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Papers by hemant kamble

International Journal for Research in Applied Science and Engineering Technology, 2022

For the past few years, there has been a considerable research on the basis of Novel drug deliver... more For the past few years, there has been a considerable research on the basis of Novel drug delivery system, using particulate vesicle systems as such drug carriers for small and large molecules. Nanoparticles, Liposomes, Microspheres, Niosomes, Pronisomes, Ethosomes, Proliposomes have been used as drug carrier in vesicle drug delivery system. Nanotechnology refers to the creation and utilization of materials whose constituents exist at the nanoscale; and, by convention, be up to 100 nm in size.. Nanoparticles are being used for diverse purposes, from medical treatments, using in various branches of industry production such as solar and oxide fuel batteries for energy storage, to wide incorporation into diverse materials of everyday use such as cosmetics or clothes, optical devices, catalytic, bactericidal, electronic, sensor technology, biological labelling and treatment of some cancers. Various polymers have been used in the formation of Nanoparticles. Nanoparticles have been improving the therapeutic effect of drugs and minimize the side effects. Basically, Nanoparticles have been prepared by using various techniques as such dispersion of preformed polymers, polymerization of monomers and ionic gelation or coacervation of hydrophilic polymer. Nanoparticles have been evaluated by using parameters of drug entrapment efficiency, particle shape, drug release study.

Journal of Clinical Ophthalmology and Research, 2018

The aim of this study is to see the effect of transportation on corneoscleral buttons and to corr... more The aim of this study is to see the effect of transportation on corneoscleral buttons and to correlate them with the weight of ice used during transportation. This is a prospective cross-sectional study. A total of 119 corneas were graded using slit-lamp examination and specular microscopy before and after transportation. Groups were made based on the weight of ice used during transportation and the number of hours of storage in McCarey-Kaufman (MK) media. The overall median percentage of endothelial cell loss (ECL) was 11.33%. The median percentage of ECL was significantly more with <500 g of ice as compared to ≥500 g (13.6% vs. 7.56%) with P = 0.006. There was no significant difference in percentage of ECL on storage in MK media for ≤48 h, ≤72 h, and ≤96 h. Corneal buttons have ECL on storage and transportation which can be minimized using the appropriate weight of ice during transportation.

All rights reserved by www.ijsrd.com 625 Arduino based Automatic Power Factor Compensation using ... more All rights reserved by www.ijsrd.com 625 Arduino based Automatic Power Factor Compensation using TSC Hemant A. Kamble Pradeep S. Mole Sunil G. Kothawale Priya A. Adsule Sonali A. Banne Student SITCOE Yadrav, India Abstract— Automatic power factor compensation is widely employed in industry to improve system performance and avoid penalty imposed by utility in case of poor power factor. Since relay based capacitor bank switching adds to THD, we present a design and performance of triac based capacitor bank switching using on arduino microcontroller. The performance of system is evaluated for different load conditions.

Bioorganic & Medicinal Chemistry, 2008

Some new substituted coumarinylthiazolines, coumarinylthiazolidin-4-ones, and substituted chromen... more Some new substituted coumarinylthiazolines, coumarinylthiazolidin-4-ones, and substituted chromenothiazoles were synthesized and evaluated for anticonvulsant activity. Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice. Compounds 3b, 6b, and 7b were the most active of the series against PTZ induced seizures. Compound 7b provided anticonvulsant activity (PD 50 = 95 mg/kg, ip) at a dose 200 mg/kg compared to phenobarbital (PD 50 = 16 mg/kg, ip) at a dose 30 mg/kg (90% protection). No clear correlation was observed between the antiepileptic activity and molecular lipophilicity descriptors of the tested compounds.

International Journal of Research Publication and Reviews

The global pandemic of SARS- CoV- 2, the causative viral pathogen of COVID- 19, has driven the bi... more The global pandemic of SARS- CoV- 2, the causative viral pathogen of COVID- 19, has driven the biomedical community to action to uncover and develop antiviral interventions. One implicit remedial approach presently being estimated in multitudinous clinical trials is the agent remdesivir, which has endured a long and winding experimental path. Remdesivir as a medicine attracted a veritably serious consideration of whole Globe in treatment of the epidemic complaint COVID19. More lately published in- vitro inhibition exertion and in- vivo case studies were showing promising clinical results and outgrowth of effective inhibition of SARS- CoV- 2 contagion by the use of remdesivir. Still at the same time, use of the remdesivir showed substantial mischievous adverse events in cases which needs a special attention during treatment course of COVID- 19. Therefore, the use of remdesivir in treatment of COVID- 19 is having current transnational interest although some further clinical attestatio...

