hossain iqbal - Academia.edu (original) (raw)
Papers by hossain iqbal
Radiotherapy and Oncology, 2014
Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ, 2013
Mental health is an important but neglected component of reproductive health. This study aimed to... more Mental health is an important but neglected component of reproductive health. This study aimed to determine the prevalence and risk factors for antenatal depression among women attending for antenatal care at an urban tertiary care hospital in Lahore, Pakistan. In a cross-sectional study, structured questionnaires were filled and screening for depression was done using the Edinburgh postnatal depression scale (EPDS). Out of 506 antenatal attendees 126 (24.9%) had no depression (EPDS scores<10), 53 (10.5%) scored 10-12 and 327 (64.6%) had EPDS scores>12. Depression scores (>or=10) were more common in mothers aged<20 years (93.7%) than those aged>35 years (55.0%). Fear of childbirth and separation from husband were identified as significant risk factors for development of antenatal depression, while family history of psychiatric illness was significant protective factor. Domestic violence, drug abuse, lack of support, previous miscarriage and personal history of previou...
JPMA. The Journal of the Pakistan Medical Association, 2004
To evaluate outcome of allogeneic BMT in beta-Thalassaemia at the Armed Forces Bone Marrow Transp... more To evaluate outcome of allogeneic BMT in beta-Thalassaemia at the Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan from August 2001 to November 2003. Nineteen patients with beta-Thalassaemia underwent allogeneic BMT/PBSC transplantation from HLA identical sibling donors. Patients were classified in three groups according to Pesaro (Italy) risk classification. Class-I (n = 9) and Class-II (n = 7) patients received conditioning with busulphan/cyclophosphamide, whereas Class-III (n = 3) patient received conditioning with hydroxyurea, azathioprine, fludarabine, along with Bu14 / Cy 200. Cyclosporine, prednisolone and methotrexate were given for GvHD prophylaxis. Stem cells dose infused was >4.0 x 10(8)/kg body weight of the patient. Engraftment was achieved in all Class-I patients, whereas in Class-II and Class-III , graft rejection was observed in one patient from each class. Median time to achieve absolute neutrophil recovery (> 0.5 x 10(9)/l) was 13 days, platel...
Molecular Syndromology, 2010
Bardet-Biedl syndrome (BBS, MIM 209900) is an autosomal recessive disorder characterized by a wid... more Bardet-Biedl syndrome (BBS, MIM 209900) is an autosomal recessive disorder characterized by a wide spectrum of clinical features, of which the most common ones are progressive retinal degeneration (rod-cone dystrophy), obesity, postaxial polydactyly, renal tract and genital anomalies, and learning difficulties or mental retardation [Beales et al., 1999]. The phenotype of BBS is highly variable, and it has been suggested that the clinical diagnosis is established if at least four of the main manifestations are present in a patient. Clinical evaluation during early infancy remains difficult as not all of the main manifestations are congenital but may occur later during childhood. Congenital postaxial polydactyly including syndactyly and/or brachydactyly is present in approximately 70% of cases and may not affect all limbs. Developmental anomalies of the renal tract are also common and can lead to chronic renal failure [Harnett et al., 1988]. Further congenital symptoms, which can be diagnosed in early infancy, are genital anomalies such as vaginal atresia and hypoplasia of the uterus and hypogonadism in males. The appearance of a rod-cone dystrophy, which is also described as atypical retinitis pigmentosa
2012 International Conference of Robotics and Artificial Intelligence, 2012
Oral Oncology Supplement, 2009
Oral Oncology Supplement, 2009
Toxicology and Industrial Health, 2013
In the present study, we evaluated the pharmacological and toxicological effects of Teucrium stoc... more In the present study, we evaluated the pharmacological and toxicological effects of Teucrium stocksianum. The crude extract of T. stocksianum (Ts.Cr) and its subsequent organic fractions: n-hexane (Ts.Hex), chloroform (Ts.CHCl3) and ethyl acetate (Ts.EtAc) exhibited 1,1-diphenyl,2-picrylhydrazyl free radical scavenging activity with different potencies. Ts.EtAc was found to be most potent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc showed significant bactericidal activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, Shigella flexneri and Bacillus subtilis at their extent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc displayed fungicidal action against Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Fusarium solani at various minimum inhibitory concentrations. Ts.Cr and Ts.EtAc exhibited marked inhibition of Leishmania tropica growth, observed after 48 and 96 hrs of treatment. These data indicate that the T. stocksianum methanolic extract and its resultant fractions possess antioxidant, antibacterial, antifungal and antileishmanial activities. Thus, the present research unearths the scientific base for T. stocksianum medicinal application as antioxidant and antimicrobial agents.
