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Research paper thumbnail of Insight into the stereoselectivity of PPL-catalyzed formation of polyesters from phenyl glycidyl ether and succinic anhydride

European Polymer Journal, Jul 1, 2012

Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed ol... more Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed oligomerization of succinic anhydride and phenyl glycidyl ether is carried out. The results show that no stereoselection was recorded at any step of the suggested mechanism of the process: opening of the chiral epoxide into 1,2-diol, nucleophilic attack of the chiral acylenzyme by a chiral diol, or by the hydroxyl group of a growing oligomer.

Research paper thumbnail of Phytochemical composition and biological activity of <i>Neurada procumbens</i> L. growing in southern Algeria

Journal of Food Processing and Preservation, Jul 23, 2020

While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pha... more While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol-glycosides and four thiophenes. The compounds were characterised using spectroscopic and spectrometric methods, including GC/MS, MS and NMR. The essential oil showed insecticidal activity against Drosophila melanogaster larvae. The methanolic extract of D. tagetiflora (DTME) had strong antioxidant activity against DPPH and ABTS radicals; DTME showed no evidence of genotoxic or cytotoxic effects. In contrast, DTME showed a cytoprotective effect attenuating the formation of H 2 O 2-induced micronuclei in Vicia faba roots. This report is the first to describe the phytochemical and biological activity of D. tagetiflora.

Research paper thumbnail of Lobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies

Molecules

Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic ... more Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phytochemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties of L. libyca methanol extract. L. libyca contains significant amounts of phenolic compounds and flavonoids. Thirteen compounds classified as flavonoids were identified. L. libyca is rich in nutrients such as Na, Fe and Ca. Moreover, the methanol extract of L. libyca showed significant antioxidant activity without cytotoxic activity on HCT116 cells (human colon cancer cell line) and HepG2 cells (human hepatoma), showing an inhibition zone of 13 mm in diameter. In silico studies showed that decanoic acid ethyl ester exhibited the best fit in β-lactamase and DNA gyrase active sites; meanwhile, oleic acid showed the best fit in reductase bindin...

Research paper thumbnail of Total phenol and flavonoid content, antioxidant and cytotoxicity assessment of Algerian Launaea glomerata (Cass.) Hook.f. extracts

El-Oued province (southeast Algeria), is located in a medicinal plant-rich area; <em>Launae... more El-Oued province (southeast Algeria), is located in a medicinal plant-rich area; <em>Launaea glomerata</em> (Cass.) Hook. f. is one among them which is a perennial herb spread widely in the arid regions of the Mediterranean Sea. The selection of the studied plant corresponds perfectly to the scientific needs due two reasons, firstly because these samples are used by the Algerian population as herbal remedies for primary health care, secondly, for the lack of published data on it. The aim of this investigation is to provide new data on quantities of phenols, which were estimated at 25.81 mg GAE/g extract and flavonoids (49.13 mg RE/g extract), and the determination of antioxidant activities by three ways (DPPH, CAT, ABTS), the results of IC<sub>50 </sub>equals to 98.07 mg TE/g extract for DPPH• and 286.5 mg eq. AG/g for ABTS assays, noted that the best inhibition was by the ABTS root. We also conducted a test for the inhibitory ability of extract against cance...

Research paper thumbnail of Phytochemical composition and biological activity of Neurada procumbens L. growing in southern Algeria

Journal of Food Processing and Preservation, 2020

While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pha... more While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol-glycosides and four thiophenes. The compounds were characterised using spectroscopic and spectrometric methods, including GC/MS, MS and NMR. The essential oil showed insecticidal activity against Drosophila melanogaster larvae. The methanolic extract of D. tagetiflora (DTME) had strong antioxidant activity against DPPH and ABTS radicals; DTME showed no evidence of genotoxic or cytotoxic effects. In contrast, DTME showed a cytoprotective effect attenuating the formation of H 2 O 2-induced micronuclei in Vicia faba roots. This report is the first to describe the phytochemical and biological activity of D. tagetiflora.

Research paper thumbnail of On the use of succinic anhydride as acylating agent for practical resolution of aryl–alkyl alcohols through lipase-catalyzed acylation

Tetrahedron Letters, 2004

A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a seri... more A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a series of secondary aryl-alkyl alcohols with enol esters versus succinic anhydride. Whereas all the substrates could be resolved by a proper choice of the lipase/enol ester couple with moderate (E ¼ 50) to good (E > 100) enantioselectivities, only some of them showed satisfactory enantioselectivity (E > 50) with the use of succinic acid as acylating agent. Notably, indanol and 1-quinolin-3-yl-ethanol were resolved in a practical way, with E > 100 and E > 80, respectively.

