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Papers by hany hassan

Evidence Based Women's Health Journal, 2017

Objective: To study pregnancy rates after vitrified-thawed embryo transfer and fresh embryo trans... more Objective: To study pregnancy rates after vitrified-thawed embryo transfer and fresh embryo transfer. Design: Retrospective study. Setting: Infertility and IVF unit, Minia University Hospital. Patients and Methods: All women undergone ICSI program during the period from first of January 2010 to December 2014, pregnancy rate was compared between two groups, first group (Group I) had fresh embryo transfer, the second group (Group II) had vitrified-thawed embryo transfer. Main outcome: Clinical pregnancy rate. Results: There was insignificant difference between two groups regarding chemical pregnancy rate it was 228 (43%) in (Group I), 36% (186) in the second group (Group II). Clinical pregnancy rate 24.5 % (130) versus 22.1% (114). Implantation rate 28.6 % versus 24%. The rate of single pregnancy was higher in the first group 80% than in the second group 76.4%. The rate of twins was higher in the second group 23.6 %. Conclusion: A program of vitrified-thawed embryo transfer should be adopted by all IVF center especially in low-income countries to maximize the benefit of the single treatment cycle, increase cumulative pregnancy rate and decrease the cost of repeated cycle stimulation, as the pregnancy rate is almost equal in FET and fresh embryo transfer.

Background: Dilation and Curettage (DC the uterus. Although it is used to be an easy intervention... more Background: Dilation and Curettage (DC the uterus. Although it is used to be an easy intervention, short and long term complications were, and will be, reported. To optimize the benefits and minimize the risks inherent to the conventional procedure, continuous ultrasound guidance was tried during dilation and curettage. Aim of the Work: To examine whether sono-guided dilation and curettage is effective and safer than the conventional procedure. Design: A randomized controlled trial. Setting: El-Minia University Hospital, El-Minia, Egypt. Study population: patients scheduled for dilation and curettage for first trimester missed abortion recruited among the attendants of the Obstetrics and Gynecology Clinics since January 2011 through February 2012. Intervention: Women were randomized to have dilation and curettage with or without continuous ultrasound monitoring. Outcome measures: The primary outcome measures were surgical short-term complications (anesthetic complication, blood loss...

Objective: Draw attention for risk factors of drug error fatal mistakes that jeopardize patient l... more Objective: Draw attention for risk factors of drug error fatal mistakes that jeopardize patient life. Case Presentation: In this study we presented a fatal drug error, intrathecal injection of tranexamic acid before caesarean section which leaded to neurotoxicity and repeated seizures, complicated by ventricular fibrillation and maternal mortality. Conclusion: We should emphasize true drug for true patient by right method of administration especially in drugs that can easily endanger patient safety, legal rules should play a role to avoid repeated mistakes.

Annals of Neonatology Journal, 2020

Introdution: The Novel coronavirus (SARS-COV-2) is a new strain of coronavirus causing Coronaviru... more Introdution: The Novel coronavirus (SARS-COV-2) is a new strain of coronavirus causing Coronavirus disease (COVID-19) first identified in Wuhan City of China and eventually was declared as a pandemic by the WHO on 11 March 2020. It has reached 210 countries and territories with more than three million cases and over 2,00,000 deaths. As of 27th of April in Egypt there are about 4782 cases with 337 deaths and 1236 recovered cases, In India there are 28,380 cases with 886 deaths and 6523 recovered cases. With this pandemic assuming a crisis of global proportions unprecedented in recent times and presenting a challenge in its control and management it will be inevitable that we will be seeing women infected with COVID-19 in pregnancy as they are proportion of this population. Unlike many of the other specialists obstetricians face the situation that matters related to childbirth cannot be delayed indefinitely. The maternity healthcare providers and facilities hence need to prepare for the situation with a view to prevent the consequences of the infection on the mother and her newborn. The article reviews the clinical features, testing criteria, preventive aspects, effects of the infection on mother and the foetus, the current management options including the general measures, pharmacological options, preparedness of the institutions, antenatal management, intrapartum and post-partum management in these patients in the light of available evidences Conclusion : The COVID 19 virus is a new strain of corona virus, little is known today about its effect on the outcome of pregnancy. Further clinical and research data are awaited for better understanding of any morbid effect of this new strain and its health hazards on both the mother and neonates.

