gaurav mehta - Academia.edu (original) (raw)

Papers by gaurav mehta

Carbohydrate polymers, Jan 15, 2014

A facile 6-aminoagarose (AA) mediated synthesis of new fluorogenic amides of agarose with nicotin... more A facile 6-aminoagarose (AA) mediated synthesis of new fluorogenic amides of agarose with nicotinic (AA-NA) and picolinic acids (AA-PA) employing carbodiimide chemistry have been described. 6-Amino agarose (AA) was synthesized in a facile Mitsunobu-inspired microwave mediated method involving the reaction of agarose with phthalimide in presence of diisopropyl azodicarboxylate and triphenylphosphene (DIAD/TPP) followed by hydrazinolysis. All compounds were characterized by GPC, UV spectrophotometry, fluorescence spectroscopy, FT-IR, (1)H and (13)C NMR spectra. The fluorescence emissions (λmax 430 and 412 nm) of 1 × 10(-3)M solutions of AA-NA and AA-PA in water were significantly higher (ca. 82% and ca. 90%) than those of the molar equivalents (0.2mg) of NA and PA present in the 1 × 10(-3)M solutions of the amides, respectively. These fluorogenic pyridine carboxylic acid amides of agarose may find applications as sensors in biomedical and pharmaceutical industries.

Journal of Applied Phycology, 2010

Superior quality non-methylated and low-sulphated galactans were extracted from two Indian agarop... more Superior quality non-methylated and low-sulphated galactans were extracted from two Indian agarophytes namely Gracilaria debilis and G. salicornia growing naturally along the west coast of India, using an eco-friendly method developed in our laboratory. The galactans were characterised by FT-IR, 13C NMR, GC-MS, ICP, GPC and rheological measurements. G. debilis produced exclusively non-methylated galactan exhibiting the greatest gel strength of 650±25 g cm−2 and lowest sulphate of 0.21±0.06%. On the contrary, G. salicornia polysaccharide was composed of non-methylated galactose (major) and mannose (minor), having gel strength of 510±25 g cm−2 and sulphate of 0.45±0.06%. Very low heavy metal contents were determined in both the galactan samples, which may thus be potentially useful in food and biological applications.

Journal of Applied Polymer Science, 2006

κ-Carrageenan-graft-PAAm, a copolymer hydrogel of κ-carrageenan (kC) and acrylamide (AAm), has be... more κ-Carrageenan-graft-PAAm, a copolymer hydrogel of κ-carrageenan (kC) and acrylamide (AAm), has been synthesized in aqueous medium at ∼ pH 7 in the presence of the initiator potassium persulfate (KPS), using microwave irradiation. The reaction conditions were optimized by varying the concentration of AAm and KPS to obtain copolymer hydrogels having different nitrogen contents e.g., %N 6.35, 10.56, and 11.05. It was observed that copolymer hydrogel having %N 11.05 gives superior adhesive properties whereas copolymer hydrogel with %N 10.56 produces superior absorbent properties in the presence of optimized concentrations of AAm (0.87 and 1.1428 mol/L respectively) and KPS (0.022 and 0.0296 mol/L respectively). The product with %N 6.35 is a soft gel (2–5% gel in 1% KCl) exhibiting low gel strength (135 g cm−2). The one with %N 10.56 showed superior swelling property and maximum swelling was observed in the alkaline pH (22 g/g). The swelling behaviors of the hydrogels were studied at different pHs (pH 1.2–12.5) as well as in 1% aqueous solutions of NaCl, KCl, and CaCl2. The 5% dispersion of the hydrogel having %N 11.05 in water had good binding properties with papers, polyethylene sheets, and wood pieces. To evaluate the measure of adhesive property, the viscosity and solid and liquid weights of the applied adhesive were measured. Characterization of the copolymer hydrogels was done by TGA, X-ray diffraction, 13C-NMR, FT-IR, elemental analyses, and rheological studies. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 5144–5152, 2006