Research paper thumbnail of Multi-substrate screening for lipase-catalyzed resolution of arylalkylethanols with succinic anhydride as acylating agent

Journal of Molecular Catalysis B: Enzymatic, 2010

ABSTRACT CAL-B lipase-catalyzed resolution of a number of arylalkylethanols using succinic anhydr... more ABSTRACT CAL-B lipase-catalyzed resolution of a number of arylalkylethanols using succinic anhydride as acylating agent has been performed to evaluate the corresponding enantioselectivity factors. Then “one-pot multi-substrate screening” reactions involving two- and four-substrate mixtures were carried out and evaluation of the enantioselectivity factors for each alcohol was undertook by a single-run analysis. It was concluded that the alcohols in the mixture behave independently, validating the “one-pot multi-substrate screening” for a rapid evaluation of the enantioselectivity of the kinetic resolution process for each individual substrate.

Research paper thumbnail of Insight into the stereoselectivity of PPL-catalyzed formation of polyesters from phenyl glycidyl ether and succinic anhydride

European Polymer Journal, 2012

Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed ol... more Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed oligomerization of succinic anhydride and phenyl glycidyl ether is carried out. The results show that no stereoselection was recorded at any step of the suggested mechanism of the process: opening of the chiral epoxide into 1,2-diol, nucleophilic attack of the chiral acylenzyme by a chiral diol, or by the hydroxyl group of a growing oligomer.

Research paper thumbnail of On the use of succinic anhydride as acylating agent for practical resolution of aryl–alkyl alcohols through lipase-catalyzed acylation

Tetrahedron Letters, 2004

A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a seri... more A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a series of secondary aryl-alkyl alcohols with enol esters versus succinic anhydride. Whereas all the substrates could be resolved by a proper choice of the lipase/enol ester couple with moderate (E ¼ 50) to good (E > 100) enantioselectivities, only some of them showed satisfactory enantioselectivity (E > 50) with the use of succinic acid as acylating agent. Notably, indanol and 1-quinolin-3-yl-ethanol were resolved in a practical way, with E > 100 and E > 80, respectively.

Research paper thumbnail of Insight into the stereoselectivity of PPL-catalyzed formation of polyesters from phenyl glycidyl ether and succinic anhydride

European Polymer Journal, Jul 1, 2012

Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed ol... more Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed oligomerization of succinic anhydride and phenyl glycidyl ether is carried out. The results show that no stereoselection was recorded at any step of the suggested mechanism of the process: opening of the chiral epoxide into 1,2-diol, nucleophilic attack of the chiral acylenzyme by a chiral diol, or by the hydroxyl group of a growing oligomer.

Research paper thumbnail of Phytochemical composition and biological activity of <i>Neurada procumbens</i> L. growing in southern Algeria

Journal of Food Processing and Preservation, Jul 23, 2020

While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pha... more While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol-glycosides and four thiophenes. The compounds were characterised using spectroscopic and spectrometric methods, including GC/MS, MS and NMR. The essential oil showed insecticidal activity against Drosophila melanogaster larvae. The methanolic extract of D. tagetiflora (DTME) had strong antioxidant activity against DPPH and ABTS radicals; DTME showed no evidence of genotoxic or cytotoxic effects. In contrast, DTME showed a cytoprotective effect attenuating the formation of H 2 O 2-induced micronuclei in Vicia faba roots. This report is the first to describe the phytochemical and biological activity of D. tagetiflora.

Research paper thumbnail of Lobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies

Molecules

Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic ... more Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phytochemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties of L. libyca methanol extract. L. libyca contains significant amounts of phenolic compounds and flavonoids. Thirteen compounds classified as flavonoids were identified. L. libyca is rich in nutrients such as Na, Fe and Ca. Moreover, the methanol extract of L. libyca showed significant antioxidant activity without cytotoxic activity on HCT116 cells (human colon cancer cell line) and HepG2 cells (human hepatoma), showing an inhibition zone of 13 mm in diameter. In silico studies showed that decanoic acid ethyl ester exhibited the best fit in β-lactamase and DNA gyrase active sites; meanwhile, oleic acid showed the best fit in reductase bindin...

