hùng lưu - Academia.edu (original) (raw)

Papers by hùng lưu

Cancer causes & control : CCC, Oct 31, 2016

While leukocyte telomere length (TL) has been associated with breast cancer risk, limited informa... more While leukocyte telomere length (TL) has been associated with breast cancer risk, limited information is available regarding the role of genetically-determined TL on breast cancer risk. We investigated whether aggregated TL-associated variants are associated with the risk of breast cancer in 2,865 breast cancer cases and 2,285 controls from the Shanghai Breast Cancer Genetics Study. Six genetic variants, identified through a genome-wide association study (GWAS) of TL in European-ancestry participants, were included in the study. A separate sample [n = 1,536, from the Shanghai Women's Health Study (SWHS), for whom information on both phenotypical leukocyte TL and genetic information was collected] was used to evaluate the association of six variants with TL in Asians. Three genetic risk scores (GRSs), based on the number of alleles associated with shorter TL that each individual carries for the six variants, were derived for the study: un-weighted, internally weighted (from the S...

JAMA internal medicine, Jan 2, 2015

High intake of nuts has been linked to a reduced risk of mortality. Previous studies, however, we... more High intake of nuts has been linked to a reduced risk of mortality. Previous studies, however, were primarily conducted among people of European descent, particularly those of high socioeconomic status. To examine the association of nut consumption with total and cause-specific mortality in Americans of African and European descent who were predominantly of low socioeconomic status (SES) and in Chinese individuals in Shanghai, China. Three large cohorts were evaluated in the study. One included 71 764 US residents of African and European descent, primarily of low SES, who were participants in the Southern Community Cohort Study (SCCS) in the southeastern United States (March 2002 to September 2009), and the other 2 cohorts included 134 265 participants in the Shanghai Women's Health Study (SWHS) (December 1996 to May 2000) and the Shanghai Men's Health Study (SMHS) (January 2002 to September 2006) in Shanghai, China. Self-reported nut consumption in the SCCS (approximately 5...

Antioxidants & redox signaling, Jan 20, 2015

Epidemiologic and experimental studies have shown that a high intake of individual dietary antiox... more Epidemiologic and experimental studies have shown that a high intake of individual dietary antioxidants is associated with reduced risk of cancers. Few studies, however, have investigated the influences of a combination of antioxidants. We evaluated the association of two dietary antioxidant indices, the Dietary Antioxidant Quality Score (DAQS) and the Composite Dietary Antioxidant Index (CDAI), with 10 oxidative stress or inflammation biomarkers (urinary F2-isoprostanes-15-F2t-IsoP; urinary 15-F2t-IsoPM; urinary prostaglandin E2 metabolite-PGEM; C-reactive protein-CRP; interleukin-1beta-IL-1β; interleukin-6-IL-6; tumor necrosis factor-alpha-TNF-α; soluble TNF-receptor 1-sTNF-R1; soluble TNF-receptor 2-sTNF-R2; and soluble GP130- sGP130) in 3,853 participants of the Shanghai Women's Health Study (SWHS). We found the DAQS and CDAI to be highly correlated (r=0.72), and both inversely associated with levels of IL-1β (Ptrend=0.02 and 0.03, respectively) and TNF-α (Ptrend=0.005 and 0...

Cancer Epidemiology, Biomarkers & Prevention, 2009

In animal models of colon cancer, n-3 polyunsaturated fatty acids (PUFA) have antineoplastic prop... more In animal models of colon cancer, n-3 polyunsaturated fatty acids (PUFA) have antineoplastic properties, whereas n-6 PUFAs may promote carcinogenesis. Prior epidemiologic studies have been inconsistent regarding the association of PUFAs and colorectal cancer. We prospectively evaluated the association between PUFA intake and colorectal cancer in a cohort of 73,242 Chinese women who were interviewed in person at the baseline survey for the Shanghai Women's Health Study. Dietary fatty acid consumption was derived using data collected from two food frequency questionnaires administered at baseline and 2 to 3 years later. The dietary total n-6 to n-3 PUFA ratio was strongly associated with colorectal cancer risk. Compared with women in the lowest quintile group, elevated relative risks (RR) were observed for the second [RR, 1.52; 95% confidence intervals (CI), 1.00-2.32], third (RR, 2.20; 95% CI, 1.41-3.45), fourth (RR, 1.65; 95% CI, 0.99-2.75), and fifth (RR, 1.95; 95% CI, 1.07-3.5...