Radiotherapy and Oncology, 2012
Radiotherapy and Oncology, 2012
Neuro-Oncology, 2013
Background. Glioblastoma multiforme, a World Health Organization grade IV glioma, has a poor prog... more Background. Glioblastoma multiforme, a World Health Organization grade IV glioma, has a poor prognosis in humans despite current treatment options. Here, we present magnetic resonance imaging (MRI) data regarding the regression of aggressive rat F98 gliomas and human U87 glioma xenografts after treatment with the nitrone compound OKN-007, a disulfonyl derivative of a-phenyl-tert-butyl nitrone. Methods. MRI was used to assess tumor volumes in F98 and U87 gliomas, and bioluminescence imaging was used to measure tumor volumes in F98 gliomas encoded with the luciferase gene (F98 luc). Immunohistochemistry was used to assess angiogenesis (vascular endothelial growth factor [VEGF] and microvessel density [MVD]), cell differentiation (carbonic anhydrase IX [CA-IX]), hypoxia (hypoxia-inducible factor-1a [HIF-1a]), cell proliferation (glucose transporter 1 [Glut-1] and MIB-1), proliferation index, and apoptosis (cleaved caspase 3) markers in F98 gliomas. VEGF, CA-IX, Glut-1, HIF-1a, and cleaved caspase 3 were assessed in U87 gliomas. Results. Animal survival was found to be significantly increased (P , .001 for F98, P , .01 for U87) in the group that received OKN-007 treatment compared with the untreated groups. After MRI detection of F98 gliomas, OKN-007, administered orally, was found to decrease tumor growth (P , .05). U87 glioma volumes were found to significantly decrease (P , .05) after OKN-007 treatment, compared with untreated animals. OKN-007 administration resulted in significant decreases in tumor hypoxia (HIF-1a [P , .05] in both F98 and U87), angiogenesis (MVD [P , .05], but not VEGF, in F98 or U87), and cell proliferation (Glut-1 [P , .05 in F98, P , .01 in U87] and MIB-1 [P , .01] in F98) and caused a significant increase in apoptosis (cleaved caspase 3 [P , .001 in F98, P , .05 in U87]), compared with untreated animals. Conclusions. OKN-007 may be considered as a promising therapeutic addition or alternative for the treatment of aggressive human gliomas.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2007
An alcoholic extract obtained from the rhizomes of Gloriosa superba Linn (Colchicaceae) was scree... more An alcoholic extract obtained from the rhizomes of Gloriosa superba Linn (Colchicaceae) was screened for enzyme inhibition activities. The crude extract and its subsequent fractions including chloroform, ethyl acetate, n-butanol and aqueous were screened against lipoxygenase, actylcholinesterase, butyrylcholinesterase and urease. An outstanding inhibition on lipoxygenase was observed. The highest enzyme inhibition potency was expressed by the chloroform fraction (90%) among the tested fractions on lipoxygenase. Overall 67-90% inhibition was found for lipoxygenase, 46-69% for acetylcholinesterase and 10-33% for butyrylcholinesterase, while urease was not inhibited.
