felipe serrano - Academia.edu (original) (raw)
Papers by felipe serrano
Nature genetics, 2017
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, whic... more Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1. To investigate the pathogenesis of aortic aneurysms in MFS, we generated a vascular model derived from human induced pluripotent stem cells (MFS-hiPSCs). Our MFS-hiPSC-derived smooth muscle cells (SMCs) recapitulated the pathology seen in Marfan aortas, including defects in fibrillin-1 accumulation, extracellular matrix degradation, transforming growth factor-β (TGF-β) signaling, contraction and apoptosis; abnormalities were corrected by CRISPR-based editing of the FBN1 mutation. TGF-β inhibition rescued abnormalities in fibrillin-1 accumulation and matrix metalloproteinase expression. However, only the noncanonical p38 pathway regulated SMC apoptosis, a pathological mechanism also governed by Krüppel-like factor 4 (KLF4). This model has enabled us to dissect the molecular mechanisms of MFS, identify novel targets for treatment (suc...
International Review of Applied Economics, 2001
The institutional design of the Spanish labour market has been subjected, during the last three d... more The institutional design of the Spanish labour market has been subjected, during the last three decades, to permanent pressure fuelled by two beliefs. On the one hand, by the assumption that a higher degree of flexibility would help to reduce unemployment; on the other, by the assumption that such increased flexibility would also help to reduce inflation rates and, consequently, the inflation gap between Spain and the rest of the European countries. The recent histor y of the Spanish labour market is, therefore, the histor y of the reforms implemented to increase the flexibility in such a market. The aim of this paper is, firstly, to describe the main features of these reforms, showing the measures implemented in order to increase the flexibility in the labour market and, secondly, to show the degree of flexibility reached in the labour market. Finally, we will briefly analyse the macroeconom ic consequences of these reforms.
International Review of Applied Economics, 2007
This paper aims to provide empirical evidence about the relative positions of European Union memb... more This paper aims to provide empirical evidence about the relative positions of European Union member states on innovation and, more specifically, on innovation in manufacturing. These positions were obtained from the aggregation of different innovation variables using the principal component analysis. We do not provide, from the statistical viewpoint, a synthetic indicator, even if, from the economic perspective, the information we obtained was similar to what such an indicator would provide. Our unit of analysis is the sector in each country, what we will term ‘country‐sector’, covering both innovative and non‐innovative firms.
Nature genetics, 2017
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, whic... more Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in FBN1, which encodes the extracellular matrix protein fibrillin-1. To investigate the pathogenesis of aortic aneurysms in MFS, we generated a vascular model derived from human induced pluripotent stem cells (MFS-hiPSCs). Our MFS-hiPSC-derived smooth muscle cells (SMCs) recapitulated the pathology seen in Marfan aortas, including defects in fibrillin-1 accumulation, extracellular matrix degradation, transforming growth factor-β (TGF-β) signaling, contraction and apoptosis; abnormalities were corrected by CRISPR-based editing of the FBN1 mutation. TGF-β inhibition rescued abnormalities in fibrillin-1 accumulation and matrix metalloproteinase expression. However, only the noncanonical p38 pathway regulated SMC apoptosis, a pathological mechanism also governed by Krüppel-like factor 4 (KLF4). This model has enabled us to dissect the molecular mechanisms of MFS, identify novel targets for treatment (suc...
International Review of Applied Economics, 2001
The institutional design of the Spanish labour market has been subjected, during the last three d... more The institutional design of the Spanish labour market has been subjected, during the last three decades, to permanent pressure fuelled by two beliefs. On the one hand, by the assumption that a higher degree of flexibility would help to reduce unemployment; on the other, by the assumption that such increased flexibility would also help to reduce inflation rates and, consequently, the inflation gap between Spain and the rest of the European countries. The recent histor y of the Spanish labour market is, therefore, the histor y of the reforms implemented to increase the flexibility in such a market. The aim of this paper is, firstly, to describe the main features of these reforms, showing the measures implemented in order to increase the flexibility in the labour market and, secondly, to show the degree of flexibility reached in the labour market. Finally, we will briefly analyse the macroeconom ic consequences of these reforms.
International Review of Applied Economics, 2007
This paper aims to provide empirical evidence about the relative positions of European Union memb... more This paper aims to provide empirical evidence about the relative positions of European Union member states on innovation and, more specifically, on innovation in manufacturing. These positions were obtained from the aggregation of different innovation variables using the principal component analysis. We do not provide, from the statistical viewpoint, a synthetic indicator, even if, from the economic perspective, the information we obtained was similar to what such an indicator would provide. Our unit of analysis is the sector in each country, what we will term ‘country‐sector’, covering both innovative and non‐innovative firms.