Journal of Applied Polymer Science, 2006

Grafting of agar and κ-carrageenan with polyvinylpyrrolidone (PVP, average molecular weight 10,00... more Grafting of agar and κ-carrageenan with polyvinylpyrrolidone (PVP, average molecular weight 10,000 D) in an aqueous medium at a pH of about 7 produced agar-graft-PVP and κ-carrageenan-graft-PVP blends capable of forming hydrogels. The reaction was carried out with microwave irradiation in the presence of a water-soluble initiator, potassium persulfate. Optimum microwave irradiation conditions for obtaining hydrogels of the grafted products were achieved. The structural characteristics and thermal stability of the grafted blends were studied by Fourier transform infrared, 13C-NMR, and thermogravimetric analyses. Appearance of new IR bands at 1661, 1465, and 1426 cm−1 in the grafted products indicated the insertion of PVP into the polysaccharide structure. Powder X-ray diffraction studies revealed the enhanced crystallinity in the products compared to in the control polysaccharides as well as PVP. Agar and κ-carrageenan were grafted to a considerable degree, with 62.5 E % and 125 G % for agar-graft-PVP and 65.5 E % and 131 G % for κ-carrageenan-graft-PVP. Optical micrographs of the grafted blends indicated considerable changes in the morphology of the agar and the κ-carrageenan, substantiating the X-ray diffraction data. A plausible mechanism for the crosslinking of PVP to agar and κ-carrageenan is proposed. These hydrogels exhibited enhanced water-holding capacity despite weaker gel strength than that in the respective control polysaccharides. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 3654–3663, 2006

Polymer Chemistry, 2011

... Gaurav K. Mehta, Stalin Kondaveeti and AK Siddhanta*. Marine Biotechnology and Ecology Discip... more ... Gaurav K. Mehta, Stalin Kondaveeti and AK Siddhanta*. Marine Biotechnology and Ecology Discipline, CSIR-Central Salt & Marine Chemicals Research Institute, G. B Marg, Bhavnagar, 364021 ... 5, R. Meena, K. Prasad and AK Siddhanta, Food Hydrocolloids, 2009, 23, 497–509 . ...

Phycological Research, 2011

... Galactans from Gracilaria millardetii and G textorii (Gracilariales, Rhodophyta) of Indian wa... more ... Galactans from Gracilaria millardetii and G textorii (Gracilariales, Rhodophyta) of Indian waters. Mihir D. Oza,; Gaurav K. Mehta,; Sanjay Kumar,; Ramavatar Meena,; Arup K. Siddhanta. ... The authors thank Dr Vaibhav A Mantri for taxonomical identification of the seaweed species. ...

Bulletin of Materials Science, 1994

Critical exponent of the electrical conductivity in the paracoherence region (γ) of the high temp... more Critical exponent of the electrical conductivity in the paracoherence region (γ) of the high temperature superconductor YBa2Cu3O7−x (YBCO) has been estimated for high quality thin film on ZrO2 substrate prepared by high pressure oxygen sputtering. High energy ion irradiation was carried out using 100 MeV16O7+ ions at liquid nitrogen temperature to see the effects of disorder on the value of the exponent. The critical exponent (γ) changes from a value of about 2 to 1·62 upon irradiation. Studies were also carried out on this film to see the effect of ageing and annealing.

Vacuum, 1997

The effects of 100 MeV Oxygen and 200MeV Silver ions on the structural and transport properties o... more The effects of 100 MeV Oxygen and 200MeV Silver ions on the structural and transport properties of YBCO thin films are reported. Both normal state and superconducting properties were studied on Laser ablated and high pressure oxygen sputtered films. Precise electrical resistance ...

Design Automation Conference, 1998

Power consumption has become one of the biggest challenges in high-performance microprocessor des... more Power consumption has become one of the biggest challenges in high-performance microprocessor design. The rapid increase in the complexity and speed of each new CPU generation is outstripping the benefits of voltage reduction and feature size scaling. Designers are thus continuously challenged to come up with innovative ways to reduce power, while trying to meet all the other constraints imposed on the design. This paper presents an overview of the issues related to power consumption in the context of Intel CPUs. The main trends that are driving the increased focus on design for low power are described. System and benchmarking issues, and sources of power consumption in a high-performance CPU are briefly described. Techniques that have been tried on real designs in the past are described. The role of CAD tools and their limitations in this domain are also discussed. In addition, areas that need increased research focus in the future are also pointed out.

