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Papers by han zhu

Finding cost-effective, active and durable catalyst materials for energy applications, such as el... more Finding cost-effective, active and durable catalyst materials for energy applications, such as electrocatalytic hydrogen production, is an intriguing challenge. Here, a facile and effective approach to the design and construction of two-dimensional MoS 2 and WS 2 interleaved nanowalls with maximum exposures of active edges on silk-derived N-doped carbon fibers (SNCF) was demonstrated. The morphological evolutions of the MoS 2 and WS 2 nanocrystals on the SNCF from crescent-like nanosheets to an interleaved nanowall network can be obtained by adjusting the concentrations of the Mo and W precursors. These robust MoS 2 /SNCF and WS 2 /SNCF electrocatalysts exhibit prominent hydrogen evolution reaction (HER) activities with onset potentials of −40 and −96 mV and Tafel slopes of 60 and 66 mV dec −1 , respectively. The overpotentials ( η ) at j = −10 mA cm −2 for MoS 2 /SNCF and WS 2 /SNCF are −102 and −157 mV, respectively. In addition, MoS 2 /SNCF and WS 2 /SNCF are both able to sustai...

Production and Operations Management

Current Cardiology Reports

It has been pointed out that the second paragraph of the section "Treatments for SARS-CoV-2 Infec... more It has been pointed out that the second paragraph of the section "Treatments for SARS-CoV-2 Infection" contains an error. The original article has been corrected. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Hematology

Objective: To investigate the impact of minimal residual disease (MRD) before allogeneic hematopo... more Objective: To investigate the impact of minimal residual disease (MRD) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) on the outcome of acute leukemia. Methods: Data from 114 patients who were diagnosed with acute leukemia (AL) and underwent allo-HSCT between Jan 2013 and Dec 2019 were collected and analyzed. The patients were attributed into MRD positive (MRD+) group and MRD negative (MRD−) group. Results: Among the 114 acute leukemia patients, there were 32 MRD+ patients before transplantation, and 82 MRD− patients. No significant difference was found between the MRD+ group and the MRD− group in the incidence of acute graft-versus-host disease (aGvHD) (p = 0.09). Compared with the MRD+ group, the MRD− group had a higher incidence of chronic graft-versus-host disease (cGvHD) (p = 0.008). There is no significance in relapse between the two groups (p = 0.084), while the incidence of relapse was seemingly higher in the MRD+ group: 36.9% Vs 19.7%. We attributed to the lack of sample size and NRM in MRD+ group was remarkably higher. The MRD+ group had significantly worse oneyear overall survival (OS) (, p = 0.003) and one-year progression-free survival (PFS) (, p = 0.009). In the multivariate analysis, MRD+ was an independent prognostic factor for OS (HR = 1.898; 95%CI 1.042-3.457; p = 0.036). Conclusion: Pre-transplantation MRD positive status is a risk factor for survival and prognosis after HSCT. Upon this, emphasis should be put on (1) screening more efficient chemo regimen with targeted agents, to help patients reach and keep MRD− status before transplantation; (2) designing better management with different GvHD prophylaxis treatment, timely disease monitoring and preemptive intervention on relapse.

International Journal of Librarianship

Information literacy instruction in various countries has expanded in a variety of ways. At unive... more Information literacy instruction in various countries has expanded in a variety of ways. At universities, it has mainly taken the form of credit-based courses, lectures, and embedded instruction. While European and American universities carry out more embedded instruction, universities in China focus more on credit-based courses and lectures, leaving embedded instruction in an exploratory stage. This paper is a preliminary study of a research project that aims to investigate the department-based, embedded information literacy instruction among the libraries of 42 "Double-First Class" universities in China. Using East China Normal University Library as an example, this paper discusses the teaching mode, teaching philosophy, teaching design, teaching methods and contents in order to explore how embedded information literacy instruction can make use of the mobile Internet platform. The specific areas to be examined include teaching resources, enhancing classroom interactions...

Materials

Erosion effect of chloride ions from the marine, deicing salt, saline-alkali land and some indust... more Erosion effect of chloride ions from the marine, deicing salt, saline-alkali land and some industrial environments will cause the corrosion of rebar in concrete, which is one of the most harmful factors affecting the durability of concrete structure. It had been proved that the incorporation of rubber aggregates increase the capillary saturation of cement concrete and reduce the corrosion degree of rebar. This paper investigated the rebar corrosion behavior in rubber aggregate concrete under the chloride electro-accelerated corrosion condition and such an investigation has not been seen in any public literature. Two water-cement ratios (0.45 and 0.55) and four rubber contents (0, 50, 100, and 150 kg/m3) were selected for experiment. Four-point bending tests of concrete beam were conducted before and after chloride ion erosion in order to determine effect of rubber aggregate on the durability of rebar. Results showed that rebar corrosion degree decreased with the increase of rubber a...