Diabetologia, Jun 7, 2017

The aims of the study were to evaluate the association between type 2 diabetes and the risk of de... more The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Sig...

Tạp chí Khoa học và công nghệ nông nghiệp Trường Đại học Nông Lâm Huế

Virus dịch tả lợn Châu Phi (ASFV) và virus dịch tả lợn cổ điển (CSFV) đã gây thiệt hại kinh tế rấ... more Virus dịch tả lợn Châu Phi (ASFV) và virus dịch tả lợn cổ điển (CSFV) đã gây thiệt hại kinh tế rất lớn cho người chăn nuôi lợn. Có nhiều phương pháp xét nghiệm để phát hiện hai virus này như: PCR, Realtime PCR, phân lập virus, ELISA. Bên cạnh đó phương pháp Multiplex Real-time RT-PCR (mReal-time RT-PCR) để phát hiện đồng thời ASFV và CSFV cũng đã được đánh giá ở một số nước trên thế giới nhưng chưa được nghiên cứu nhiều tại Việt Nam. Trong nghiên cứu này chúng tôi đánh giá mReal-time RT-PCR để xét nghiệm phát hiện đồng thời ASFV và CSFV. Kết quả cho thấy giới hạn phát hiện của phương pháp là 12,5×101 copies/µL đối với ASFV và CSFV. Kiểm tra độ lặp lại bằng cách sử dụng mẫu chuẩn (p-ASFV và p-CSFV) cho thấy hệ số biến đổi giữa các lần lặp lại <2%. Áp dụng xét nghiệm 90 mẫu thực địa thu thập từ năm 2019-2022 với kết quả tỷ lệ dương tính ASFV và CSFV là 42,22% và 8,89% theo thứ tự; đồng cảm nhiễm ASFV và CSFV là 2,2%.

2019 6th NAFOSTED Conference on Information and Computer Science (NICS)

One of the major topics in photogrammetry is the automated extraction of building from data acqui... more One of the major topics in photogrammetry is the automated extraction of building from data acquired by airborne sensors. What makes this task challenging is the very heterogeneous appearance and dense distribution of buildings in urban areas. While many dataset has been established, none of them pay attention to developing cities where buildings are not well planned. To complement the development of building extraction algorithms, a dataset of high resolution satellite image is constructed in this paper covering Cau Giay district, Hanoi, Vietnam. The dataset consists of 2100 images of size 1024× 1024 pixels extracted from Google Earth. Shape, size, and construction material differ greatly from building to building, thus make it challenging for state-of-the-art algorithm to accurately extract building location. Some baselines are provided using Convolutional Neural Networks (CNNs). Experimental results show that U-Net model trained with Mean Square Error loss is able to achieve comparable results (OA = 92.04).

Japanese Journal of Clinical Oncology

Background Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vi... more Background Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vietnam. Although screening is considered an effective measure to prevent and control colorectal cancer, there is no such effort in Vietnam. Methods Between 01 January 2018 and 31 October 2019, a population-based colorectal cancer screening program was conducted in Hanoi, Vietnam. A health advocacy campaign and follow-up phone calls were used to enroll residents aged ≥40 years old to complete an immunochemical-fecal occult blood testing. Positive immunochemical-fecal occult blood testing was followed by a colonoscopy. We also conducted a systematic review of the colorectal cancer screening programs in the Asia-Pacific region that used similar approach by searching Ovid Medline and PubMed databases. Results During study period, 103 542 individuals among 672 742 eligible residents attended the screening of whom 81.5% participants finished immunochemical-fecal occult blood testing test and th...

