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Sohag Medical Journal
Primary immune thrombocytopenia (ITP) is a common condition characterized by a low peripheral pla... more Primary immune thrombocytopenia (ITP) is a common condition characterized by a low peripheral platelet count (100000/L) caused by cell-mediated and humoral-mediated destruction of the platelet. Immunological tolerance to platelet antigens is lost in these patients. The main step in the pathogenesis includes the overactivation of T-cells, particularly T-helper cells, the release of various cytokines, and the interaction of autoantibodies with platelet surface antigens, which results in platelet destruction by the immune system in the spleen. The most common PLT antigens against which autoantibodies are directed are CD41 and CD61. These antigens are occupied by autoantibodies so there is decreased detection of these antigens on the surface of platelets. PD1 is an important negative stimulatory molecule of the immune system a member of the CD28/B7 family. ITP patients have considerably increased levels of PD-1 on CD4+Tcells in their peripheral blood than healthy people., indicating that the PD1 molecule plays an important role in illness etiology.
Parasites & Vectors, 2011
Background Diagnosis of blood borne infectious diseases relies primarily on the detection of the... more Background Diagnosis of blood borne infectious diseases relies primarily on the detection of the causative agent in the blood sample. Molecular techniques offer sensitive and specific tools for this although considerable difficulties exist when using these approaches in the field environment. In large scale epidemiological studies, FTA®cards are becoming increasingly popular for the rapid collection and archiving of a large number
Sohag Medical Journal
Primary immune thrombocytopenia (ITP) is a common condition characterized by a low peripheral pla... more Primary immune thrombocytopenia (ITP) is a common condition characterized by a low peripheral platelet count (100000/L) caused by cell-mediated and humoral-mediated destruction of the platelet. Immunological tolerance to platelet antigens is lost in these patients. The main step in the pathogenesis includes the overactivation of T-cells, particularly T-helper cells, the release of various cytokines, and the interaction of autoantibodies with platelet surface antigens, which results in platelet destruction by the immune system in the spleen. The most common PLT antigens against which autoantibodies are directed are CD41 and CD61. These antigens are occupied by autoantibodies so there is decreased detection of these antigens on the surface of platelets. PD1 is an important negative stimulatory molecule of the immune system a member of the CD28/B7 family. ITP patients have considerably increased levels of PD-1 on CD4+Tcells in their peripheral blood than healthy people., indicating that the PD1 molecule plays an important role in illness etiology.
Parasites & Vectors, 2011
Background Diagnosis of blood borne infectious diseases relies primarily on the detection of the... more Background Diagnosis of blood borne infectious diseases relies primarily on the detection of the causative agent in the blood sample. Molecular techniques offer sensitive and specific tools for this although considerable difficulties exist when using these approaches in the field environment. In large scale epidemiological studies, FTA®cards are becoming increasingly popular for the rapid collection and archiving of a large number