Advanced Materials Research

High-cencentration slurry transport can reduce the water content in bottom sludges and relieve th... more High-cencentration slurry transport can reduce the water content in bottom sludges and relieve the dehydration pressure in slurry storage areas, therefore accelerating the follow-up dealings with sludges and improving resource utilization. To meet such demand for high-concentration slurry transport, this article makes designs for a set of pipeline transportation testing apparatuses, and offers possible follow-up research with testing evidences such as measurements of pipeline pressure and concentration distribution, as well as monitored slurry flow regimes inside the pipes.

Advanced materials (Deerfield Beach, Fla.), Jan 10, 2018

Iron-nitrogen-carbon (Fe-N-C) is hitherto considered as one of the most satisfactory alternatives... more Iron-nitrogen-carbon (Fe-N-C) is hitherto considered as one of the most satisfactory alternatives to platinum for the oxygen reduction reaction (ORR). Major efforts currently are devoted to the identification and maximization of carbon-enclosed FeN moieties, which act as catalytically active centers. However, fine-tuning of their intrinsic ORR activity remains a huge challenge. Herein, a twofold activity improvement of pristine Fe-N-C through introducing TiCT MXene as a support is realized. A series of spectroscopy and magnetic measurements reveal that the marriage of FeN moiety and MXene can induce remarkable Fe 3d electron delocalization and spin-state transition of Fe(II) ions. The lower local electron density and higher spin state of the Fe(II) centers greatly favor the Fe electron transfer, and lead to an easier oxygen adsorption and reduction on active FeN sites, and thus an enhanced ORR activity. The optimized catalyst shows a two- and fivefold higher specific ORR activity th...

The EMBO journal, Jan 26, 2018

Adult mouse muscle satellite cells (MuSCs) are quiescent in uninjured muscles. Upon injury, MuSCs... more Adult mouse muscle satellite cells (MuSCs) are quiescent in uninjured muscles. Upon injury, MuSCs exit quiescenceto become activated, re-enter the cell cycle to proliferate, and differentiate to repair the damaged muscles. It remains unclear which extrinsic cues and intrinsic signaling pathways regulate quiescence exit during MuSC activation. Here, we demonstrated that inducible MuSC-specific deletion of, a catalytic subunit of phosphatidylinositol 3-kinase (PI3K), rendered MuSCs unable to exit quiescence, resulting in severely impaired MuSC proliferation and muscle regeneration. Genetic reactivation of mTORC1, or knockdown ofs, in-null MuSCs partially rescued the above defects, making them key effectors downstream of PI3K in regulating quiescence exit.was found to be a key transcriptional target of the PI3K/mTORC1 signaling axis essential for MuSC quiescence exit. Moreover, induction of a constitutively active PI3K in quiescent MuSCs resulted in spontaneous MuSC activation in uninj...

Materials (Basel, Switzerland), Jan 29, 2016

Studies on the properties and applications of rubber cement-based materials are well documented. ... more Studies on the properties and applications of rubber cement-based materials are well documented. The sizes of rubbers used in these materials varied. However, information about the effects of rubber size on the properties of rubber cement-based materials, especially pore structure, mechanical strengths, and drying shrinkage properties, remains limited. Three groups of rubber with major particle sizes of 2-4 mm, 1-3 mm, and 0-2 mm were selected in this study. This paper presents experimental studies on the effects of rubber size on the consistency, fresh density, pore structure, mechanical properties, and drying shrinkage properties of crumb rubber mortars (CRMs). Results demonstrated that the consistency and fresh density of CRMs decreased with the rubber size. As to the pore structure, the total pore volume increased with the decrease of the rubber size. By contrast, the influence of the rubber size on the mesopore (<50 nm) volume is not as significant as that of the rubber cont...

