gabriel rodrigues - Academia.edu (original) (raw)

Papers by gabriel rodrigues

Journal of the American Society of Hypertension : JASH, 2014

The electrocardiographic (ECG) strain pattern (Strain) is a marker of left ventricular hypertroph... more The electrocardiographic (ECG) strain pattern (Strain) is a marker of left ventricular hypertrophy (LVH) severity that provides additional prognostic information beyond echocardiography (ECHO) in the community level. We sought to evaluate its clinical determinants and prognostic usefulness in chronic kidney disease (CKD) patients. We evaluated 284 nondialysis-dependent patients with CKD stages 3 to 5 (mean age, 61 years [interquartile range, 53-67 years]; 62% men). Patients were followed for 23 months (range, 13-32 months) for cardiovascular (CV) events and/or death. Strain patients (n ¼ 37; 13%) were using more antihypertensive drugs, had higher prevalence of peripheral vascular disease and smoking, and higher levels of C-reactive protein, cardiac troponin, and brain natriuretic peptide (BNP). The independent predictors of Strain were: left ventricular mass index (LVMI), BNP, and smoking. During follow-up, there were 44 cardiovascular events (fatal and non-fatal) and 22 non-CV deaths; and Strain was associated with a worse prognosis independently of LVMI. Adding Strain to a prognostic model of LVMI improved in 15% the risk discrimination for the composite endpoint and in 12% for the CV events. Strain associates with CV risk factors and adds prognostic information over and above that of ECHO-assessed LVMI. Its routine screening may allow early identification of high risk CKD patients. J Am Soc Hypertens 2014;-(-):1-9.

Memórias do Instituto Oswaldo Cruz, 2014

Rivers in the state of Amazonas (AM). However, little is known about the presence of this parasit... more Rivers in the state of Amazonas (AM). However, little is known about the presence of this parasite in communities located in regions bordering AM and the state of Acre. The prevalence rate of M. ozzardi infections was determined in blood samples from volunteers according to the Knott method. A total of 355 volunteers from six riverine communities were enrolled in the study and 65 (18.3%) were found to be infected with M. ozzardi. As expected, most of the infections (25%) occurred in individuals involved in agriculture, cattle rearing and fishing and an age/sex group analysis revealed that the prevalence increased beginning in the 40-50-years-of-age group and reached 33% in both sexes in individuals over 50 years of age. Based on the described symptomatology, articular pain and headache were found to be significantly higher among infected individuals (56 and 65% prevalence, respectively, p < 0.05). Sera from volunteers were subjected to ELISA using a cocktail of recombinant proteins from Onchocerca volvulus to evaluate the specificity of the test in an endemic M. ozzardi region. No cross-reactions between M. ozzardi-infected individuals and recombinant O. volvulus proteins were detected, thus providing information on the secure use of this particular cocktail in areas where these parasites are sympatric.

Medical Hypotheses, 2013

Gut-produced ammonia plays a vital role in the pathogenesis of hepatic encephalopathy because cir... more Gut-produced ammonia plays a vital role in the pathogenesis of hepatic encephalopathy because cirrhotic liver fails to clear toxic metabolites. Small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhosis add to the pathogenesis. Lactulose is a mainstay in the treatment of hepatic encephalopathy. Another benefit of lactulose is its prebiotic effect on probiotics that reduce the activity of bacterial urease, resulting in decreased hyperammoneamia and increased elimination of ammonia and other nitrogenous waste through enteric toxin reduction technology. Synbiotic formulation of probiotic and lactulose can synergistically/additively reduce ammonia production, increase utilization and excretion of ammonia and other nitrogenous wastes, thereby improving the well-being of patients with hepatic encephalopathy. We hypothesize that oral administration of a synbiotic formulation prepared from a combination of selected microbial strains of probiotics and lactulose will offer additional protection against hepatic encephalopathy via intra-intestinal extraction of toxic solutes in patients with cirrhosis.