Materials Chemistry and Physics, 1998

The strain field generated by 200 MeV Ag14+ ions in Si (001) crystals has been investigated using... more The strain field generated by 200 MeV Ag14+ ions in Si (001) crystals has been investigated using X-ray topography. By choosing suitable diffraction vectors it has been possible to explore the lattice distortion in the inelastic and elastic loss regions separately. Stationary reflection topographs gave two spatially separated images—one originating from the surface and the other from the region affected by elastic nuclear collisions close to the end of the ion range. The spatial separation of these two images is geometrically related to the depth of this elastic loss region. These topographic findings are compared with TRIM calculations.

Bioresource Technology, 2009

Cellulose contents were estimated in 12 seaweed samples belonging to different families e.g. red,... more Cellulose contents were estimated in 12 seaweed samples belonging to different families e.g. red, brown and green, growing in Indian waters. Each cellulose sample was fractionated to yield alpha (α) and beta (β) celluloses. Characterization was done using various analytical tools and results were validated by comparison with those of the cellulose obtained from Whatman filter paper No. 4. The greatest yields of cellulose (crude), α- and β-cellulose were obtained from Gelidiella acerosa (13.65%), Chamaedoris auriculata (9.0%) and G. acerosa (3.10%). G. acerosa was also found to contain relatively high amount of α-cellulose (8.19%). The lowest cellulose contents were recorded from Kappaphycus alvarezii (2.00%) and Sarconema scinaioides (2.1%), while the latter contained the lowest α-, and β-celluloses (1.0% and 0.30%, respectively). It appears that agarophytic and alginophytic algae contain high cellulose and α-cellulose contents, while the carrageenophyte contains low cellulose. The brown algae, in general contain high cellulose as well as α- and β-celluloses.

Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics & Photonics Technical Digest, 2009

1. Introduction Photonic crystal fibers (PCFs) offer exceptional opportunities for manipulation o... more 1. Introduction Photonic crystal fibers (PCFs) offer exceptional opportunities for manipulation of light propagation and realization of novel photonic devices. In particular, PCFs provide a new platform for the development of compact, multi-functional optical sensors [1-3]. ...

Pharmacogenomics, 2014

Lung carcinoma is the most common malignancy and the leading cause of cancer deaths worldwide. Al... more Lung carcinoma is the most common malignancy and the leading cause of cancer deaths worldwide. Although clinical factors including age, performance status and stage influence the likelihood of benefit from and tolerability of chemotherapy, the genetic profile of individual patients may be an independent predictor of response and toxicity. The present study aimed to identify pharmacogenetic markers associated with clinical response and toxicity in patients with advanced non-small cell lung cancer (NSCLC) treated primarily with carboplatin and paclitaxel. Genomic DNA samples from 90 adult male patients diagnosed with stage IIIB/IV NSCLC were genotyped for SNPs in candidate genes of relevance to platinating agents and paclitaxel and analyzed for association with survival and toxicities in univariate and multivariate models. After adjusting for performance status and stage, SNPs in the drug transporters ABCB1 and ABCC1, as well as within NQO1 were associated with progression-free survival. With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ABCG2) were associated with thrombocytopenia, nausea and neutropenia, whereas SNPs in the DNA repair pathway genes ERCC4 and XPC were significantly associated with neutropenia and sensory neuropathy, respectively. Our study evaluated and identified SNPs in key candidate genes in platinating agent and taxane pathways associated with outcome and toxicity in advanced NSCLC. If validated in large prospective studies, these findings might provide opportunities to personalize therapeutic strategies.

2014 IEEE 64th Electronic Components and Technology Conference (ECTC), 2014

2013 IEEE 63rd Electronic Components and Technology Conference, 2013

ABSTRACT While copper or palladium coated copper wire bonding in IC packaging have shown tremendo... more ABSTRACT While copper or palladium coated copper wire bonding in IC packaging have shown tremendous surge recently driven by huge cost saving and competitiveness across OSAT and IDM, there are new challenges when trying to qualify copper wire bond packages especially for fine pitch devices. This paper will study on the probe mark and its effects for copper wire bond integrity and stress test reliability performances. The increased probe touchdowns on bond pad exhibited greater risk resulting to deeper probe depth. Recent studies using gold wire bonding have reported that the limit for probe mark area damage should be limited to maximum of 30% [1] for 45μm ball size whilst other paper suggested maximum of 20% [2] of the probe mark area in order to achieve reliable gold ball bonding. While this paper focused on palladium coated copper (PdCu) wire bonding, the 10% ~ 50% range of probe mark area studied did not exhibit any related wire bonding failures across all legs during assembly. Failure analysis data results i.e intermetallic (IMC), pad crater test and ball bond cross-section for aluminum remains did not show much significant difference. Remarkably stress reliability test followed by destructive test did show some degradation results from unbiased HAST while HTS and temp cycle test did not reveal any failure during ball pull test. Reliability test data analysis concluded that the probe mark area should be limited to max of 30% for 35±2μm ball bond size while probe depth maximum at 80% from the original Al pad thickness or 20% of the Al thickness remains after probe as shown in figure 5 in order to achieve a reliable copper wire bonding process. This paper will share those probe marks criteria for considerations, challenges and recommendations when qualifying new packages for copper wire bonding process.