Cancer Research Communications

Dietary fiber or nonstarch polysaccharides (NSP) may provide protection from colorectal cancer de... more Dietary fiber or nonstarch polysaccharides (NSP) may provide protection from colorectal cancer development. Epidemiologic studies on the association between dietary fiber and colorectal cancer is inconsistent are limited on NSP as a modifiable risk factor. Using the Singapore Chinese Health Study, a population-based prospective cohort of 61,321 cancer-free middle-aged or older Chinese Singaporeans, we examined the association between dietary fiber and NSP intakes and colorectal cancer risk. Fiber and NSP intakes at baseline were obtained using a validated semiquantitative food frequency questionnaire coupled with the Singapore Food Composition Database. Cox proportional hazard regression model was used to estimate the HRs and respective 95% confidence intervals (CI) for colorectal cancer associated with dietary fiber and NSP intakes after adjusting for potential confounders. After an average of 17.5 years of follow-up, 2,140 participants developed colorectal cancer. NSP was inversel...

International Journal of Cancer

Evidence from animal models suggests that dietary fatty acids have both anticancer and tumor‐prom... more Evidence from animal models suggests that dietary fatty acids have both anticancer and tumor‐promoting effects. Whether dietary fatty acids are associated with colorectal cancer (CRC) in humans remains inconclusive. We investigated associations between dietary fatty acids and risk of CRC among 59 986 men who participated in the Shanghai Men's Health Study (SMHS), an ongoing population‐based prospective cohort study. We identified 876 incident CRC cases in the SMHS during a mean follow‐up of 9.8 years. Associations between dietary fatty acid intake and CRC risk were evaluated by Cox proportional hazard regression analyses. Consumption of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) was not significantly associated with CRC risk. Multivariate hazard ratios (HRs) and respective 95% confidence intervals (CIs) for Quartile 4 vs Quartile 1 were 0.92 (0.74‐1.14; Ptrend = 0.47) for SFA, 0.95 (0.79‐1.16; Ptrend = 0.74) for MUFA an...

Cancer Epidemiology, Biomarkers & Prevention

Background: Evidence on associations between dietary intake and risk of breast cancer subtypes is... more Background: Evidence on associations between dietary intake and risk of breast cancer subtypes is limited and inconsistent. We evaluated associations of fruit, vegetable, meat, and fish consumption with risk of breast cancer overall and by molecular subtype in the Vietnamese Breast Cancer Study (VBCS). Method: VBCS includes 476 incident breast cancer cases and 454 age-matched controls. Dietary habits over the past 5 years were assessed by in-person interviews using a validated food frequency questionnaire. Associations of food groups with breast cancer were evaluated via logistic regression for overall and molecular subtype with adjustment for age, education, income, family history of cancer, menopausal status, body mass index, exercise, total energy intake, and other potential dietary confounders. Odds ratio (OR) was used to approximate relative risk. Results: High fruit intake was inversely associated with breast cancer risk, with adjusted ORs [95% confidence intervals (CI)] of 0....

Cancer Epidemiology, Biomarkers & Prevention, 2021

Purpose: Delay in diagnosis and initiation of treatment from the first noticeable breast cancer s... more Purpose: Delay in diagnosis and initiation of treatment from the first noticeable breast cancer symptoms are associated with poor outcome. Understanding the reasons and barriers why patients delay seeking medical care is critical to mitigate the problem, particularly in low- and middle-income countries (LMICs) where breast cancer incidence is increasing. Methods: In-person surveys were conducted in 462 incident breast cancer cases, aged 18-79, recruited from two major cancer hospitals in Northern Vietnam. Delay in diagnosis and treatment was defined as no delay (<3 months), moderate delay (3-8 months) and serious delay (≥9 months). Multivariable polynomial logistic regression was applied in data analyses. Results: More than one quarter patients (27.5%) experienced moderate delays, and close to one-fifth (18.8%) experienced serious delays. Adjusted odds ratios (OR) and 95% confidence intervals (CI) for moderate and serious delays were 4.81 (2.62-8.85) and 3.46 (1.72-6.97) for fina...

