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Research paper thumbnail of CSF markers of neurodegeneration in Parkinson’s disease

Journal of Neural Transmission, 2010

Parkinson’s disease (PD) is a chronic, progressive, neurodegenerative disease with a multifactori... more Parkinson’s disease (PD) is a chronic, progressive, neurodegenerative disease with a multifactorial etiology. Protein accumulation is speculated by some to play a prominent role in the pathogenesis of PD. The severity of neurodegeneration should correlate with cerebrospinal fluid (CSF) levels of these neurodegenerative markers (NDMs). The aims of the study were to assess the CSF levels of tau protein, beta-amyloid (1–42), cystatin C, and clusterin in patients suffering from PD and in a control group, to compare the CSF levels between the two groups and to correlate them to PD duration. NDMs in the CSF were assessed in 32 patients suffering from PD and in a control group (CG) of 30 patients. The following statistically significant differences in the CSF were found: higher tau protein (p = 0.045) and clusterin levels (p = 0.004) in PD patients versus CG; higher tau protein levels (p = 0.033), tau protein/beta-amyloid (1–42) ratio (p = 0.011), and clusterin (p = 0.044) in patients suffering from PD for

Research paper thumbnail of Contributory presentations/posters

Journal of Biosciences, 1999

Research paper thumbnail of H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded AntiHemagglutinin Antibodies Than Influenza Vaccination

Research paper thumbnail of Practice Language Work

Research paper thumbnail of CSF markers of neurodegeneration in Parkinson’s disease

Journal of Neural Transmission, 2010

Parkinson’s disease (PD) is a chronic, progressive, neurodegenerative disease with a multifactori... more Parkinson’s disease (PD) is a chronic, progressive, neurodegenerative disease with a multifactorial etiology. Protein accumulation is speculated by some to play a prominent role in the pathogenesis of PD. The severity of neurodegeneration should correlate with cerebrospinal fluid (CSF) levels of these neurodegenerative markers (NDMs). The aims of the study were to assess the CSF levels of tau protein, beta-amyloid (1–42), cystatin C, and clusterin in patients suffering from PD and in a control group, to compare the CSF levels between the two groups and to correlate them to PD duration. NDMs in the CSF were assessed in 32 patients suffering from PD and in a control group (CG) of 30 patients. The following statistically significant differences in the CSF were found: higher tau protein (p = 0.045) and clusterin levels (p = 0.004) in PD patients versus CG; higher tau protein levels (p = 0.033), tau protein/beta-amyloid (1–42) ratio (p = 0.011), and clusterin (p = 0.044) in patients suffering from PD for

Research paper thumbnail of Contributory presentations/posters

Journal of Biosciences, 1999

Research paper thumbnail of H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded AntiHemagglutinin Antibodies Than Influenza Vaccination

Research paper thumbnail of Practice Language Work

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