gülin keskin - Academia.edu (original) (raw)

Papers by gülin keskin

Demiroğlu Bilim University Florence Nightingale Journal of Medicine, 2019

Objectives: In this study, we aimed to analyze the laboratory data of patients with idiopathic th... more Objectives: In this study, we aimed to analyze the laboratory data of patients with idiopathic thrombotic thrombocytopenic purpura (TTP). Patients and methods: A total of 20 patients (7 males, 13 females; median age 42.5 years, range 20 to 75 years) diagnosed with idiopathic TTP were retrospectively evaluated. Age, sex, median plasmapheresis count, LDH, platelet count, hemoglobin, hematocrit, indirect bilirubin levels, and treatment responses of the patients were assessed. Groups were formed according to plasmic score. Results: Lactate dehydrogenase (LDH) levels before and after plasmapheresis, on day 1, 3, and 7, total and indirect bilirubin levels, creatinine, AST/ALT, hemoglobin, leukocyte values, and platelet counts were compared. The median LDH levels of patients regressed to normal in an average of three days (range: 1-19). Mean platelet count was 47,100/µL at admission. Platelet count returned to normal in a median of 7 (3-32) days. The median number of plasmapheresis procedures was 8.5 (5-58). All patients underwent prednisolone treatment. Three patients died, in which one had severe neurological involvement. Mortality rate was 15%. Conclusion: In the treatment of TTP, monitoring of LDH, platelet count and bilurubin values is important in evaluating the treatment response of plasmapheresis process. Further studies involving patient data are needed for the plasmic score used to assess severe idiopathic ADAMTS13 deficiency.

Amac: Bu calismada idiyopatik trombotik trombositopenik purpura (TTP) hastalarinin laboratuvar ve... more Amac: Bu calismada idiyopatik trombotik trombositopenik purpura (TTP) hastalarinin laboratuvar verileri degerlendirildi. Hastalar ve yontemler: Idiyopatik TTP tanisi konulan 20 hasta (7 erkek, 13 kadin; ortanca yas 42,5 yil; dagilim 20-75 yil) retrospektif olarak degerlendirildi. Hastalarin yas, cinsiyet, ortanca plazmaferez sayisi, laktat dehidrogenaz (LDH), trombosit sayisi, hemoglobin, hematokrit, indirekt bilirubin duzeyleri ve tedavi yanitlari degerlendirildi. Gruplar plasmic skora gore olusturuldu. Bulgular: Hastalarin plazmaferez islemi oncesi ve sonrasi 1. gun, 3. gun ve 7. gun LDH, total ve indirekt bilirubin duzeyi, kreatinin, AST/ALT, hemoglobin, lokosit degerleri ve trombosit sayilari karsilastirildi. Hastalarin islem oncesi yuksek olan ortanca LDH degeri, ortalama uc gunde (1-19 gun) normale geriledi. Hastalarin basvuru aninda trombosit degerleri ortalama 47100/µL idi. Hastalarin tedavi sonrasi trombosit degerleri ortanca yedi gunde (3-32 gun) normale dondu. Plazmafere...

Demiroğlu Bilim University Florence Nightingale Journal of Medicine, 2019

Objectives: In this study, we aimed to analyze the laboratory data of patients with idiopathic th... more Objectives: In this study, we aimed to analyze the laboratory data of patients with idiopathic thrombotic thrombocytopenic purpura (TTP). Patients and methods: A total of 20 patients (7 males, 13 females; median age 42.5 years, range 20 to 75 years) diagnosed with idiopathic TTP were retrospectively evaluated. Age, sex, median plasmapheresis count, LDH, platelet count, hemoglobin, hematocrit, indirect bilirubin levels, and treatment responses of the patients were assessed. Groups were formed according to plasmic score. Results: Lactate dehydrogenase (LDH) levels before and after plasmapheresis, on day 1, 3, and 7, total and indirect bilirubin levels, creatinine, AST/ALT, hemoglobin, leukocyte values, and platelet counts were compared. The median LDH levels of patients regressed to normal in an average of three days (range: 1-19). Mean platelet count was 47,100/µL at admission. Platelet count returned to normal in a median of 7 (3-32) days. The median number of plasmapheresis procedures was 8.5 (5-58). All patients underwent prednisolone treatment. Three patients died, in which one had severe neurological involvement. Mortality rate was 15%. Conclusion: In the treatment of TTP, monitoring of LDH, platelet count and bilurubin values is important in evaluating the treatment response of plasmapheresis process. Further studies involving patient data are needed for the plasmic score used to assess severe idiopathic ADAMTS13 deficiency.

Amac: Bu calismada idiyopatik trombotik trombositopenik purpura (TTP) hastalarinin laboratuvar ve... more Amac: Bu calismada idiyopatik trombotik trombositopenik purpura (TTP) hastalarinin laboratuvar verileri degerlendirildi. Hastalar ve yontemler: Idiyopatik TTP tanisi konulan 20 hasta (7 erkek, 13 kadin; ortanca yas 42,5 yil; dagilim 20-75 yil) retrospektif olarak degerlendirildi. Hastalarin yas, cinsiyet, ortanca plazmaferez sayisi, laktat dehidrogenaz (LDH), trombosit sayisi, hemoglobin, hematokrit, indirekt bilirubin duzeyleri ve tedavi yanitlari degerlendirildi. Gruplar plasmic skora gore olusturuldu. Bulgular: Hastalarin plazmaferez islemi oncesi ve sonrasi 1. gun, 3. gun ve 7. gun LDH, total ve indirekt bilirubin duzeyi, kreatinin, AST/ALT, hemoglobin, lokosit degerleri ve trombosit sayilari karsilastirildi. Hastalarin islem oncesi yuksek olan ortanca LDH degeri, ortalama uc gunde (1-19 gun) normale geriledi. Hastalarin basvuru aninda trombosit degerleri ortalama 47100/µL idi. Hastalarin tedavi sonrasi trombosit degerleri ortanca yedi gunde (3-32 gun) normale dondu. Plazmafere...