Cancer Epidemiology, Biomarkers & Prevention, 2021

Background: Limited research has been conducted on the effect of quality diet index (QDI), which ... more Background: Limited research has been conducted on the effect of quality diet index (QDI), which represents a comprehensive assessment of healthy diet quality and quantity, on pancreatic cancer risk in Asian populations. Methods: Using data from the Singapore Chinese Health Study, a prospective cohort of 63,257 middle-aged or older Chinese men and women, four QDI scores: the Alternative Health Eating Index-2010 (AHEI-2010), the alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH), and the Heathy Diet Indicator (HDI), at baseline were calculated. After 25 years of follow-up, 311 cohort participants developed pancreatic cancer. Cox proportional hazard regression method was used to estimate HR and 95% confidence interval (CI) for pancreatic cancer associated with higher QDI scores. Results: Higher scores of AHEI-2010, aMED, and DASH were significantly associated with lower pancreatic cancer risk (all Ptrend < 0.05). Compared with the lowest quartil...

International Journal of Cancer, 2021

Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is ... more Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is an important precursor of colorectal cancer. There is currently no study to determine the modifiable risk factors for colorectal adenomas, including body mass index (BMI) in Vietnam. We conducted an individually matched case‐control study of 1149 colorectal adenomas and 1145 controls in a large‐scale colorectal screening program involving 103 542 individuals aged 40‐75 years old in Hanoi, Vietnam. Conditional logistic regression was used to evaluate the association between BMI and colorectal adenomas prevalence, after controlling for potential confounders. Overall, comparing to normal weight (ie, 18.5‐22.9 kg/m2), underweight (ie, BMI < 18.5) was associated with a non‐statistically significant increased prevalence of colorectal adenomas (odd ratio [OR] = 1.29 and 95% confident interval [CI]: 0.88‐1.87). This association became significant among male (OR = 1.98, 95% CI: 1.20‐3.27), mal...

Cancer causes & control : CCC, Oct 31, 2016

While leukocyte telomere length (TL) has been associated with breast cancer risk, limited informa... more While leukocyte telomere length (TL) has been associated with breast cancer risk, limited information is available regarding the role of genetically-determined TL on breast cancer risk. We investigated whether aggregated TL-associated variants are associated with the risk of breast cancer in 2,865 breast cancer cases and 2,285 controls from the Shanghai Breast Cancer Genetics Study. Six genetic variants, identified through a genome-wide association study (GWAS) of TL in European-ancestry participants, were included in the study. A separate sample [n = 1,536, from the Shanghai Women's Health Study (SWHS), for whom information on both phenotypical leukocyte TL and genetic information was collected] was used to evaluate the association of six variants with TL in Asians. Three genetic risk scores (GRSs), based on the number of alleles associated with shorter TL that each individual carries for the six variants, were derived for the study: un-weighted, internally weighted (from the S...

JAMA internal medicine, Jan 2, 2015

High intake of nuts has been linked to a reduced risk of mortality. Previous studies, however, we... more High intake of nuts has been linked to a reduced risk of mortality. Previous studies, however, were primarily conducted among people of European descent, particularly those of high socioeconomic status. To examine the association of nut consumption with total and cause-specific mortality in Americans of African and European descent who were predominantly of low socioeconomic status (SES) and in Chinese individuals in Shanghai, China. Three large cohorts were evaluated in the study. One included 71 764 US residents of African and European descent, primarily of low SES, who were participants in the Southern Community Cohort Study (SCCS) in the southeastern United States (March 2002 to September 2009), and the other 2 cohorts included 134 265 participants in the Shanghai Women's Health Study (SWHS) (December 1996 to May 2000) and the Shanghai Men's Health Study (SMHS) (January 2002 to September 2006) in Shanghai, China. Self-reported nut consumption in the SCCS (approximately 5...

