jayani kariyawasam - Academia.edu (original) (raw)

Uploads

Papers by jayani kariyawasam

Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals global... more Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals globally and caused over 5.3 million deaths. With an effective vaccine, disease and infection could be prevented, whereas with antivirals and monoclonal antibodies, disease progression could be mitigated. In recent months, there has been much interest in evaluating the use of oral antivirals, in those having mild disease and associated risk factors for disease progression (such as multiple comorbidities),in view of preventing severe COVID-19. Our review discusses the known properties and identified effectiveness of three oral antiviral drugs (Molnupiravir, Paxlovid and AT-527) for COVID-19 (as at end of December 2021) and explores their potential role in mitigating the ill effects of the ongoing COVID-19 pandemic.

Asian Journal of Internal Medicine, 2022

Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals global... more Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals globally and caused over 5.3 million deaths. With an effective vaccine, disease and infection could be prevented, whereas with antivirals and monoclonal antibodies, disease progression could be mitigated. In recent months, there has been much interest in evaluating the use of oral antivirals, in those having mild disease and associated risk factors for disease progression (such as multiple comorbidities), in view of preventing severe COVID-19. Our review discusses the known properties and identified effectiveness of three oral antiviral drugs (Molnupiravir, Paxlovid and AT-527) for COVID-19 (as at end of December 2021) and explores their potential role in mitigating the ill effects of the on-going COVID-19 pandemic.

Gut, 2020

Figure 1 Forest plot for the pooled prevalence of liver injury in patients with COVID-19. 2-10 Ev... more Figure 1 Forest plot for the pooled prevalence of liver injury in patients with COVID-19. 2-10 Ev/ Trt, events/treated. Figure 2 Forest plot for the prognosis of patients with COVID-19 with liver injury. (A) Severity. 2 4 5 9 (B) Mortality. 6-9

1. Eirin A, Irazabal MV, Gertz MA et al. Clinical features of patients with immunoglobulin light ... more 1. Eirin A, Irazabal MV, Gertz MA et al. Clinical features of patients with immunoglobulin light chain amyloidosis (AL) with vascular-limited deposition in the kidney. Nephrol. Dial. Transplant. 2012; 27: 1097–101. 2. Murakami Y, Hattori S, Sugiyama F, Yoshikawa K, Sugiura T, Matsushima H. A case of primary (AL) amyloidosis with predominantly vascular amyloid deposition in the kidney. CEN Case Rep. 2014. doi: 10.1007/s13730-014-0157-7

COVID-19, a respiratory viral infection, has affected more than 10 million individuals worldwide.... more COVID-19, a respiratory viral infection, has affected more than 10 million individuals worldwide. Common symptoms include fever, dry cough, fatigue and shortness of breath. Some patients show neurological manifestations such as headache, dizziness, cerebrovascular disease, peripheral nerve and muscle symptoms and smell and taste impairment. In previous studies, SARS-CoV-1 and MERS-CoV were found to affect the nervous system. Given the high similarity between SARS-CoV-1 and SARS-CoV-2, effects on the nervous system by SARS-CoV-2 are a possibility. We have outlined the common neurological manifestations in COVID-19 (information are up-to-date as of June 2020) and discussed the possible pathogenetic mechanisms and management options.

Transactions of The Royal Society of Tropical Medicine and Hygiene

Coronavirus disease 2019 (COVID-19), a respiratory viral infection, has affected more than 78 mil... more Coronavirus disease 2019 (COVID-19), a respiratory viral infection, has affected more than 78 million individuals worldwide as of the end of December 2020. Previous studies reported that severe acute respiratory syndrome coronavirus 1 and Middle East respiratory syndrome–related coronavirus infections may affect the gastrointestinal (GI) system. In this review we outline the important GI manifestations of COVID-19 and discuss the possible underlying pathophysiological mechanisms and their diagnosis and management. GI manifestations are reported in 11.4–61.1% of individuals with COVID-19, with variable onset and severity. The majority of COVID-19-associated GI symptoms are mild and self-limiting and include anorexia, diarrhoea, nausea, vomiting and abdominal pain/discomfort. A minority of patients present with an acute abdomen with aetiologies such as acute pancreatitis, acute appendicitis, intestinal obstruction, bowel ischaemia, haemoperitoneum or abdominal compartment syndrome. Se...

World Journal of Pediatrics

Cytogenetic analysis is a valuable investigation in the diagnostic work up of children with suspe... more Cytogenetic analysis is a valuable investigation in the diagnostic work up of children with suspected chromosomal disorders. The objective of this study was to describe the prevalence of various types of chromosomal abnormalities in Sri Lankan children undergoing cytogenetic analysis. Cytogenetic reports of 1554 consecutive children with suspected chromosomal disorders who underwent karyotyping in two genetic centers in Sri Lanka from January 2006 to December 2011 were reviewed retrospectively. A total of 1548 children were successfully karyotyped. Abnormal karyotypes were found in 783 (50.6%) children. Numerical and structural abnormalities accounted for 90.8% and 9.2%, respectively. Down syndrome was the commonest aneuploidy identified. Other various autosomal and sex chromosomal aneuploidies as well as micro-deletion syndromes were also detected. The prevalence of chromosomal abnormalities in Sri Lankan children undergoing cytogenetic analysis for suspected chromosomal disorders ...