Medical Hypotheses, 2014

Treatment of chronic conditions like diabetic foot ulcer (DFU) is challenging due to increased su... more Treatment of chronic conditions like diabetic foot ulcer (DFU) is challenging due to increased susceptibility for infection and delayed wound healing. Complexity of existing therapy, adverse effects and microbial resistance emphasizes the need of an alternative approach for the management of DFU. The increasing body of evidence associated with probiotic application in diverse disease states merits its use in wound healing and infection too. Different probiotic strains have shown their efficacy in various infections like gut infections, oral infections and urogenital infections. Experimental studies have demonstrated probiotics&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; ability for gastric ulcer healing. Underlying mechanism of the above therapeutic effects of probiotics involves modulation of local and systemic immunity. The hypothesis is based on the concept that mechanism of anti-infective and ulcer healing action of probiotics will be similar in peripheral wounds and ulcers as on any other part of the body. This paper focuses on the hypothesis that topical applications/formulation of probiotics may be effective for the treatment of diabetic foot ulcers.

Developmental Dynamics, 2012

Background: Skeletal myogenesis is extensively influenced by the surrounding environment. However... more Background: Skeletal myogenesis is extensively influenced by the surrounding environment. However, how the extracellular matrix (ECM) affects morphogenesis of muscles is not well understood. Results: We mapped the three-dimensional (3D) organization of fibronectin, tenascin, and laminin by immunofluorescence during early epaxial myogenesis in mouse embryos. We define four stages of dermomyotome/myotome development and reveal the 3D organization of myogenic cells within their ECM during those stages. Fibronectin is abundant in all interstitial tissues, while tenascin is restricted to intersegmental borders. Bundles of fibronectin and tenascin also penetrate into the myotome, possibly promoting myocyte alignment. A laminin matrix delineates the dermomyotome and myotome and undergoes dynamic changes, correlating with key developmental events. Conclusion: Our observations cast new light on how myotomal cells interact with their environment and suggest that, as the segmented myotomes transform into the epaxial muscle masses, the laminin matrix disassembles and myocytes use the abundant fibronectin matrix to reach their final organization. Developmental Dynamics 241:350-364,

Saudi journal of gastroenterology: …, 2008

Sphincter of Oddi though mostly heard about in ‘anatomy textbooks’ is making its way into surgica... more Sphincter of Oddi though mostly heard about in ‘anatomy textbooks’ is making its way into surgical practice due to various disease states affecting it and its dysfunction seems to be an important condition to be observed while treating patients with abdominal pain. In this review, we have attempted to discuss all the relevant conditions affecting it, particularly the dysfunction with a detailed literature review.

World Journal of …, 2008

The overall incidence of male breast cancer is around 1% of all breast cancers and is on the rise... more The overall incidence of male breast cancer is around 1% of all breast cancers and is on the rise. In this review we aim to present various aspects of male breast cancer with particular emphasis on incidence, risk factors, patho-physiology, treatment, prognostic factors, and outcome.

Tissue & cell, 2014

Induction of NF-κB-mediated gene expression has been identified in the pathogenesis of alcoholic ... more Induction of NF-κB-mediated gene expression has been identified in the pathogenesis of alcoholic liver disease (ALD). Diethylcarbamazine (DEC) is a piperazine derivative drug with anti-inflammatory properties. The present study was designed to evaluate the effect of DEC on NF-κB pathways in mice undergoing alcoholism induced hepatic inflammation. Forty male C57BL/6 mice were divided equally into four groups: control group (C); DEC-treated group, which received 50mg/kg (DEC50); alcoholic group (EtOH), submitted to chronic alcohol consumption and the alcohol-DEC treated group (EtOH50), submitted to chronic alcoholism consumption plus DEC treatment. Histological analysis of the alcoholic group showed evident hepatocellular damage which was reduced in EtOH50 group. Immunohistochemistry and western blot results showed elevated expression of inflammatory markers such as MDA, TNF-α, IL-1β, COX-2 and iNOS in hepatocytes of EtOH group. However, low immunopositivity for these markers was detected following DEC treatment. In the EtOH group the activation of NF-κB was observed by an increase in the expression of both NF-κB and pNF-κB in hepatocytes. This expression was significantly reduced in livers of EtOH50 group. Protein expression of Iκβα was measured to determine whether activation of NF-κB might be the result of Iκβα degradation. It was observed that expression of this protein was low in EtOH group, while animals treated with DEC had a high expression of Iκβα. The results of the present study indicate that DEC alleviates alcoholic liver injury, in part by the inhibiting activation of NF-κB and by suppressing the induction of NF-κB-dependent genes.