Antioxidants & redox signaling, Jan 20, 2015

Epidemiologic and experimental studies have shown that a high intake of individual dietary antiox... more Epidemiologic and experimental studies have shown that a high intake of individual dietary antioxidants is associated with reduced risk of cancers. Few studies, however, have investigated the influences of a combination of antioxidants. We evaluated the association of two dietary antioxidant indices, the Dietary Antioxidant Quality Score (DAQS) and the Composite Dietary Antioxidant Index (CDAI), with 10 oxidative stress or inflammation biomarkers (urinary F2-isoprostanes-15-F2t-IsoP; urinary 15-F2t-IsoPM; urinary prostaglandin E2 metabolite-PGEM; C-reactive protein-CRP; interleukin-1beta-IL-1β; interleukin-6-IL-6; tumor necrosis factor-alpha-TNF-α; soluble TNF-receptor 1-sTNF-R1; soluble TNF-receptor 2-sTNF-R2; and soluble GP130- sGP130) in 3,853 participants of the Shanghai Women's Health Study (SWHS). We found the DAQS and CDAI to be highly correlated (r=0.72), and both inversely associated with levels of IL-1β (Ptrend=0.02 and 0.03, respectively) and TNF-α (Ptrend=0.005 and 0...

Cancer Epidemiology, Biomarkers & Prevention, 2009

In animal models of colon cancer, n-3 polyunsaturated fatty acids (PUFA) have antineoplastic prop... more In animal models of colon cancer, n-3 polyunsaturated fatty acids (PUFA) have antineoplastic properties, whereas n-6 PUFAs may promote carcinogenesis. Prior epidemiologic studies have been inconsistent regarding the association of PUFAs and colorectal cancer. We prospectively evaluated the association between PUFA intake and colorectal cancer in a cohort of 73,242 Chinese women who were interviewed in person at the baseline survey for the Shanghai Women's Health Study. Dietary fatty acid consumption was derived using data collected from two food frequency questionnaires administered at baseline and 2 to 3 years later. The dietary total n-6 to n-3 PUFA ratio was strongly associated with colorectal cancer risk. Compared with women in the lowest quintile group, elevated relative risks (RR) were observed for the second [RR, 1.52; 95% confidence intervals (CI), 1.00-2.32], third (RR, 2.20; 95% CI, 1.41-3.45), fourth (RR, 1.65; 95% CI, 0.99-2.75), and fifth (RR, 1.95; 95% CI, 1.07-3.5...

Diabetologia, Jun 7, 2017

The aims of the study were to evaluate the association between type 2 diabetes and the risk of de... more The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Sig...

Tạp chí Khoa học và công nghệ nông nghiệp Trường Đại học Nông Lâm Huế

Virus dịch tả lợn Châu Phi (ASFV) và virus dịch tả lợn cổ điển (CSFV) đã gây thiệt hại kinh tế rấ... more Virus dịch tả lợn Châu Phi (ASFV) và virus dịch tả lợn cổ điển (CSFV) đã gây thiệt hại kinh tế rất lớn cho người chăn nuôi lợn. Có nhiều phương pháp xét nghiệm để phát hiện hai virus này như: PCR, Realtime PCR, phân lập virus, ELISA. Bên cạnh đó phương pháp Multiplex Real-time RT-PCR (mReal-time RT-PCR) để phát hiện đồng thời ASFV và CSFV cũng đã được đánh giá ở một số nước trên thế giới nhưng chưa được nghiên cứu nhiều tại Việt Nam. Trong nghiên cứu này chúng tôi đánh giá mReal-time RT-PCR để xét nghiệm phát hiện đồng thời ASFV và CSFV. Kết quả cho thấy giới hạn phát hiện của phương pháp là 12,5×101 copies/µL đối với ASFV và CSFV. Kiểm tra độ lặp lại bằng cách sử dụng mẫu chuẩn (p-ASFV và p-CSFV) cho thấy hệ số biến đổi giữa các lần lặp lại <2%. Áp dụng xét nghiệm 90 mẫu thực địa thu thập từ năm 2019-2022 với kết quả tỷ lệ dương tính ASFV và CSFV là 42,22% và 8,89% theo thứ tự; đồng cảm nhiễm ASFV và CSFV là 2,2%.

