islam amer - Academia.edu (original) (raw)

Papers by islam amer

International Journal of Radiation Oncology Biology Physics, 2006

International Journal of Radiation Oncology*Biology*Physics, 2008

The Aurora kinases represent a novel family of serine/threonine kinases critical for cell cycle c... more The Aurora kinases represent a novel family of serine/threonine kinases critical for cell cycle control. As knowledge of the roles that the Aurora kinases play in mitotic events continues to grow, so too does the interest in targeting these kinases therapeutically. In this report, we explore the use of irradiation in combination with an Aurora kinase inhibitor in prostate cancer cell lines. Materials/Methods: We use a commercially available Aurora kinase inhibitor (EMD Biosciences) to inhibit the activity of both Aurora A and Aurora B in human DU-145 and PC-3 prostate cancer models. We also use siRNA to knock down Aurora A and/or Aurora B in prostate cancer cells. Radiosensitivities are compared in Aurora kinase-inhibited cells and in control cells. Results: We demonstrate that use of an inhibitor that targets the activity of both Aurora A and Aurora B can sensitize the prostate cancer cell lines DU-145 and PC-3 to irradiation, as indicated by a decreased cell viability and a reduced clonogenic survival in Aurora kinase inhibitor treated cells compared with control cells. This inhibitor induces cell death through polyploidy resulting in mitotic catastrophe. Using siRNA we also show that the inhibitor phenotype is not duplicated with Aurora A knockdown, but is readily visible in Aurora B knockdown and double knockdown cells. Individual knockdown of Aurora A or Aurora B was found to increase radiation sensitivity in prostate cancer cells. Furthermore, it is by two different mechanisms that cell death occurs, with Aurora A knockdown triggering caspase-mediated apoptosis while Aurora B knockdown inducing caspase-independent mitotic catastrophe. We have also shown that use of an Aurora kinase inhibitor with irradiation can significantly reduce tumor formation in athymic nu/nu mice. Conclusions: Our data suggests that the Aurora kinases are potential therapeutic targets for radiation sensitization in prostate cancer.

Arab journal of urology, 2016

Snodgrass urethroplasty remains the preferred technique in primary distal hypospadias but develop... more Snodgrass urethroplasty remains the preferred technique in primary distal hypospadias but development of meatal stenosis often limits distal extension of the midline incision of the urethral plate (MIUP), which remains a limiting factor in reconstructing an apical neomeatus (NM). We here-in assess the cosmetic and functional outcome with distal extension of the MIUP in grafted tubularised incised-plate urethroplasty (G-TIP) repair. This prospective study included the surgical experience of 263 cases of primary hypospadias operated upon between 2012 and 2015. The G-TIP technique included standard steps of Snodgrass urethroplasty, including degloving and harvesting of glans wings, followed by MIUP that was extended distally beyond the margins of the urethral plate (UP) into the glans. The incised bed was grafted with a free preputial skin graft and fixed to the bed with polydioxanone 7-0 suture. The UP was tubularised and the suture line reinforced with a Dartos flap. The urethral cat...

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: One of the most frequent problems after thyroidectomies is an injury to the recurrent... more Background: One of the most frequent problems after thyroidectomies is an injury to the recurrent laryngeal nerve (RLN) that will lead to vocal cord palsy. This study aimed to assessed the outcomes of intraoperative repair of the recurrent laryngeal nerve. Patients and Methods: In the period of the study we retrived the data of patients who had been underwent thyroid surgery and they sufferd from RLN injery or scarification with immediate intraoperative nerve repair. This retrospective study has been conducted between 2012 and 2020, 813 patients underwent thyroid surgery, 27 (3.3%) of them diagnosed with RLN injury and divided into 2 groups: group A (n = 9), with intraoperative proof of iatrogenic injury of the RLN, and group B (n = 18), in which malignant invasion was diagnosed intraoperative or recognized during thyroidectomy with a therapeutic transection. Immediate microsurgical reconstruction of the RLN was performed. The evaluation was performed at 3, 6, and 9 months post-surgical repair utilizing aspiration and voice improvement as subjective tests, fiberoptic direct laryngoscopy as an objective test. Results: Aspiration significantly improved in both groups (p < 0.05). Voice quality improved in both groups but better in group A (p = 0.02). Conclusion: Immediate RLN reconstruction during thyroidectomies gave excellent postoperative voice quality especially after thyroidectomies in benign thyroid lesions.

