hamzeh hosseinzadeh - Academia.edu (original) (raw)

Papers by hamzeh hosseinzadeh

Medical journal of Tabriz University of Medical Sciences and Health Services, Jun 12, 2012

The Journal of Immunology

Studies of the functional properties and developmental potentials of immediate post-thymic cells ... more Studies of the functional properties and developmental potentials of immediate post-thymic cells have been hampered by the lack of reliable markers with which to distinguish recent thymic emigrants (RTE) from the bulk of peripheral T cells. In the present study, the intrathymic FITC-labeling technique was used in concert with three-color flow-cytometric analysis to identify, phenotypically characterize, and study the short term fate of RTE in normal rats. The results indicated that between 3 and 4% of total T cells in lymph node and spleen of 5- to 8-wk-old rats had been released from the thymus within the preceding 24 h. Unlike the bulk of the peripheral T cells, which had a Thy1-, CD45RC+, and/or RT6+ phenotype, these RTE were Thy1+, CD45RC-, and RT6-. Furthermore, two discrete subsets of RTE were defined: a major subset (approximately 95%) of CD4+ or 8+ (single positive), TCR-alpha beta hi T cells that resembled medullary thymocytes; and a minor subset (approximately 5%) of CD4+ ...

Introduction: Tonsillectomy is among commonest otorhinolaryngologic surgeries. Many methods have ... more Introduction: Tonsillectomy is among commonest otorhinolaryngologic surgeries. Many methods have been used to control post surgical pain, but despite it, pain is still one of the problems related to this operation. Recently, due to the non invasiveness of low level lasers, this modality has attracted attention. The purpose of this study is to evaluate the effects of low level laser irradiation at the end of surgery on reduction of pain after tonsillectomy in adults.

Objectives: Perianesthesia aspiration is a threatening side effect, whose severity depends on pH ... more Objectives: Perianesthesia aspiration is a threatening side effect, whose severity depends on pH and volume of aspirated gastric juice. Because of the loss of consciousness while anesthesia, the protec-tive reflexes disappear and expose the person in the risk of aspiration. Pharmacological attempts have been made to eliminate the risk of pulmonary aspiration. The aim of this study was to compare oral pantoprazole and famotidine on gastric volume and pH in elective surgeries. Methods: In a double-blind randomized clinical trial, 120 candidates of elective surgery were ran-domized into 3 groups (control or C, pantoprazole or P and famotidine or F groups). The patients in group C ،P and F were given placebo ،pantoprazole 40mg and famotidine 40mg orally at 11 pm a night before surgery respectively. After induction of anesthesia, gastric contents were aspirated and analyzed for the pH and volume. Results: PH values were 2.87 ± 0.92 in group C, 4.53 ± 1.29 in group P and 3.79 ± 1.97 in gr...

Large airway stenosis is common in patients with Wegener's granulomatosis. We used high frequency... more Large airway stenosis is common in patients with Wegener's granulomatosis. We used high frequency jet ventilation for management of anesthesia during rigid bronchoscopy for dilation of left main bronchus in a patient with Wegener's granulomatosis.

Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pa... more Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pain. Methods: Sixty patients referred from departments of oncology and surgery to pain clinic were allocated to two groups. In group A, stellate ganglion block was performed with 8ml bupivacaine 0.25%. In group B, patients were treated with gabapentin 900mg per day in three divided doses. Drug dose was increased if necessary until eight weeks. Pain score and quality of life were determined. Data were collected before treatment, 48 hours and every 15 days after treatment until three months. Results: Pain scores at 48 hours after treating were higher in group B than group A and lower at one week, one month and three months after treatment which were statically significant. (P<0.001, 0.024, 0.047 and <0.001 respectively) Conclusions: Gabapentin was found to be superior treatment for chronic pain following breast surgery.