2019 6th NAFOSTED Conference on Information and Computer Science (NICS)

One of the major topics in photogrammetry is the automated extraction of building from data acqui... more One of the major topics in photogrammetry is the automated extraction of building from data acquired by airborne sensors. What makes this task challenging is the very heterogeneous appearance and dense distribution of buildings in urban areas. While many dataset has been established, none of them pay attention to developing cities where buildings are not well planned. To complement the development of building extraction algorithms, a dataset of high resolution satellite image is constructed in this paper covering Cau Giay district, Hanoi, Vietnam. The dataset consists of 2100 images of size 1024× 1024 pixels extracted from Google Earth. Shape, size, and construction material differ greatly from building to building, thus make it challenging for state-of-the-art algorithm to accurately extract building location. Some baselines are provided using Convolutional Neural Networks (CNNs). Experimental results show that U-Net model trained with Mean Square Error loss is able to achieve comparable results (OA = 92.04).

Japanese Journal of Clinical Oncology

Background Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vi... more Background Colorectal cancer is a leading cancer incidence and cause of death worldwide and in Vietnam. Although screening is considered an effective measure to prevent and control colorectal cancer, there is no such effort in Vietnam. Methods Between 01 January 2018 and 31 October 2019, a population-based colorectal cancer screening program was conducted in Hanoi, Vietnam. A health advocacy campaign and follow-up phone calls were used to enroll residents aged ≥40 years old to complete an immunochemical-fecal occult blood testing. Positive immunochemical-fecal occult blood testing was followed by a colonoscopy. We also conducted a systematic review of the colorectal cancer screening programs in the Asia-Pacific region that used similar approach by searching Ovid Medline and PubMed databases. Results During study period, 103 542 individuals among 672 742 eligible residents attended the screening of whom 81.5% participants finished immunochemical-fecal occult blood testing test and th...

Cancer Research Communications

Dietary fiber or nonstarch polysaccharides (NSP) may provide protection from colorectal cancer de... more Dietary fiber or nonstarch polysaccharides (NSP) may provide protection from colorectal cancer development. Epidemiologic studies on the association between dietary fiber and colorectal cancer is inconsistent are limited on NSP as a modifiable risk factor. Using the Singapore Chinese Health Study, a population-based prospective cohort of 61,321 cancer-free middle-aged or older Chinese Singaporeans, we examined the association between dietary fiber and NSP intakes and colorectal cancer risk. Fiber and NSP intakes at baseline were obtained using a validated semiquantitative food frequency questionnaire coupled with the Singapore Food Composition Database. Cox proportional hazard regression model was used to estimate the HRs and respective 95% confidence intervals (CI) for colorectal cancer associated with dietary fiber and NSP intakes after adjusting for potential confounders. After an average of 17.5 years of follow-up, 2,140 participants developed colorectal cancer. NSP was inversel...

International Journal of Cancer

Evidence from animal models suggests that dietary fatty acids have both anticancer and tumor‐prom... more Evidence from animal models suggests that dietary fatty acids have both anticancer and tumor‐promoting effects. Whether dietary fatty acids are associated with colorectal cancer (CRC) in humans remains inconclusive. We investigated associations between dietary fatty acids and risk of CRC among 59 986 men who participated in the Shanghai Men's Health Study (SMHS), an ongoing population‐based prospective cohort study. We identified 876 incident CRC cases in the SMHS during a mean follow‐up of 9.8 years. Associations between dietary fatty acid intake and CRC risk were evaluated by Cox proportional hazard regression analyses. Consumption of saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) was not significantly associated with CRC risk. Multivariate hazard ratios (HRs) and respective 95% confidence intervals (CIs) for Quartile 4 vs Quartile 1 were 0.92 (0.74‐1.14; Ptrend = 0.47) for SFA, 0.95 (0.79‐1.16; Ptrend = 0.74) for MUFA an...