Journal of Maxillofacial and Oral Surgery

The Egyptian Journal of Surgery, 2021

Context Appendicular mass is one of the most common surgical problems and constitutes ∼2–6% of ca... more Context Appendicular mass is one of the most common surgical problems and constitutes ∼2–6% of cases presented with acute appendicitis. Management is still controversial, with three different approaches: emergency surgery, conservative management followed by interval surgery, and totally conservative management without interval surgery. Recently, laparoscopic appendectomy has become the preferred method in the management of acute appendicitis; however, its role in the management of complicated appendicitis is still debatable. Aims The current study aimed to assess the outcome, benefit, and feasibility of laparoscopic surgery versus conservative approach for management of appendicular mass. Patients and methods This double-blinded randomized controlled trial study included 60 patients with appendicular mass, recruited from the emergency unit at Sohag University Hospital during the period from January 2019 to February 2021. They were randomly assigned into two groups: group A patients...

Current Opinion in Anaesthesiology, 2008

of surgery and a 6% 30-day mortality rate. Many patients with complications had more than one com... more of surgery and a 6% 30-day mortality rate. Many patients with complications had more than one complication leading to an overall rate of 31 complications per 100 patients.

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: The most commonly observed emergency, contributing to high morbidity and mortality is... more Background: The most commonly observed emergency, contributing to high morbidity and mortality is pediatric trauma. The purpose of this research is to analysis the incidence and pattern of maxillofacial trauma in children in Upper Egypt and to assess its management regarding to the successful healing with the least complications.

The Egyptian Journal of Surgery, 2021

Context Choledochotomy followed by T-tube has long been a standard surgical treatment for choledo... more Context Choledochotomy followed by T-tube has long been a standard surgical treatment for choledocholithiasis. Till now, it is the first choice in many hospitals where minimal invasive procedures are not feasible, although it has many complications. To avoid these complications, primary closure of the common bile duct (CBD) after exploration is performed. Aims This study aimed to assess the safety of primary closure of CBD, which would help for its implementation on a wider scale. Settings and design This randomized controlled trial was conducted in outpatient clinic of the Surgical Department, Faculty of Medicine, Sohag University Patients and methods A total of 50 patients were recruited from the outpatient clinic at Sohag University Hospital during the period from July 2019 to December 2020. They were randomly assigned into two groups: group A patients underwent CBD exploration with primary closure, and group B patients underwent CBD exploration with insertion of T-tube. Statisti...

Journal of Surgery, 2021

Background: The aim was to assess the efficacy and safety of Desarda’s no-mesh repair in comparis... more Background: The aim was to assess the efficacy and safety of Desarda’s no-mesh repair in comparison to Lichtenstein’s tension -free mesh repair in treatment of primary inguinal hernia. Methods: a prospective study of 80 patients suffering from unilateral primary inguinal hernia who underwent elective operation for hernia repair. The patients were of both males and females their age ranged from 20 - 60 years. They were divided into two groups (A and B). Group A: 40 patients were subjected to Desarda’s no mesh repair. Group B: 40 patients were subjected to Lichtenstein’s tension free mesh repair. The data were collected within one year including sociodemograghic data, general and local examination, co-morbidities, type and duration of inguinal hernia, type of operation, intra- and post -operative parameters, hospital stay and recurrence. Results: Demographic parameters, general examination, duration, type of hernia and co-morbidities in the two intervention arms were similar and shows...

The Egyptian Journal of Hospital Medicine, 2021

Background: For both children and their caregivers, postoperative pain is an irritating experienc... more Background: For both children and their caregivers, postoperative pain is an irritating experience. Several approaches have been used to treat postoperative pain in pediatric patients improving sleep quality, and extending sedation time. Objectives: This work aimed to compare the postoperative analgesic effect and any complications of addition of one of these drugs nalbuphine versus fentanyl versus dexamethasone to levobupivacaine in caudal block (CB) in pediatric patients undergoing hypospadias repair. Patient and Methods: 90 ASA status I and II patients aged 2 to 9 years underwent hypospadias repair were prospectively involved in this study. Patients were randomized into three equal groups (Group N, Group F and Group D). Result: There was no statistically significant difference between three groups as regards systolic blood pressure (SBP) except after 60 and 70 minutes after caudal block as there was a significant difference as SBP decreased in the group (N) more than in both grou...