International Journal of Engineering Applied Sciences and Technology

Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance o... more Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs when bacteria change in response to the use of these medicines.Bacteria, not humans or animals, become antibiotic-resistant. These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria.Antibiotic resistance leads to higher medical costs, prolonged hospital stays, and increased mortality.The world urgently needs to change the way it prescribes and uses antibiotics. Even if new medicines are developed, without behaviour change, antibiotic resistance will remain a major threat. Behaviour changes must also include actions to reduce the spread of infections through vaccination, hand washing, practising safer sex, and good food hygiene.

International Journal for Research in Applied Science and Engineering Technology

High-Performance Liquid Chromatography (HPLC) is a technique used to separate components from the... more High-Performance Liquid Chromatography (HPLC) is a technique used to separate components from the mixture. The technology consists of two phases, the stationary phase, and the mobile phase. Component separation is based on differences in partition coefficients in two phases. The present review article focuses on the principle, types, instrumentation, process validation, application, advantages, disadvantages of HPLC. HPLC methods development and validation play important roles in the discovery, development, manufacture of pharmaceutical drugs, and various other studies related to humans and animals. An analytical procedure is developed to test a defining characteristic of the drug substance or drug product against established acceptance criteria for that characteristic. Validation of HPLC method as per ICH Guidelines covers all the performance characteristics of validation, like Accuracy, precision, specificity, linearity, range, the limit of detection, the limit of quantification, robustness, and system suitability testing.

In today's pharmaceutical industry, optimization has arisen as a technique for finding the be... more In today's pharmaceutical industry, optimization has arisen as a technique for finding the best compromise response to a specific problem. The term optimization refers to the process of improving something or making it work better. Finding a perfect, effective, or functional solution is what optimization is all about. The goal of this review article is to identify the many strategies that can be used to improve the quality, safety, and efficacy of pharmaceutical formulations by looking at the most appropriate and practicable experimental designs and optimization techniques, by investigating the most appropriate and practical experimental designs and optimization approaches for pharmaceutical formulations.

La presente invention porte sur un procede pour la preparation des intermediaires de la rosuvasta... more La presente invention porte sur un procede pour la preparation des intermediaires de la rosuvastatine et leur conversion en rosuvastatine ou ses sels pharmaceutiquement acceptables.

La presente invention concerne du calcium de rosuvastatine amorphe ayant un degre de cristallinit... more La presente invention concerne du calcium de rosuvastatine amorphe ayant un degre de cristallinite inferieur a environ 5 %, et son procede de preparation.

The objective of the present study was to investiga te the effect of concomitant administration o... more The objective of the present study was to investiga te the effect of concomitant administration of trig onelline (TRIG) along with sitagliptin (SITA) on glucose level, beh avior, oxidative stress and histological studies in n cotinamidestreptozotocin induced diabetic neuropathy in Wista r rats. Diabetes was induced by administration of s treptozotocin (65 mg/kg i.p), 15 min after nicotinamide (110mg/kg ) injection. After developing hyperglycemia, contro l and diabetic rats were randomly selected and divided in to five groups (n=6). These includes , Group 1 was: nondiabetic, Group 2: diabetic control, Group 3: diabetic + TRIG (50 mg/kg), Group 4: diabetic + SITA (5 mg/kg), Group 5: diabetic + TRIG (50mg/kg) + SITA (5 mg/kg). TRIG, S ITA and TRIG+SITA administered for 4 weeks. Serum glucose (SG) levels and body weights of anima ls were measured at every week of study period. Mot or nerve conduction velocity and behavioral parameters were also screened at 0, 4 th and at 8 weeks of stud...

Objective: The objective of present study was to evaluate the effect of trigonelline (TRIG), sita... more Objective: The objective of present study was to evaluate the effect of trigonelline (TRIG), sitagliptin (SITA) alone and concomitant administration in nicotinamide-streptozotocin induced diabetic nephropathy in Wistar rats. Methods: Diabetes was induced by streptozotocin (65 mg/kg i.p.) injected 15 min after nicotinamide (110 mg/kg, i.p.). Four week later rats were randomly selected and divided into five groups (n=6). The rats were divided into following groups. Group I: non-diabetic. Group II: diabetic control, Group III: diabetic + TRIG (50 mg/kg), Group IV: diabetic + SITA (5 mg/kg), Group V: diabetic + [TRIG (50 mg/kg) + SITA (5 mg/kg)].The drugs were administered for next 4 weeks starting from 5th week post nicotinamide-STZ injection. Serum glucose (SG) and body weight were measured weekly. Serum creatinine, blood urea nitrogen, serum uric acid, urine volume and creatinine were measured at 0, 4th and 8th week of the study. While superoxide dismutase, reduced glutathione, malon...