Hepatocellular Carcinoma, 2009

The clinical presentation of hepatocellular carcinoma may take on a vari-ety of different forms, ... more The clinical presentation of hepatocellular carcinoma may take on a vari-ety of different forms, ranging from asymptomatic (diagnosed via tumor markers or imaging studies) to a catastrophic hemoperitoneum with shock due to tumor rupture. This chapter will highlight the many ...

Paripex - Indian Journal Of Research, 2012

2006 8th International Conference on Solid-State and Integrated Circuit Technology Proceedings, 2006

1. Introduction The complexities of SOC, high expectations and the severe time-to-market pressure... more 1. Introduction The complexities of SOC, high expectations and the severe time-to-market pressure are forcing everyone to rethink their SOC design strategies and design methodologies. In reality, more than 80% of chips cannot meet the original project schedule because of ...

IEEE Transactions on Components, Packaging and Manufacturing Technology, 2011

2010 Proceedings 60th Electronic Components and Technology Conference (ECTC), 2010

Abstract As the progression of 45/40nm ELK devices into mainstream semiconductor assembly manufac... more Abstract As the progression of 45/40nm ELK devices into mainstream semiconductor assembly manufacturing process increases, the drive to achieve adoption without major changes to process and equipment infrastructure while meeting the superior yield necessary is high. The ...

Carbohydrate polymers, Jan 15, 2014

A facile 6-aminoagarose (AA) mediated synthesis of new fluorogenic amides of agarose with nicotin... more A facile 6-aminoagarose (AA) mediated synthesis of new fluorogenic amides of agarose with nicotinic (AA-NA) and picolinic acids (AA-PA) employing carbodiimide chemistry have been described. 6-Amino agarose (AA) was synthesized in a facile Mitsunobu-inspired microwave mediated method involving the reaction of agarose with phthalimide in presence of diisopropyl azodicarboxylate and triphenylphosphene (DIAD/TPP) followed by hydrazinolysis. All compounds were characterized by GPC, UV spectrophotometry, fluorescence spectroscopy, FT-IR, (1)H and (13)C NMR spectra. The fluorescence emissions (λmax 430 and 412 nm) of 1 × 10(-3)M solutions of AA-NA and AA-PA in water were significantly higher (ca. 82% and ca. 90%) than those of the molar equivalents (0.2mg) of NA and PA present in the 1 × 10(-3)M solutions of the amides, respectively. These fluorogenic pyridine carboxylic acid amides of agarose may find applications as sensors in biomedical and pharmaceutical industries.

Journal of Applied Phycology, 2010

Superior quality non-methylated and low-sulphated galactans were extracted from two Indian agarop... more Superior quality non-methylated and low-sulphated galactans were extracted from two Indian agarophytes namely Gracilaria debilis and G. salicornia growing naturally along the west coast of India, using an eco-friendly method developed in our laboratory. The galactans were characterised by FT-IR, 13C NMR, GC-MS, ICP, GPC and rheological measurements. G. debilis produced exclusively non-methylated galactan exhibiting the greatest gel strength of 650±25 g cm−2 and lowest sulphate of 0.21±0.06%. On the contrary, G. salicornia polysaccharide was composed of non-methylated galactose (major) and mannose (minor), having gel strength of 510±25 g cm−2 and sulphate of 0.45±0.06%. Very low heavy metal contents were determined in both the galactan samples, which may thus be potentially useful in food and biological applications.