Advanced Materials Research

ABSTRACT

Particle & Particle Systems Characterization

kinetics of water splitting and the high overpotentials necessitate high-performance catalysts to... more kinetics of water splitting and the high overpotentials necessitate high-performance catalysts to decrease the electrolysis cell voltage and power consumption. [9,10] However, the platinum-and iridium-based catalysts are still the most active HER and OER catalysts and the low reserves and the high cost limits its application in largescale water splitting. [11,12] Designing and developing active, robust, and noble-metal-free catalysts with superior stability is of critical importance but remains a grand challenge. [13-15] Recently, transition metal compounds including chalcogenides, oxides, nitrides, and carbides exhibit high stability, corrosion resistance, and low cost and thus have been widely used in electrocatalysis, [16,17] lithium-air batteries, [18,19] and solar cells. [20,21] In view of thermodynamic convenience, transition metal chalcogenides such as MoS 2 , [22] WS 2 , [23] and CoS [24] have shown promising HER catalytic performance in acidic electrolytes, while many nonprecious OER catalysts based on transition metal oxides/hydroxides such as Fe 2 O 3 , [25] Co 3 O 4 /C, [26] MnO 2 , [27] NiFe LDH, [28] etc. The current prevailing strategies often result in incompatible integration of the two catalysts or mediocre performance for complete water splitting. It is therefore highly imperative to develop electrocatalysts for both HER and OER to achieve efficient water splitting. Recently, great effort has been devoted to developing efficient nanostructured for water splitting. [29,30] In order to enhance the electrocatalytic efficiency, the nanoscyrtal catalysts usually supported on carbon matrix, which also plays a critical role in catalysis. The large variety of carbon nanostructures such as carbon nanotubes, graphene, and porous carbon, have shown promising performance as substrates for many electrocatalysts. [31-33] The carbon nanostructures can protect the nanocrystal catalysts from acid corrosion and enhance the stability in acid. In addition, the heteroatoms, especially N or S doping in carbon nanostructures, will further modify the electronic structure of the catalysts and optimize the adsorption energy of the key intermediates on the surface. [34-36] Here, we provide a facile strategy to synthesize a series of Co-based self-supported electrode materials by combining electrospinning and chemical vapor deposition (CVD) technologies. The Co salt were first dissolved in polyacrilonitrile/N,Ndimethylformamide (PAN/DMF) solution and the mixture were electrospun into Co salt/PAN nanofiber membrane. The Co, Designing and developing active, robust, and noble-metal-free catalysts with superior stability for electrocatalytic water splitting is of critical importance but remains a grand challenge. Here, a facile strategy is provided to synthesize a series of Co-based self-supported electrode materials by combining electrospinning and chemical vapor deposition (CVD) technologies. The Co, Co 3 O 4 , Co 9 S 8 nanoparticles (NPs) are formed in situ simultaneously with the formation of carbon nanofibers (CNFs) during the CVD process, respectively. The Co-based NPs are uniformly distributed through the CNFs and they can be directly used as the electrode materials for hydrogen evolution reaction (HER) in acid and oxygen evolution reaction (OER) in alkaline. The Co 9 S 8 / CNFs membrane exhibits the best HER activity with overpotential of 165 mV at j = 10 mA cm −2 and Tafel slope of 83 mV dec −1 and OER activity with overpotential of 230 mV at j = 10 mA cm −2 and Tafel slope of 72 mV dec −1. The onion-like graphitic layers formed around the NPs not only improve the electrical conductivity of the electrode but also prevent the separation of the NPs from the carbon matrix as well as the aggregation. Water Splitting

Journal of Constructional Steel Research

Oncotarget

Acute kidney injury (AKI) predisposes patients to an increased risk into progressive chronic kidn... more Acute kidney injury (AKI) predisposes patients to an increased risk into progressive chronic kidney disease (CKD), however effective treatments are still elusive. This study aimed to investigate the therapeutic efficacy of human adiposederived MSCs (hAD-MSCs) in the prevention of AKI-CKD transition, and illuminate the role of Sox9, a vital transcription factor in the development of kidney, in this process. C57BL/6 mice were subjected to unilateral renal ischemia/reperfusion (I/R) with or without hAD-MSC treatment. We found that hAD-MSC treatment upregulated the expression of tubular Sox9, promoted tubular regeneration, attenuated AKI, and mitigated subsequent renal fibrosis. However, these beneficial effects were abolished by a drug inhibiting the release of exosomes from hAD-MSCs. Similarly, Sox9 inhibitors reversed these protective effects. Further, we verified that hAD-MSCs activated tubular Sox9 and prevented TGF-β1-induced transformation of TECs into pro-fibrotic phenotype through exosome shuttling in vitro, but the cells did not inhibit TGF-β1-induced transition of fibroblasts into myofibroblasts. Inhibiting the release of exosomes from hAD-MSCs or the expression of Sox9 in TECs reversed these antifibrotic effects. In conclusion, hAD-MSCs employed exosomes to mitigate AKI-CKD transition through tubular epithelial cell dependent activation of Sox9.