Introduction The tongue is the most important organ involved in voice, bolus formation, and swall... more Introduction The tongue is the most important organ involved in voice, bolus formation, and swallowing. As the tongue is a highly specialized tissue, restoring of the tongue is one of the major challenges facing oncological reconstructive surgeons. Patient and methods Since 2013, we have reconstructed 60 resections of the tongue using a free flap [radial forearm, anterolateral thigh (ALT)]. The complete mobile tongue resection (total and near-total tongue resection) represented a small group of 10 patients. We checked the records of the seven patients who had been reconstructed with an ALT flap with a cathedral design. The seven patients (five males and two females) underwent a complete mobile tongue reconstruction with an ALT free flap with a cathedral design. Result All flaps survived with no need for flap revision. All flaps had a natural shape and volume of the tongue, even after radiotherapy, allowing adequate dental and palatal contact. Conclusion This kind of shaping of the A...

La transferencia de tejido libre microvascular se ha convertido en la mejor modalidad reconstruct... more La transferencia de tejido libre microvascular se ha convertido en la mejor modalidad reconstructiva de eleccion para muchos pacientes despues de cirugia de ablacion de cancer de cabeza y cuello. La evaluacion moderna del resultado despues de estos procedimientos quirurgicos incluye ahora la evaluacion de la CDV. Nuestra serie es un estudio prospectivo que ha analizado la CDV despues de cirugia reconstructiva de cabeza y cuello en Espana y en Egipto utilizando UW-QOL. Los cirujanos oncologicos deben pensar en todas las opciones disponibles de la escala reconstructiva para el manejo de los defectos del cancer, ya que a menudo es posible llevar a cabo una reseccion quirurgica adecuadamente segura y proporcionar una buena funcion usando colgajos libres. microvascular libre-flaps ofrecen un metodo razonable para la reconstruccion de grandes oral y cabeza y cuello defectos. Este trabajo de investigacion es primer trabajo de investigacion en Espana medido QOL despues de cirugia reconstruc...

Background: Thyroidectomy is the most common endocrine surgical procedure, and many challenges ar... more Background: Thyroidectomy is the most common endocrine surgical procedure, and many challenges are encountered during the preoperative, intraoperative, and postoperative periods. After thyroidectomy, bilateral superficial cervical block is the most successful option reducing postoperative pain, analgesic needs and post-operative complications such as vomiting. Objective: Our study aimed to evaluate the analgesic effect, onset time of sensory block, duration time, postoperative visual analogue score (VAS) and complications of adding dexmedetomidine versus dexamethasone to levobupivacaine for cervical plexus block. Patients and Methods: A prospective-randomized clinical trial study that was conducted at Sohag University between April 2018 and March 2020. The study included fifty patients with (ASA) Class I or II, aged 30 to 60 years were scheduled for euthyroid surgeries (including thyroid adenoma, Hashimoto's goiter, and nodosity thyroiditis) Results: The addition of dexmedetomid...

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: Many non-surgical and surgical procedures have been used to treat patients with chron... more Background: Many non-surgical and surgical procedures have been used to treat patients with chronic recurrent temporomandibular joint dislocation (CRTMJD). Autologous blood injection (ABI) represents a promising approach. Aim of the work: To evaluate the effectiveness and safety of ABI in the treatment of patients with CRTMJD. Patients and Methods: This prospective comparative study involved patients with CRTMJD who were treated by arthrocentesis and ABI with those treated with arthrocentesis alone between January 2017 and January 2020. Analysis of clinical presentation, diagnosis, close observation of patients has been carried out. Results: 140 patients were included in this study, 87 were males and 53 were females. Their ages ranged between 16 to 82 years. They were randomly divided into two groups of 70 each. Group-1 received arthrocentesis followed by ABI and Group-2 received arthrocentesis alone. In group-1, only one ABI was required and was successful in 63 patients and reinjection was required in 7 patients. None of the patients need surgery due to re-injection failure. Conclusion: Positive results on this modality were observed, some questions are still noted about the effect of blood injection on the articular cartilage and on the development of fibrous or bony ankylosis.