Journal of Applied Polymer Science, 2006

κ-Carrageenan-graft-PAAm, a copolymer hydrogel of κ-carrageenan (kC) and acrylamide (AAm), has be... more κ-Carrageenan-graft-PAAm, a copolymer hydrogel of κ-carrageenan (kC) and acrylamide (AAm), has been synthesized in aqueous medium at ∼ pH 7 in the presence of the initiator potassium persulfate (KPS), using microwave irradiation. The reaction conditions were optimized by varying the concentration of AAm and KPS to obtain copolymer hydrogels having different nitrogen contents e.g., %N 6.35, 10.56, and 11.05. It was observed that copolymer hydrogel having %N 11.05 gives superior adhesive properties whereas copolymer hydrogel with %N 10.56 produces superior absorbent properties in the presence of optimized concentrations of AAm (0.87 and 1.1428 mol/L respectively) and KPS (0.022 and 0.0296 mol/L respectively). The product with %N 6.35 is a soft gel (2–5% gel in 1% KCl) exhibiting low gel strength (135 g cm−2). The one with %N 10.56 showed superior swelling property and maximum swelling was observed in the alkaline pH (22 g/g). The swelling behaviors of the hydrogels were studied at different pHs (pH 1.2–12.5) as well as in 1% aqueous solutions of NaCl, KCl, and CaCl2. The 5% dispersion of the hydrogel having %N 11.05 in water had good binding properties with papers, polyethylene sheets, and wood pieces. To evaluate the measure of adhesive property, the viscosity and solid and liquid weights of the applied adhesive were measured. Characterization of the copolymer hydrogels was done by TGA, X-ray diffraction, 13C-NMR, FT-IR, elemental analyses, and rheological studies. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 5144–5152, 2006

Journal of Applied Polymer Science, 2006

Grafting of agar and κ-carrageenan with polyvinylpyrrolidone (PVP, average molecular weight 10,00... more Grafting of agar and κ-carrageenan with polyvinylpyrrolidone (PVP, average molecular weight 10,000 D) in an aqueous medium at a pH of about 7 produced agar-graft-PVP and κ-carrageenan-graft-PVP blends capable of forming hydrogels. The reaction was carried out with microwave irradiation in the presence of a water-soluble initiator, potassium persulfate. Optimum microwave irradiation conditions for obtaining hydrogels of the grafted products were achieved. The structural characteristics and thermal stability of the grafted blends were studied by Fourier transform infrared, 13C-NMR, and thermogravimetric analyses. Appearance of new IR bands at 1661, 1465, and 1426 cm−1 in the grafted products indicated the insertion of PVP into the polysaccharide structure. Powder X-ray diffraction studies revealed the enhanced crystallinity in the products compared to in the control polysaccharides as well as PVP. Agar and κ-carrageenan were grafted to a considerable degree, with 62.5 E % and 125 G % for agar-graft-PVP and 65.5 E % and 131 G % for κ-carrageenan-graft-PVP. Optical micrographs of the grafted blends indicated considerable changes in the morphology of the agar and the κ-carrageenan, substantiating the X-ray diffraction data. A plausible mechanism for the crosslinking of PVP to agar and κ-carrageenan is proposed. These hydrogels exhibited enhanced water-holding capacity despite weaker gel strength than that in the respective control polysaccharides. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 3654–3663, 2006

Polymer Chemistry, 2011

... Gaurav K. Mehta, Stalin Kondaveeti and AK Siddhanta*. Marine Biotechnology and Ecology Discip... more ... Gaurav K. Mehta, Stalin Kondaveeti and AK Siddhanta*. Marine Biotechnology and Ecology Discipline, CSIR-Central Salt & Marine Chemicals Research Institute, G. B Marg, Bhavnagar, 364021 ... 5, R. Meena, K. Prasad and AK Siddhanta, Food Hydrocolloids, 2009, 23, 497–509 . ...

Phycological Research, 2011

... Galactans from Gracilaria millardetii and G textorii (Gracilariales, Rhodophyta) of Indian wa... more ... Galactans from Gracilaria millardetii and G textorii (Gracilariales, Rhodophyta) of Indian waters. Mihir D. Oza,; Gaurav K. Mehta,; Sanjay Kumar,; Ramavatar Meena,; Arup K. Siddhanta. ... The authors thank Dr Vaibhav A Mantri for taxonomical identification of the seaweed species. ...