ACS applied materials & interfaces, Jan 14, 2017

The bimetallic Au-Cu alloy nanoparticles have been constructed in electrospun carbon nanofibers (... more The bimetallic Au-Cu alloy nanoparticles have been constructed in electrospun carbon nanofibers (Au-Cu/CNFs), employing as high efficient hydrogen evolution reaction (HER) electrode. The morphology, structure, and composition of bimetallic Au-Cu alloy can be controlled by adjusting the precursor nanofibers through a facile approach. With the increased Cu content, the Au-Cu alloy have a transition from the homogeneous AuCu3 alloy phase to the Au3Cu phase with Cu shell. The self-supported bimetallic Au-Cu/CNFs hybrid can be directly employed as electrode materials for water splitting, and it showed excellent electrochemical activity, including long-term stability, high exchange current density, and low overpotential. The outstanding HER performance could be mainly attributed to the synergistic interactions and interfacial effects of Au-Cu alloy with high densities of uncoordinated surface atoms. In addition, the fast charge transport and the fast kinetic for the desorption of the gas ...

International journal of oncology, Jan 18, 2017

Hepatocellular carcinoma (HCC) is a prevalent malignancy with aggressive biological behavior and ... more Hepatocellular carcinoma (HCC) is a prevalent malignancy with aggressive biological behavior and poor prognosis. Early growth response 3 (EGR3) is a zinc finger transcription factor, and has been studied primarily in the context of neurodevelopment, autoimmunity, inflammation and angiogenesis. Accumulating evidence indicates that EGR3 is a novel suppressor gene of tumor initiation and progression in certain cancer events, but little work has been carried out in exploring the relationship between EGR3 and HCC growth. The purpose of this study was to investigate the possible effects of EGR3 on cell proliferation and apoptosis in HCC, and determine the underlying mechanisms. Here, we observed that EGR3 expression was frequently downregulated in HCC tissues and cell lines. Ectopic expression of EGR3 contributed to cell proliferation inhibition and apoptosis induction in HCC cells in vitro. Furthermore, the expression of Fas ligand (FasL) was significantly enhanced following upregulation...

Leukemia research, Nov 15, 2016

Circulating chronic lymphocytic leukemia (CLL) cells appear not to be overly utilizing aerobic gl... more Circulating chronic lymphocytic leukemia (CLL) cells appear not to be overly utilizing aerobic glycolysis. However, recurrent contact with CLL cells in a stromal microenvironment leads to increased aerobic glycolysis and the cells' overall glycolytic capacity, which promotes cell survival and proliferation. TP53-induced glycolysis and apoptosis regulator (TIGAR) has been directly implicated in cellular metabolism in the control of glycolysis. TIGAR inhibits glycolysis and protects cells from intracellular reactive oxygen species (ROS)-associated apoptosis. TIGAR mRNA expression was investigated by quantitative PCR in 102 newly diagnosed CLL patients. Furthermore, the relationship between the expression of TIGAR and its clinical characteristics and prognosis were investigated. Moreover, we also investigated the correlation between TIGAR expression and apoptosis in primary CLL cells. Our data revealed that TIGAR overexpression was correlated with the protection from spontaneous ap...

ACS applied materials & interfaces, Jan 20, 2016

The search for non-noble metal catalysts with high activity for the hydrogen evolution reaction (... more The search for non-noble metal catalysts with high activity for the hydrogen evolution reaction (HER) is crucial for efficient hydrogen production at low cost and on a large scale. Herein, we report a novel WO3-x catalyst synthesized on carbon nanofiber mats (CFMs) by electrospinning and followed by a carbonization process in a tubal furnace. The morphology and composition of the catalysts were tailored via a simple method, and the hybrid catalyst mats were used directly as cathodes to investigate their HER performance. Notably, the as-prepared catalysts exhibit substantially enhanced activity for the HER, demonstrating a small overpotential, a high exchange current density, and a large cathodic current density. The remarkable electrocatalytic performances result from the poor crystallinity of WO3-x, the high electrical conductivity of WO3-x, and the use of electrospun CNFs. The present work outlines a straightforward approach for the synthesis of transition metal oxide (TMO)-based ...

Circulation Research, Jul 18, 2014

Applied Mechanics and Materials, Nov 26, 2014

The landing gear occupies an important position in the design, manufacture and use of the aircraf... more The landing gear occupies an important position in the design, manufacture and use of the aircraft. But it spends a lot of time and resources in a real experiment. The rapid development of computer simulation technology makes it possible to have a virtual analysis of the landing gear. Based on typical CAD software UG, finite element simulation software ANSYS and virtual prototyping software ADAMS, a mixed rigid-flexible nose landing gear model is constructed in this paper. The joint application will play their advantages respectively.

