janhavi mishra - Academia.edu (original) (raw)

Papers by janhavi mishra

International Journal for Research in Applied Science and Engineering Technology

: A simple and accurate simultaneous method was developed for tetracycline hydrochloride (TH) and... more : A simple and accurate simultaneous method was developed for tetracycline hydrochloride (TH) and clotrimazole with a mixture of solvents. the combination is used to Validate the developed UV-spectrophotometric method as per ICH guidelines, The concentration of Tetracycline hydrochloride & clotrimazole in the sample solution was determined by solving the respective simultaneous equations generated by using absorptivity coefficients and absorbance values of TH & Clotrimazole at these wavelengths 361 nm and 259 nm respectively. and both satisfy Beer's law in concentration ranges of 4-20 µg/ml for TH and 10- 30 µg/ml for Clotrimazole. The method was effectively used to estimate TH and clotrimazole in Buccal film without the interference of common excipients.

International Journal of Nanotechnology & Nanomedicine, 2023

Background: In this review Novel strategies for site-specific delivery of active pharmaceutical i... more Background: In this review Novel strategies for site-specific delivery of active pharmaceutical ingredients to different types of liver cells like Hepatic stellate cells [HSCs], active Kupffer cells, sinusoidal endothelial cells etc. have been discussed. The most prevalent liver ailments are hepatitis, alcoholic or non-alcoholic liver disease, hepatocellular carcinoma, hepatic venous-occlusive disease, liver fibrosis, and cirrhosis. Method: Literature was searched through various online resources for the recent advances in liver-targeted site-specific delivery using various approaches. We focused on the use of novel targeted delivery to improve Drug efficacy, dose reduction and Rapid onset of action. Results: Novel medicines aim to minimize unfavorable side effects by either sustaining drug action at a set rate or delivering the drug at a suitable time in the body. Therapeutic nanocarriers and their surface modification with particular ligands including carbohydrates, peptides, proteins, and antibodies are two main strategies that have been suggested to optimize the transport of various medications to the liver and hepatocytes. It subsequently lowers the toxicity and prolongs the drug's time in the systemic circulation. Conclusion: The current review provides information on various liver illnesses as well as the targeting techniques used to concern hepatic anatomy and disease etiologies.

SPAST Abstracts, Sep 16, 2021

Strategies to Enhance the Stability of Herbal Active, 2022

The market for natural products has experienced rapid expansion in recent years. It leads to the ... more The market for natural products has experienced rapid expansion in recent years. It leads to the creation of numerous proprietary herbal products, the majority of which are composed of multiple ingredients. The development of herbal drug therapies has led to the discovery that many of the drug's components may interact with one another, which has led to severe concerns regarding the stability of such formulations, a crucial topic in the study of phytochemistry and natural medicines. National pharmacovigilance centers (or analogous institutions) will need to have specialized technical knowledge in order to manage herbal medications, in particular, to analyze the reasons of adverse occurrences. This will include qualified professionals in pertinent technical fields and resources to analyze the products in question, for which there is frequently little data and limited access to trustworthy information sources. Additionally, an effort has been made to gather a profile of herbal substances that improve drug bioavailability together with their mechanism of action (where known) and research on this enhancement.

Acta scientific pharmaceutical sciences, Dec 1, 2022

The market for natural products has experienced rapid expansion in recent years. It leads to the ... more The market for natural products has experienced rapid expansion in recent years. It leads to the creation of numerous proprietary herbal products, the majority of which are composed of multiple ingredients. The development of herbal drug therapies has led to the discovery that many of the drug's components may interact with one another, which has led to severe concerns regarding the stability of such formulations, a crucial topic in the study of phytochemistry and natural medicines. National pharmacovigilance centers (or analogous institutions) will need to have specialized technical knowledge in order to manage herbal medications, in particular, to analyze the reasons of adverse occurrences. This will include qualified professionals in pertinent technical fields and resources to analyze the products in question, for which there is frequently little data and limited access to trustworthy information sources. Additionally, an effort has been made to gather a profile of herbal substances that improve drug bioavailability together with their mechanism of action (where known) and research on this enhancement.

International Journal for Research in Applied Science and Engineering Technology

: A simple and accurate simultaneous method was developed for tetracycline hydrochloride (TH) and... more : A simple and accurate simultaneous method was developed for tetracycline hydrochloride (TH) and clotrimazole with a mixture of solvents. the combination is used to Validate the developed UV-spectrophotometric method as per ICH guidelines, The concentration of Tetracycline hydrochloride & clotrimazole in the sample solution was determined by solving the respective simultaneous equations generated by using absorptivity coefficients and absorbance values of TH & Clotrimazole at these wavelengths 361 nm and 259 nm respectively. and both satisfy Beer's law in concentration ranges of 4-20 µg/ml for TH and 10- 30 µg/ml for Clotrimazole. The method was effectively used to estimate TH and clotrimazole in Buccal film without the interference of common excipients.

International Journal of Nanotechnology & Nanomedicine, 2023

Background: In this review Novel strategies for site-specific delivery of active pharmaceutical i... more Background: In this review Novel strategies for site-specific delivery of active pharmaceutical ingredients to different types of liver cells like Hepatic stellate cells [HSCs], active Kupffer cells, sinusoidal endothelial cells etc. have been discussed. The most prevalent liver ailments are hepatitis, alcoholic or non-alcoholic liver disease, hepatocellular carcinoma, hepatic venous-occlusive disease, liver fibrosis, and cirrhosis. Method: Literature was searched through various online resources for the recent advances in liver-targeted site-specific delivery using various approaches. We focused on the use of novel targeted delivery to improve Drug efficacy, dose reduction and Rapid onset of action. Results: Novel medicines aim to minimize unfavorable side effects by either sustaining drug action at a set rate or delivering the drug at a suitable time in the body. Therapeutic nanocarriers and their surface modification with particular ligands including carbohydrates, peptides, proteins, and antibodies are two main strategies that have been suggested to optimize the transport of various medications to the liver and hepatocytes. It subsequently lowers the toxicity and prolongs the drug's time in the systemic circulation. Conclusion: The current review provides information on various liver illnesses as well as the targeting techniques used to concern hepatic anatomy and disease etiologies.

SPAST Abstracts, Sep 16, 2021

Strategies to Enhance the Stability of Herbal Active, 2022

The market for natural products has experienced rapid expansion in recent years. It leads to the ... more The market for natural products has experienced rapid expansion in recent years. It leads to the creation of numerous proprietary herbal products, the majority of which are composed of multiple ingredients. The development of herbal drug therapies has led to the discovery that many of the drug's components may interact with one another, which has led to severe concerns regarding the stability of such formulations, a crucial topic in the study of phytochemistry and natural medicines. National pharmacovigilance centers (or analogous institutions) will need to have specialized technical knowledge in order to manage herbal medications, in particular, to analyze the reasons of adverse occurrences. This will include qualified professionals in pertinent technical fields and resources to analyze the products in question, for which there is frequently little data and limited access to trustworthy information sources. Additionally, an effort has been made to gather a profile of herbal substances that improve drug bioavailability together with their mechanism of action (where known) and research on this enhancement.

Acta scientific pharmaceutical sciences, Dec 1, 2022

The market for natural products has experienced rapid expansion in recent years. It leads to the ... more The market for natural products has experienced rapid expansion in recent years. It leads to the creation of numerous proprietary herbal products, the majority of which are composed of multiple ingredients. The development of herbal drug therapies has led to the discovery that many of the drug's components may interact with one another, which has led to severe concerns regarding the stability of such formulations, a crucial topic in the study of phytochemistry and natural medicines. National pharmacovigilance centers (or analogous institutions) will need to have specialized technical knowledge in order to manage herbal medications, in particular, to analyze the reasons of adverse occurrences. This will include qualified professionals in pertinent technical fields and resources to analyze the products in question, for which there is frequently little data and limited access to trustworthy information sources. Additionally, an effort has been made to gather a profile of herbal substances that improve drug bioavailability together with their mechanism of action (where known) and research on this enhancement.