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Papers by ferdinando di Orio
The Journal of Clinical Endocrinology & Metabolism, 2006
Context: Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related t... more Context: Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related to mitochondrial function, particularly with maximal oxygen consumption (VO 2max). At the moment, no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed.
The Stata Journal: Promoting communications on statistics and Stata, 2007
The Stata Journal and the contents of the supporting files (programs, datasets, and help files) a... more The Stata Journal and the contents of the supporting files (programs, datasets, and help files) are copyright c by StataCorp LP. The contents of the supporting files (programs, datasets, and help files) may be copied or reproduced by any means whatsoever, in whole or in part, as long as any copy or reproduction includes attribution to both (1) the author and (2) the Stata Journal. The articles appearing in the Stata Journal may be copied or reproduced as printed copies, in whole or in part, as long as any copy or reproduction includes attribution to both (1) the author and (2) the Stata Journal. Written permission must be obtained from StataCorp if you wish to make electronic copies of the insertions. This precludes placing electronic copies of the Stata Journal, in whole or in part, on publicly accessible web sites, fileservers, or other locations where the copy may be accessed by anyone other than the subscriber.
International Journal of Epidemiology, 1997
The analysis of mortality of psychiatric patients has been an important research topic since the ... more The analysis of mortality of psychiatric patients has been an important research topic since the first half of the nineteenth century. 1-3 Many studies have been conducted in recent decades examining the evidence of excess mortality in psychiatric patients with respect to the general population and analysing risk factors for death. Some authors 4,5 have highlighted the importance of mortality studies, and have concluded that an ample conceptual basis for continued interest in this type of research still exists. Evidence for excess mortality has been recently demonstrated in studies conducted upon hospitalized patients, 6-9 outpatients, 10-11 and in community 12 or general medicine. 13 Analyses of mortality have been carried out after stratification according to psychiatric diagnosis 14,15 and cause of death. 16 Several studies have attempted to analyse age, marital status, educational level, diagnosis, pharmacotherapy and length of hospitalization, as prognostic factors for death. 11,17-22 The analysis of deinstitutionalization as a prognostic factor for death holds theoretical and practical interest, but few authors have faced this problem. 20,23 Those that have describe a possible beneficial effect of deinstitutionalization on mortality from infectious diseases like pneumonia, as well as an adverse effect due to increased incidence of accident or suicide. Few studies have been conducted in Italy on the effects of 1227
The study investigates the prevalence of reading difficulties among children in scholar age and a... more The study investigates the prevalence of reading difficulties among children in scholar age and analyses the socio-demographic characteristics of learners who presented reading difficulties in central Italy. A sample of 623 students 7-11 aged, was assessed with the Italian MT standardized tests. Information on gender, age, handedness, and other socio-demographic variables were also gathered. The study showed that 11% of learners presented poor comprehension skills. The reading speed difficulties were more common than the reading correctness problems: about 7% of children vs 1% were dyslexics due to slow reading. There were no significant differences regarding gender, age. However, dominant hand and the school location seemed to affect the speed difficulties and the comprehension problems. The analyses showed that attending a school located in a rural area was statistically associated with the reading difficulties. Left-handed children were more likely to be slow decoders and/or poor comprehenders. These findings may be used in the early diagnosis of poor readers. These difficulties often have a chronic progression with substantial psychosocial limitations and psychological stress, so children with reading difficulties should be identified as early as possible.