Finding cost-effective, active and durable catalyst materials for energy applications, such as el... more Finding cost-effective, active and durable catalyst materials for energy applications, such as electrocatalytic hydrogen production, is an intriguing challenge. Here, a facile and effective approach to the design and construction of two-dimensional MoS 2 and WS 2 interleaved nanowalls with maximum exposures of active edges on silk-derived N-doped carbon fibers (SNCF) was demonstrated. The morphological evolutions of the MoS 2 and WS 2 nanocrystals on the SNCF from crescent-like nanosheets to an interleaved nanowall network can be obtained by adjusting the concentrations of the Mo and W precursors. These robust MoS 2 /SNCF and WS 2 /SNCF electrocatalysts exhibit prominent hydrogen evolution reaction (HER) activities with onset potentials of −40 and −96 mV and Tafel slopes of 60 and 66 mV dec −1 , respectively. The overpotentials ( η ) at j = −10 mA cm −2 for MoS 2 /SNCF and WS 2 /SNCF are −102 and −157 mV, respectively. In addition, MoS 2 /SNCF and WS 2 /SNCF are both able to sustai...

Production and Operations Management

Current Cardiology Reports

It has been pointed out that the second paragraph of the section "Treatments for SARS-CoV-2 Infec... more It has been pointed out that the second paragraph of the section "Treatments for SARS-CoV-2 Infection" contains an error. The original article has been corrected. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Hematology

Objective: To investigate the impact of minimal residual disease (MRD) before allogeneic hematopo... more Objective: To investigate the impact of minimal residual disease (MRD) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) on the outcome of acute leukemia. Methods: Data from 114 patients who were diagnosed with acute leukemia (AL) and underwent allo-HSCT between Jan 2013 and Dec 2019 were collected and analyzed. The patients were attributed into MRD positive (MRD+) group and MRD negative (MRD−) group. Results: Among the 114 acute leukemia patients, there were 32 MRD+ patients before transplantation, and 82 MRD− patients. No significant difference was found between the MRD+ group and the MRD− group in the incidence of acute graft-versus-host disease (aGvHD) (p = 0.09). Compared with the MRD+ group, the MRD− group had a higher incidence of chronic graft-versus-host disease (cGvHD) (p = 0.008). There is no significance in relapse between the two groups (p = 0.084), while the incidence of relapse was seemingly higher in the MRD+ group: 36.9% Vs 19.7%. We attributed to the lack of sample size and NRM in MRD+ group was remarkably higher. The MRD+ group had significantly worse oneyear overall survival (OS) (, p = 0.003) and one-year progression-free survival (PFS) (, p = 0.009). In the multivariate analysis, MRD+ was an independent prognostic factor for OS (HR = 1.898; 95%CI 1.042-3.457; p = 0.036). Conclusion: Pre-transplantation MRD positive status is a risk factor for survival and prognosis after HSCT. Upon this, emphasis should be put on (1) screening more efficient chemo regimen with targeted agents, to help patients reach and keep MRD− status before transplantation; (2) designing better management with different GvHD prophylaxis treatment, timely disease monitoring and preemptive intervention on relapse.

International Journal of Librarianship

Information literacy instruction in various countries has expanded in a variety of ways. At unive... more Information literacy instruction in various countries has expanded in a variety of ways. At universities, it has mainly taken the form of credit-based courses, lectures, and embedded instruction. While European and American universities carry out more embedded instruction, universities in China focus more on credit-based courses and lectures, leaving embedded instruction in an exploratory stage. This paper is a preliminary study of a research project that aims to investigate the department-based, embedded information literacy instruction among the libraries of 42 "Double-First Class" universities in China. Using East China Normal University Library as an example, this paper discusses the teaching mode, teaching philosophy, teaching design, teaching methods and contents in order to explore how embedded information literacy instruction can make use of the mobile Internet platform. The specific areas to be examined include teaching resources, enhancing classroom interactions...

Materials

Erosion effect of chloride ions from the marine, deicing salt, saline-alkali land and some indust... more Erosion effect of chloride ions from the marine, deicing salt, saline-alkali land and some industrial environments will cause the corrosion of rebar in concrete, which is one of the most harmful factors affecting the durability of concrete structure. It had been proved that the incorporation of rubber aggregates increase the capillary saturation of cement concrete and reduce the corrosion degree of rebar. This paper investigated the rebar corrosion behavior in rubber aggregate concrete under the chloride electro-accelerated corrosion condition and such an investigation has not been seen in any public literature. Two water-cement ratios (0.45 and 0.55) and four rubber contents (0, 50, 100, and 150 kg/m3) were selected for experiment. Four-point bending tests of concrete beam were conducted before and after chloride ion erosion in order to determine effect of rubber aggregate on the durability of rebar. Results showed that rebar corrosion degree decreased with the increase of rubber a...

