicotici sulle funzioni cognitive stesse: anche se alcune evidenze mostrano che i farmaci antipsicotici atipici possono produrre dei benefici sul piano cognitivo maggiori di quelli conseguiti con i neurolettici tradizionali, è ancora presto per poter affermare che tali benefici sono ampi, durevoli nel tempo ed associati a parallele evoluzioni del quadro clinico.
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Epidemiologia e Psichiatria …, 2005
Bookmarks Related papers MentionsView impact
Psychiatry Research: Neuroimaging
Bookmarks Related papers MentionsView impact
Rivista Di Psichiatria, 2002
Schizofrenia e funzioni cognitive: una revisione critica della letteratura 1. Modelli sperimental... more Schizofrenia e funzioni cognitive: una revisione critica della letteratura 1. Modelli sperimentali e valutazione dei deficit cognitivi ... Schizophrenia and cognitive functioning: 1. Experimental models and assessment of cognitive deficits ... JAMES GOLD1, GIOVANNI DE ...
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European Psychiatry, 2013
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Epidemiologia e psichiatria sociale, Oct 1, 2005
To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disor... more To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disorders in Italy; and the socio-demographic correlates and comorbidity patterns of these estimated disorders. A representative random sample of non-institutionalised citizens of Italy aged 18 or older (N=4,712) was interviewed between January 2001 and July 2003, with a weighted response rate of 71.3%. DSM-IV disorders were assessed by lay interviewers using Version 3.0 of the Composite International Diagnostic Interview (CIDI). A total of 11% of respondents reported a lifetime history of any mood disorder, 10.3% any anxiety disorder and 1.3% any alcohol disorder. About 5% reported having an anxiety disorder in the past 12 months compared to 3.3% for any mood disorder and 0.2% for any alcohol disorder. Major depression and specific phobia were the most common mental disorders. Women were twice as likely as men to report a mood disorder and four times as likely as men to report an anxiety disorder, while men were twice as likely as women to report an alcohol disorder. High comorbidity of mood and anxiety disorders was observed. Prevalence estimates were generally lower than in parallel surveys carried out in other Western European countries. A high proportion of adults in Italy have a history of mood, anxiety or alcohol disorders. The lower than expected prevalence estimate of alcohol use disorder may be due to under-reporting or to low social harm from alcohol consumption.
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International Journal of Social Psychiatry, Jun 2, 2013
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Social Psychiatry and Psychiatric Epidemiology, Jun 19, 2011
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Acta Psychiatrica Scandinavica, Jun 1, 2004
Objective: The European Study of Epidemiology of Mental Disorders (ESEMeD) project was designed t... more Objective: The European Study of Epidemiology of Mental Disorders (ESEMeD) project was designed to evaluate the prevalence, the impact and the treatment patterns in Europe. This paper presents an overview of the methods implemented in the project.Method: ESEMeD is a cross‐sectional study in a representative sample of 21 425 adults, 18 or older, from the general population of Belgium, France, Germany, Italy, the Netherlands and Spain. The Composite International Diagnostic Interview (WMH‐CIDI) was administered by home interviews from January 2001 to August 2003 using Computer Assisted Personal Interview (CAPI) technology. Data quality was controlled to ensure reliability and validity of the information obtained.Results: Response rate varied from 78.6% in Spain to 45.9% in France. Less than 4% of the individuals had errors in the checking procedures performed.Conclusion: The sampling methodologies, comprehensive psychiatric instruments and quality control procedures used have rendered the ESEMeD database a unique and important source of information about the prevalence, the disability burden and unmet medical needs of mental disorders within Europe.
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International Journal of Methods in Psychiatric Research, Jun 1, 2002
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Social Psychiatry and Psychiatric Epidemiology, Aug 16, 2006
To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disor... more To present 1-month, 12-month and lifetime prevalence estimates of mood, anxiety and alcohol disorders in Italy; and the socio-demographic correlates and comorbidity patterns of these estimated disorders. A representative random sample of non-institutionalised citizens of Italy aged 18 or older (N=4,712) was interviewed between January 2001 and July 2003, with a weighted response rate of 71.3%. DSM-IV disorders were assessed by lay interviewers using Version 3.0 of the Composite International Diagnostic Interview (CIDI). A total of 11% of respondents reported a lifetime history of any mood disorder, 10.3% any anxiety disorder and 1.3% any alcohol disorder. About 5% reported having an anxiety disorder in the past 12 months compared to 3.3% for any mood disorder and 0.2% for any alcohol disorder. Major depression and specific phobia were the most common mental disorders. Women were twice as likely as men to report a mood disorder and four times as likely as men to report an anxiety disorder, while men were twice as likely as women to report an alcohol disorder. High comorbidity of mood and anxiety disorders was observed. Prevalence estimates were generally lower than in parallel surveys carried out in other Western European countries. A high proportion of adults in Italy have a history of mood, anxiety or alcohol disorders. The lower than expected prevalence estimate of alcohol use disorder may be due to under-reporting or to low social harm from alcohol consumption.
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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Acta Psychiatrica Scandinavica, Jun 1, 2004
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European Psychiatry, 2015
Background We aimed is to describe the phenomenology of mental disorders in migrants referred to ... more Background We aimed is to describe the phenomenology of mental disorders in migrants referred to Bologna West Community Mental Health Centre(CMHC), by analysing the psychopathological dimensions that underlie their clinical diagnoses. Methods We recruited all migrants who attended the Bologna West CMHC between May 1999 andJuly 2009. The psychopathological assessment was conducted with the Association for Methodology and Documentation in Psychiatry (AMDP) and clinical diagnoses were formulated according to ICD-10. We proceeded through a two-step analysis:(1) comparing the prevalence rates of psychopathological symptoms across diagnoses; then (2) conducting a factor analysis to assess how those symptoms configure psychopathological dimensions and how these dimensions underlieclinical diagnoses. Results We found significant associations between diagnoses and the prevalence of their core psychopathological symptoms. Factor analysis revealed a strong polymorphism ofthe psychopathological presentation of mental disorders and unexpectedly showed that in each diagnostic cluster, the first extracted factor was not composed of core symptoms. Conclusions A mixed categorical-dimensional approach adds relevant information regarding psychopathological dimensions useful to the understanding of the peculiar clinical expressivity of migrants patients.
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Transplantation Proceedings, 2008
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