Cornea, Jan 9, 2018

To report a case of Pythium insidiosum keratitis leading to fatal cavernous sinus thrombophlebiti... more To report a case of Pythium insidiosum keratitis leading to fatal cavernous sinus thrombophlebitis. Case report. A 70-year-old man presented with excruciating pain, redness, and diminution of vision in his left eye for 2 weeks after washing his hair with tap water. A total corneal ulcer with surrounding infiltrates and associated corneal thinning was present. Corneal scraping revealed the presence of Gram-positive cocci. KOH wet mount and in vivo confocal microscopy revealed branching hyphae. Combined antibacterial and antifungal treatment was started, but 4 days later, the ulcer showed signs of worsening with perforation for which a large therapeutic penetrating keratoplasty was done. The host cornea showed branching septate hyphae on Sabarouds Dextrose Agar. Two weeks later, the patient developed left eye proptosis with associated extraocular movement restriction. Magnetic resonance imaging of the head and orbit revealed cavernous sinus thrombophlebitis. Lid sparing partial exente...

The British journal of ophthalmology, Jan 2, 2015

To evaluate aetiology, demographic profile, clinical features and outcomes in cases of peripheral... more To evaluate aetiology, demographic profile, clinical features and outcomes in cases of peripheral ulcerative keratitis (PUK). Seventy-six eyes of 65 consecutive patients with PUK were evaluated in this prospective interventional study over an 18 month period, which were followed for 3 years. The main outcome measures were sociodemographic profile, aetiology, clinical features, management strategies and outcome. Sixty per cent (39/65) of cases were men and mean age was 45.5±17.9 years. Two-thirds (43/65) of the patients were from rural areas with majority (48/65) belonging to low socioeconomic status. Unilateral disease was present in 83% of patients (54/65) with nasal involvement in 60.5% (46/76) cases. The most common aetiology was Mooren's ulcer (31.5% cases (24/76 eyes)) followed by infection and systemic collagen vascular disease. Meibomian gland dysfunction (17/76: 22.3%) was the most common extraocular association and complicated cataract (12/76:15.7%) was the most common ...

World Journal of Pharmaceutical Research

Recent WHO guidelines recommend combination antihypertensive therapy as the first-line therapy fo... more Recent WHO guidelines recommend combination antihypertensive therapy as the first-line therapy for hypertension because monotherapies are often abortive and may lead to delayed BP control, increased risk of stroke and death. Present work was focused on designing a thioester- linked mutual prodrug of captopril and as a combination therapy. The main objectives were to extend duration of action of furosemide, conserve normal potassium levels in body, minimize thiol- induced side effects of captopril, lower the gastric irritant effect of furosemide and achieve synergistic antihypertensive effect. The thioester prodrug FC was synthesized and characterized by spectral analysis. In vitro release was studied by HPTLC. It was screened for diuretic and antihypertensive effects in experimental models in Wistar rats. In the small intestinal homogenates, 95% hydrolysis of FC was observed at the end of 7h. FC showed many promising features like prolonged duration of diuretic activity, synergistic...

The objective of the present study was to evaluate the protective effect of trigonelline (TRIG) a... more The objective of the present study was to evaluate the protective effect of trigonelline (TRIG) and sitagliptin (SITA) combination in streptozotocin-nicotinamide induced diabetes in Wistar rats. Diabetes was induced by streptozotocin (65 mg/kg i.p.) injected 15 min after nicotinamide (110 mg/kg, i.p.). The rats were divided into following groups: Group 1: non-diabetic control, Group 2: diabetic control (saline), Groups 3, 4, 5 received TRIG as 25, 50, 100 mg/kg p.o., Groups 6, 7, 8 received SITA as 2.5, 5, 10 mg/kg p.o. respectively. For acute study, serum glucose (SG) levels were measured at 0, 2nd, 4th, 6th and 24th hour after administration. To find out effective combination, acute study of TRIG + SITA combination was done. The doses used are in combination TRIG + SITA as Groups 9, 10, 11 as 70% + 30%, 50% + 50%, 30 + 70%. SG was measured as per above-mentioned pattern. A 28-day subacute study was performed by taking effective percentage combination of TRIG + SITA. For subacute study SG, body weight was measured on 7th, 14th, 21st, 28th day; while serum insulin, HbA 1c and pancreatic histopathological study were done on 28th day. In acute study, TRIG + SITA (50% + 50%) were more effectively 43.08% reduction in SG level at 6 h with onset at 2 h and effect waned at 24 h. Subacute study reveals that the TRIG + SITA (50% + 50%) reduces SG by 54.72% than alone on 28th day. Serum insulin levels, body weight, pancreatic mass were increased with reduction in HbA 1c levels in animals receiving 50% + 50% combination of TRIG + SITA. The concomitant administration of TRIG + SITA (50% + 50%) contributes in the prevention to development diabetes and showed synergistic antihyperglycemic effect.