Annals of Neurology, 2011
Objective: Limited data are available on health-related quality of life (HR-QoL) in pediatric str... more Objective: Limited data are available on health-related quality of life (HR-QoL) in pediatric stroke survivors. The aim of the present study was to assess HR-QoL by self-assessment and parent/proxy-assessment in children and adolescents who survived a first stroke episode. Methods: We investigated HR-QoL in pediatric stroke survivors (71 preschool children [G1] and 62 school children/ adolescents [G2]) and in 169 healthy controls. HR-QoL was assessed in patients and parents/proxies with the generic KINDL-R questionnaire exploring overall well-being and 6 well-being subdimensions (physical, psychological, selfesteem, family-related, friend-related, and school-related). In pediatric stroke survivors the neurological long-term outcome was measured with the standardized Pediatric Stroke Outcome Measure. Results: Of stroke survivors, 65% exhibited at least 1 neurologic disability. Pediatric stroke survivors reported lower overall well-being compared with healthy controls. In G2 stroke patients, friend-related well-being respectively emotional well-being was significantly reduced compared with healthy controls (73.0 vs 85.0 points; p < 0.001 respectively 80.2 vs 84.5 points; p ¼ 0.049). Parents/proxies of both stroke survivors rated the overall well-being and all subdimensions (except family-related and school-related well-being in G1 and G2 stroke survivors and physical functioning in G2 stroke survivors) lower compared with parents/proxies of healthy children/adolescents. Overall well-being was significantly reduced in children with moderate/severe neurological deficits compared with normal/ mildly affected patients (75.5 vs 83.3 points, p ¼ 0.01). Neonatal stroke survivors reported a significantly better neurological long-term outcome compared to childhood stroke survivors (82.0 vs 75.0 points; p ¼ 0.005). Interpretation: Pediatric stroke survivors compared with healthy controls are strongly affected regarding their overall well-being and older children/adolescents regarding their well-being with peers.
Computer Methods and Programs in Biomedicine, 2008
Currently, large efforts are spent to develop standards and architectures useful to achieve more ... more Currently, large efforts are spent to develop standards and architectures useful to achieve more effective interoperability among medical information systems. Despite such efforts, there are no researches produced so far to directly analyse, with statistical methods, biomedical data represented as eXtensible Markup Language (XML) documents. Thus, the paper proposes an architecture which offers a twofold approach to the statistical analysis of XML data, i.e. via a web service and by extending the query languages used in XML databases. To show how the architecture can be used, a sample system is also reported. Finally, the paper ends by reporting the advantages and drawbacks of the proposed approach in comparison with classic statistical packages.
The Journal of Clinical Endocrinology & Metabolism, 2006
Context: Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related t... more Context: Insulin resistance is a feature of polycystic ovary syndrome (PCOS), and it is related to mitochondrial function, particularly with maximal oxygen consumption (VO 2max). At the moment, no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed.
The Stata Journal: Promoting communications on statistics and Stata, 2007
The Stata Journal and the contents of the supporting files (programs, datasets, and help files) a... more The Stata Journal and the contents of the supporting files (programs, datasets, and help files) are copyright c by StataCorp LP. The contents of the supporting files (programs, datasets, and help files) may be copied or reproduced by any means whatsoever, in whole or in part, as long as any copy or reproduction includes attribution to both (1) the author and (2) the Stata Journal. The articles appearing in the Stata Journal may be copied or reproduced as printed copies, in whole or in part, as long as any copy or reproduction includes attribution to both (1) the author and (2) the Stata Journal. Written permission must be obtained from StataCorp if you wish to make electronic copies of the insertions. This precludes placing electronic copies of the Stata Journal, in whole or in part, on publicly accessible web sites, fileservers, or other locations where the copy may be accessed by anyone other than the subscriber.