Anesthesia & Analgesia, 2013

I know that time, for me, is but a breath, And all of living but a passing sigh, A little wind th... more I know that time, for me, is but a breath, And all of living but a passing sigh, A little wind that stirs the calm of death.-Hakim Omar Khayyam (1048-1131 CE) T racheostomy has been known for millennia as an effective procedure for establishing an emergency airway in patients with upper respiratory tract obstruction. However, it was always a highly controversial procedure, with most scholars dreading it and even warning their successors not to perform it. 1 According to tablets found in Egypt, tracheostomy is believed to have been first performed by Egyptians in 3600 BCE. However, the earliest references to tracheostomy have been made in the "Rig Veda," the sacred book of Hindu medicine (ca. 2000-1000 BCE) and the Ebers Papyrus (ca. 1550 BCE). 2 Around 1000 BCE Homer reported that Alexander the Great saved a soldier from suffocation by making an opening in the trachea using the tip of his sword. 3 Although Hippocrates (460-370 BCE) theoretically knew about tracheostomy, he avoided performing it due to the fear of carotid artery damage. 4 Later, Asclepiades of Bithynia (ca. 100 BCE) and Antyllus of Rome (340 CE) were credited with the first surgical tracheostomies. 5,6 At the start of the Middle Ages, Paulus of Aegina (ca. 625-690 CE) presented the first detailed surgical description of tracheostomy. 7 Tracheostomy appeared in medical texts during the Islamic Golden Age (ca. 750-1257 CE), along with technical innovations and changes. The history of tracheostomy in Renaissance and modern Europe has been extensively studied, and readers are referred to the reviews by Szmuk et al. 3 and Missori et al. 8 Nonetheless, in these historical reviews, relatively little has been devoted to the topic of tracheostomy in Islamic medicine. Therefore, the aim of the present review is to describe how physicians during the Islamic Golden Age contributed to the development and progress of the procedure of tracheostomy. Their brief biographies highlight Islamic physicians' leading roles in the evolution of medicine. ABUBAKR MUHAMMAD IBN ZAKARIYYA AL-RAZI, RHAZES (865-925 CE) Abubakr Muhammad ibn Zakariyya al-Razi (Fig. 1), known as Rhazes in the West, was born in Ray, a town in the vicinity of Tehran, in 865 CE. 9 Until his thirties, Rhazes was a musician and a money changer. He wrote an encyclopedia of music (On the Beauty of Music) before pursuing his interest in science. 10,11 Later, Rhazes studied philosophy, mathematics, literature, astronomy, and alchemy. 12 Sometime after 30 years of age, Rhazes went to Baghdad, where he completed his medical education (probably) under the supervision of al-Tabari (807-870 CE). 13 During his 10-year residence in Baghdad (895-905 CE), Rhazes was the head of the Bimaristan-i Muqtadiri (Al-Muqtadir Hospital) founded by Al-Muqtadir of the Abbasid caliphate. In 981 CE, the hospital was renovated by Emir Adud al-dowleh Fana Khusraw (reigning from 949 to 982 CE) of the Buyid dynasty and renamed as the Bimaristan-i Adudi (Al-Adudi Hospital). 14 Although inspired by the theories of Galen, Rhazes primarily adhered to knowledge derived from his own observations and scientific experiments. 15 Rhazes questioned many of Galen's medical and philosophical theories in his book Al-Shukuk ala Jalinus (Doubts about Galen). 9 Having written >200 books and treatises on a variety of subjects, Rhazes' 2 major medical contributions are Kitab al-Mansuri (Liber Al Mansuri) and Kitab al-Hawi (Liber Continens). Combining ancient and contemporary knowledge of his era, Rhazes is considered one of the authorities who established the basis of

Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pa... more Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pain. Methods: Sixty patients referred from departments of oncology and surgery to pain clinic were allocated to two groups. In group A, stellate ganglion block was performed with 8ml bupivacaine 0.25%. In group B, patients were treated with gabapentin 900mg per day in three divided doses.

Objective: To evaluate the effect of preincisional ipsilateral stellate ganglion block for acute ... more Objective: To evaluate the effect of preincisional ipsilateral stellate ganglion block for acute post operative pain control in unilateral mastectomy. Methodology: In a randomized clinical trial, 62 patients selected for unilateral mastectomy were recruited in Tabriz Imam Reza educational Hospital during 18-month period. They were randomly divided into two equal groups; receiving either preincisional ipsilateral stellate ganglion block using bupivacaine (study group) or without these blocks (control group). Postoperative pain was evaluated based on visual analogue scale (VAS). The total dose of analgesics were also compared between the two groups. Results: Thirty one female patients with a mean age of 48.7±7.4 (36-60) years and 31 other female patients with a mean age of 50.7±6.9 (36-60) years were enrolled in the study and control groups, respectively (p=0.292). The number of patients with decrease in postoperative pain was significantly higher in the case study group comparing wit...