Clinical and Experimental Pharmacology and Physiology, 2015

Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Diethylcarbama... more Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Diethylcarbamazine (DEC) is a drug that has anti-inflammatory properties due to its effects on the metabolism of arachidonic acid. Thus, the present study examined the anti-inflammatory effects of DEC on the mechanisms of ALD. C57BL/6 mice were divided into seven groups: 1) control, 2) DEC 50 mg/kg, 3) alcohol, 4) alcohol + DEC 50 mg/kg, 5) alcohol + celecoxib 50mg/kg 6) alcohol + pyrrolidine dithiocarbamate (PDTC) 100 mg/kg and 7) alcohol + PDTC 100 mg/kg + DEC 50mg/kg. Liver fragments were stained with HE and Sirius red, and processed for immunofluorescence, western blot and immunohistochemistry. Furthermore, serum was collected for biochemical measurements. Alcohol induced liver damage, elevation in collagen content and increased expression of NF-κB and inflammatory markers (TNF-α, IFN-γ, IL- 1β, iNOS, COX-2 and TGF-β). Treatment with DEC was able to reduce liver damage and the collagen content, the NF-κB and inflammatory markers expression, ameliorated biochemistry parameters (total cholesterol, HDL cholesterol, triglyceride content and aspartate aminotransferase) and increased the expression of anti-inflammatory markers (p-AMPK and IL -10). Future clinical trials may demonstrate that oral administration of DEC may be suitable for the treatment of ALD as other liver diseases. This article is protected by copyright. All rights reserved.

Horticultura Brasileira, 2009

duração do ciclo vegetativo em batata e relação com a produtividade de tubérculos. Horticultura B... more duração do ciclo vegetativo em batata e relação com a produtividade de tubérculos. Horticultura Brasileira 27: 280-285.

Mediators of Inflammation, 2014

This study investigated the anti-inflammatory effects of DEC on the CCl 4 -induced hepatotoxicity... more This study investigated the anti-inflammatory effects of DEC on the CCl 4 -induced hepatotoxicity in C57BL/6 mice. Chronic inflammation was induced by i.p. administration of CCl 4 0.5 L/g of body weight through two injections a week for 6 weeks. DEC (50 mg/kg) was administered by gavage for 12 days before finishing the CCl 4 induction. Histological analyses of the DEC-treated group exhibited reduced inflammatory process and prevented liver necrosis and fibrosis. Immunohistochemical and immunofluorescence analyses of the DEC-treated group showed reduced COX-2, IL1 , MDA, TGF-, and SMA immunopositivity, besides exhibiting decreased IL1 , COX-2, NF B, IFN , and TGF expressions in the western blot analysis. The DEC group enhanced significantly the IL-10 expression. The reduction of hepatic injury in the DEC-treated group was confirmed by the COX-2 and iNOS mRNA expression levels. Based on the results of the present study, DEC can be used as a potential antiinflammatory drug for chronic hepatic inflammation.

Hortic. Bras., 2006

SIDALC - Servicio de Informacion y Documentacion Agropecuaria de las Americas.

Bragantia, 2009

JOSÉ DONIZETI ALVES ( 2 ); FLÁVIO RODRIGO GANDOLFI BENITES ( 2 ); CRISTIANA MOURA ANDRADE ( 2 ); ... more JOSÉ DONIZETI ALVES ( 2 ); FLÁVIO RODRIGO GANDOLFI BENITES ( 2 ); CRISTIANA MOURA ANDRADE ( 2 ); GABRIEL BELFORT RODRIGUES ( 2 ); ANDRÉ LUIZ LEPRE ( 2 ); LEONARDO LOPES BHERING ( 2 )