Advanced Materials Research

High-cencentration slurry transport can reduce the water content in bottom sludges and relieve th... more High-cencentration slurry transport can reduce the water content in bottom sludges and relieve the dehydration pressure in slurry storage areas, therefore accelerating the follow-up dealings with sludges and improving resource utilization. To meet such demand for high-concentration slurry transport, this article makes designs for a set of pipeline transportation testing apparatuses, and offers possible follow-up research with testing evidences such as measurements of pipeline pressure and concentration distribution, as well as monitored slurry flow regimes inside the pipes.

Advanced materials (Deerfield Beach, Fla.), Jan 10, 2018

Iron-nitrogen-carbon (Fe-N-C) is hitherto considered as one of the most satisfactory alternatives... more Iron-nitrogen-carbon (Fe-N-C) is hitherto considered as one of the most satisfactory alternatives to platinum for the oxygen reduction reaction (ORR). Major efforts currently are devoted to the identification and maximization of carbon-enclosed FeN moieties, which act as catalytically active centers. However, fine-tuning of their intrinsic ORR activity remains a huge challenge. Herein, a twofold activity improvement of pristine Fe-N-C through introducing TiCT MXene as a support is realized. A series of spectroscopy and magnetic measurements reveal that the marriage of FeN moiety and MXene can induce remarkable Fe 3d electron delocalization and spin-state transition of Fe(II) ions. The lower local electron density and higher spin state of the Fe(II) centers greatly favor the Fe electron transfer, and lead to an easier oxygen adsorption and reduction on active FeN sites, and thus an enhanced ORR activity. The optimized catalyst shows a two- and fivefold higher specific ORR activity th...

The EMBO journal, Jan 26, 2018

Adult mouse muscle satellite cells (MuSCs) are quiescent in uninjured muscles. Upon injury, MuSCs... more Adult mouse muscle satellite cells (MuSCs) are quiescent in uninjured muscles. Upon injury, MuSCs exit quiescenceto become activated, re-enter the cell cycle to proliferate, and differentiate to repair the damaged muscles. It remains unclear which extrinsic cues and intrinsic signaling pathways regulate quiescence exit during MuSC activation. Here, we demonstrated that inducible MuSC-specific deletion of, a catalytic subunit of phosphatidylinositol 3-kinase (PI3K), rendered MuSCs unable to exit quiescence, resulting in severely impaired MuSC proliferation and muscle regeneration. Genetic reactivation of mTORC1, or knockdown ofs, in-null MuSCs partially rescued the above defects, making them key effectors downstream of PI3K in regulating quiescence exit.was found to be a key transcriptional target of the PI3K/mTORC1 signaling axis essential for MuSC quiescence exit. Moreover, induction of a constitutively active PI3K in quiescent MuSCs resulted in spontaneous MuSC activation in uninj...

Materials (Basel, Switzerland), Jan 29, 2016

Studies on the properties and applications of rubber cement-based materials are well documented. ... more Studies on the properties and applications of rubber cement-based materials are well documented. The sizes of rubbers used in these materials varied. However, information about the effects of rubber size on the properties of rubber cement-based materials, especially pore structure, mechanical strengths, and drying shrinkage properties, remains limited. Three groups of rubber with major particle sizes of 2-4 mm, 1-3 mm, and 0-2 mm were selected in this study. This paper presents experimental studies on the effects of rubber size on the consistency, fresh density, pore structure, mechanical properties, and drying shrinkage properties of crumb rubber mortars (CRMs). Results demonstrated that the consistency and fresh density of CRMs decreased with the rubber size. As to the pore structure, the total pore volume increased with the decrease of the rubber size. By contrast, the influence of the rubber size on the mesopore (<50 nm) volume is not as significant as that of the rubber cont...

