gurmeet singh bindra - Academia.edu (original) (raw)
Papers by gurmeet singh bindra
American Journal of Gastroenterology, 2014
Introduction-Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunologically mediate... more Introduction-Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunologically mediated diseases with a progressive relapsing remitting course. There is considerable heterogeneity in disease course and accurate prediction of natural history has been challenging. The phenotypic implication of increasing genetic predisposition to CD or UC is unknown. Methods-The data source for our study was a prospective cohort of CD and UC patients recruited from a tertiary referral center. All patients underwent genotyping on the Illumina Immunochip. A genetic risk score (GRS) incorporating strength of association (log odds ratio) and allele dose for each of the 163 IBD-risk loci was calculated and phenotypic associations examined across GRS quartiles. Results-Our study cohort included 1,105 patients (697 CD, 408 UC). Increasing genetic burden was associated with earlier age of diagnosis of CD (P trend =0.008). Patients in the highest GRS quartile were likely to develop disease 5 years earlier than those in the lowest quartile. Increasing genetic burden was also associated with ileal involvement in CD (Ptrend < 0.0001). The effect of genetic burden was independent of the NOD2 locus and was stronger among those with no NOD2 variants, and in never smokers. UC patients with an involved first degree relative had a higher genetic burden, but GRS was not associated with disease phenotype in UC. Conclusion-Increasing genetic burden is associated with early age of diagnosis in CD but not UC. The expanded panel of IBD risk loci explains only a fraction of variance of disease phenotype suggesting limited clinical utility of genetics in predicting natural history.
Organometallics, Oct 27, 2017
Reported here are several new adducts of the type (R BDI)M(HE) 2 where R BDI is the β-diiminate l... more Reported here are several new adducts of the type (R BDI)M(HE) 2 where R BDI is the β-diiminate ligand [2,6-R 2 C 6 H 3 NCMe] 2 CH (R = Me, Et, MeO; M = Rh, Ir; HE = HSiEt 3 , HGeEt 3 , HSn n Bu 3 , HBPin). DFT calculations are used to analyze the bonding in these and related Cp* complexes, in particular with respect to the degree of oxidative addition (OA) of the H−E bonds: this increases in the order H 2 < HBPin < HSiEt 3 ≈ HGeEt 3 ≈ HSn n Bu 3 , it proceeds further for Ir than for Rh, and Cp* promotes OA to a larger degree in comparison to the BDI ligand. The f irst metal−HE dissociation energy is rather sensitive to steric effects and increases in the order CH 4 ≪ H 2 ≈ HBPin ≈ HSiMe 3 ≈ HGeMe 3 < HSnMe 3 , with Ir uniformly binding HE more strongly than Rh by about 10 kcal/mol. M−HE dissociation is the first step of the intramolecular ligand functionalization first reported for (Me BDI)Rh(HSiEt 3) 2. Such functionalization was not observed for any of the new complexes reported here. On the basis of the idea that stannane dissociation might be prohibitive, we obtained evidence that it is possible to effect such functionalization via generation of a stannane within the coordination sphere of the metal: treatment of (Me BDI)Rh(COE)(N 2) with SnMe 4 and H 2 produced a mixture of (Me BDI)Rh(HSnMe 3) 2 and its functionalized derivative (Me BDI∧SnHMe 2)Rh(HSnMe 3) via Sn−C cleavage.
Organometallics, May 26, 2016
Rhodium β-diiminate complexes of conjugated dienes, (R BDI)Rh(diene) (R BDI = [2,6-R 2 C 6 H 3-NC... more Rhodium β-diiminate complexes of conjugated dienes, (R BDI)Rh(diene) (R BDI = [2,6-R 2 C 6 H 3-NCMe] 2 CH; R = Me, Et; diene = 1,3-hexadiene, 1,3-pentadiene, 1,3butadiene, 2-Me 3 SiO-1,3-cyclohexadiene) as well as (Me BDI)-Ir(1,3-butadiene) show fluxional behavior caused by squareplanar−tetrahedral interconversion where the diene rotates relative to the diiminate ligand. The mechanism involves neither (partial) ligand dissociation nor a change in spin state. Density functional calculations support the rotation mechanism and indicate that it is assisted by a partial valence isomerization of the diene to an enediyl ligand at the tetrahedral geometry. Nonconjugated dienes, which cannot undergo such valence isomerization, are predicted to have much larger barriers to rotation.
aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True thr... more aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True throughout the ages True here and now. O Nanak, God shall forever be True. ||1|| With due respect and devotion, I would thank my God, "Waheguru Ji" to give me this opportunity to have knowledge, strength to do my work and always show me the right path to go and right way to do. I would like to give my special thank to Prof. Han Vos and Dr. Mary T. Pryce for invaluable support and guidance throughout the work. My Parents Satinderpal Singh Bindra (Dad) and Harjeet Kaur Bindra (Mom) without their love, support and blessings this would have been impossible. My sister (Manmeet Kaur), whose eyes were always looking towards my success and prosperity. I would give them my million thanks for there invaluable support. My wife (Pavneet Kaur), her great support and unconditional love, for giving me great inspiration and passion to become a scientist. I sincerely thank to my parents in law, sister in law (Kamalpreet Kaur), brother in law (Gurpreet Singh Kanwal and Prabhsimran Singh) and to my little niece's Avi and Jot. I dedicated this thesis to my sweetheart my daughter "Gurbaani".
aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True thr... more aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True throughout the ages True here and now. O Nanak, God shall forever be True. ||1|| With due respect and devotion, I would thank my God, "Waheguru Ji" to give me this opportunity to have knowledge, strength to do my work and always show me the right path to go and right way to do. I would like to give my special thank to Prof. Han Vos and Dr. Mary T. Pryce for invaluable support and guidance throughout the work. My Parents Satinderpal Singh Bindra (Dad) and Harjeet Kaur Bindra (Mom) without their love, support and blessings this would have been impossible. My sister (Manmeet Kaur), whose eyes were always looking towards my success and prosperity. I would give them my million thanks for there invaluable support. My wife (Pavneet Kaur), her great support and unconditional love, for giving me great inspiration and passion to become a scientist. I sincerely thank to my parents in law, sister in law (Kamalpreet Kaur), brother in law (Gurpreet Singh Kanwal and Prabhsimran Singh) and to my little niece's Avi and Jot. I dedicated this thesis to my sweetheart my daughter "Gurbaani".
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
American Journal of Gastroenterology, 2014
Introduction-Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunologically mediate... more Introduction-Crohn's disease (CD) and ulcerative colitis (UC) are chronic immunologically mediated diseases with a progressive relapsing remitting course. There is considerable heterogeneity in disease course and accurate prediction of natural history has been challenging. The phenotypic implication of increasing genetic predisposition to CD or UC is unknown. Methods-The data source for our study was a prospective cohort of CD and UC patients recruited from a tertiary referral center. All patients underwent genotyping on the Illumina Immunochip. A genetic risk score (GRS) incorporating strength of association (log odds ratio) and allele dose for each of the 163 IBD-risk loci was calculated and phenotypic associations examined across GRS quartiles. Results-Our study cohort included 1,105 patients (697 CD, 408 UC). Increasing genetic burden was associated with earlier age of diagnosis of CD (P trend =0.008). Patients in the highest GRS quartile were likely to develop disease 5 years earlier than those in the lowest quartile. Increasing genetic burden was also associated with ileal involvement in CD (Ptrend < 0.0001). The effect of genetic burden was independent of the NOD2 locus and was stronger among those with no NOD2 variants, and in never smokers. UC patients with an involved first degree relative had a higher genetic burden, but GRS was not associated with disease phenotype in UC. Conclusion-Increasing genetic burden is associated with early age of diagnosis in CD but not UC. The expanded panel of IBD risk loci explains only a fraction of variance of disease phenotype suggesting limited clinical utility of genetics in predicting natural history.