Objective: After neuraxial anesthesia, back pain is the most common complaint. The back pain may ... more Objective: After neuraxial anesthesia, back pain is the most common complaint. The back pain may be related to needle trauma or surgical positioning or transient neurotoxicity of concentrated local anesthetics. The goal of this study was to compare the incidence of back pain following spinal anesthesia with hyperbaric lidocaine 5% and bupivacaine 0.5% and spinal needle insertion spaces. Methodology: In this clinical trial after approving ethics committee and obtaining patients consent, we included 176 adult patients with physical status of I- II ASA from May 2006 to May 2008 undergoing various elective urologic surgeries under spinal anesthesia in Imam Hospital in Tabriz, Iran. Patients were allocated randomly in two equal groups. Group lidocaine, a nesthetized with hyperbaric 5% lidocaine and group bupivacaine. All patients were interviewed 6, 24, 48 hours after surgery for back pain. Results: This study indicated no statistically significance difference in the incidence of back pa...

Background: Nausea and vomiting are common complications of anesthesia and surgery. Patients unde... more Background: Nausea and vomiting are common complications of anesthesia and surgery. Patients undergoing tympanoplasty are exposed to a higher risk of postoperative nausea vomiting (PONV). These complications may alter the results of reconstruction and anatomical alignments. Numerous antiemetics have been studied to prevent and treat PONV in patients undergoing tympanoplasty. The aim of this study was to compare the effect of intravenous ondansetron and dexamethasone on post-tympanoplasty PONV. Methods: In a double-blind randomized controlled clinical trial, 219 patients were divided into three groups including one receiving ondansetron, one receiving dexamethazone, and one receiving distilled water. All patients were subjected to tympanoplasty type I. The patients in the first group received ondansetron (4 mg IV), second group received oexamethasone (8 mg IV), and third group received distilled water prior to induction of anesthesia. Using Bellivelle’s scoring system, the incidence ...

Objective: To compare the efficacy of esmolol with remifentanil in maintaining haemodynamic stabi... more Objective: To compare the efficacy of esmolol with remifentanil in maintaining haemodynamic stability at the end of a neurosurgical procedure and recovery stages and reducing the length of the recovery phase. Methods: The double-blind prospective randomised clinical trial was conducted at Imam Reza Hospital, Tabriz, Iran, from May 2010 to November 2011. It comprised 90 adult patients who were scheduled to undergo elective neurosurgery operations and were randomly divided into three groups receiving esmolol, remifentanil and placebo for 14 minutes. The intravenous infusion was started four minutes prior to extubation and continued for 10 minutes after extubation. SPSS 16 was used for statistical analysis. Results: There was a significant difference between the three groups regarding the changes of mean arterial pressure after extubation and five minutes after extubation (p<0.001 in all groups). The esmolol group compared with the placebo group and the remifentanil group compared w...

Background and Objectives: There are different anesthetic methods for hemodynamic stabilization d... more Background and Objectives: There are different anesthetic methods for hemodynamic stabilization during lumbar disc surgery. Anesthesias with intravenous drug including propofol-remifentanil and isoflurane have acceptable results inthis regard. In this study we compared the hemodynamic effects of these two anesthesia methods in patients, candidate for lumbar disc surgery. Materials and Methods: In this study, 70 patients, who were candidate for lumbar disc surgery underwent general anesthesia using propofol-remifentanil or isoflurane. After induction with lidocaine, propofol and sisatracorium, anesthesia was maintained in isoflurane group with controlled respiration using oxygen and N2O with 50% ratio with isoflurane 1% and in propofol-remifentanil group, with controlled respiration using 100% oxygen with propofol 5 mg/kg/h and remifentanil 0.125 μg/kg/min. Hemodynamic findings during surgery and after surgery were recorded in both groups. Results: There were no significant differenc...

Conclusion: Premedication of the kidney transplant donors with low-dose dopamine accelerates earl... more Conclusion: Premedication of the kidney transplant donors with low-dose dopamine accelerates early kidney function after transplantation, but has no effect on the hemodynamic status and serum levels of creatinine and urea in the donors.

Journal of North Khorasan University of Medical Sciences

Journal of North Khorasan University of Medical Sciences, Sep 1, 2011

Anesthesiology and Pain Medicine

Background: One-lung ventilation (OLV) is commonly used during thoracic surgery. At this time, hy... more Background: One-lung ventilation (OLV) is commonly used during thoracic surgery. At this time, hypoxemia is considered one of the remarkable consequences of the anesthesia management. Hypoxic pulmonary vasoconstriction (HPV) is the defense mechanism against hypoxia. Objectives: The aim of the present study was to investigate the effect of infusion of dexmedetomidine on improving the oxygenation during OLV among the adult patients undergoing thoracic surgery. Methods: A total of 42 patients undergoing OLV by general anesthesia with isoflurane inhalation were randomly assigned into two groups: IV infusion of dexmedetomidine at 0.3 microgram/kg/h (DISO) and IV infusion of normal saline (NISO). Three Arterial Blood Gas (ABG) samples were obtained throughout the surgery. Hemodynamic parameters, PaO2, PaCO2, and complications at recovery phase were recorded. The collected information was analyzed using SPSS software version 22. Results: In the dexmedetomidine group, the mean hemodynamic parameters had a significant reduction at 30 and 60 minutes following OLV. Administration of dexmedetomidine resulted in a significant increase in the PaCO2 and a reduction in the PaO2 when changing from two-lung ventilation to OLV, where PaO2 reached its maximum value within 10 minutes after OLV in the DISO group, and it began to gradually increase to the end of operation. The duration of the recovery phase, also complications at the recovery phase decreased significantly in DISO group. Conclusions: The results of the study showed that, dexmedetomidine may improve arterial oxygenation during OLV in adult patients undergoing thoracic surgery, and can be a suitable anesthetic agent for thoracic surgery.

Medical journal of Tabriz University of Medical Sciences and Health Services, Jun 12, 2012

The Journal of Immunology

Studies of the functional properties and developmental potentials of immediate post-thymic cells ... more Studies of the functional properties and developmental potentials of immediate post-thymic cells have been hampered by the lack of reliable markers with which to distinguish recent thymic emigrants (RTE) from the bulk of peripheral T cells. In the present study, the intrathymic FITC-labeling technique was used in concert with three-color flow-cytometric analysis to identify, phenotypically characterize, and study the short term fate of RTE in normal rats. The results indicated that between 3 and 4% of total T cells in lymph node and spleen of 5- to 8-wk-old rats had been released from the thymus within the preceding 24 h. Unlike the bulk of the peripheral T cells, which had a Thy1-, CD45RC+, and/or RT6+ phenotype, these RTE were Thy1+, CD45RC-, and RT6-. Furthermore, two discrete subsets of RTE were defined: a major subset (approximately 95%) of CD4+ or 8+ (single positive), TCR-alpha beta hi T cells that resembled medullary thymocytes; and a minor subset (approximately 5%) of CD4+ ...

Introduction: Tonsillectomy is among commonest otorhinolaryngologic surgeries. Many methods have ... more Introduction: Tonsillectomy is among commonest otorhinolaryngologic surgeries. Many methods have been used to control post surgical pain, but despite it, pain is still one of the problems related to this operation. Recently, due to the non invasiveness of low level lasers, this modality has attracted attention. The purpose of this study is to evaluate the effects of low level laser irradiation at the end of surgery on reduction of pain after tonsillectomy in adults.

Objectives: Perianesthesia aspiration is a threatening side effect, whose severity depends on pH ... more Objectives: Perianesthesia aspiration is a threatening side effect, whose severity depends on pH and volume of aspirated gastric juice. Because of the loss of consciousness while anesthesia, the protec-tive reflexes disappear and expose the person in the risk of aspiration. Pharmacological attempts have been made to eliminate the risk of pulmonary aspiration. The aim of this study was to compare oral pantoprazole and famotidine on gastric volume and pH in elective surgeries. Methods: In a double-blind randomized clinical trial, 120 candidates of elective surgery were ran-domized into 3 groups (control or C, pantoprazole or P and famotidine or F groups). The patients in group C ،P and F were given placebo ،pantoprazole 40mg and famotidine 40mg orally at 11 pm a night before surgery respectively. After induction of anesthesia, gastric contents were aspirated and analyzed for the pH and volume. Results: PH values were 2.87 ± 0.92 in group C, 4.53 ± 1.29 in group P and 3.79 ± 1.97 in gr...

Large airway stenosis is common in patients with Wegener's granulomatosis. We used high frequency... more Large airway stenosis is common in patients with Wegener's granulomatosis. We used high frequency jet ventilation for management of anesthesia during rigid bronchoscopy for dilation of left main bronchus in a patient with Wegener's granulomatosis.

Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pa... more Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pain. Methods: Sixty patients referred from departments of oncology and surgery to pain clinic were allocated to two groups. In group A, stellate ganglion block was performed with 8ml bupivacaine 0.25%. In group B, patients were treated with gabapentin 900mg per day in three divided doses. Drug dose was increased if necessary until eight weeks. Pain score and quality of life were determined. Data were collected before treatment, 48 hours and every 15 days after treatment until three months. Results: Pain scores at 48 hours after treating were higher in group B than group A and lower at one week, one month and three months after treatment which were statically significant. (P<0.001, 0.024, 0.047 and <0.001 respectively) Conclusions: Gabapentin was found to be superior treatment for chronic pain following breast surgery.

Anesthesia & Analgesia, 2013

I know that time, for me, is but a breath, And all of living but a passing sigh, A little wind th... more I know that time, for me, is but a breath, And all of living but a passing sigh, A little wind that stirs the calm of death.-Hakim Omar Khayyam (1048-1131 CE) T racheostomy has been known for millennia as an effective procedure for establishing an emergency airway in patients with upper respiratory tract obstruction. However, it was always a highly controversial procedure, with most scholars dreading it and even warning their successors not to perform it. 1 According to tablets found in Egypt, tracheostomy is believed to have been first performed by Egyptians in 3600 BCE. However, the earliest references to tracheostomy have been made in the "Rig Veda," the sacred book of Hindu medicine (ca. 2000-1000 BCE) and the Ebers Papyrus (ca. 1550 BCE). 2 Around 1000 BCE Homer reported that Alexander the Great saved a soldier from suffocation by making an opening in the trachea using the tip of his sword. 3 Although Hippocrates (460-370 BCE) theoretically knew about tracheostomy, he avoided performing it due to the fear of carotid artery damage. 4 Later, Asclepiades of Bithynia (ca. 100 BCE) and Antyllus of Rome (340 CE) were credited with the first surgical tracheostomies. 5,6 At the start of the Middle Ages, Paulus of Aegina (ca. 625-690 CE) presented the first detailed surgical description of tracheostomy. 7 Tracheostomy appeared in medical texts during the Islamic Golden Age (ca. 750-1257 CE), along with technical innovations and changes. The history of tracheostomy in Renaissance and modern Europe has been extensively studied, and readers are referred to the reviews by Szmuk et al. 3 and Missori et al. 8 Nonetheless, in these historical reviews, relatively little has been devoted to the topic of tracheostomy in Islamic medicine. Therefore, the aim of the present review is to describe how physicians during the Islamic Golden Age contributed to the development and progress of the procedure of tracheostomy. Their brief biographies highlight Islamic physicians' leading roles in the evolution of medicine. ABUBAKR MUHAMMAD IBN ZAKARIYYA AL-RAZI, RHAZES (865-925 CE) Abubakr Muhammad ibn Zakariyya al-Razi (Fig. 1), known as Rhazes in the West, was born in Ray, a town in the vicinity of Tehran, in 865 CE. 9 Until his thirties, Rhazes was a musician and a money changer. He wrote an encyclopedia of music (On the Beauty of Music) before pursuing his interest in science. 10,11 Later, Rhazes studied philosophy, mathematics, literature, astronomy, and alchemy. 12 Sometime after 30 years of age, Rhazes went to Baghdad, where he completed his medical education (probably) under the supervision of al-Tabari (807-870 CE). 13 During his 10-year residence in Baghdad (895-905 CE), Rhazes was the head of the Bimaristan-i Muqtadiri (Al-Muqtadir Hospital) founded by Al-Muqtadir of the Abbasid caliphate. In 981 CE, the hospital was renovated by Emir Adud al-dowleh Fana Khusraw (reigning from 949 to 982 CE) of the Buyid dynasty and renamed as the Bimaristan-i Adudi (Al-Adudi Hospital). 14 Although inspired by the theories of Galen, Rhazes primarily adhered to knowledge derived from his own observations and scientific experiments. 15 Rhazes questioned many of Galen's medical and philosophical theories in his book Al-Shukuk ala Jalinus (Doubts about Galen). 9 Having written >200 books and treatises on a variety of subjects, Rhazes' 2 major medical contributions are Kitab al-Mansuri (Liber Al Mansuri) and Kitab al-Hawi (Liber Continens). Combining ancient and contemporary knowledge of his era, Rhazes is considered one of the authorities who established the basis of

Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pa... more Objective: To evaluate the effect of stellate ganglion block and gabapentin on post mastectomy pain. Methods: Sixty patients referred from departments of oncology and surgery to pain clinic were allocated to two groups. In group A, stellate ganglion block was performed with 8ml bupivacaine 0.25%. In group B, patients were treated with gabapentin 900mg per day in three divided doses.

Objective: To evaluate the effect of preincisional ipsilateral stellate ganglion block for acute ... more Objective: To evaluate the effect of preincisional ipsilateral stellate ganglion block for acute post operative pain control in unilateral mastectomy. Methodology: In a randomized clinical trial, 62 patients selected for unilateral mastectomy were recruited in Tabriz Imam Reza educational Hospital during 18-month period. They were randomly divided into two equal groups; receiving either preincisional ipsilateral stellate ganglion block using bupivacaine (study group) or without these blocks (control group). Postoperative pain was evaluated based on visual analogue scale (VAS). The total dose of analgesics were also compared between the two groups. Results: Thirty one female patients with a mean age of 48.7±7.4 (36-60) years and 31 other female patients with a mean age of 50.7±6.9 (36-60) years were enrolled in the study and control groups, respectively (p=0.292). The number of patients with decrease in postoperative pain was significantly higher in the case study group comparing wit...

Objective: After neuraxial anesthesia, back pain is the most common complaint. The back pain may ... more Objective: After neuraxial anesthesia, back pain is the most common complaint. The back pain may be related to needle trauma or surgical positioning or transient neurotoxicity of concentrated local anesthetics. The goal of this study was to compare the incidence of back pain following spinal anesthesia with hyperbaric lidocaine 5% and bupivacaine 0.5% and spinal needle insertion spaces. Methodology: In this clinical trial after approving ethics committee and obtaining patients consent, we included 176 adult patients with physical status of I- II ASA from May 2006 to May 2008 undergoing various elective urologic surgeries under spinal anesthesia in Imam Hospital in Tabriz, Iran. Patients were allocated randomly in two equal groups. Group lidocaine, a nesthetized with hyperbaric 5% lidocaine and group bupivacaine. All patients were interviewed 6, 24, 48 hours after surgery for back pain. Results: This study indicated no statistically significance difference in the incidence of back pa...

Background: Nausea and vomiting are common complications of anesthesia and surgery. Patients unde... more Background: Nausea and vomiting are common complications of anesthesia and surgery. Patients undergoing tympanoplasty are exposed to a higher risk of postoperative nausea vomiting (PONV). These complications may alter the results of reconstruction and anatomical alignments. Numerous antiemetics have been studied to prevent and treat PONV in patients undergoing tympanoplasty. The aim of this study was to compare the effect of intravenous ondansetron and dexamethasone on post-tympanoplasty PONV. Methods: In a double-blind randomized controlled clinical trial, 219 patients were divided into three groups including one receiving ondansetron, one receiving dexamethazone, and one receiving distilled water. All patients were subjected to tympanoplasty type I. The patients in the first group received ondansetron (4 mg IV), second group received oexamethasone (8 mg IV), and third group received distilled water prior to induction of anesthesia. Using Bellivelle’s scoring system, the incidence ...

Objective: To compare the efficacy of esmolol with remifentanil in maintaining haemodynamic stabi... more Objective: To compare the efficacy of esmolol with remifentanil in maintaining haemodynamic stability at the end of a neurosurgical procedure and recovery stages and reducing the length of the recovery phase. Methods: The double-blind prospective randomised clinical trial was conducted at Imam Reza Hospital, Tabriz, Iran, from May 2010 to November 2011. It comprised 90 adult patients who were scheduled to undergo elective neurosurgery operations and were randomly divided into three groups receiving esmolol, remifentanil and placebo for 14 minutes. The intravenous infusion was started four minutes prior to extubation and continued for 10 minutes after extubation. SPSS 16 was used for statistical analysis. Results: There was a significant difference between the three groups regarding the changes of mean arterial pressure after extubation and five minutes after extubation (p<0.001 in all groups). The esmolol group compared with the placebo group and the remifentanil group compared w...

Background and Objectives: There are different anesthetic methods for hemodynamic stabilization d... more Background and Objectives: There are different anesthetic methods for hemodynamic stabilization during lumbar disc surgery. Anesthesias with intravenous drug including propofol-remifentanil and isoflurane have acceptable results inthis regard. In this study we compared the hemodynamic effects of these two anesthesia methods in patients, candidate for lumbar disc surgery. Materials and Methods: In this study, 70 patients, who were candidate for lumbar disc surgery underwent general anesthesia using propofol-remifentanil or isoflurane. After induction with lidocaine, propofol and sisatracorium, anesthesia was maintained in isoflurane group with controlled respiration using oxygen and N2O with 50% ratio with isoflurane 1% and in propofol-remifentanil group, with controlled respiration using 100% oxygen with propofol 5 mg/kg/h and remifentanil 0.125 μg/kg/min. Hemodynamic findings during surgery and after surgery were recorded in both groups. Results: There were no significant differenc...

Conclusion: Premedication of the kidney transplant donors with low-dose dopamine accelerates earl... more Conclusion: Premedication of the kidney transplant donors with low-dose dopamine accelerates early kidney function after transplantation, but has no effect on the hemodynamic status and serum levels of creatinine and urea in the donors.

Journal of North Khorasan University of Medical Sciences

Journal of North Khorasan University of Medical Sciences, Sep 1, 2011

Anesthesiology and Pain Medicine

Background: One-lung ventilation (OLV) is commonly used during thoracic surgery. At this time, hy... more Background: One-lung ventilation (OLV) is commonly used during thoracic surgery. At this time, hypoxemia is considered one of the remarkable consequences of the anesthesia management. Hypoxic pulmonary vasoconstriction (HPV) is the defense mechanism against hypoxia. Objectives: The aim of the present study was to investigate the effect of infusion of dexmedetomidine on improving the oxygenation during OLV among the adult patients undergoing thoracic surgery. Methods: A total of 42 patients undergoing OLV by general anesthesia with isoflurane inhalation were randomly assigned into two groups: IV infusion of dexmedetomidine at 0.3 microgram/kg/h (DISO) and IV infusion of normal saline (NISO). Three Arterial Blood Gas (ABG) samples were obtained throughout the surgery. Hemodynamic parameters, PaO2, PaCO2, and complications at recovery phase were recorded. The collected information was analyzed using SPSS software version 22. Results: In the dexmedetomidine group, the mean hemodynamic parameters had a significant reduction at 30 and 60 minutes following OLV. Administration of dexmedetomidine resulted in a significant increase in the PaCO2 and a reduction in the PaO2 when changing from two-lung ventilation to OLV, where PaO2 reached its maximum value within 10 minutes after OLV in the DISO group, and it began to gradually increase to the end of operation. The duration of the recovery phase, also complications at the recovery phase decreased significantly in DISO group. Conclusions: The results of the study showed that, dexmedetomidine may improve arterial oxygenation during OLV in adult patients undergoing thoracic surgery, and can be a suitable anesthetic agent for thoracic surgery.