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: The thyroid gland is one of the highly vascular tissues in the body. Hemostasis is on... more Background: The thyroid gland is one of the highly vascular tissues in the body. Hemostasis is one of the important and essential components of the procedure. Nowadays with the widespread use of energy instruments like ultrasonic coagulation (Harmonic Scalpel, Ethicon) and bipolar control (LigaSure, Valleylab) or cutting and hemostasis which integrates new approaches to vessel ligation and division without increase the postoperative complications. In a prospective comparative analysis of open complete thyroidectomy, this work aimed to examine the effect of modern suture ligation procedures using the Harmonic ® process in comparison with conventional suture ligation.

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: The aim of this research was to assess the pattern of presentation and outcome of Cys... more Background: The aim of this research was to assess the pattern of presentation and outcome of Cystic neck swelling in pediatric patients following surgery. Patients and Methods: This study included 126 patients (69 males and 57 females) their age ranged from 9 days to 16 years with cystic neck swellings and had been treated by Excision in surgical procedure in the Maxillofacial/Head and Neck Surgical Unit, Pediatric Surgery Unit at Sohag University Hospitals, in the period from March 2014 to March 2019. Analysis of the clinical presentation, the type of neck swelling was done. All patients were eligible for this study. Results: Total of 126 cases were included in this study, Majority of cases present as midline neck swelling 90 (71.4%) and 31 (24.6%) as lateral neck swelling and 5 (4%) as submandibular swelling, and as regard diagnosis thyroglossal cyst were 82 (65.1%) and 19 (15.1%) were cystic hygroma and 16 (12.7%) were branchial cyst (10 left and 5 right and 1 bilateral) and 8 (6.3%) were dermoid cyst, and one case (0.8%) were cystic teratoma Conclusion: Surgical resection is the best treatment option not only for esthetic purposes but also to get rid of the recurrent infection and risk of fistula formation and possible pressure on neck structures.

Sohag Medical Journal

Background: Trauma in children is the most frequent injury seen in the Emergency Department leadi... more Background: Trauma in children is the most frequent injury seen in the Emergency Department leading to morbidity and mortality. Maxillofacial fractures occur in a significant proportion worldwide and the incidence of maxillofacial pediatric trauma is less compared to adults. However, they may lead to serious complications. The aim of this study is to study the incidence and pattern of pediatric maxillofacial trauma in Upper Egypt and to determine the management of this trauma as regard as bone and soft tissue injuries. Methods:This study was a prospective study which was conducted at

International Journal of Radiation Oncology Biology Physics, 2006

International Journal of Radiation Oncology*Biology*Physics, 2008

The Aurora kinases represent a novel family of serine/threonine kinases critical for cell cycle c... more The Aurora kinases represent a novel family of serine/threonine kinases critical for cell cycle control. As knowledge of the roles that the Aurora kinases play in mitotic events continues to grow, so too does the interest in targeting these kinases therapeutically. In this report, we explore the use of irradiation in combination with an Aurora kinase inhibitor in prostate cancer cell lines. Materials/Methods: We use a commercially available Aurora kinase inhibitor (EMD Biosciences) to inhibit the activity of both Aurora A and Aurora B in human DU-145 and PC-3 prostate cancer models. We also use siRNA to knock down Aurora A and/or Aurora B in prostate cancer cells. Radiosensitivities are compared in Aurora kinase-inhibited cells and in control cells. Results: We demonstrate that use of an inhibitor that targets the activity of both Aurora A and Aurora B can sensitize the prostate cancer cell lines DU-145 and PC-3 to irradiation, as indicated by a decreased cell viability and a reduced clonogenic survival in Aurora kinase inhibitor treated cells compared with control cells. This inhibitor induces cell death through polyploidy resulting in mitotic catastrophe. Using siRNA we also show that the inhibitor phenotype is not duplicated with Aurora A knockdown, but is readily visible in Aurora B knockdown and double knockdown cells. Individual knockdown of Aurora A or Aurora B was found to increase radiation sensitivity in prostate cancer cells. Furthermore, it is by two different mechanisms that cell death occurs, with Aurora A knockdown triggering caspase-mediated apoptosis while Aurora B knockdown inducing caspase-independent mitotic catastrophe. We have also shown that use of an Aurora kinase inhibitor with irradiation can significantly reduce tumor formation in athymic nu/nu mice. Conclusions: Our data suggests that the Aurora kinases are potential therapeutic targets for radiation sensitization in prostate cancer.