Advanced Materials Research

ABSTRACT

Particle & Particle Systems Characterization

kinetics of water splitting and the high overpotentials necessitate high-performance catalysts to... more kinetics of water splitting and the high overpotentials necessitate high-performance catalysts to decrease the electrolysis cell voltage and power consumption. [9,10] However, the platinum-and iridium-based catalysts are still the most active HER and OER catalysts and the low reserves and the high cost limits its application in largescale water splitting. [11,12] Designing and developing active, robust, and noble-metal-free catalysts with superior stability is of critical importance but remains a grand challenge. [13-15] Recently, transition metal compounds including chalcogenides, oxides, nitrides, and carbides exhibit high stability, corrosion resistance, and low cost and thus have been widely used in electrocatalysis, [16,17] lithium-air batteries, [18,19] and solar cells. [20,21] In view of thermodynamic convenience, transition metal chalcogenides such as MoS 2 , [22] WS 2 , [23] and CoS [24] have shown promising HER catalytic performance in acidic electrolytes, while many nonprecious OER catalysts based on transition metal oxides/hydroxides such as Fe 2 O 3 , [25] Co 3 O 4 /C, [26] MnO 2 , [27] NiFe LDH, [28] etc. The current prevailing strategies often result in incompatible integration of the two catalysts or mediocre performance for complete water splitting. It is therefore highly imperative to develop electrocatalysts for both HER and OER to achieve efficient water splitting. Recently, great effort has been devoted to developing efficient nanostructured for water splitting. [29,30] In order to enhance the electrocatalytic efficiency, the nanoscyrtal catalysts usually supported on carbon matrix, which also plays a critical role in catalysis. The large variety of carbon nanostructures such as carbon nanotubes, graphene, and porous carbon, have shown promising performance as substrates for many electrocatalysts. [31-33] The carbon nanostructures can protect the nanocrystal catalysts from acid corrosion and enhance the stability in acid. In addition, the heteroatoms, especially N or S doping in carbon nanostructures, will further modify the electronic structure of the catalysts and optimize the adsorption energy of the key intermediates on the surface. [34-36] Here, we provide a facile strategy to synthesize a series of Co-based self-supported electrode materials by combining electrospinning and chemical vapor deposition (CVD) technologies. The Co salt were first dissolved in polyacrilonitrile/N,Ndimethylformamide (PAN/DMF) solution and the mixture were electrospun into Co salt/PAN nanofiber membrane. The Co, Designing and developing active, robust, and noble-metal-free catalysts with superior stability for electrocatalytic water splitting is of critical importance but remains a grand challenge. Here, a facile strategy is provided to synthesize a series of Co-based self-supported electrode materials by combining electrospinning and chemical vapor deposition (CVD) technologies. The Co, Co 3 O 4 , Co 9 S 8 nanoparticles (NPs) are formed in situ simultaneously with the formation of carbon nanofibers (CNFs) during the CVD process, respectively. The Co-based NPs are uniformly distributed through the CNFs and they can be directly used as the electrode materials for hydrogen evolution reaction (HER) in acid and oxygen evolution reaction (OER) in alkaline. The Co 9 S 8 / CNFs membrane exhibits the best HER activity with overpotential of 165 mV at j = 10 mA cm −2 and Tafel slope of 83 mV dec −1 and OER activity with overpotential of 230 mV at j = 10 mA cm −2 and Tafel slope of 72 mV dec −1. The onion-like graphitic layers formed around the NPs not only improve the electrical conductivity of the electrode but also prevent the separation of the NPs from the carbon matrix as well as the aggregation. Water Splitting

Journal of Constructional Steel Research

Oncotarget

Acute kidney injury (AKI) predisposes patients to an increased risk into progressive chronic kidn... more Acute kidney injury (AKI) predisposes patients to an increased risk into progressive chronic kidney disease (CKD), however effective treatments are still elusive. This study aimed to investigate the therapeutic efficacy of human adiposederived MSCs (hAD-MSCs) in the prevention of AKI-CKD transition, and illuminate the role of Sox9, a vital transcription factor in the development of kidney, in this process. C57BL/6 mice were subjected to unilateral renal ischemia/reperfusion (I/R) with or without hAD-MSC treatment. We found that hAD-MSC treatment upregulated the expression of tubular Sox9, promoted tubular regeneration, attenuated AKI, and mitigated subsequent renal fibrosis. However, these beneficial effects were abolished by a drug inhibiting the release of exosomes from hAD-MSCs. Similarly, Sox9 inhibitors reversed these protective effects. Further, we verified that hAD-MSCs activated tubular Sox9 and prevented TGF-β1-induced transformation of TECs into pro-fibrotic phenotype through exosome shuttling in vitro, but the cells did not inhibit TGF-β1-induced transition of fibroblasts into myofibroblasts. Inhibiting the release of exosomes from hAD-MSCs or the expression of Sox9 in TECs reversed these antifibrotic effects. In conclusion, hAD-MSCs employed exosomes to mitigate AKI-CKD transition through tubular epithelial cell dependent activation of Sox9.