Bulletin of Materials Science, 1994

Critical exponent of the electrical conductivity in the paracoherence region (γ) of the high temp... more Critical exponent of the electrical conductivity in the paracoherence region (γ) of the high temperature superconductor YBa2Cu3O7−x (YBCO) has been estimated for high quality thin film on ZrO2 substrate prepared by high pressure oxygen sputtering. High energy ion irradiation was carried out using 100 MeV16O7+ ions at liquid nitrogen temperature to see the effects of disorder on the value of the exponent. The critical exponent (γ) changes from a value of about 2 to 1·62 upon irradiation. Studies were also carried out on this film to see the effect of ageing and annealing.

Vacuum, 1997

The effects of 100 MeV Oxygen and 200MeV Silver ions on the structural and transport properties o... more The effects of 100 MeV Oxygen and 200MeV Silver ions on the structural and transport properties of YBCO thin films are reported. Both normal state and superconducting properties were studied on Laser ablated and high pressure oxygen sputtered films. Precise electrical resistance ...

Design Automation Conference, 1998

Power consumption has become one of the biggest challenges in high-performance microprocessor des... more Power consumption has become one of the biggest challenges in high-performance microprocessor design. The rapid increase in the complexity and speed of each new CPU generation is outstripping the benefits of voltage reduction and feature size scaling. Designers are thus continuously challenged to come up with innovative ways to reduce power, while trying to meet all the other constraints imposed on the design. This paper presents an overview of the issues related to power consumption in the context of Intel CPUs. The main trends that are driving the increased focus on design for low power are described. System and benchmarking issues, and sources of power consumption in a high-performance CPU are briefly described. Techniques that have been tried on real designs in the past are described. The role of CAD tools and their limitations in this domain are also discussed. In addition, areas that need increased research focus in the future are also pointed out.

Materials Chemistry and Physics, 1998

The strain field generated by 200 MeV Ag14+ ions in Si (001) crystals has been investigated using... more The strain field generated by 200 MeV Ag14+ ions in Si (001) crystals has been investigated using X-ray topography. By choosing suitable diffraction vectors it has been possible to explore the lattice distortion in the inelastic and elastic loss regions separately. Stationary reflection topographs gave two spatially separated images—one originating from the surface and the other from the region affected by elastic nuclear collisions close to the end of the ion range. The spatial separation of these two images is geometrically related to the depth of this elastic loss region. These topographic findings are compared with TRIM calculations.

Bioresource Technology, 2009

Cellulose contents were estimated in 12 seaweed samples belonging to different families e.g. red,... more Cellulose contents were estimated in 12 seaweed samples belonging to different families e.g. red, brown and green, growing in Indian waters. Each cellulose sample was fractionated to yield alpha (α) and beta (β) celluloses. Characterization was done using various analytical tools and results were validated by comparison with those of the cellulose obtained from Whatman filter paper No. 4. The greatest yields of cellulose (crude), α- and β-cellulose were obtained from Gelidiella acerosa (13.65%), Chamaedoris auriculata (9.0%) and G. acerosa (3.10%). G. acerosa was also found to contain relatively high amount of α-cellulose (8.19%). The lowest cellulose contents were recorded from Kappaphycus alvarezii (2.00%) and Sarconema scinaioides (2.1%), while the latter contained the lowest α-, and β-celluloses (1.0% and 0.30%, respectively). It appears that agarophytic and alginophytic algae contain high cellulose and α-cellulose contents, while the carrageenophyte contains low cellulose. The brown algae, in general contain high cellulose as well as α- and β-celluloses.

Frontiers in Optics 2009/Laser Science XXV/Fall 2009 OSA Optics & Photonics Technical Digest, 2009

1. Introduction Photonic crystal fibers (PCFs) offer exceptional opportunities for manipulation o... more 1. Introduction Photonic crystal fibers (PCFs) offer exceptional opportunities for manipulation of light propagation and realization of novel photonic devices. In particular, PCFs provide a new platform for the development of compact, multi-functional optical sensors [1-3]. ...