Arab journal of urology, 2016

Snodgrass urethroplasty remains the preferred technique in primary distal hypospadias but develop... more Snodgrass urethroplasty remains the preferred technique in primary distal hypospadias but development of meatal stenosis often limits distal extension of the midline incision of the urethral plate (MIUP), which remains a limiting factor in reconstructing an apical neomeatus (NM). We here-in assess the cosmetic and functional outcome with distal extension of the MIUP in grafted tubularised incised-plate urethroplasty (G-TIP) repair. This prospective study included the surgical experience of 263 cases of primary hypospadias operated upon between 2012 and 2015. The G-TIP technique included standard steps of Snodgrass urethroplasty, including degloving and harvesting of glans wings, followed by MIUP that was extended distally beyond the margins of the urethral plate (UP) into the glans. The incised bed was grafted with a free preputial skin graft and fixed to the bed with polydioxanone 7-0 suture. The UP was tubularised and the suture line reinforced with a Dartos flap. The urethral cat...

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: One of the most frequent problems after thyroidectomies is an injury to the recurrent... more Background: One of the most frequent problems after thyroidectomies is an injury to the recurrent laryngeal nerve (RLN) that will lead to vocal cord palsy. This study aimed to assessed the outcomes of intraoperative repair of the recurrent laryngeal nerve. Patients and Methods: In the period of the study we retrived the data of patients who had been underwent thyroid surgery and they sufferd from RLN injery or scarification with immediate intraoperative nerve repair. This retrospective study has been conducted between 2012 and 2020, 813 patients underwent thyroid surgery, 27 (3.3%) of them diagnosed with RLN injury and divided into 2 groups: group A (n = 9), with intraoperative proof of iatrogenic injury of the RLN, and group B (n = 18), in which malignant invasion was diagnosed intraoperative or recognized during thyroidectomy with a therapeutic transection. Immediate microsurgical reconstruction of the RLN was performed. The evaluation was performed at 3, 6, and 9 months post-surgical repair utilizing aspiration and voice improvement as subjective tests, fiberoptic direct laryngoscopy as an objective test. Results: Aspiration significantly improved in both groups (p < 0.05). Voice quality improved in both groups but better in group A (p = 0.02). Conclusion: Immediate RLN reconstruction during thyroidectomies gave excellent postoperative voice quality especially after thyroidectomies in benign thyroid lesions.

Journal of Maxillofacial and Oral Surgery

The Egyptian Journal of Surgery, 2021

Context Appendicular mass is one of the most common surgical problems and constitutes ∼2–6% of ca... more Context Appendicular mass is one of the most common surgical problems and constitutes ∼2–6% of cases presented with acute appendicitis. Management is still controversial, with three different approaches: emergency surgery, conservative management followed by interval surgery, and totally conservative management without interval surgery. Recently, laparoscopic appendectomy has become the preferred method in the management of acute appendicitis; however, its role in the management of complicated appendicitis is still debatable. Aims The current study aimed to assess the outcome, benefit, and feasibility of laparoscopic surgery versus conservative approach for management of appendicular mass. Patients and methods This double-blinded randomized controlled trial study included 60 patients with appendicular mass, recruited from the emergency unit at Sohag University Hospital during the period from January 2019 to February 2021. They were randomly assigned into two groups: group A patients...

Current Opinion in Anaesthesiology, 2008

of surgery and a 6% 30-day mortality rate. Many patients with complications had more than one com... more of surgery and a 6% 30-day mortality rate. Many patients with complications had more than one complication leading to an overall rate of 31 complications per 100 patients.

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: The most commonly observed emergency, contributing to high morbidity and mortality is... more Background: The most commonly observed emergency, contributing to high morbidity and mortality is pediatric trauma. The purpose of this research is to analysis the incidence and pattern of maxillofacial trauma in children in Upper Egypt and to assess its management regarding to the successful healing with the least complications.

The Egyptian Journal of Surgery, 2021

Context Choledochotomy followed by T-tube has long been a standard surgical treatment for choledo... more Context Choledochotomy followed by T-tube has long been a standard surgical treatment for choledocholithiasis. Till now, it is the first choice in many hospitals where minimal invasive procedures are not feasible, although it has many complications. To avoid these complications, primary closure of the common bile duct (CBD) after exploration is performed. Aims This study aimed to assess the safety of primary closure of CBD, which would help for its implementation on a wider scale. Settings and design This randomized controlled trial was conducted in outpatient clinic of the Surgical Department, Faculty of Medicine, Sohag University Patients and methods A total of 50 patients were recruited from the outpatient clinic at Sohag University Hospital during the period from July 2019 to December 2020. They were randomly assigned into two groups: group A patients underwent CBD exploration with primary closure, and group B patients underwent CBD exploration with insertion of T-tube. Statisti...