The Journal of Maternal-Fetal & Neonatal Medicine, 2019

Abstract Objective: To evaluate the efficacy and safety of amniopatch in pregnancies associated w... more Abstract Objective: To evaluate the efficacy and safety of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes (PPROM). Methods: A randomized controlled trial that involved 100 women diagnosed with PPROM between 24 and 34 weeks of gestational age. Participants were randomized equally into two groups. Group I in which amniopatch was done in addition to the routine management. Group II was treated with routine management including antibiotics and corticosteroids. Results: Amniopatch was successful in complete sealing of the membrane defect in 6/50 (12%) of women while none the control group have undergone similar sealing (p = .0144, RR = 0.88). Women in the amniopatch group showed a significant increase of AFI compared to controls (12 versus 0, p = .0001, RR = 0.56). Conclusion: The amniopatch procedure is a successful technique that safely enhances sealing of fetal membranes and restore the AFI. Clinical trial registration: NCT03473210 Synopsis The amniopatch procedure is a successful technique that could be done safely to enhance sealing the fetal membranes and restoring the AFI after PPROM.

International Journal of Pregnancy & Child Birth, 2018

Objective: Infection with hepatitis B virus (HBV) and hepatitis C (HVC) in pregnant women is not ... more Objective: Infection with hepatitis B virus (HBV) and hepatitis C (HVC) in pregnant women is not uncommon and have a threat for both mothers and fetuses. This study was performed to explore the true prevalence of HBV and HCV and incidence of neonatal transmission in Minia locality. Methods: This is a prospective cohort study was conducted at the maternity and pediatric Hospital Minia University in the period between January 2015 till December 2016 all women coming in labour was included in this study. The main outcomes were the prevalence of hepatitis B and C in women and incidence of neonatal transmission. Results: Total number of women accepted sharing in our study was 11250 ladies. Total number of infected cases was 135 patients (1.2%), 84 of them were HCV +ve (0.75%) and 41 cases HBV+VE (0.364%) while 10 cases were mixed infection(0.089%), 102 patient (75.5%) of infected cases from rural areas while 33 patient (24.5%) from the urban areas. Total number of acquired neonatal hepatitis at delivery was 7 cases only, then after 3 months reassessment shows another 3 cases, So total number of infected babies after three months follow up was 10 cases out of 135 maternal cases in a percentage of 7.4%. Conclusion: Hepatitis infection is a public and social problem affecting some pregnant women in Egypt and need to be fully discovered and to be well investigated to reduce the incidence of new cases and to counteract against flare up of new infection with consequences for both mothers and newborns, and the relative lack of data, make this a critical medical challenge.

BMC pregnancy and childbirth, Jan 29, 2018

Placenta previa is major obstetric surgical risk as it is associated with higher percentage of in... more Placenta previa is major obstetric surgical risk as it is associated with higher percentage of intraoperative and postpartum hemorrhage (PPH), increased requirement of blood transfusion and further surgical procedures. The current study aimed to evaluate uterine artery ligation prior to uterine incision as a procedure to minimize blood loss during cesarean section in patients with central placenta previa. One hundred and four patients diagnosed with central placenta previa antenatally and planned to have elective caesarean section were recruited from the antenatal clinic at Minia Maternity University hospital. Patients were randomly allocated into either ligation group or control group. Both groups were similar regarding demographic features and preoperative risk factors for bleeding. The intraoperative blood loss was significantly lower in the ligation group as compared with the control group (569.3 ± 202.1 mL vs. 805.1 ± 224.5 mL respectively, p = 0.002). There was a significant i...

