nao ishida - Academia.edu (original) (raw)

Papers by nao ishida

Oral and Maxillofacial Surgery Cases, 2020

Herein, we present a sporadic case of white sponge nevus (WSN) on the cheek mucosa in a 27-year-o... more Herein, we present a sporadic case of white sponge nevus (WSN) on the cheek mucosa in a 27-year-old Japanese man. A definite diagnosis of WSN was obtained using the typical clinical appearance and microscopic features of the lesions. Histopathological and cytological studies should be conducted to differentiate this condition from other oral premalignant white lesions. A molecular mutation analysis revealed a missense mutation in exon 1A of the keratin 4 gene, which is correlated with the development of WSN. Hence, genetic analysis must be performed to obtain an accurate diagnosis in sporadic cases. The temporary regression of the lesion after treatment with oral amoxicillin hydrate (AMPC) 750 mg/day indicates that antibiotics are effective in symptomatic cases.

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2021

Sunitinib is an antiangiogenic drug for the treatment of metastatic renal cell carcinoma (mRCC) a... more Sunitinib is an antiangiogenic drug for the treatment of metastatic renal cell carcinoma (mRCC) and imatinibresistant gastrointestinal stromal tumor (GIST). Toxicities derived from sunitinib, such as altered taste, dry mouth, mucosal sensitivity, oral pain, gingival bleeding, and oral mucositis/stomatitis (OM/S) are widely reported. Additionally, in recent years, osteonecrosis of the jaw (ONJ) is reported to be related with sunitinib. We present here a rare case of ONJ involving mRCC receiving sunitinib monotherapy. A-76-year-old man, treated with sunitinib only, complained about oral pain in April 2019. In the lower mandibular, bone exposure and stomatitis were observed. The patient did not receive bisphosphonates or denosumab. Furthermore, he has not undergone tooth extraction or worn a denture in the left mandibular region. Panoramic radiograph and computed tomography (CT) did not show any obvious radiological changes or bone pathology. During the follow up, healing and bone exposure were repeated with sunitinib dosing and withdrawal. Finally, 3 months later (July 2019), a diameter of 3 × 3 mm necrotic bone was exposed and separated from the left lower mandible. Finally, sunitinib-related jaw osteonecrosis diagnosis was made.

Journal of Cancer, 2019

Centromere protein N (CENP-N), an important member of the centromere protein family, is essential... more Centromere protein N (CENP-N), an important member of the centromere protein family, is essential for kinetochore assembly and chromosome segregation; however, the relevance of CENP-N in cancers remains unknown. The aim of this study was to investigate CENP-N expression and its functional mechanisms in oral squamous cell carcinoma (OSCC). CENP-N expression was up-regulated significantly in vitro and in vivo in OSCCs. Overexpressed CENP-N was closely (p < 0.05) correlated with tumor growth using quantitative reverse transcriptase-polymerase chain reaction, immunoblot analysis, and immunohistochemistry. CENP-N knockdown (shCENP-N) cells showed depressed cellular proliferation by cell-cycle arrest at the G1 phase with up-regulation of p21 Cip1 and p27 Kip1 and down-regulation of cyclin D1, CDK2, and CDK4. Interestingly, we newly discovered that calcitriol (1, 25-dihydroxyvitamin D3) controlled the CENP-N expression level, leading to inhibition of tumor growth similar to shCENP-N cells. These results suggested that CENP-N plays a critical role in determining proliferation of OSCCs and that calcitriol might be a novel therapeutic drug for OSCCs by regulating CENP-N.

Breast Cancer, 2007

Background: Invasive micropapillary carcinoma (IMP) of the breast is uncommon and has only recent... more Background: Invasive micropapillary carcinoma (IMP) of the breast is uncommon and has only recently been characterized. Knowing the cytological appearance of IMP is important to enable early diagnosis by fine needle aspiration cytology (FNAC). We describe a case of IMP diagnosed by preoperative FNAC. Case: A 48-year-old menopausal woman presented in 2003 with a mass in her left breast. Mammagram and ultrasound findings indicated that the tumor was malignant. Cytological examination showed papillary clusters of hyperchromatic cells with irregular and crowded nuclei, but lacking papillary cores. No myoepithelial cells were seen. Based on the cytological findings, invasive micropapillary carcinoma was diagnosed. Microscopic findings showed cancer cells with moderate atypia in abundant micropapillary cancer nests without a fibrovascular core. These cancer nests were morula-like, surrounded by empty, clear spaces lined with delicate strands of fibrocollagenous stroma. The polarity of each cancer nest was reversed, with the secretion border facing fibrocollagenous stroma. These pathological features occupied the invasive part of the primary tumor. Conclusion: The cytologic features of IMP are distinctive and correlate with histology. FNAC of IMP is important role to confirm the diagnosis.

Applied Mechanics and Materials, 2013

Coal gasification plays an important role in hydrogen production technologies. In this study, the... more Coal gasification plays an important role in hydrogen production technologies. In this study, the processes of the syngas passing through the quench chamber were investigated for an entrained flow gasifier. First, a 3D physical model was established for the gaseliquid two-phase flow in a simplified quench chamber. The gaseliquid flow was modeled as turbulent, described by the RNG k-ε model. The interface between the liquid and the gas phases was modeled with the volume of fluid model by tracking interface of the two-phase flow in the quench chamber. Second, the flow behavior of the entrained flow was numerically investigated accompanied by some experiments. The detailed evolution of air bubbles was visually presented, including the formation, the growth and the upward movement. Third, the amount of the entraining water and the residence time for the syngas passing through the quench chamber were analyzed with the consideration of the major influences, including the air velocity, the initial water level, the interval between the ascending tube and the descending tube, and the water velocity from the cooling ring. Numerical results indicate that the major influences all have obvious effect on the flow behavior and the entraining water problem. The tendencies from the computational results were also compared with relevant experimental results, and reasonable agreements could be obtained. Moreover, the residence time for the syngas passing through the quench chamber also varies with different conditions. The present results on the entraining water provide an insight into the competing process of the gaseliquid two-phase flow in the entrained flow gasifier.