Journal of Surgery, 2021

Background: The aim was to assess the efficacy and safety of Desarda’s no-mesh repair in comparis... more Background: The aim was to assess the efficacy and safety of Desarda’s no-mesh repair in comparison to Lichtenstein’s tension -free mesh repair in treatment of primary inguinal hernia. Methods: a prospective study of 80 patients suffering from unilateral primary inguinal hernia who underwent elective operation for hernia repair. The patients were of both males and females their age ranged from 20 - 60 years. They were divided into two groups (A and B). Group A: 40 patients were subjected to Desarda’s no mesh repair. Group B: 40 patients were subjected to Lichtenstein’s tension free mesh repair. The data were collected within one year including sociodemograghic data, general and local examination, co-morbidities, type and duration of inguinal hernia, type of operation, intra- and post -operative parameters, hospital stay and recurrence. Results: Demographic parameters, general examination, duration, type of hernia and co-morbidities in the two intervention arms were similar and shows...

The Egyptian Journal of Hospital Medicine, 2021

Background: For both children and their caregivers, postoperative pain is an irritating experienc... more Background: For both children and their caregivers, postoperative pain is an irritating experience. Several approaches have been used to treat postoperative pain in pediatric patients improving sleep quality, and extending sedation time. Objectives: This work aimed to compare the postoperative analgesic effect and any complications of addition of one of these drugs nalbuphine versus fentanyl versus dexamethasone to levobupivacaine in caudal block (CB) in pediatric patients undergoing hypospadias repair. Patient and Methods: 90 ASA status I and II patients aged 2 to 9 years underwent hypospadias repair were prospectively involved in this study. Patients were randomized into three equal groups (Group N, Group F and Group D). Result: There was no statistically significant difference between three groups as regards systolic blood pressure (SBP) except after 60 and 70 minutes after caudal block as there was a significant difference as SBP decreased in the group (N) more than in both grou...

Introduction The tongue is the most important organ involved in voice, bolus formation, and swall... more Introduction The tongue is the most important organ involved in voice, bolus formation, and swallowing. As the tongue is a highly specialized tissue, restoring of the tongue is one of the major challenges facing oncological reconstructive surgeons. Patient and methods Since 2013, we have reconstructed 60 resections of the tongue using a free flap [radial forearm, anterolateral thigh (ALT)]. The complete mobile tongue resection (total and near-total tongue resection) represented a small group of 10 patients. We checked the records of the seven patients who had been reconstructed with an ALT flap with a cathedral design. The seven patients (five males and two females) underwent a complete mobile tongue reconstruction with an ALT free flap with a cathedral design. Result All flaps survived with no need for flap revision. All flaps had a natural shape and volume of the tongue, even after radiotherapy, allowing adequate dental and palatal contact. Conclusion This kind of shaping of the A...

La transferencia de tejido libre microvascular se ha convertido en la mejor modalidad reconstruct... more La transferencia de tejido libre microvascular se ha convertido en la mejor modalidad reconstructiva de eleccion para muchos pacientes despues de cirugia de ablacion de cancer de cabeza y cuello. La evaluacion moderna del resultado despues de estos procedimientos quirurgicos incluye ahora la evaluacion de la CDV. Nuestra serie es un estudio prospectivo que ha analizado la CDV despues de cirugia reconstructiva de cabeza y cuello en Espana y en Egipto utilizando UW-QOL. Los cirujanos oncologicos deben pensar en todas las opciones disponibles de la escala reconstructiva para el manejo de los defectos del cancer, ya que a menudo es posible llevar a cabo una reseccion quirurgica adecuadamente segura y proporcionar una buena funcion usando colgajos libres. microvascular libre-flaps ofrecen un metodo razonable para la reconstruccion de grandes oral y cabeza y cuello defectos. Este trabajo de investigacion es primer trabajo de investigacion en Espana medido QOL despues de cirugia reconstruc...