Cancer Epidemiology, Biomarkers & Prevention

Background: Evidence on associations between dietary intake and risk of breast cancer subtypes is... more Background: Evidence on associations between dietary intake and risk of breast cancer subtypes is limited and inconsistent. We evaluated associations of fruit, vegetable, meat, and fish consumption with risk of breast cancer overall and by molecular subtype in the Vietnamese Breast Cancer Study (VBCS). Method: VBCS includes 476 incident breast cancer cases and 454 age-matched controls. Dietary habits over the past 5 years were assessed by in-person interviews using a validated food frequency questionnaire. Associations of food groups with breast cancer were evaluated via logistic regression for overall and molecular subtype with adjustment for age, education, income, family history of cancer, menopausal status, body mass index, exercise, total energy intake, and other potential dietary confounders. Odds ratio (OR) was used to approximate relative risk. Results: High fruit intake was inversely associated with breast cancer risk, with adjusted ORs [95% confidence intervals (CI)] of 0....

Cancer Epidemiology, Biomarkers & Prevention, 2021

Purpose: Delay in diagnosis and initiation of treatment from the first noticeable breast cancer s... more Purpose: Delay in diagnosis and initiation of treatment from the first noticeable breast cancer symptoms are associated with poor outcome. Understanding the reasons and barriers why patients delay seeking medical care is critical to mitigate the problem, particularly in low- and middle-income countries (LMICs) where breast cancer incidence is increasing. Methods: In-person surveys were conducted in 462 incident breast cancer cases, aged 18-79, recruited from two major cancer hospitals in Northern Vietnam. Delay in diagnosis and treatment was defined as no delay (<3 months), moderate delay (3-8 months) and serious delay (≥9 months). Multivariable polynomial logistic regression was applied in data analyses. Results: More than one quarter patients (27.5%) experienced moderate delays, and close to one-fifth (18.8%) experienced serious delays. Adjusted odds ratios (OR) and 95% confidence intervals (CI) for moderate and serious delays were 4.81 (2.62-8.85) and 3.46 (1.72-6.97) for fina...

Cancer Epidemiology, Biomarkers & Prevention, 2021

Background: Limited research has been conducted on the effect of quality diet index (QDI), which ... more Background: Limited research has been conducted on the effect of quality diet index (QDI), which represents a comprehensive assessment of healthy diet quality and quantity, on pancreatic cancer risk in Asian populations. Methods: Using data from the Singapore Chinese Health Study, a prospective cohort of 63,257 middle-aged or older Chinese men and women, four QDI scores: the Alternative Health Eating Index-2010 (AHEI-2010), the alternate Mediterranean Diet (aMED), the Dietary Approaches to Stop Hypertension (DASH), and the Heathy Diet Indicator (HDI), at baseline were calculated. After 25 years of follow-up, 311 cohort participants developed pancreatic cancer. Cox proportional hazard regression method was used to estimate HR and 95% confidence interval (CI) for pancreatic cancer associated with higher QDI scores. Results: Higher scores of AHEI-2010, aMED, and DASH were significantly associated with lower pancreatic cancer risk (all Ptrend < 0.05). Compared with the lowest quartil...

International Journal of Cancer, 2021

Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is ... more Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is an important precursor of colorectal cancer. There is currently no study to determine the modifiable risk factors for colorectal adenomas, including body mass index (BMI) in Vietnam. We conducted an individually matched case‐control study of 1149 colorectal adenomas and 1145 controls in a large‐scale colorectal screening program involving 103 542 individuals aged 40‐75 years old in Hanoi, Vietnam. Conditional logistic regression was used to evaluate the association between BMI and colorectal adenomas prevalence, after controlling for potential confounders. Overall, comparing to normal weight (ie, 18.5‐22.9 kg/m2), underweight (ie, BMI < 18.5) was associated with a non‐statistically significant increased prevalence of colorectal adenomas (odd ratio [OR] = 1.29 and 95% confident interval [CI]: 0.88‐1.87). This association became significant among male (OR = 1.98, 95% CI: 1.20‐3.27), mal...