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Papers by habib emre

PubMed, Aug 1, 2012

Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to t... more Rhabdomyolysis is defined as a pathological condition of skeletal muscle cell damage leading to the release of toxic intracellular components into the circulation. Several factors may lead to rhabdomyolysis. Fenofibrate is a fibric acid derivative agent that is used in the treatment of hyperlipidaemia. Although several case reports of rhabdomyolysis have been reported due to the combination of statin and fenofibrate, fenofibrate alone rarely causes rhabdomyolysis. When administering fenofibrate in chronic renal failure, dose should be adjusted. Here, we report a case with fenofibrate-induced rhabdomyolysis in a patient with chronic renal failure.

Van Tıp Dergisi, 2012

Özet Peritonit periton diyalizinin en sık görülen komplikasyonudur. Stenotrophomonas maltophilia ... more Özet Peritonit periton diyalizinin en sık görülen komplikasyonudur. Stenotrophomonas maltophilia peritoniti nadir görülmesine rağmen etkenin birçok ilaca karşı dirençli olmasından dolayı tedavisi zordur. Biz, antibiyotik tedavisine cevap vermeyen ve ancak ...

Clinical Biochemistry, 2012

Objectives: Fenofibrate is a fibric acid derivative that is used alone or combination with statin... more Objectives: Fenofibrate is a fibric acid derivative that is used alone or combination with statins in the treatment of hyperlipidemia. These drugs have potential risks, including rhabdomyolysis and acute renal failure. Despite reports of rhabdomyolysis with the use of fenofibrate alone or with statin-fibrate combinations, there have been no cases of rhabdomyolysis described when fenofibrate was used alone to treat patients with chronic renal failure owing to nephrotic syndrome. Design and methods: We report on a 26-year-old male who presented with fenofibrate-induced rhabdomyolysis with chronic renal failure due to nephrotic syndrome. Results: After the discontinuation of fenofibrate, the patient was treated with intravenous fluid replacement and urine alkalization. Subsequently, his clinical and biochemical findings improved. Conclusions: Before starting fenofibrate therapy, the causes of secondary hyperlipidemia, especially nephrotic syndrome, should be investigated. In the presence of chronic renal failure and hypoalbuminemia, the fenofibrate dose should be adjusted. Physicians should be aware of the potential toxicities of fenofibrate, and patients should be informed about its potential side effects.

Atherosclerosis, Sep 1, 2011

Objective: It has been shown that low paraoxonase-1 (PON1) activity is associated with a risk of ... more Objective: It has been shown that low paraoxonase-1 (PON1) activity is associated with a risk of an early development of atherosclerosis. In the present study, we investigated serum paraoxonase, and arylesterase activities and oxidative stress in patients with adult nephrotic syndrome (NS). In addition, we examined the relationship between these measurements and atherosclerosis. Methods: Twenty-one patients with NS and 21 healthy controls were enrolled in the study. Serum basal and salt-stimulated paraoxonase activities, arylesterase activity, lipid hydroperoxide (LOOH) and total thiol (SH) levels were measured. Results: Serum basal and salt-stimulated paraoxonase activities, arylesterase activity and total SH levels were significantly lower in patients with NS than in controls (p < 0.05, p < 0.05, p < 0.01 and p < 0.05, respectively), whereas LOOH levels were significantly higher (p < 0.05). Serum LOOH levels were significantly correlated with total-SH levels in patients with NS (r = −0.467; p < 0.01). Moreover, proteinuria levels were significantly correlated with serum LOOH levels (r = 0.397; p < 0.01), whereas no correlation was found among serum paraoxonase activity, arylesterase activity and total-SH levels in NS patients (p > 0.05). Conclusions: We concluded that oxidative stress is increased, while serum PON1 activity is decreased in patients with adult NS. In addition, these results indicate that lower PON1 activity is associated with an oxidant-antioxidant imbalance that may contribute to atherosclerosis in adult patients with NS.

vantipdergisi.yyu.edu.tr

Journal of Pharmacy Technology, 2011

ABSTRACT Objective: To increase awareness of amlodipine-induced gingival hyperplasia in children,... more ABSTRACT Objective: To increase awareness of amlodipine-induced gingival hyperplasia in children, as well as review whether a dose-related relationship exists.

Kidney International Reports

Central venous catheters are commonly used in renal failure for hemodialysis. One of the most com... more Central venous catheters are commonly used in renal failure for hemodialysis. One of the most common complications of central venous catheterization is catheter malposition. Before inserting a catheter procedure, risk factors that could cause malposition are well-identified and after inserting a catheter procedure chest radiograph should be perform to verify the location of the catheter. We wanted to attract attention to the catheter malpositions by presenting a seven cases with catheter malposition.

Oxidative medicine and cellular longevity, 2011

Cisplatin (CDDP) is one of the most active cytotoxic agents in the treatment of cancer and has ad... more Cisplatin (CDDP) is one of the most active cytotoxic agents in the treatment of cancer and has adverse side effects such as nephrotoxicity and hepatotoxicity. The present study was designed to determine the effects of royal jelly (RJ) against oxidative stress caused by CDDP injury of the kidneys and liver, by measuring tissue biochemical and antioxidant parameters and investigating apoptosis immunohistochemically. Twenty-four Sprague Dawley rats were divided into four groups, group C: control group received 0.9% saline; group CDDP: injected i.p. with cisplatin (CDDP, 7 mg kg(-1) body weight i.p., single dose); group RJ: treated for 15 consecutive days by gavage with RJ (300 mg/kg/day); group RJ + CDDP: treated by gavage with RJ 15 days following a single injection of CDDP. Malondialdehyde (MDA) and glutathione (GSH) levels, glutathione S-transferase (GST), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities were determined in liver and kidney homogenates, and ...