Background: Thyroidectomy is the most common endocrine surgical procedure, and many challenges ar... more Background: Thyroidectomy is the most common endocrine surgical procedure, and many challenges are encountered during the preoperative, intraoperative, and postoperative periods. After thyroidectomy, bilateral superficial cervical block is the most successful option reducing postoperative pain, analgesic needs and post-operative complications such as vomiting. Objective: Our study aimed to evaluate the analgesic effect, onset time of sensory block, duration time, postoperative visual analogue score (VAS) and complications of adding dexmedetomidine versus dexamethasone to levobupivacaine for cervical plexus block. Patients and Methods: A prospective-randomized clinical trial study that was conducted at Sohag University between April 2018 and March 2020. The study included fifty patients with (ASA) Class I or II, aged 30 to 60 years were scheduled for euthyroid surgeries (including thyroid adenoma, Hashimoto's goiter, and nodosity thyroiditis) Results: The addition of dexmedetomid...

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: Many non-surgical and surgical procedures have been used to treat patients with chron... more Background: Many non-surgical and surgical procedures have been used to treat patients with chronic recurrent temporomandibular joint dislocation (CRTMJD). Autologous blood injection (ABI) represents a promising approach. Aim of the work: To evaluate the effectiveness and safety of ABI in the treatment of patients with CRTMJD. Patients and Methods: This prospective comparative study involved patients with CRTMJD who were treated by arthrocentesis and ABI with those treated with arthrocentesis alone between January 2017 and January 2020. Analysis of clinical presentation, diagnosis, close observation of patients has been carried out. Results: 140 patients were included in this study, 87 were males and 53 were females. Their ages ranged between 16 to 82 years. They were randomly divided into two groups of 70 each. Group-1 received arthrocentesis followed by ABI and Group-2 received arthrocentesis alone. In group-1, only one ABI was required and was successful in 63 patients and reinjection was required in 7 patients. None of the patients need surgery due to re-injection failure. Conclusion: Positive results on this modality were observed, some questions are still noted about the effect of blood injection on the articular cartilage and on the development of fibrous or bony ankylosis.

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: The thyroid gland is one of the highly vascular tissues in the body. Hemostasis is on... more Background: The thyroid gland is one of the highly vascular tissues in the body. Hemostasis is one of the important and essential components of the procedure. Nowadays with the widespread use of energy instruments like ultrasonic coagulation (Harmonic Scalpel, Ethicon) and bipolar control (LigaSure, Valleylab) or cutting and hemostasis which integrates new approaches to vessel ligation and division without increase the postoperative complications. In a prospective comparative analysis of open complete thyroidectomy, this work aimed to examine the effect of modern suture ligation procedures using the Harmonic ® process in comparison with conventional suture ligation.

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

Background: The aim of this research was to assess the pattern of presentation and outcome of Cys... more Background: The aim of this research was to assess the pattern of presentation and outcome of Cystic neck swelling in pediatric patients following surgery. Patients and Methods: This study included 126 patients (69 males and 57 females) their age ranged from 9 days to 16 years with cystic neck swellings and had been treated by Excision in surgical procedure in the Maxillofacial/Head and Neck Surgical Unit, Pediatric Surgery Unit at Sohag University Hospitals, in the period from March 2014 to March 2019. Analysis of the clinical presentation, the type of neck swelling was done. All patients were eligible for this study. Results: Total of 126 cases were included in this study, Majority of cases present as midline neck swelling 90 (71.4%) and 31 (24.6%) as lateral neck swelling and 5 (4%) as submandibular swelling, and as regard diagnosis thyroglossal cyst were 82 (65.1%) and 19 (15.1%) were cystic hygroma and 16 (12.7%) were branchial cyst (10 left and 5 right and 1 bilateral) and 8 (6.3%) were dermoid cyst, and one case (0.8%) were cystic teratoma Conclusion: Surgical resection is the best treatment option not only for esthetic purposes but also to get rid of the recurrent infection and risk of fistula formation and possible pressure on neck structures.

Sohag Medical Journal

Background: Trauma in children is the most frequent injury seen in the Emergency Department leadi... more Background: Trauma in children is the most frequent injury seen in the Emergency Department leading to morbidity and mortality. Maxillofacial fractures occur in a significant proportion worldwide and the incidence of maxillofacial pediatric trauma is less compared to adults. However, they may lead to serious complications. The aim of this study is to study the incidence and pattern of pediatric maxillofacial trauma in Upper Egypt and to determine the management of this trauma as regard as bone and soft tissue injuries. Methods:This study was a prospective study which was conducted at