giuseppe mento - Academia.edu (original) (raw)
Papers by giuseppe mento
Neurophysiologie Clinique/Clinical Neurophysiology, 1995
Blood Pressure, 1998
The objective of this study was to determine whether abnormal microstructure of sleep in non-dipp... more The objective of this study was to determine whether abnormal microstructure of sleep in non-dipper hypertensive patients was present in their offspring. Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normotensive parents (Controls). We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnographically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the subjects were awake and during all stages of sleep; sleep efficiency (SE), sleep latency (SL), delta-sleep latency (delta-SL), REM sleep latency (REM-SL), Stage 1, Stage 2, Stage 3, Stage 4 and REM duration and percentage values, and microstructural aspects of sleep (arousal and microarousal temporization and features). FH + D and controls showed a fall in blood pressure greater than 10% in all stages of NREM sleep and in the FH + ND blood pressure fall in less than 10% of waking values in all NREM stages. REM sleep and heart rate were similar in the three groups during all stages of sleep. FH + ND showed the same number of arousals but more microarousals than FH + D and controls (p < 0.0001). Microarousals induced several stage shifts through lighter sleep. For this reason, FH + ND spent more time in stage 2 than FH + D and controls. In conclusion, offspring of non-dipper hypertension parents showed a greater number of microarousals than the other two groups.
Blood Pressure, 1995
The objective of this study was to determine whether the macrostructure and microstructure of sle... more The objective of this study was to determine whether the macrostructure and microstructure of sleep were altered in non-dipper essential hypertensive patients. Patients included 9 non-dipper essential hypertensive patients and 10 dippers. We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnografically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the patients were awake and during all stages of sleep; sleep-efficiency (SE), sleep-latency (SL), delta sleep-latency (delta-SL), REM sleep-latency (REM-SL), St. 1, St.2, St.3, St.4 and REM duration and percentage (%) values, and microstructural aspects of sleep (arousal and microarousal temporisation and features). Dipper patients showed a fall in blood pressure (BP) greater than 10% in all stages of NREM sleep; in the non-dipper patients BP fell by less than 10% of waking values in all NREM stages. REM sleep as well as HR were similar in both groups during all stages of sleep. Non-dippers showed the same number of arousals but more microarousals than dippers (p < 0.001). During and after microarousals BP and HR increased in non-dippers, but showed light variation in dippers. Microarousals induced several stage shifts towards lighter sleep. For this reason non-dippers spent less time in stage 4 than dippers (p < 0.001). In conclusion, non-dipper essential hypertensive patients are a subset of patients with central sympathetic hyperactivity responsible for quantitative and qualitative alteration of sleep.
American Journal of Hypertension, 1996
Functional neurology
Parasympathetic and sympathetic controls on cardiovascular systems were studied during wakefulnes... more Parasympathetic and sympathetic controls on cardiovascular systems were studied during wakefulness and sleep in 8 diabetic patients (3 IDDM and 5 NIDDM), in order to detect the presence of autonomic dysfunction. In particular, cardiovascular assessment during sleep allowed to detect minimal autonomic abnormalities in the absence of a documented pathology during wakefulness.
Rivista di neurologia
Periodic movements during sleep (PMS) are discussed in relation to several hypotheses concerning ... more Periodic movements during sleep (PMS) are discussed in relation to several hypotheses concerning their etiology and their possible nosographic classification. In particular the role of central and peripheral events able to determine PMS is emphasized. The possible existence of space-intensity-time (SIT) patterns responsible for the vigilance profiles and the state of activity of central and peripheral effectors is also discussed. Finally the authors examine the modulating role of GABA on the circadian system and a possible metabolic instability of the GABAergic neurons responsible for PMS. This hypothesis is confirmed by the usefulness of clonazepam to treat such disorders.
The Journal of international medical research
In a single-blind study six male patients (mean age 39.5 years) with moderate insomnia were treat... more In a single-blind study six male patients (mean age 39.5 years) with moderate insomnia were treated with placebo for three nights, 100 mg indole-3-pyruvic acid (IPA) for three nights, 200 mg IPA for three nights, 100 mg IPA for two nights and placebo for two nights. Polygraphic recordings were made and total sleep time, sleep efficiency, sleep latency, slow wave sleep latency, rapid eye movement (REM) sleep latency, number of arousals (greater than 1 min), percentage and duration of wakefulness after sleep onset, percentage and duration of wakefulness after sleep onset, percentage and duration of sleep stages 1, 2, 3, 4 and REM were recorded. At the end of 13 days, total sleep time, duration of stage 2 sleep and total non-REM were significantly increased when compared with baseline. Total sleep time and duration of stage 2 and total non-REM sleep on completion were significantly decreased when compared with after 200 mg IPA (night 9). Results suggest an action of IPA on human sleep ...