1 Olá pessoal! Continuaremos em Técnicas de Vendas. Hoje estudaremos: Técnicas de Vendas de Produ... more 1 Olá pessoal! Continuaremos em Técnicas de Vendas. Hoje estudaremos: Técnicas de Vendas de Produtos e Serviços financeiros no setor bancário: Planejamento Técnicas Motivação para vendas. As críticas ou sugestões poderão ser enviadas para: cesar.frade@pontodosconcursos.com.br henriquecampolina@pontodosconcursos.com.br Boa aula para todos nós! Prof. Henrique Campolina Dezembro/2012 AULA 02 TÉCNICAS DE VENDAS -BANCO DO BRASIL PROFESSORES CÉSAR FRADE E HENRIQUE CAMPOLINA Prof. Henrique Campolina www.pontodosconcursos.com.br 2 TÉCNICAS DE VENDAS (continuação) TÉCNICAS DE VENDAS DE PRODUTOS E SERVIÇOS FINANCEIROS NO SETOR BANCÁRIO: Planejamento, Técnicas e Motivação para Vendas. Antes de entrarmos nos tópicos deste item (planejamento, técnicas e motivação para vendas), vamos tecer alguns comentários introdutórios, começando pela listagem dos principais produtos e serviços financeiros comercializados no setor bancário. Em decorrência do perfil do público-alvo, pessoa física ou jurídica, as instituições financeiras possuem produtos e serviços diferenciados, adequados a cada um destes grupos de consumidores. Vejamos: Produtos ofertados para PESSOA FÍSICA: Crédito: Crédito Pessoal, Cartões de crédito, Cheque especial, com limites de crédito previamente definidos e liberados, com utilização imediata, assim que o saldo da conta corrente é zerado, Empréstimos pessoais, que podem, inclusive, ser consignados na folha de pagamento do cliente (as parcelas são descontadas automaticamente no pagamento mensal, quando se tratar cliente assalariado, com emprego fixo e formal), Financiamentos pessoais, que podem possuir características específicas em função do bem a ser adquirido, como, por exemplo: -Imóveis (aquisição de imóvel pronto ou para construção), -Veículos e motos e -Outros bens (tais como computadores, eletroeletrônicos e eletrodomésticos), AULA 02 TÉCNICAS DE VENDAS -BANCO DO BRASIL PROFESSORES CÉSAR FRADE E HENRIQUE CAMPOLINA Prof. Henrique Campolina www.pontodosconcursos.com.br 3 Leasing: também denominado Arrendamento Mercantil, é uma modalidade de credito, formalizada mediante contrato entre o cliente (arrendatário) e a instituição financeira (arrendadora). O arrendador adquire o bem escolhido pelo arrendatário, que paga pelo seu uso e posse durante a vigência deste acordo. Por se tratar de uma aquisição à vista (pelo arrendador), é possível a obtenção de boas condições durante a negociação do valor do bem, pelo valor residual 1 . O arrendatário tem a opção de compra do bem, que, durante a vigência do contrato, é de propriedade do arrendador. Outra vantagem deste tipo de crédito é não sofrer incidência de IOF, o que pode tornar os valores das parcelas mais atraentes. Investimentos: Caderneta de Poupança: Uma das aplicações mais conhecidas no mercado brasileiro, a poupança é o sinônimo de segurança para muitos investidores, pois conta com a garantia do Fundo Garantidor de Crédito (FGC). Através dele o investidor que aplica na poupança tem garantia de recebimento dos valores aplicados, mesmo em caso de quebra do banco, para valores de até R$ 20mil por CPF. Uma das maiores críticas com relação à poupança reside na sua baixa rentabilidade comparativa, os depósitos de poupança são isentos da cobrança do imposto de renda, tendo remuneração composta pela TR (correção monetária) + 0,5% (juros) ao mês, com aniversário a cada 30 dias 2 . Fundos de Investimento: Forma mais conhecida de aplicação financeira, e funcionam como uma espécie de condomínio de recursos individuais de pessoas físicas ou jurídicas. Na maioria dos casos esses fundos funcionam como um condomínio aberto, sem limite máximo de participantes, administrado com a finalidade de aplicar estes recursos no mercado e maximizar o retorno para o investidor (cotista). 1 Valor residual: valor a pagar nas operações de Leasing/Arrendamento Mercantil, caso o arrendatário deseje adquirir o bem ao final do contrato. Sua forma de pagamento é definida pelas partes no contrato (pagamento antecipado, mensalmente (diluído nas parcelas do contrato) ou ao final do acordo). 2 Glossário Financeiro do Banco Bradesco (www.bradesco.com.br)