Organometallics, Oct 27, 2017
Reported here are several new adducts of the type (R BDI)M(HE) 2 where R BDI is the β-diiminate l... more Reported here are several new adducts of the type (R BDI)M(HE) 2 where R BDI is the β-diiminate ligand [2,6-R 2 C 6 H 3 NCMe] 2 CH (R = Me, Et, MeO; M = Rh, Ir; HE = HSiEt 3 , HGeEt 3 , HSn n Bu 3 , HBPin). DFT calculations are used to analyze the bonding in these and related Cp* complexes, in particular with respect to the degree of oxidative addition (OA) of the H−E bonds: this increases in the order H 2 < HBPin < HSiEt 3 ≈ HGeEt 3 ≈ HSn n Bu 3 , it proceeds further for Ir than for Rh, and Cp* promotes OA to a larger degree in comparison to the BDI ligand. The f irst metal−HE dissociation energy is rather sensitive to steric effects and increases in the order CH 4 ≪ H 2 ≈ HBPin ≈ HSiMe 3 ≈ HGeMe 3 < HSnMe 3 , with Ir uniformly binding HE more strongly than Rh by about 10 kcal/mol. M−HE dissociation is the first step of the intramolecular ligand functionalization first reported for (Me BDI)Rh(HSiEt 3) 2. Such functionalization was not observed for any of the new complexes reported here. On the basis of the idea that stannane dissociation might be prohibitive, we obtained evidence that it is possible to effect such functionalization via generation of a stannane within the coordination sphere of the metal: treatment of (Me BDI)Rh(COE)(N 2) with SnMe 4 and H 2 produced a mixture of (Me BDI)Rh(HSnMe 3) 2 and its functionalized derivative (Me BDI∧SnHMe 2)Rh(HSnMe 3) via Sn−C cleavage.
Organometallics, May 26, 2016
Rhodium β-diiminate complexes of conjugated dienes, (R BDI)Rh(diene) (R BDI = [2,6-R 2 C 6 H 3-NC... more Rhodium β-diiminate complexes of conjugated dienes, (R BDI)Rh(diene) (R BDI = [2,6-R 2 C 6 H 3-NCMe] 2 CH; R = Me, Et; diene = 1,3-hexadiene, 1,3-pentadiene, 1,3butadiene, 2-Me 3 SiO-1,3-cyclohexadiene) as well as (Me BDI)-Ir(1,3-butadiene) show fluxional behavior caused by squareplanar−tetrahedral interconversion where the diene rotates relative to the diiminate ligand. The mechanism involves neither (partial) ligand dissociation nor a change in spin state. Density functional calculations support the rotation mechanism and indicate that it is assisted by a partial valence isomerization of the diene to an enediyl ligand at the tetrahedral geometry. Nonconjugated dienes, which cannot undergo such valence isomerization, are predicted to have much larger barriers to rotation.
aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True thr... more aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True throughout the ages True here and now. O Nanak, God shall forever be True. ||1|| With due respect and devotion, I would thank my God, "Waheguru Ji" to give me this opportunity to have knowledge, strength to do my work and always show me the right path to go and right way to do. I would like to give my special thank to Prof. Han Vos and Dr. Mary T. Pryce for invaluable support and guidance throughout the work. My Parents Satinderpal Singh Bindra (Dad) and Harjeet Kaur Bindra (Mom) without their love, support and blessings this would have been impossible. My sister (Manmeet Kaur), whose eyes were always looking towards my success and prosperity. I would give them my million thanks for there invaluable support. My wife (Pavneet Kaur), her great support and unconditional love, for giving me great inspiration and passion to become a scientist. I sincerely thank to my parents in law, sister in law (Kamalpreet Kaur), brother in law (Gurpreet Singh Kanwal and Prabhsimran Singh) and to my little niece's Avi and Jot. I dedicated this thesis to my sweetheart my daughter "Gurbaani".
aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True thr... more aadh sach jugaadh sach ||, hai bh sach naanak hosee bh sach ||1|| True in the beginning, True throughout the ages True here and now. O Nanak, God shall forever be True. ||1|| With due respect and devotion, I would thank my God, "Waheguru Ji" to give me this opportunity to have knowledge, strength to do my work and always show me the right path to go and right way to do. I would like to give my special thank to Prof. Han Vos and Dr. Mary T. Pryce for invaluable support and guidance throughout the work. My Parents Satinderpal Singh Bindra (Dad) and Harjeet Kaur Bindra (Mom) without their love, support and blessings this would have been impossible. My sister (Manmeet Kaur), whose eyes were always looking towards my success and prosperity. I would give them my million thanks for there invaluable support. My wife (Pavneet Kaur), her great support and unconditional love, for giving me great inspiration and passion to become a scientist. I sincerely thank to my parents in law, sister in law (Kamalpreet Kaur), brother in law (Gurpreet Singh Kanwal and Prabhsimran Singh) and to my little niece's Avi and Jot. I dedicated this thesis to my sweetheart my daughter "Gurbaani".
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.