Journal of Coordination Chemistry, 2012
Cyclohexylcarbamodithioic acid has been synthesized by the reaction of cyclohexylamine with carbo... more Cyclohexylcarbamodithioic acid has been synthesized by the reaction of cyclohexylamine with carbon disulfide at room temperature. Its complexes have been synthesized by the reaction of cyclohexylcarbamodithioic acid with organotin(IV) chlorides in 1 : 1/1 : 2 molar ratio. The ligand and complexes have been characterized by elemental analysis, infrared (IR), and multinuclear (H, C, and Sn) NMR spectroscopy. Elemental data show good agreement between
International Journal of Radiation Oncology*Biology*Physics, 2013
International Journal of Radiation Oncology*Biology*Physics, 2013
Radiotherapy and Oncology, 2014
Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ, 2013
Mental health is an important but neglected component of reproductive health. This study aimed to... more Mental health is an important but neglected component of reproductive health. This study aimed to determine the prevalence and risk factors for antenatal depression among women attending for antenatal care at an urban tertiary care hospital in Lahore, Pakistan. In a cross-sectional study, structured questionnaires were filled and screening for depression was done using the Edinburgh postnatal depression scale (EPDS). Out of 506 antenatal attendees 126 (24.9%) had no depression (EPDS scores<10), 53 (10.5%) scored 10-12 and 327 (64.6%) had EPDS scores>12. Depression scores (>or=10) were more common in mothers aged<20 years (93.7%) than those aged>35 years (55.0%). Fear of childbirth and separation from husband were identified as significant risk factors for development of antenatal depression, while family history of psychiatric illness was significant protective factor. Domestic violence, drug abuse, lack of support, previous miscarriage and personal history of previou...
JPMA. The Journal of the Pakistan Medical Association, 2004
To evaluate outcome of allogeneic BMT in beta-Thalassaemia at the Armed Forces Bone Marrow Transp... more To evaluate outcome of allogeneic BMT in beta-Thalassaemia at the Armed Forces Bone Marrow Transplant Centre, Rawalpindi, Pakistan from August 2001 to November 2003. Nineteen patients with beta-Thalassaemia underwent allogeneic BMT/PBSC transplantation from HLA identical sibling donors. Patients were classified in three groups according to Pesaro (Italy) risk classification. Class-I (n = 9) and Class-II (n = 7) patients received conditioning with busulphan/cyclophosphamide, whereas Class-III (n = 3) patient received conditioning with hydroxyurea, azathioprine, fludarabine, along with Bu14 / Cy 200. Cyclosporine, prednisolone and methotrexate were given for GvHD prophylaxis. Stem cells dose infused was >4.0 x 10(8)/kg body weight of the patient. Engraftment was achieved in all Class-I patients, whereas in Class-II and Class-III , graft rejection was observed in one patient from each class. Median time to achieve absolute neutrophil recovery (> 0.5 x 10(9)/l) was 13 days, platel...
Molecular Syndromology, 2010
Bardet-Biedl syndrome (BBS, MIM 209900) is an autosomal recessive disorder characterized by a wid... more Bardet-Biedl syndrome (BBS, MIM 209900) is an autosomal recessive disorder characterized by a wide spectrum of clinical features, of which the most common ones are progressive retinal degeneration (rod-cone dystrophy), obesity, postaxial polydactyly, renal tract and genital anomalies, and learning difficulties or mental retardation [Beales et al., 1999]. The phenotype of BBS is highly variable, and it has been suggested that the clinical diagnosis is established if at least four of the main manifestations are present in a patient. Clinical evaluation during early infancy remains difficult as not all of the main manifestations are congenital but may occur later during childhood. Congenital postaxial polydactyly including syndactyly and/or brachydactyly is present in approximately 70% of cases and may not affect all limbs. Developmental anomalies of the renal tract are also common and can lead to chronic renal failure [Harnett et al., 1988]. Further congenital symptoms, which can be diagnosed in early infancy, are genital anomalies such as vaginal atresia and hypoplasia of the uterus and hypogonadism in males. The appearance of a rod-cone dystrophy, which is also described as atypical retinitis pigmentosa
2012 International Conference of Robotics and Artificial Intelligence, 2012
Oral Oncology Supplement, 2009
Oral Oncology Supplement, 2009
Toxicology and Industrial Health, 2013
In the present study, we evaluated the pharmacological and toxicological effects of Teucrium stoc... more In the present study, we evaluated the pharmacological and toxicological effects of Teucrium stocksianum. The crude extract of T. stocksianum (Ts.Cr) and its subsequent organic fractions: n-hexane (Ts.Hex), chloroform (Ts.CHCl3) and ethyl acetate (Ts.EtAc) exhibited 1,1-diphenyl,2-picrylhydrazyl free radical scavenging activity with different potencies. Ts.EtAc was found to be most potent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc showed significant bactericidal activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, Shigella flexneri and Bacillus subtilis at their extent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc displayed fungicidal action against Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Fusarium solani at various minimum inhibitory concentrations. Ts.Cr and Ts.EtAc exhibited marked inhibition of Leishmania tropica growth, observed after 48 and 96 hrs of treatment. These data indicate that the T. stocksianum methanolic extract and its resultant fractions possess antioxidant, antibacterial, antifungal and antileishmanial activities. Thus, the present research unearths the scientific base for T. stocksianum medicinal application as antioxidant and antimicrobial agents.