International Journal of Epidemiology, 1997
The analysis of mortality of psychiatric patients has been an important research topic since the ... more The analysis of mortality of psychiatric patients has been an important research topic since the first half of the nineteenth century. 1-3 Many studies have been conducted in recent decades examining the evidence of excess mortality in psychiatric patients with respect to the general population and analysing risk factors for death. Some authors 4,5 have highlighted the importance of mortality studies, and have concluded that an ample conceptual basis for continued interest in this type of research still exists. Evidence for excess mortality has been recently demonstrated in studies conducted upon hospitalized patients, 6-9 outpatients, 10-11 and in community 12 or general medicine. 13 Analyses of mortality have been carried out after stratification according to psychiatric diagnosis 14,15 and cause of death. 16 Several studies have attempted to analyse age, marital status, educational level, diagnosis, pharmacotherapy and length of hospitalization, as prognostic factors for death. 11,17-22 The analysis of deinstitutionalization as a prognostic factor for death holds theoretical and practical interest, but few authors have faced this problem. 20,23 Those that have describe a possible beneficial effect of deinstitutionalization on mortality from infectious diseases like pneumonia, as well as an adverse effect due to increased incidence of accident or suicide. Few studies have been conducted in Italy on the effects of 1227
The study investigates the prevalence of reading difficulties among children in scholar age and a... more The study investigates the prevalence of reading difficulties among children in scholar age and analyses the socio-demographic characteristics of learners who presented reading difficulties in central Italy. A sample of 623 students 7-11 aged, was assessed with the Italian MT standardized tests. Information on gender, age, handedness, and other socio-demographic variables were also gathered. The study showed that 11% of learners presented poor comprehension skills. The reading speed difficulties were more common than the reading correctness problems: about 7% of children vs 1% were dyslexics due to slow reading. There were no significant differences regarding gender, age. However, dominant hand and the school location seemed to affect the speed difficulties and the comprehension problems. The analyses showed that attending a school located in a rural area was statistically associated with the reading difficulties. Left-handed children were more likely to be slow decoders and/or poor comprehenders. These findings may be used in the early diagnosis of poor readers. These difficulties often have a chronic progression with substantial psychosocial limitations and psychological stress, so children with reading difficulties should be identified as early as possible.
Annals of Neurology, 2011
Objective: Limited data are available on health-related quality of life (HR-QoL) in pediatric str... more Objective: Limited data are available on health-related quality of life (HR-QoL) in pediatric stroke survivors. The aim of the present study was to assess HR-QoL by self-assessment and parent/proxy-assessment in children and adolescents who survived a first stroke episode. Methods: We investigated HR-QoL in pediatric stroke survivors (71 preschool children [G1] and 62 school children/ adolescents [G2]) and in 169 healthy controls. HR-QoL was assessed in patients and parents/proxies with the generic KINDL-R questionnaire exploring overall well-being and 6 well-being subdimensions (physical, psychological, selfesteem, family-related, friend-related, and school-related). In pediatric stroke survivors the neurological long-term outcome was measured with the standardized Pediatric Stroke Outcome Measure. Results: Of stroke survivors, 65% exhibited at least 1 neurologic disability. Pediatric stroke survivors reported lower overall well-being compared with healthy controls. In G2 stroke patients, friend-related well-being respectively emotional well-being was significantly reduced compared with healthy controls (73.0 vs 85.0 points; p < 0.001 respectively 80.2 vs 84.5 points; p ¼ 0.049). Parents/proxies of both stroke survivors rated the overall well-being and all subdimensions (except family-related and school-related well-being in G1 and G2 stroke survivors and physical functioning in G2 stroke survivors) lower compared with parents/proxies of healthy children/adolescents. Overall well-being was significantly reduced in children with moderate/severe neurological deficits compared with normal/ mildly affected patients (75.5 vs 83.3 points, p ¼ 0.01). Neonatal stroke survivors reported a significantly better neurological long-term outcome compared to childhood stroke survivors (82.0 vs 75.0 points; p ¼ 0.005). Interpretation: Pediatric stroke survivors compared with healthy controls are strongly affected regarding their overall well-being and older children/adolescents regarding their well-being with peers.
Computer Methods and Programs in Biomedicine, 2008
Currently, large efforts are spent to develop standards and architectures useful to achieve more ... more Currently, large efforts are spent to develop standards and architectures useful to achieve more effective interoperability among medical information systems. Despite such efforts, there are no researches produced so far to directly analyse, with statistical methods, biomedical data represented as eXtensible Markup Language (XML) documents. Thus, the paper proposes an architecture which offers a twofold approach to the statistical analysis of XML data, i.e. via a web service and by extending the query languages used in XML databases. To show how the architecture can be used, a sample system is also reported. Finally, the paper ends by reporting the advantages and drawbacks of the proposed approach in comparison with classic statistical packages.