Evidence Based Womenʼs Health Journal, 2013

Objective To compare the serum concentrations of insulin and insulin-like growth factor-1 (IGF-1)... more Objective To compare the serum concentrations of insulin and insulin-like growth factor-1 (IGF-1) and the insulin resistance index, which is the fasting glucose/insulin ratio, in women with pre-eclampsia and in healthy control subjects. Methods In this prospective study, we investigated 20 severe pre-eclamptic, 20 mildly pre-eclamptic, and 40 healthy pregnant women in the third trimester. Serum levels of insulin, fasting glucose, and IGF-1 were measured, and fasting glucose/insulin ratios were calculated. Serum uric acid, SGOT, SGPT, urea, creatinine, total protein, and albumin were also investigated. Fetal IGF-1 was also measured; the neonatal birth weight and the APGAR score were reported to be statistically analyzed. Results Serum levels of IGF-1 were lower in patients with pre-eclampsia than in the control group (230.2±48.8 vs. 381.4±48.3 ng/ml, P=0.0001). There was no statistically significant difference between the fasting insulin levels and the glucose/insulin ratios, respectively (P=0.3, P=0.5) A statistically significant correlation was found between maternal and fetal IGF-1 and the neonatal birth weight in the pre-eclampsia and the normal group. Conclusion Serum concentrations of IGF-I were found to be lower in pre-eclamptic women than in healthy pregnant women, but there was no difference between the groups in terms of insulin resistance. Also, pre-eclampsia is associated with a low umbilical level of IGF-I and low birth weight.

International Journal of Gynecology & Obstetrics, 2012

would you or would you not engage in sexual activity in this phase of your life?'. Methods: 50 un... more would you or would you not engage in sexual activity in this phase of your life?'. Methods: 50 unaccompanied students of 18-22 years were recruited outside the gates of a major private university in Beirut. Participation included no identifiers, was voluntary, and consent was verbal. This study used an emergent, exploratory, deductive qualitative approach. Each transcript was repeatedly read and analyzed via examining keywords, phrases or explanations. Coding of keywords/phrases captured emergent and repetitive themes. Results: Responses were divided into 3 categories; intra-personal, inter-personal and external factors. Intra-personal reasons for engagement or postponement of sexual activity consisted of experience (18%), desire (14%), abstinence/waiting for marriage (14%), and values & beliefs (14%). Inter-personal reasons were relationship status (30%), communication (22%), closeness & comfort (20%) were mentioned most after loyalty & trust. The minority stated intimacy (16%), love (14%), and attraction (14%). Finally, external factors influencing postponement or engagement in sexual activity were society's perception of sex (40%), religion (38%), availability of protective methods (24%), such as contraceptives (18%) and condoms (6%), cultural factors (22%), upbringing & family (18%), and level of education (10%) represent more the social external factors. Alcohol intoxication (8%) and drug use (6%) were also mentioned. Conclusions: Responses about whether or not to have sexual intercourse for the first time mostly fell into the category of fear of social consequences. Fear was the most dominant emotion in all three categories; the fear of becoming pregnant, the fear of deception or the fear of being disowned by family and society. In the Lebanese society there is pressure restricting sexual activity among the youth, however premarital sex does take place, which then leads to marginalization of the sexually active youth from society. We believe this study contributes to the growing interest and work on youth sexuality, presenting new insight into a very "taboo" topic, thereby aiming to inform researchers and policy makers in Lebanon and the Region regarding program design & implementation, education, and services related to youth.

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013

To study the role of a phyto-oestrogen, Cimicifuga racimosa extract (Klimadynon(®), Bionorica, Ne... more To study the role of a phyto-oestrogen, Cimicifuga racimosa extract (Klimadynon(®), Bionorica, Neumarkt i.d.OBf., Germany), in ovulation induction in women with polycystic ovarian syndrome (PCOS). Prospective randomized controlled trial in Minia University Hospital, Minia, Egypt. One hundred women with PCOS were allocated into one of two groups: one group (n=50) received clomiphene citrate 100mg daily for 5 days, and the other group (n=50) received C. racimosa 20mg daily for 10 days. Both groups received medication starting from the second day of the cycle for three consecutive cycles, during which changes in follicle-stimulating hormone (FSH), luteinizing hormone (LH), FSH/LH ratio, progesterone, endometrial thickness and pregnancy rate were measured. The groups were similar in terms of age, clinical presentation and hormonal levels before treatment. Following treatment, significant favourable changes in LH level and FSH/LH ratio (p=0.007 and 0.06, respectively) were seen in the Klimadynon group. In this group the progesterone level was higher from the first treatment cycle, indicating better ovulation (p=0.0001), and endometrial thickness was greater (p=0.0004). The pregnancy rate was higher in the Klimadynon group but the difference between the groups was not significant (p=0.1). Phyto-oestrogen can be used as an alternative to clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome.