ilham yamani - Academia.edu (original) (raw)

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Papers by ilham yamani

Research paper thumbnail of Decision letter: An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein

A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structur... more A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structures of E2 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HCV-infected individuals, revealed a disulfide bond-containing CDRH3 that adopts straight (individuals who clear infection) or bent (individuals with chronic infection) conformation. To investigate whether a straight versus bent disulfide bond-containing CDRH3 is specific to particular HCV-infected individuals, we solved a crystal structure of the HCV E2 ectodomain in complex with AR3X, a bNAb with an unusually long CDRH2 that was isolated from the chronically-infected individual from whom the bent CDRH3 bNAbs were derived. The structure revealed that AR3X utilizes both its ultralong CDRH2 and a disulfide motif-containing straight CDRH3 to recognize the E2 front layer. These results demonstrate that both the straight and bent CDRH3 classes of HCV bNAb can be elicited in a single individual, revealing a structural plasticity of VH1-69-derived bNAbs.

Research paper thumbnail of Hubungan Power Otot Lengan dan Kekuatan Pergelangan Tangan terhadap Hasil Tembakan dari Samping Badan (Side Shoot)

Jurnal Olahraga

This research was conducted with the aim to study the relationship of arm strength and fighting s... more This research was conducted with the aim to study the relationship of arm strength and fighting strength to the side shot results. This study discusses the presence or absence of a relationship. The method used in this research is descriptive research method with quantitative research. In this study data collection techniques using the test, for arm strength using the ball medicine test, for the strength of the battle using the hand grip test. The population used in this study were 12 members of the STKIP Pasundan Cimahi Student Activity Unit (UKM). Based on the research data, the results of the experimental arm strength and side shoot results are as broad as 0.1643, then the arm muscle strength has a positive relationship to the side shoot results. To challenge the existing power and the side shot result of 0.5534, the strength of hand combat has a positive relationship with the side shot result. And to fight the strength of the arm muscles and the strength of the side shot results...

Research paper thumbnail of Hubungan Power Otot Lengan dan Kekuatan Pergelangan Tangan terhadap Hasil Tembakan dari Samping Badan (Side Shoot)

Jurnal Olahraga, Nov 30, 2017

Research paper thumbnail of Decision letter: An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein

A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structur... more A vaccine protective against diverse HCV variants is needed to control the HCV epidemic. Structures of E2 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HCV-infected individuals, revealed a disulfide bond-containing CDRH3 that adopts straight (individuals who clear infection) or bent (individuals with chronic infection) conformation. To investigate whether a straight versus bent disulfide bond-containing CDRH3 is specific to particular HCV-infected individuals, we solved a crystal structure of the HCV E2 ectodomain in complex with AR3X, a bNAb with an unusually long CDRH2 that was isolated from the chronically-infected individual from whom the bent CDRH3 bNAbs were derived. The structure revealed that AR3X utilizes both its ultralong CDRH2 and a disulfide motif-containing straight CDRH3 to recognize the E2 front layer. These results demonstrate that both the straight and bent CDRH3 classes of HCV bNAb can be elicited in a single individual, revealing a structural plasticity of VH1-69-derived bNAbs.

Research paper thumbnail of Hubungan Power Otot Lengan dan Kekuatan Pergelangan Tangan terhadap Hasil Tembakan dari Samping Badan (Side Shoot)

Jurnal Olahraga

This research was conducted with the aim to study the relationship of arm strength and fighting s... more This research was conducted with the aim to study the relationship of arm strength and fighting strength to the side shot results. This study discusses the presence or absence of a relationship. The method used in this research is descriptive research method with quantitative research. In this study data collection techniques using the test, for arm strength using the ball medicine test, for the strength of the battle using the hand grip test. The population used in this study were 12 members of the STKIP Pasundan Cimahi Student Activity Unit (UKM). Based on the research data, the results of the experimental arm strength and side shoot results are as broad as 0.1643, then the arm muscle strength has a positive relationship to the side shoot results. To challenge the existing power and the side shot result of 0.5534, the strength of hand combat has a positive relationship with the side shot result. And to fight the strength of the arm muscles and the strength of the side shot results...

Research paper thumbnail of Hubungan Power Otot Lengan dan Kekuatan Pergelangan Tangan terhadap Hasil Tembakan dari Samping Badan (Side Shoot)

Jurnal Olahraga, Nov 30, 2017

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