American Journal of Hypertension, 1997
Body maas index (BMI) has been reported to be correlated with plasma angiotenainogen (AGT) concen... more Body maas index (BMI) has been reported to be correlated with plasma angiotenainogen (AGT) concentrations. Plasma AGT has alao been reported to be elevated in patient with esaential hypertension who have 235T alleles of AGT genotypes. It has been shown that waiat-hip ratio (WHR) correlates better with risk factors of cardiovascular diaeases and targed organ damage than BMI, Therefore we evaluate the association batwaen molecular variants T174M and M235T of the AGT gene and BMI and WHR in the random sample of young normotansive males. The study group consisted of 145 normotensive subjects aged 18-27 years (mean 22,8+3,0 yeara), BMI ranged 18-32 kg/m2 (mean 23,1+2,7 kg/m2), WHR ranged 0,72-0,96 (mean 0,83*0,04). The two points mutations were detected using restriction digests of a misparing polimerase chain reaction product. The BMI and WHR were compared among molecular variants T174M and M235T of the AGT gene. T174M genotype
American Journal of Hypertension, 1995
PrevlOUl ourINdy (High Slood PrtllUro 1eH, [Suppi 31]:47) .hawed thlt CIIntraitymplllhllllc hypll... more PrevlOUl ourINdy (High Slood PrtllUro 1eH, [Suppi 31]:47) .hawed thlt CIIntraitymplllhllllc hypllractMty Is responllble 01 lleep dlltVrblnCII and lack 0' blood prIHur. fill In the non-dlpper pItIentI (NOH). Therephore we mUlured blood prMUre but-to-blflt by contributing tothedevelopment ofhypertension in Mrican•Americans.
Neurophysiologie Clinique/Clinical Neurophysiology, 1990
Neurophysiologie Clinique/Clinical Neurophysiology, 1995
Journal of Stroke and Cerebrovascular Diseases, 2009
European Neurology, 1989
A 16-year-old patient presenting with complex partial seizures occurring in the transition from a... more A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, carried out for several nights, showed that after nearly each REM period, he would wake up briefly, presenting eye blinking followed by a burst of generalized hypersynchronous theta to start his seizures. These were characterized by moaning and autoaggressive behaviour, the ictal EEG showing generalized slow spike and wave complexes in the midst of several movement artifacts. At the end of each fit he fell back to REM sleep. Carbamazepine treatment completely resolved his symptoms, with full normalization of EEG activity.
European Neurology, 1989
A 16-year-old patient presenting with complex partial seizures occurring in the transition from a... more A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, carried out for several nights, showed that after nearly each REM period, he would wake
Neurophysiologie Clinique/Clinical Neurophysiology, 1995
Blood Pressure, 1998
The objective of this study was to determine whether abnormal microstructure of sleep in non-dipp... more The objective of this study was to determine whether abnormal microstructure of sleep in non-dipper hypertensive patients was present in their offspring. Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normotensive parents (Controls). We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnographically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the subjects were awake and during all stages of sleep; sleep efficiency (SE), sleep latency (SL), delta-sleep latency (delta-SL), REM sleep latency (REM-SL), Stage 1, Stage 2, Stage 3, Stage 4 and REM duration and percentage values, and microstructural aspects of sleep (arousal and microarousal temporization and features). FH + D and controls showed a fall in blood pressure greater than 10% in all stages of NREM sleep and in the FH + ND blood pressure fall in less than 10% of waking values in all NREM stages. REM sleep and heart rate were similar in the three groups during all stages of sleep. FH + ND showed the same number of arousals but more microarousals than FH + D and controls (p < 0.0001). Microarousals induced several stage shifts through lighter sleep. For this reason, FH + ND spent more time in stage 2 than FH + D and controls. In conclusion, offspring of non-dipper hypertension parents showed a greater number of microarousals than the other two groups.
Blood Pressure, 1995
The objective of this study was to determine whether the macrostructure and microstructure of sle... more The objective of this study was to determine whether the macrostructure and microstructure of sleep were altered in non-dipper essential hypertensive patients. Patients included 9 non-dipper essential hypertensive patients and 10 dippers. We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnografically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the patients were awake and during all stages of sleep; sleep-efficiency (SE), sleep-latency (SL), delta sleep-latency (delta-SL), REM sleep-latency (REM-SL), St. 1, St.2, St.3, St.4 and REM duration and percentage (%) values, and microstructural aspects of sleep (arousal and microarousal temporisation and features). Dipper patients showed a fall in blood pressure (BP) greater than 10% in all stages of NREM sleep; in the non-dipper patients BP fell by less than 10% of waking values in all NREM stages. REM sleep as well as HR were similar in both groups during all stages of sleep. Non-dippers showed the same number of arousals but more microarousals than dippers (p < 0.001). During and after microarousals BP and HR increased in non-dippers, but showed light variation in dippers. Microarousals induced several stage shifts towards lighter sleep. For this reason non-dippers spent less time in stage 4 than dippers (p < 0.001). In conclusion, non-dipper essential hypertensive patients are a subset of patients with central sympathetic hyperactivity responsible for quantitative and qualitative alteration of sleep.