The journal of obstetrics and gynaecology research, 2013

Chromosomal abnormalities are implicated in the etiology of primary amenorrhea. The underlying ch... more Chromosomal abnormalities are implicated in the etiology of primary amenorrhea. The underlying chromosomal aberrations are varied and regional differences have been reported. The objective of this study is to describe the prevalence of various types of chromosomal abnormalities in Sri Lankan women with primary amenorrhea. Medical records of all patients diagnosed with primary amenorrhea referred for cytogenetic analysis to two genetic centers in Sri Lanka from January 2005 to December 2011 were reviewed. Chromosome culture and karyotyping was performed on peripheral blood samples obtained from each patient. Data were analyzed using standard descriptive statistics. Altogether 338 patients with primary amenorrhea were karyotyped and mean age at testing was 20.5 years. Numerical and structural chromosomal abnormalities were noted in 115 (34.0%) patients which included 45,X Turner syndrome (10.7%), Turner syndrome variants (13.9%), XY females (6.5%), 45,X/46,XY (0.9%), 46,XX/46,XY (0.6%...

Indian journal of endocrinology and metabolism, 2012

48,XXYY is a rare sex chromosome aneuploidy affecting 1 in 18,000 to 50,000 male births. They pre... more 48,XXYY is a rare sex chromosome aneuploidy affecting 1 in 18,000 to 50,000 male births. They present with developmental delay, hypogonadism, gynecomastia, intention tremors, and a spectrum of neurodevelopmental and psychiatric disorders. At one time this condition was considered a variant of Klinefelter syndrome. In clinically suspected cases, 48,XXYY syndrome can be diagnosed by chromosome culture and karyotyping. This patient presented with hypergonadotrophic hypogonadism, attention deficit hyperactive disorder, and renal malformatons. Klinefelter syndrome was clinically suspected. The karyotype confirmed the diagnosis of 48,XXYY syndrome. This is the first reported case of 48,XXYY syndrome from Sri Lanka.

Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals global... more Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals globally and caused over 5.3 million deaths. With an effective vaccine, disease and infection could be prevented, whereas with antivirals and monoclonal antibodies, disease progression could be mitigated. In recent months, there has been much interest in evaluating the use of oral antivirals, in those having mild disease and associated risk factors for disease progression (such as multiple comorbidities),in view of preventing severe COVID-19. Our review discusses the known properties and identified effectiveness of three oral antiviral drugs (Molnupiravir, Paxlovid and AT-527) for COVID-19 (as at end of December 2021) and explores their potential role in mitigating the ill effects of the ongoing COVID-19 pandemic.

Asian Journal of Internal Medicine, 2022

Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals global... more Coronavirus Disease-2019 (COVID-19), has so far affected more than 275 million individuals globally and caused over 5.3 million deaths. With an effective vaccine, disease and infection could be prevented, whereas with antivirals and monoclonal antibodies, disease progression could be mitigated. In recent months, there has been much interest in evaluating the use of oral antivirals, in those having mild disease and associated risk factors for disease progression (such as multiple comorbidities), in view of preventing severe COVID-19. Our review discusses the known properties and identified effectiveness of three oral antiviral drugs (Molnupiravir, Paxlovid and AT-527) for COVID-19 (as at end of December 2021) and explores their potential role in mitigating the ill effects of the on-going COVID-19 pandemic.

Gut, 2020

Figure 1 Forest plot for the pooled prevalence of liver injury in patients with COVID-19. 2-10 Ev... more Figure 1 Forest plot for the pooled prevalence of liver injury in patients with COVID-19. 2-10 Ev/ Trt, events/treated. Figure 2 Forest plot for the prognosis of patients with COVID-19 with liver injury. (A) Severity. 2 4 5 9 (B) Mortality. 6-9

1. Eirin A, Irazabal MV, Gertz MA et al. Clinical features of patients with immunoglobulin light ... more 1. Eirin A, Irazabal MV, Gertz MA et al. Clinical features of patients with immunoglobulin light chain amyloidosis (AL) with vascular-limited deposition in the kidney. Nephrol. Dial. Transplant. 2012; 27: 1097–101. 2. Murakami Y, Hattori S, Sugiyama F, Yoshikawa K, Sugiura T, Matsushima H. A case of primary (AL) amyloidosis with predominantly vascular amyloid deposition in the kidney. CEN Case Rep. 2014. doi: 10.1007/s13730-014-0157-7