Pharmacogenomics, 2014

Lung carcinoma is the most common malignancy and the leading cause of cancer deaths worldwide. Al... more Lung carcinoma is the most common malignancy and the leading cause of cancer deaths worldwide. Although clinical factors including age, performance status and stage influence the likelihood of benefit from and tolerability of chemotherapy, the genetic profile of individual patients may be an independent predictor of response and toxicity. The present study aimed to identify pharmacogenetic markers associated with clinical response and toxicity in patients with advanced non-small cell lung cancer (NSCLC) treated primarily with carboplatin and paclitaxel. Genomic DNA samples from 90 adult male patients diagnosed with stage IIIB/IV NSCLC were genotyped for SNPs in candidate genes of relevance to platinating agents and paclitaxel and analyzed for association with survival and toxicities in univariate and multivariate models. After adjusting for performance status and stage, SNPs in the drug transporters ABCB1 and ABCC1, as well as within NQO1 were associated with progression-free survival. With respect to hematological and nonhematological toxicities, SNPs in drug transporters (ABCB1 and ABCG2) were associated with thrombocytopenia, nausea and neutropenia, whereas SNPs in the DNA repair pathway genes ERCC4 and XPC were significantly associated with neutropenia and sensory neuropathy, respectively. Our study evaluated and identified SNPs in key candidate genes in platinating agent and taxane pathways associated with outcome and toxicity in advanced NSCLC. If validated in large prospective studies, these findings might provide opportunities to personalize therapeutic strategies.

2014 IEEE 64th Electronic Components and Technology Conference (ECTC), 2014

2013 IEEE 63rd Electronic Components and Technology Conference, 2013

ABSTRACT While copper or palladium coated copper wire bonding in IC packaging have shown tremendo... more ABSTRACT While copper or palladium coated copper wire bonding in IC packaging have shown tremendous surge recently driven by huge cost saving and competitiveness across OSAT and IDM, there are new challenges when trying to qualify copper wire bond packages especially for fine pitch devices. This paper will study on the probe mark and its effects for copper wire bond integrity and stress test reliability performances. The increased probe touchdowns on bond pad exhibited greater risk resulting to deeper probe depth. Recent studies using gold wire bonding have reported that the limit for probe mark area damage should be limited to maximum of 30% [1] for 45μm ball size whilst other paper suggested maximum of 20% [2] of the probe mark area in order to achieve reliable gold ball bonding. While this paper focused on palladium coated copper (PdCu) wire bonding, the 10% ~ 50% range of probe mark area studied did not exhibit any related wire bonding failures across all legs during assembly. Failure analysis data results i.e intermetallic (IMC), pad crater test and ball bond cross-section for aluminum remains did not show much significant difference. Remarkably stress reliability test followed by destructive test did show some degradation results from unbiased HAST while HTS and temp cycle test did not reveal any failure during ball pull test. Reliability test data analysis concluded that the probe mark area should be limited to max of 30% for 35±2μm ball bond size while probe depth maximum at 80% from the original Al pad thickness or 20% of the Al thickness remains after probe as shown in figure 5 in order to achieve a reliable copper wire bonding process. This paper will share those probe marks criteria for considerations, challenges and recommendations when qualifying new packages for copper wire bonding process.

Hepatocellular Carcinoma, 2009

The clinical presentation of hepatocellular carcinoma may take on a vari-ety of different forms, ... more The clinical presentation of hepatocellular carcinoma may take on a vari-ety of different forms, ranging from asymptomatic (diagnosed via tumor markers or imaging studies) to a catastrophic hemoperitoneum with shock due to tumor rupture. This chapter will highlight the many ...

Paripex - Indian Journal Of Research, 2012

2006 8th International Conference on Solid-State and Integrated Circuit Technology Proceedings, 2006

1. Introduction The complexities of SOC, high expectations and the severe time-to-market pressure... more 1. Introduction The complexities of SOC, high expectations and the severe time-to-market pressure are forcing everyone to rethink their SOC design strategies and design methodologies. In reality, more than 80% of chips cannot meet the original project schedule because of ...

IEEE Transactions on Components, Packaging and Manufacturing Technology, 2011

2010 Proceedings 60th Electronic Components and Technology Conference (ECTC), 2010

Abstract As the progression of 45/40nm ELK devices into mainstream semiconductor assembly manufac... more Abstract As the progression of 45/40nm ELK devices into mainstream semiconductor assembly manufacturing process increases, the drive to achieve adoption without major changes to process and equipment infrastructure while meeting the superior yield necessary is high. The ...