Radiotherapy and Oncology, 2012
Radiotherapy and Oncology, 2012
Neuro-Oncology, 2013
Background. Glioblastoma multiforme, a World Health Organization grade IV glioma, has a poor prog... more Background. Glioblastoma multiforme, a World Health Organization grade IV glioma, has a poor prognosis in humans despite current treatment options. Here, we present magnetic resonance imaging (MRI) data regarding the regression of aggressive rat F98 gliomas and human U87 glioma xenografts after treatment with the nitrone compound OKN-007, a disulfonyl derivative of a-phenyl-tert-butyl nitrone. Methods. MRI was used to assess tumor volumes in F98 and U87 gliomas, and bioluminescence imaging was used to measure tumor volumes in F98 gliomas encoded with the luciferase gene (F98 luc). Immunohistochemistry was used to assess angiogenesis (vascular endothelial growth factor [VEGF] and microvessel density [MVD]), cell differentiation (carbonic anhydrase IX [CA-IX]), hypoxia (hypoxia-inducible factor-1a [HIF-1a]), cell proliferation (glucose transporter 1 [Glut-1] and MIB-1), proliferation index, and apoptosis (cleaved caspase 3) markers in F98 gliomas. VEGF, CA-IX, Glut-1, HIF-1a, and cleaved caspase 3 were assessed in U87 gliomas. Results. Animal survival was found to be significantly increased (P , .001 for F98, P , .01 for U87) in the group that received OKN-007 treatment compared with the untreated groups. After MRI detection of F98 gliomas, OKN-007, administered orally, was found to decrease tumor growth (P , .05). U87 glioma volumes were found to significantly decrease (P , .05) after OKN-007 treatment, compared with untreated animals. OKN-007 administration resulted in significant decreases in tumor hypoxia (HIF-1a [P , .05] in both F98 and U87), angiogenesis (MVD [P , .05], but not VEGF, in F98 or U87), and cell proliferation (Glut-1 [P , .05 in F98, P , .01 in U87] and MIB-1 [P , .01] in F98) and caused a significant increase in apoptosis (cleaved caspase 3 [P , .001 in F98, P , .05 in U87]), compared with untreated animals. Conclusions. OKN-007 may be considered as a promising therapeutic addition or alternative for the treatment of aggressive human gliomas.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2007
An alcoholic extract obtained from the rhizomes of Gloriosa superba Linn (Colchicaceae) was scree... more An alcoholic extract obtained from the rhizomes of Gloriosa superba Linn (Colchicaceae) was screened for enzyme inhibition activities. The crude extract and its subsequent fractions including chloroform, ethyl acetate, n-butanol and aqueous were screened against lipoxygenase, actylcholinesterase, butyrylcholinesterase and urease. An outstanding inhibition on lipoxygenase was observed. The highest enzyme inhibition potency was expressed by the chloroform fraction (90%) among the tested fractions on lipoxygenase. Overall 67-90% inhibition was found for lipoxygenase, 46-69% for acetylcholinesterase and 10-33% for butyrylcholinesterase, while urease was not inhibited.
Journal of Coordination Chemistry, 2012
Cyclohexylcarbamodithioic acid has been synthesized by the reaction of cyclohexylamine with carbo... more Cyclohexylcarbamodithioic acid has been synthesized by the reaction of cyclohexylamine with carbon disulfide at room temperature. Its complexes have been synthesized by the reaction of cyclohexylcarbamodithioic acid with organotin(IV) chlorides in 1 : 1/1 : 2 molar ratio. The ligand and complexes have been characterized by elemental analysis, infrared (IR), and multinuclear (H, C, and Sn) NMR spectroscopy. Elemental data show good agreement between
International Journal of Radiation Oncology*Biology*Physics, 2013
International Journal of Radiation Oncology*Biology*Physics, 2013