COVID-19, a respiratory viral infection, has affected more than 10 million individuals worldwide.... more COVID-19, a respiratory viral infection, has affected more than 10 million individuals worldwide. Common symptoms include fever, dry cough, fatigue and shortness of breath. Some patients show neurological manifestations such as headache, dizziness, cerebrovascular disease, peripheral nerve and muscle symptoms and smell and taste impairment. In previous studies, SARS-CoV-1 and MERS-CoV were found to affect the nervous system. Given the high similarity between SARS-CoV-1 and SARS-CoV-2, effects on the nervous system by SARS-CoV-2 are a possibility. We have outlined the common neurological manifestations in COVID-19 (information are up-to-date as of June 2020) and discussed the possible pathogenetic mechanisms and management options.

Transactions of The Royal Society of Tropical Medicine and Hygiene

Coronavirus disease 2019 (COVID-19), a respiratory viral infection, has affected more than 78 mil... more Coronavirus disease 2019 (COVID-19), a respiratory viral infection, has affected more than 78 million individuals worldwide as of the end of December 2020. Previous studies reported that severe acute respiratory syndrome coronavirus 1 and Middle East respiratory syndrome–related coronavirus infections may affect the gastrointestinal (GI) system. In this review we outline the important GI manifestations of COVID-19 and discuss the possible underlying pathophysiological mechanisms and their diagnosis and management. GI manifestations are reported in 11.4–61.1% of individuals with COVID-19, with variable onset and severity. The majority of COVID-19-associated GI symptoms are mild and self-limiting and include anorexia, diarrhoea, nausea, vomiting and abdominal pain/discomfort. A minority of patients present with an acute abdomen with aetiologies such as acute pancreatitis, acute appendicitis, intestinal obstruction, bowel ischaemia, haemoperitoneum or abdominal compartment syndrome. Se...

World Journal of Pediatrics

Cytogenetic analysis is a valuable investigation in the diagnostic work up of children with suspe... more Cytogenetic analysis is a valuable investigation in the diagnostic work up of children with suspected chromosomal disorders. The objective of this study was to describe the prevalence of various types of chromosomal abnormalities in Sri Lankan children undergoing cytogenetic analysis. Cytogenetic reports of 1554 consecutive children with suspected chromosomal disorders who underwent karyotyping in two genetic centers in Sri Lanka from January 2006 to December 2011 were reviewed retrospectively. A total of 1548 children were successfully karyotyped. Abnormal karyotypes were found in 783 (50.6%) children. Numerical and structural abnormalities accounted for 90.8% and 9.2%, respectively. Down syndrome was the commonest aneuploidy identified. Other various autosomal and sex chromosomal aneuploidies as well as micro-deletion syndromes were also detected. The prevalence of chromosomal abnormalities in Sri Lankan children undergoing cytogenetic analysis for suspected chromosomal disorders ...

The journal of obstetrics and gynaecology research, 2013

Chromosomal abnormalities are implicated in the etiology of primary amenorrhea. The underlying ch... more Chromosomal abnormalities are implicated in the etiology of primary amenorrhea. The underlying chromosomal aberrations are varied and regional differences have been reported. The objective of this study is to describe the prevalence of various types of chromosomal abnormalities in Sri Lankan women with primary amenorrhea. Medical records of all patients diagnosed with primary amenorrhea referred for cytogenetic analysis to two genetic centers in Sri Lanka from January 2005 to December 2011 were reviewed. Chromosome culture and karyotyping was performed on peripheral blood samples obtained from each patient. Data were analyzed using standard descriptive statistics. Altogether 338 patients with primary amenorrhea were karyotyped and mean age at testing was 20.5 years. Numerical and structural chromosomal abnormalities were noted in 115 (34.0%) patients which included 45,X Turner syndrome (10.7%), Turner syndrome variants (13.9%), XY females (6.5%), 45,X/46,XY (0.9%), 46,XX/46,XY (0.6%...

Indian journal of endocrinology and metabolism, 2012

48,XXYY is a rare sex chromosome aneuploidy affecting 1 in 18,000 to 50,000 male births. They pre... more 48,XXYY is a rare sex chromosome aneuploidy affecting 1 in 18,000 to 50,000 male births. They present with developmental delay, hypogonadism, gynecomastia, intention tremors, and a spectrum of neurodevelopmental and psychiatric disorders. At one time this condition was considered a variant of Klinefelter syndrome. In clinically suspected cases, 48,XXYY syndrome can be diagnosed by chromosome culture and karyotyping. This patient presented with hypergonadotrophic hypogonadism, attention deficit hyperactive disorder, and renal malformatons. Klinefelter syndrome was clinically suspected. The karyotype confirmed the diagnosis of 48,XXYY syndrome. This is the first reported case of 48,XXYY syndrome from Sri Lanka.