Background: Plant-derived polysaccharides such as galactomannans (GAL) have very interesting and ... more Background: Plant-derived polysaccharides such as galactomannans (GAL) have very interesting and useful applications in the biomedical and biopharmaceutical field. GAL from fenugreek (Trigonella foenum graecum L.) seeds has been shown to have promising but inconsistent anti-hyperglycemic activity due to variable composition. Aim: We have isolated and characterized low molecular weight GAL fraction from fenugreek seeds (LMWGAL-TF) and evaluated its anti-hyperglycemic potential. Materials and methods: LMWGAL-TF was isolated, well characterized (HPLC and LC-MS) and evaluated for anti-hyperglycemic activity after acute and subacute oral treatment in doses of 50, 100 and 200 mg/kg in alloxan-induced hyperglycemia in mice. Results: The isolated LMWGAL-TF was of 91.5% purity with low molecular weight. LMWGAL-TF showed dose-dependent anti-hyperglycemic activity against alloxan-induced hyperglycemia without body weight gain, and protected mice pancreas from alloxan-induced histological changes. Conclusions: LMWGAL-TF showed promising and dose-dependent anti-hyperglycemic effects in animal model of DM.

Aim of the study: The present study was designed to investigate the possible association of conco... more Aim of the study: The present study was designed to investigate the possible association of concomitant administration of trigonelline (TRIG) and sitagliptin (SITA) on cardiomyopathy in diabetic rats. Methods: Diabetes was induced in Wistar rats by administration of nicotinamide (NICO; 110 mg/kg) and streptozotocin (STZ; 65 mg/kg) intraperitonelly (i.p.). After confirmation of diabetes, rats were divided into following groups i.e. group 1: non-diabetic rats (ND); Group 2: diabetic rats (DC); Group 3: TRIG (50 mg/kg, p.o.); Group 4: SITA (5 mg/kg, p.o.); Group 5: TRIG + SITA (50 + 5 mg/kg, p.o.). Treatment with selected dose of TRIG and SITA was started from 3rd week after NICO-STZ injection and was continued up to 11th week. Cardiomyopathy was assessed by measuring serum glucose level, enzymatic cardiac markers, electrographic abnormalities, heamodynamic changes, lipid levels and histological examination of isolated heart tissue of treated animals. Results: NICO-STZ diabetic rats showed extensive hyperglycemia, hyperlipidemia, and elevated levels of enzymatic cardiac markers compared to non-diabetic rats. Concomitant and monotherapy treatment of TRIG and SITA exhibited significant decrease in hyperglycemia as compared to diabetic rats. Whereas TRIG + SITA considerably reduced hyperlipidemia, alteration in levels enzymatic cardiac markers and improvement in cardiac function by improved electrographic abnormalities and heamodynamic changes. Overall, the findings revealed in this investigation demonstrated that concomitant administration of TRIG + SITA can be strong pharmacological therapy as compared to monotherapy used for the treatment of hyperglycemia, hyperlipidemia and cardiac dysfunctions in NICO-STZ-induced cardiomyopathy in Wistar rats. Conclusion: We conclude that concomitant administration of TROG and SITA showed additive cardioprotective effect compared to monotherapy.

Research Journal of Pharmacy and Technology, 2010

The decoction of the leaves of Cinamomum tamala of family Lauraceae widely used in the field of m... more The decoction of the leaves of Cinamomum tamala of family Lauraceae widely used in the field of medicine for the treatment of vitiated conditions of vata, diarrhea, proctitis, proctalgia. Preliminary phytochemical investigation of alcoholic and water extracts of the leaves of Cinnamomum tamala showed the presence of flavonoids, sterols, tannins and glycosides.