Research paper thumbnail of Total phenol and flavonoid content, antioxidant and cytotoxicity assessment of Algerian Launaea glomerata (Cass.) Hook.f. extracts

El-Oued province (southeast Algeria), is located in a medicinal plant-rich area; <em>Launae... more El-Oued province (southeast Algeria), is located in a medicinal plant-rich area; <em>Launaea glomerata</em> (Cass.) Hook. f. is one among them which is a perennial herb spread widely in the arid regions of the Mediterranean Sea. The selection of the studied plant corresponds perfectly to the scientific needs due two reasons, firstly because these samples are used by the Algerian population as herbal remedies for primary health care, secondly, for the lack of published data on it. The aim of this investigation is to provide new data on quantities of phenols, which were estimated at 25.81 mg GAE/g extract and flavonoids (49.13 mg RE/g extract), and the determination of antioxidant activities by three ways (DPPH, CAT, ABTS), the results of IC<sub>50 </sub>equals to 98.07 mg TE/g extract for DPPH• and 286.5 mg eq. AG/g for ABTS assays, noted that the best inhibition was by the ABTS root. We also conducted a test for the inhibitory ability of extract against cance...

Research paper thumbnail of Phytochemical composition and biological activity of Neurada procumbens L. growing in southern Algeria

Journal of Food Processing and Preservation, 2020

While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pha... more While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol-glycosides and four thiophenes. The compounds were characterised using spectroscopic and spectrometric methods, including GC/MS, MS and NMR. The essential oil showed insecticidal activity against Drosophila melanogaster larvae. The methanolic extract of D. tagetiflora (DTME) had strong antioxidant activity against DPPH and ABTS radicals; DTME showed no evidence of genotoxic or cytotoxic effects. In contrast, DTME showed a cytoprotective effect attenuating the formation of H 2 O 2-induced micronuclei in Vicia faba roots. This report is the first to describe the phytochemical and biological activity of D. tagetiflora.

Research paper thumbnail of On the use of succinic anhydride as acylating agent for practical resolution of aryl–alkyl alcohols through lipase-catalyzed acylation

Tetrahedron Letters, 2004

A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a seri... more A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a series of secondary aryl-alkyl alcohols with enol esters versus succinic anhydride. Whereas all the substrates could be resolved by a proper choice of the lipase/enol ester couple with moderate (E ¼ 50) to good (E > 100) enantioselectivities, only some of them showed satisfactory enantioselectivity (E > 50) with the use of succinic acid as acylating agent. Notably, indanol and 1-quinolin-3-yl-ethanol were resolved in a practical way, with E > 100 and E > 80, respectively.

Research paper thumbnail of Multi-substrate screening for lipase-catalyzed resolution of arylalkylethanols with succinic anhydride as acylating agent

Journal of Molecular Catalysis B: Enzymatic, 2010

ABSTRACT CAL-B lipase-catalyzed resolution of a number of arylalkylethanols using succinic anhydr... more ABSTRACT CAL-B lipase-catalyzed resolution of a number of arylalkylethanols using succinic anhydride as acylating agent has been performed to evaluate the corresponding enantioselectivity factors. Then “one-pot multi-substrate screening” reactions involving two- and four-substrate mixtures were carried out and evaluation of the enantioselectivity factors for each alcohol was undertook by a single-run analysis. It was concluded that the alcohols in the mixture behave independently, validating the “one-pot multi-substrate screening” for a rapid evaluation of the enantioselectivity of the kinetic resolution process for each individual substrate.

Research paper thumbnail of Insight into the stereoselectivity of PPL-catalyzed formation of polyesters from phenyl glycidyl ether and succinic anhydride

European Polymer Journal, 2012

Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed ol... more Analysis of the stereoselectivity that would be expected in the Pig Pancreatic Lipasecatalyzed oligomerization of succinic anhydride and phenyl glycidyl ether is carried out. The results show that no stereoselection was recorded at any step of the suggested mechanism of the process: opening of the chiral epoxide into 1,2-diol, nucleophilic attack of the chiral acylenzyme by a chiral diol, or by the hydroxyl group of a growing oligomer.

Research paper thumbnail of On the use of succinic anhydride as acylating agent for practical resolution of aryl–alkyl alcohols through lipase-catalyzed acylation

Tetrahedron Letters, 2004

A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a seri... more A comparison is carried out of the E-values recorded in the lipase-catalyzed resolution of a series of secondary aryl-alkyl alcohols with enol esters versus succinic anhydride. Whereas all the substrates could be resolved by a proper choice of the lipase/enol ester couple with moderate (E ¼ 50) to good (E > 100) enantioselectivities, only some of them showed satisfactory enantioselectivity (E > 50) with the use of succinic acid as acylating agent. Notably, indanol and 1-quinolin-3-yl-ethanol were resolved in a practical way, with E > 100 and E > 80, respectively.