American Journal of Hypertension, 1996
Functional neurology
Parasympathetic and sympathetic controls on cardiovascular systems were studied during wakefulnes... more Parasympathetic and sympathetic controls on cardiovascular systems were studied during wakefulness and sleep in 8 diabetic patients (3 IDDM and 5 NIDDM), in order to detect the presence of autonomic dysfunction. In particular, cardiovascular assessment during sleep allowed to detect minimal autonomic abnormalities in the absence of a documented pathology during wakefulness.
Rivista di neurologia
Periodic movements during sleep (PMS) are discussed in relation to several hypotheses concerning ... more Periodic movements during sleep (PMS) are discussed in relation to several hypotheses concerning their etiology and their possible nosographic classification. In particular the role of central and peripheral events able to determine PMS is emphasized. The possible existence of space-intensity-time (SIT) patterns responsible for the vigilance profiles and the state of activity of central and peripheral effectors is also discussed. Finally the authors examine the modulating role of GABA on the circadian system and a possible metabolic instability of the GABAergic neurons responsible for PMS. This hypothesis is confirmed by the usefulness of clonazepam to treat such disorders.
The Journal of international medical research
In a single-blind study six male patients (mean age 39.5 years) with moderate insomnia were treat... more In a single-blind study six male patients (mean age 39.5 years) with moderate insomnia were treated with placebo for three nights, 100 mg indole-3-pyruvic acid (IPA) for three nights, 200 mg IPA for three nights, 100 mg IPA for two nights and placebo for two nights. Polygraphic recordings were made and total sleep time, sleep efficiency, sleep latency, slow wave sleep latency, rapid eye movement (REM) sleep latency, number of arousals (greater than 1 min), percentage and duration of wakefulness after sleep onset, percentage and duration of wakefulness after sleep onset, percentage and duration of sleep stages 1, 2, 3, 4 and REM were recorded. At the end of 13 days, total sleep time, duration of stage 2 sleep and total non-REM were significantly increased when compared with baseline. Total sleep time and duration of stage 2 and total non-REM sleep on completion were significantly decreased when compared with after 200 mg IPA (night 9). Results suggest an action of IPA on human sleep ...
American Journal of Hypertension, 1997
Body maas index (BMI) has been reported to be correlated with plasma angiotenainogen (AGT) concen... more Body maas index (BMI) has been reported to be correlated with plasma angiotenainogen (AGT) concentrations. Plasma AGT has alao been reported to be elevated in patient with esaential hypertension who have 235T alleles of AGT genotypes. It has been shown that waiat-hip ratio (WHR) correlates better with risk factors of cardiovascular diaeases and targed organ damage than BMI, Therefore we evaluate the association batwaen molecular variants T174M and M235T of the AGT gene and BMI and WHR in the random sample of young normotansive males. The study group consisted of 145 normotensive subjects aged 18-27 years (mean 22,8+3,0 yeara), BMI ranged 18-32 kg/m2 (mean 23,1+2,7 kg/m2), WHR ranged 0,72-0,96 (mean 0,83*0,04). The two points mutations were detected using restriction digests of a misparing polimerase chain reaction product. The BMI and WHR were compared among molecular variants T174M and M235T of the AGT gene. T174M genotype
American Journal of Hypertension, 1995
PrevlOUl ourINdy (High Slood PrtllUro 1eH, [Suppi 31]:47) .hawed thlt CIIntraitymplllhllllc hypll... more PrevlOUl ourINdy (High Slood PrtllUro 1eH, [Suppi 31]:47) .hawed thlt CIIntraitymplllhllllc hypllractMty Is responllble 01 lleep dlltVrblnCII and lack 0' blood prIHur. fill In the non-dlpper pItIentI (NOH). Therephore we mUlured blood prMUre but-to-blflt by contributing tothedevelopment ofhypertension in Mrican•Americans.
Neurophysiologie Clinique/Clinical Neurophysiology, 1990
Neurophysiologie Clinique/Clinical Neurophysiology, 1995
Journal of Stroke and Cerebrovascular Diseases, 2009
European Neurology, 1989
A 16-year-old patient presenting with complex partial seizures occurring in the transition from a... more A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, carried out for several nights, showed that after nearly each REM period, he would wake up briefly, presenting eye blinking followed by a burst of generalized hypersynchronous theta to start his seizures. These were characterized by moaning and autoaggressive behaviour, the ictal EEG showing generalized slow spike and wave complexes in the midst of several movement artifacts. At the end of each fit he fell back to REM sleep. Carbamazepine treatment completely resolved his symptoms, with full normalization of EEG activity.
European Neurology, 1989
A 16-year-old patient presenting with complex partial seizures occurring in the transition from a... more A 16-year-old patient presenting with complex partial seizures occurring in the transition from a REM period to wakefulness is described. His baseline EEG showed generalized and symmetrical slow spike and wave complexes, on a normal background activity, activated by NREM sleep. Polygraphic and videotape recordings, carried out for several nights, showed that after nearly each REM period, he would wake