Eastern Journal of …, 2011

... Habib Emrea, Mustafa Kelesb,*, Abdullah Uyanik b, Mucahit Emet c, Yusuf Bilend, Dilara Bayrak... more ... Habib Emrea, Mustafa Kelesb,*, Abdullah Uyanik b, Mucahit Emet c, Yusuf Bilend, Dilara Bayraktutand ... Correspondence: Dr. Mustafa Keles, MD, Atatürk University, Medical Faculty, Department of Internal Medicine 25240 Erzurum, Turkey E-mail: keles.m@gmail.com. ...

Neurological disorders can be observed in hemodialysis patients due to uremic encephalopathy, ele... more Neurological disorders can be observed in hemodialysis patients due to uremic encephalopathy, electrolyte imbalance, infection, medications, glucose intolerance, hypoxia and psychiatric disorders. We present a case of hydrocephalus consequent to central vein thrombosis that is rarely seen in an adult hemodialysis patient and which causes neuro-psychiatric symptoms.

Hellenic journal of nuclear medicine, 2010

The purpose of this study was to evaluate the alterations in salivary gland function in patients ... more The purpose of this study was to evaluate the alterations in salivary gland function in patients who receiving continuous ambulatory peritoneal dialysis (CAPD) for chronic renal failure (CRF) using technetium-99m pertechnetate ((99m)Tc-P) salivary gland scintigraphy. The study population consisted of 36 CAPD patients (16 males and 20 females, ranging in age from 19 to 73 years, mean age 44.94+/-15.01 years) and 20 healthy controls (11 males and 9 females, ranging in age from 31 to 51 years, mean age 41.25+/-5.62 years). All patients and healthy controls underwent salivary gland scintigraphy. After the intravenous administration of 185MBq of (99m)Tc-P, dynamic salivary gland scintigraphy was performed for 25min. On the basis of the time-activity curves, the following glandular function parameters were calculated for the parotid and submandibular salivary glands: uptake ratio, maximum accumulation, and ejection fraction. Our results showed: All functional parameters obtained for CAPD ...

Abstract. Bentazone (Basagran®) is a commonly used and easily available agricultural herbicide. W... more Abstract. Bentazone (Basagran®) is a commonly used and easily available agricultural herbicide. We report a 41-year-old-man who developed rhabdomyolysis with acute renal failure after bentazone toxicity. Four hours later after oral intake of liquid bentazone for suicidal attempt, the patient admitted to emergency service and his initial renal function tests were in normal range. However on the 15 th hour of intake, urine output decreased, and blood urine nitrogen, creatinine and creatinine kinase levels were increased. On the fifth day of hospitalization, creatinine and creatinine kinase levels had turned to normal levels. As a result, bentazone intoxication may cause rhabdomyolysis with acute renal failure. Thus, renal functions must be followed up closely. Key words: Bentazone intoxication; rhabdomyolysis; acute renal failure

Giris Lokositoklastik vaskulit, kucuk damarlari tutan, venul, arteryol ve kapillerlerin inflamasy... more Giris Lokositoklastik vaskulit, kucuk damarlari tutan, venul, arteryol ve kapillerlerin inflamasyonu ile karakterize klinik olarak genis spektrumlu kutanoz lezyonlarin goruldugu bir vaskulittir. Lokositoklastik vaskulit ilaclara, enfeksiyonlara, sistemik lupus eritematozis gibi kollajen doku hastaliklarina, malignitelere sekonder olabilecegi gibi bazen idiyopatik de gorulebilir (1). Baslica klinik bulgular pruritis, palpabl purpura, makulopapuler dokuntuler, urtiker, pustul, iskemiye sekonder gelisen ulserasyonlardir (2). Fokal segmental glomeruloskleroz (FSGS) glomerullerin bir kisminda skar olusturarak renal yetersizlige yol acan proteinuri ile klinik bulgularinin sekillendigi bir hastaliktir. FSGS idiyopatik olabildigi gibi cesitli farkli nedenlere sekonder olarak da gorulebilir. FSGS’ye yol acabilen sebepler, eroin kullanimi, HIV enfeksiyonu, orak hucreli anemi, vesikoureteral reflu, obezite olarak sayilabilir (3). Lokositoklastik vaskulit olgularinda nefrotik sendrom etyolojisi...

A 23-year-old pregnant woman was admitted to our hospital due to pruritus and right upper quadran... more A 23-year-old pregnant woman was admitted to our hospital due to pruritus and right upper quadrant pain. Her abdominal ultrasound revealed hepatomegaly and the fetal ultrasonography was normal. Her HBS antigen was positive and HBe antigen was negative. HBV-DNA level was 350,000 copies / ml. Coincidental hepatobiliary diseases in pregnancy were ruled out. The patient received a diagnosis of HBe antigen negative hepatitis B and tenofovir disoproxil 245 mg / day was prescribed. At a follow-up visit one month later, she reported no improvement in her pruritus. The levels of liver transaminases were near-normal and HBV DNA was zero. However, her biochemistry revealed raised alkaline phosphatase and gamma glutamyl transferase levels. Her consecutively calculated fasting serum bile acid levels were too high. A diagnosis of severe intrahepatic cholestasis of pregnancy associated with hepatitis B infection was made and a treatment of ursodeoxycholic acid 1000 mg / day was prescribed while sh...