ACS applied materials & interfaces, Jan 14, 2017

The bimetallic Au-Cu alloy nanoparticles have been constructed in electrospun carbon nanofibers (... more The bimetallic Au-Cu alloy nanoparticles have been constructed in electrospun carbon nanofibers (Au-Cu/CNFs), employing as high efficient hydrogen evolution reaction (HER) electrode. The morphology, structure, and composition of bimetallic Au-Cu alloy can be controlled by adjusting the precursor nanofibers through a facile approach. With the increased Cu content, the Au-Cu alloy have a transition from the homogeneous AuCu3 alloy phase to the Au3Cu phase with Cu shell. The self-supported bimetallic Au-Cu/CNFs hybrid can be directly employed as electrode materials for water splitting, and it showed excellent electrochemical activity, including long-term stability, high exchange current density, and low overpotential. The outstanding HER performance could be mainly attributed to the synergistic interactions and interfacial effects of Au-Cu alloy with high densities of uncoordinated surface atoms. In addition, the fast charge transport and the fast kinetic for the desorption of the gas ...

International journal of oncology, Jan 18, 2017

Hepatocellular carcinoma (HCC) is a prevalent malignancy with aggressive biological behavior and ... more Hepatocellular carcinoma (HCC) is a prevalent malignancy with aggressive biological behavior and poor prognosis. Early growth response 3 (EGR3) is a zinc finger transcription factor, and has been studied primarily in the context of neurodevelopment, autoimmunity, inflammation and angiogenesis. Accumulating evidence indicates that EGR3 is a novel suppressor gene of tumor initiation and progression in certain cancer events, but little work has been carried out in exploring the relationship between EGR3 and HCC growth. The purpose of this study was to investigate the possible effects of EGR3 on cell proliferation and apoptosis in HCC, and determine the underlying mechanisms. Here, we observed that EGR3 expression was frequently downregulated in HCC tissues and cell lines. Ectopic expression of EGR3 contributed to cell proliferation inhibition and apoptosis induction in HCC cells in vitro. Furthermore, the expression of Fas ligand (FasL) was significantly enhanced following upregulation...

Leukemia research, Nov 15, 2016

Circulating chronic lymphocytic leukemia (CLL) cells appear not to be overly utilizing aerobic gl... more Circulating chronic lymphocytic leukemia (CLL) cells appear not to be overly utilizing aerobic glycolysis. However, recurrent contact with CLL cells in a stromal microenvironment leads to increased aerobic glycolysis and the cells' overall glycolytic capacity, which promotes cell survival and proliferation. TP53-induced glycolysis and apoptosis regulator (TIGAR) has been directly implicated in cellular metabolism in the control of glycolysis. TIGAR inhibits glycolysis and protects cells from intracellular reactive oxygen species (ROS)-associated apoptosis. TIGAR mRNA expression was investigated by quantitative PCR in 102 newly diagnosed CLL patients. Furthermore, the relationship between the expression of TIGAR and its clinical characteristics and prognosis were investigated. Moreover, we also investigated the correlation between TIGAR expression and apoptosis in primary CLL cells. Our data revealed that TIGAR overexpression was correlated with the protection from spontaneous ap...

ACS applied materials & interfaces, Jan 20, 2016

The search for non-noble metal catalysts with high activity for the hydrogen evolution reaction (... more The search for non-noble metal catalysts with high activity for the hydrogen evolution reaction (HER) is crucial for efficient hydrogen production at low cost and on a large scale. Herein, we report a novel WO3-x catalyst synthesized on carbon nanofiber mats (CFMs) by electrospinning and followed by a carbonization process in a tubal furnace. The morphology and composition of the catalysts were tailored via a simple method, and the hybrid catalyst mats were used directly as cathodes to investigate their HER performance. Notably, the as-prepared catalysts exhibit substantially enhanced activity for the HER, demonstrating a small overpotential, a high exchange current density, and a large cathodic current density. The remarkable electrocatalytic performances result from the poor crystallinity of WO3-x, the high electrical conductivity of WO3-x, and the use of electrospun CNFs. The present work outlines a straightforward approach for the synthesis of transition metal oxide (TMO)-based ...

Circulation Research, Jul 18, 2014

Applied Mechanics and Materials, Nov 26, 2014

The landing gear occupies an important position in the design, manufacture and use of the aircraf... more The landing gear occupies an important position in the design, manufacture and use of the aircraft. But it spends a lot of time and resources in a real experiment. The rapid development of computer simulation technology makes it possible to have a virtual analysis of the landing gear. Based on typical CAD software UG, finite element simulation software ANSYS and virtual prototyping software ADAMS, a mixed rigid-flexible nose landing gear model is constructed in this paper. The joint application will play their advantages respectively.